DNA double strand break repair, aging and the chromatin connection

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212 · see citing works

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1× · see citing works

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works

Evolution of the mutation rate

Lynch, M. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.05.003 · Cited by 1,138 · see citing works

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M., Wiemels, J. L., Nelson, H. H., Karagas, M. R., Padbury, J. F., Bueno, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000602 · Cited by 1,062 · see citing works

The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., & Gorbunova, V. (2011) · Science · doi:10.1126/science.1202723 · Cited by 867 · see citing works

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Satoh, A., Brace, C. S., Rensing, N., Cliften, P. F., Wozniak, D. F., Herzog, E. D., Yamada, K. A., & Imai, S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.013 · Cited by 734 · see citing works

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

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RecQ helicases: caretakers of the genome

Hickson, I. D. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1012 · Cited by 680 · see citing works

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works

Genomic instability in laminopathy-based premature aging

Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650 · see citing works

Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing

Boulton, S. J., & Jackson, S. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1819 · Cited by 641 · see citing works

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

Bollati, V., Schwartz, J. D., Wright, R. O., Litonjua, A. A., Tarantini, L., Suh, H. H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.003 · Cited by 594 · see citing works

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551 · see citing works

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 455 · cited 2× · see citing works

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435 · see citing works

The 3D genome in transcriptional regulation and pluripotency

Gorkin, D. U., Leung, D., & Ren, B. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.017 · Cited by 391 · see citing works

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

Michishita, E., McCord, R. A., Boxer, L. D., Barber, M. F., Hong, T., Gozani, O., & Chua, K. F. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9367 · Cited by 384 · see citing works

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

Toiber, D., Erdel, F., Bouazoune, K., Silberman, D. M., Zhong, L., Mulligan, P., Sebastian, C., Cosentino, C., Martinez-Pastor, B., Giacosa, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.018 · Cited by 381 · see citing works

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R. C., Vissers, C. J., Nigg, A. L., STEEG, H. V., Bootsma, D., & Hoeijmakers, J. H. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00190-4 · Cited by 380 · see citing works

Deletion of Ku86 causes early onset of senescence in mice

Vogel, H., Lim, D.-S., Karsenty, G., Finegold, M., & Hasty, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10770 · Cited by 368 · see citing works

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

Mills, K. D., Sinclair, D. A., & Guarente, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80772-2 · Cited by 334 · see citing works

Physiologic Frailty As a Sign of Accelerated Aging Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

Ness, K. K., Krull, K. R., Jones, K., Mulrooney, D. A., Armstrong, G. T., Green, D. M., Chemaitilly, W., Smith, W. A., Wilson, C. L., Sklar, C. A., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.52.2268 · Cited by 334 · see citing works

Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs

Talens, R. P., Christensen, K., Putter, H., Willemsen, G. A. H. M., Christiansen, L., Kremer, D., Suchiman, H. E. D., Slagboom, P. E., Boomsma, D. I., & Heijmans, B. T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00835.x · Cited by 326 · see citing works

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., et al. (2009) · Aging · doi:10.18632/aging.100011 · Cited by 313 · see citing works

SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

Rajamohan, S. B., Pillai, V. B., Gupta, M., Sundaresan, N. R., Birukov, K. G., Samant, S. A., Hottiger, M. O., & Gupta, M. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00121-09 · Cited by 303 · see citing works

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

Grube, K., & Bürkle, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11759 · Cited by 301 · see citing works

ATM: Genome stability, neuronal development, and cancer cross paths

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The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, L. A., Senft, J. R., & Tucker, J. D. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00015-x · Cited by 278 · see citing works

DNA end joining becomes less efficient and more error-prone during cellular senescence

Seluanov, A., Mittelman, D., Pereira-Smith, O. M., Wilson, J. H., & Gorbunova, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400726101 · Cited by 278 · see citing works

PARP1 ADP-ribosylates lysine residues of the core histone tails

Messner, S., Altmeyer, M., Zhao, H., Pozivil, A., Roschitzki, B., Gehrig, P., Rutishauser, D., Danzhi Huang, A., Caflisch, A., & Hottiger, M. O. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq463 · Cited by 264 · see citing works

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

Yang, B., Zwaans, B. M. M., Eckersdorff, M., & Lombard, D. B. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9329 · Cited by 254 · see citing works

Global heterochromatin loss

Tsurumi, A., & Li, W. X. (2012) · Epigenetics · doi:10.4161/epi.20540 · Cited by 248 · see citing works

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

Dollé, M. E. T., Giese, H., Hopkins, C. L., Martus, H., Hausdorff, J. M., & Vijg, J. (1997) · Nature Genetics · doi:10.1038/ng1297-431 · Cited by 248 · see citing works

Somatic mutations and aging: a re-evaluation

Vijg, J. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00202-x · Cited by 243 · see citing works

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

Dollé, M. E. T., Snyder, W. K., Gossen, J. A., Lohman, P. H. M., & Vijg, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8403 · Cited by 242 · see citing works

Comparative genetics of longevity and cancer: insights from long-lived rodents

Gorbunova, V. A., Seluanov, A., Zhang, Z., Gladyshev, V. N., & Vijg, J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3728 · Cited by 234 · see citing works

DNA damage and rpair with age in individual human lymphocytes

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Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

Liu, B., Ghosh, S., Yang, X., Zheng, H., Liu, X., Wang, Z., Jin, G., Zheng, B., Kennedy, B. K., Suh, Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.007 · Cited by 211 · see citing works

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

Opresko, P. L. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg034 · Cited by 187 · see citing works

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

Mao, Z., Tian, X., Van Meter, M., Ke, Z., Gorbunova, V., & Seluanov, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200583109 · Cited by 176 · see citing works

DNA methylation in aging of mice

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In vivo human somatic mutation: frequency and spectrum with age

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Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families

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Somatic mutations, genome mosaicism, cancer and aging

Vijg, J. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.04.002 · Cited by 134 · see citing works

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

Ghosh, S., Liu, B., Wang, Y., Hao, Q., & Zhou, Z. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.006 · Cited by 129 · see citing works

Shorter telomeres, accelerated ageing and increased lymphoma in DNA‐PKcs‐deficient mice

Espejel, S., Martı́n, M., Klatt, P., Martín‐Caballero, J., Flores, J. M., & Blasco, M. A. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400127 · Cited by 127 · see citing works

Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

Vaidya, A. M., Mao, Z., Tian, X., Spencer, B., Seluanov, A., & Gorbunova, V. A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004511 · Cited by 119 · see citing works

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

White, R. R., Milholland, B., de Bruin, A., Curran, S., Laberge, R.-M., van Steeg, H., Campisi, J., Maslov, A. Y., & Vijg, J. (2015) · Nature Communications · doi:10.1038/ncomms7790 · Cited by 107 · see citing works

Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells

Garm, C., Moreno‐Villanueva, M., Bürkle, A., Petersen, I., Bohr, V. A., Christensen, K., & Stevnsner, T. (2012) · Aging Cell · doi:10.1111/acel.12019 · Cited by 102 · see citing works

Mutation Frequency and Specificity With Age in Liver, Bladder and Brain of lacI Transgenic Mice

Stuart, G. R., Oda, Y., de Boer, J. G., & Glickman, B. W. (2000) · Genetics · doi:10.1093/genetics/154.3.1291 · Cited by 102 · see citing works

Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence

Ju, Y.-J., Lee, K.-H., Park, J.-E., Yi, Y.-S., Yun, M., Ham, Y. H., Kim, T., Choi, H. M., Han, G. J., Lee, J., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.81 · Cited by 86 · see citing works

DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons

Vyjayanti, V. N., & Rao, K. S. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.053 · Cited by 83 · see citing works

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

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Frequency of spontaneous chromosome aberrations in mice: effects of age

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Changes in the level and distribution of Ku proteins during cellular senescence

Seluanov, A., Danek, J., Hause, N., & Gorbunova, V. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.06.010 · Cited by 70 · see citing works

Non‐homologous DNA end joining in the mature rat brain

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Unphosphorylated STAT and heterochromatin protect genome stability

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Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction

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Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes

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Werner Syndrome

Chen, L., & Oshima, J. (2002) · BioMed Research International · doi:10.1155/s1110724302201011 · Cited by 52 · see citing works

The Werner syndrome protein at the crossroads of DNA repair and apoptosis

Comai, L., & Li, B. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.004 · Cited by 44 · see citing works

Human premature aging syndromes and genomic instability

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Through a Glass, Darkly: Reflections of Mutation From lacI Transgenic Mice

Stuart, G. R., & Glickman, B. W. (2000) · Genetics · doi:10.1093/genetics/155.3.1359 · Cited by 29 · see citing works

The Werner Syndrome Helicase-Nuclease--One Protein, Many Mysteries

Fry, M. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.13.re2 · Cited by 26 · see citing works

Maintaining Genetic Integrity in Aging: A Zero Sum Game

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[Features of carcinogenesis and aging in knockout male mice PARP-1].

Ts, P., Zabezhinskiĭ, M. A., Popovich, I. G., Semenchenko, A. V., Kovalenko, I. G., Евгеньевна, П. Т., Ml, T., & Anisimov, V. N. (2010) · PubMed · Cited by 1 · see citing works

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · see citing works

Why does COVID-19 disproportionately affect older people?

Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works

SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.043 · Cited by 353 · see citing works

Aging Atlas: a multi-omics database for aging biology

Liu, G., Bào, Y., Qu, J. T., Zhang, W., Zhāng, T., Kang, W., Yang, F., Ji, Q., Jiang, X., Ma, Y., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa894 · Cited by 325 · see citing works

Cellular and epigenetic drivers of stem cell ageing

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Do DNA Double-Strand Breaks Drive Aging?

White, R. R., & Vijg, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.004 · Cited by 232 · see citing works

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 169 · see citing works

Contributions of DNA Damage to Alzheimer’s Disease

Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117 · see citing works

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

Shiloh, Y., & Lederman, H. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.002 · Cited by 113 · see citing works

Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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Sirtuin 6: linking longevity with genome and epigenome stability

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Genomic Instability and Epigenetic Changes during Aging

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Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres

Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 91 · see citing works

Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes

Lidzbarsky, G. A., Gutman, D., Shekhidem, H. A., Sharvit, L. E., & Atzmon, G. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00104 · Cited by 80 · see citing works

Biological effects of space environmental factors: A possible interaction between space radiation and microgravity

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Shared genetic and epigenetic changes link aging and cancer

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NAD+ Deficits in Age-Related Diseases and Cancer

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Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese Women

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Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 Pandemic

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Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms

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Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

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Frailty Syndrome and Genomic Instability in Older Adults: Suitability of the Cytome Micronucleus Assay As a Diagnostic Tool

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Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging

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Comparison of several commonly used detection indicators of cell senescence

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Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan

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SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience

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Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest‐Old Population

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Dangerous Entrapment for NRF2

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Genetic Networks of Alzheimer’s Disease, Aging, and Longevity in Humans

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APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

Zhang, Q., Yang, L., Gao, H. J., Kuang, X., He, X., Chen, Y., Cheng, Y., Zhang, L., Guo, X., Zhong, Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04022-9 · Cited by 16 · see citing works

Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling Cascade

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Impact of aging on gene expression response to x-ray irradiation using mouse blood

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New Views of the DNA Repair Protein Ataxia–Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases

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Regulation of Drosophila Lifespan by bellwether Promoter Alleles

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Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect

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Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations

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Proteomics of Long‐Lived Mammals

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A Mechanistic Theory of Development-Aging Continuity in Humans and Other Mammals

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Increased double-strand breaks in aged mouse male germ cells may result from changed expression of the genes essential for homologous recombination or nonhomologous end joining repair

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Use of Micronucleus Assays to Measure DNA Damage Caused by Coal Dust and Ash

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Huntington Disease

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R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements

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Evolution, Chance, and Aging

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Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility

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Previously uncharacterized amino acid residues in histone H3 and H4 mutants with roles in DNA damage repair response and cellular aging

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Impact of Schistosoma sp., Infection on Biological, Feeding, Physiological, Histological, and Genotoxicological Aspects of Biomphalaria alexandrina and Bulinus truncatus Snails

Dokmak, H. A., Hammam, O. A., & Ibrahim, A. M. (2024) · Acta Parasitologica · doi:10.1007/s11686-023-00760-4 · Cited by 7 · see citing works

Molecular and Clinical Considerations for Anesthesia in the Aging Brain

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Genotoxic effect of caffeine in Yarrowia lipolytica cells deficient in DNA repair mechanisms

Quiñones-González, C. A., Arredondo-Mendoza, G. I., Jiménez‐Salas, Z., Larriba-Calle, G., Ruíz-Herrera, J., & Campos‐Góngora, E. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01658-4 · Cited by 6 · see citing works

The Most Severe Paradigm of Early Cardiovascular Disease: Hutchinson-Gilford Progeria. Focus on the Role of Oxidative Stress

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Genomic instability and aging

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Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia

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Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish ( Nothobranchius furzeri )Preprint

Morabito, G., Dönertaş, H. M., Sperti, L., Seidel, J., Zonouzi, A. P., Poeschla, M., & Valenzano, D. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.06.527346 · Cited by 6 · see citing works

Gene Expression, Epigenetics and Ageing

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Study of the DNA Damage in Peripheral Blood Lymphocytes Using Micronucleus Test in Residents of the Techa Riverside Villages Who Were Chronically Exposed in Utero and Postnatally

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The effect of short-term activation of AHL15 on long-term plant developmental change and transcriptome profilePreprint

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Senataxin Attenuates DNA Damage Response Activation and Suppresses Senescence

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Genomic Destabilization Triggered by Replication Stress during Senescence

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Neurodegenerative Diseases and the Aging Brain

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Study of the Individual Radiosensitivity in Humans Based on the Assessment of the Frequency of Chromosome Aberrations and Micronuclei in Peripheral Blood T Lymphocytes

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Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy

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Bioinformatics-based identification and validation of hub genes associated with aging in patients with coronary artery disease

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Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice

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DNA Damage Response Pathways in Cancer Predisposition and Metastasis

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Nutrigenomics of Aging

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R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangementsPreprint

Ellis, D., Martín, F. R., Rodríguez‐López, M., Cotobal, C., Sun, X.-M., Jeffares, D. C., Marguerat, S., Tallada, V. A., & Bähler, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/522524 · Cited by 1 · see citing works

Inflammaging: Expanding the Molecular Palette of Cellular ImmunophenotypePreprint

Иванов, Д. О., Дробинцева, А. О., Rodichkina, V. R., Mironova, E. S., Zubareva, T. S., Krylova, Y. S., Morozkina, S. N., Nasyrov, R. A., & Kvetnoy, I. M. (2024) · Preprints.org · doi:10.20944/preprints202404.0644.v1 · Cited by 1 · see citing works

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Experimental and human population studies of DNA lesions in healthy individuals

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Helicases and Their Relevance to Aging

Crouch, J. D., Banerjee, T., Awate, S., Bharti, S. K., & Brosh, R. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00072-5

Cellular Repair Processes

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Cellular Repair Processes

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Cellular Repair Processes

de Grey, A. D. N. J., & Rae, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-319-69892-2_436-2

Faculty Opinions recommendation of SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

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Changes in DNA Double-Strand Break Repair during Aging Correlate with An Increased Rate of Genomic MutationsPreprint

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Bioinformatics analysis revealed aging-related diagnostic genes and therapeutic targets in pulmonary arterial hypertensionPreprint

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Inferring Sex, Ethnicity, and Age from RNA-seq DataPreprint

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Efficiency of DNA repair mechanisms of domestic dog primary fibroblasts isolated from small and large breeds of different ages in response to double stranded breaks (DSB)

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Conserved 3D genome reorganization during DNA repair

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Additional file 1 of APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

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Aging and Reproductive Cancers: An Integrative View on Cell-Free DNA and Transposable Elements

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Microfluidic Mechanical Reactivation of Senescent Stem Cells

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The sources and potential hazards of mutagens in complex environmental matrices—Part II

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Chromatin Remodeling, DNA Damage Repair and Aging

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DNA double-strand breaks: A potential causative factor for mammalian aging?

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