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Cited by 85Cancer, Stress, Anesthesia, and Immune ResponseImmune Cell Function and InteractionSleep and Wakefulness Research

Sleep-deprivation reduces NK cell number and function mediated by β-adrenergic signalling

De Lorenzo, Beatriz H.P., de Oliveira Marchioro, Laís, Greco, Carollina Ribeiro, Suchecki, Deborah·2015·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2015.04.006
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Abstract

Reduction of sleep time triggers a stress response, leading to augmented levels of glucocorticoids and adrenaline. These hormones regulate components of the innate immune system such as natural killer (NK) and NKT cells. In the present study, we sought to investigate whether and how stress hormones could alter the population and function of NK and NKT cells of mice submitted to different lengths of paradoxical sleep deprivation (PSD, from 24 to 72 h). Results showed that 72h of PSD decreased not only NK and NKT cell counts, but also their cytotoxic activity against B16F10 melanoma cells in vitro. Propranolol treatment during PSD reversed these effects, indicating a major inhibitory role of beta-adrenergic receptors (β-AR) on NK cells function. Moreover, both corticosterone plasma levels and expression of beta 2-adrenergic receptors (β2-AR) in NK cells increased by 48 h of PSD. In vitro incubation of NK cells with dexamethasone augmented the level of β2-AR in the cell surface, suggesting that glucocorticoids could induce β2-AR expression. In summary, we propose that reduction of NK and NKT cell number and cytotoxic activity appears to be mediated by glucocorticoids-induced increased expression of β2-AR in these cells.

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  • Sleep disturbances can increase allergic reactions and worsen tumor-related immune responses.

    “For instance, sleep disturbances can increase allergic reactions and worsen tumor-related immune responses (138, 226, 289, 404), which indicates that patients with these diseases could profit from sleep improvements.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [138]

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Authors
De Lorenzo, B. H. P., de Oliveira Marchioro, L., Greco, C. R., & Suchecki, D.
Affiliations
Universidade Federal de São Paulo (BR)
ORCID
Suchecki, Deborah
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2015-07
Volume
57
Pages
134-143
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2015.04.006
OpenAlex
W2136198578
Cited by
85
References
90
Citations by year
2026: 10 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 3 · 2016: 2
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep deprivation, REM sleep deprivation, natural killer cells, NKT cells, beta-adrenergic receptors, beta2-adrenergic receptor, glucocorticoids, corticosterone, propranolol, dexamethasone, stress response, NK cell cytotoxicity, melanoma, innate immunity
MeSH terms
Animals, Disease Models, Animal, Killer Cells, Natural, Male, Melanoma, Experimental, Mice, Inbred C57BL, Receptors, Adrenergic, beta, Sleep Deprivation, Stress, Physiological, Mice, Natural Killer T-Cells

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