The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
RNA catalysis and the origins of life
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gilbert, W. (1986) · Nature · doi:10.1038/319618a0 · Cited by 2,721
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
Evolution of the genetic apparatus
Orgel, L. E. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90393-8 · Cited by 996
Self-citationPrebiotic chemistry and nucleic acid replication
Orgel, L. E., & Lohrmann, R. (1974) · Accounts of Chemical Research · doi:10.1021/ar50083a002 · Cited by 247
Self-citationStudies on Some Interactions and Reactions of Oligonucleotides in Aqueous Solution*
Naylor, R., & Gilham, P. T. (1966) · Biochemistry · doi:10.1021/bi00872a032 · Cited by 238
Non-enzymatic template-directed synthesis on RNA random copolymers
Joyce, G. F., Inoue, T., & Orgel, L. E. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90425-x · Cited by 178
Self-citationTemplate-directed synthesis on the pentanucleotide CpCpGpCpC
Inoue, T., Joyce, G. F., Grzeskowiak, K., Orgel, L. E., Brown, J. M., & Reese, C. B. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90244-4 · Cited by 80
Self-citationHeteropolynucleotides as templates for non-enzymatic polymerizations
Ninio, J., & Orgel, L. E. (1978) · Journal of Molecular Evolution · doi:10.1007/bf01733260 · Cited by 48
Self-citation
Cited by
Isolation of New Ribozymes from a Large Pool of Random Sequences
Bartel, D. P., & Szostak, J. W. (1993) · Science · doi:10.1126/science.7690155 · Cited by 900
RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension.
Johnston, W. K., Unrau, P. J., Lawrence, M. S., Glasner, M. E., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1060786 · Cited by 768
The origin and amplification of biomolecular chirality
Bonner, W. A. (1991) · Origins of life and evolution of the biosphere · doi:10.1007/bf01809580 · Cited by 557
Modern metabolism as a palimpsest of the RNA world
Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7054 · Cited by 478
The first living systems: a bioenergetic perspective
Deamer, D. W. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.2.239-261.1997 · Cited by 305
Prebiotic Ribose Synthesis: A Critical Analysis
Shapiro, R. (1988) · Origins of life and evolution of the biosphere · doi:10.1007/bf01808782 · Cited by 276
Poole, A. M., Jeffares, D. C., & Penny, D. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006275 · Cited by 274
Ferris, J. P., & Ertem, G. (1992) · Science · doi:10.1126/science.1529338 · Cited by 259
RNA-catalysed RNA polymerization using nucleoside triphosphates
Ekland, E. H., & Bartel, D. P. (1996) · Nature · doi:10.1038/382373a0 · Cited by 250
Müller, D., Pitsch, S., Kittaka, A., Wagner, E., Wintner, C. E., Eschenmoser, A., & Ohlofjgewidmet, G. (1990) · Helvetica Chimica Acta · doi:10.1002/hlca.19900730526 · Cited by 216
TRANSITION METAL SULFIDES AND THE ORIGINS OF METABOLISM
Cody, G. D. (2004) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.32.101802.120225 · Cited by 174
Rohatgi, R., Bartel, D. P., & Szostak, J. W. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9537134 · Cited by 134
Smith, J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3370 · Cited by 123
RNA oligomerization in laboratory analogues of alkaline hydrothermal vent systems
Burcar, B. T., Barge, L. M., Trail, D., Watson, E. B., Russell, M. J., & McGown, L. B. (2015) · Astrobiology · doi:10.1089/ast.2014.1280 · Cited by 68
New ligase-derived RNA polymerase ribozymes
LAWRENCE, M. S., & BARTEL, D. P. (2005) · RNA · doi:10.1261/rna.2110905 · Cited by 68
Processivity of Ribozyme-Catalyzed RNA Polymerization
Lawrence, M. S., & Bartel, D. P. (2003) · Biochemistry · doi:10.1021/bi034228l · Cited by 62
Kawamura, K., & Ferris, J. P. (1999) · Origins of life and evolution of the biosphere · doi:10.1023/a:1006648524187 · Cited by 61
On the applicability of Darwinian principles to chemical evolution that led to life
Perry, R. S., & Kolb, V. M. (2004) · International Journal of Astrobiology · doi:10.1017/s1473550404001892 · Cited by 24
The basic reproductive ratio of life
Manapat, M. L., Chen, I. A., & Nowak, M. A. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.12.020 · Cited by 19
The chemistry of materials for artificial Darwinian systems
Cairns-smith, A. G. (1988) · International Reviews in Physical Chemistry · doi:10.1080/01442358809353213 · Cited by 20
Metadata
- Authors
- Orgel, L. E.
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 123
- Issue
- 2
- Pages
- 127-149
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W1964272262
- Cited by
- 252
- References
- 8
- FWCI
- 13.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.