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Cited by 934

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells

Touyz, Rhian M., Schiffrin, Ernesto L.·2000·Pharmacological Reviews
DOI 10.1016/s0031-6997(24)01471-6
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Abstract

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II (Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways, where intracellular targets of the phospholipase C-diacylglycerol-Ca(2+) axis were distinct from those of the tyrosine kinase- and mitogen-activated protein kinase- dependent pathways. However, these major intracellular signaling cascades do not function independently and are actively engaged in cross-talk. Downstream signals from the Ang II-bound receptors converge to elicit complex and multiple responses. The exact adapter proteins or "go-between" molecules that link the multiple intracellular pathways await clarification. Ang II induces a multitude of actions in various tissues, and the signaling events following occupancy and activation of angiotensin receptors are tightly controlled and extremely complex. Alterations of these highly regulated signaling pathways in vascular smooth cells may be pivotal in structural and functional abnormalities that underlie vascular pathological processes in cardiovascular diseases such as hypertension, atherosclerosis, and post-interventional restenosis.

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Metadata

Authors
Touyz, R. M., & Schiffrin, E. L.
Venue
Pharmacological Reviews
Publisher
Elsevier BV
Published
2000-12
Volume
52
Issue
4
Pages
639-672
ISSN
0031-6997 (ISSN-L)
DOI
10.1016/s0031-6997(24)01471-6
OpenAlex
W2166507618
Cited by
934
References
4
FWCI
24.44
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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