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Cell-cycle responses to DNA damage in G2

Cuddihy, Andrew R., O'Connell, Matthew J.·2003·International Review of Cytology
DOI 10.1016/s0074-7696(02)22013-6
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Abstract

Cellular reproduction, at its basic level, is simply the passing of genetic information from a single parent cell into two daughter cells. As the cellular genome encodes all the information that defines a cell, it is crucial that the genome be accurately replicated. Furthermore, the duplicated genome must be properly segregated so that each daughter cell contains the exact same information as the parent cell. The processes by which this occurs is known as the cell cycle. The failure of either duplication or segregation of the genome can have disastrous consequences for an organism, including cancer and death. This article discusses what is known about checkpoints, the surveillance mechanisms that monitor both the fidelity and accuracy of DNA replication and segregation. Specifically, we will focus on the G2 checkpoint that is responsible for ensuring proper segregation of the duplicated genome into the daughter cells and how this checkpoint functions to arrest entry into mitosis in response to DNA damage.

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Research works printed but not linked: 228

  1. Abraham, 2001, Cell cycle checkpoint signaling through the ATM and ATR kinases, Genes Dev., 15, 2177, 10.1101/gad.914401 · DOI · Paper page
  2. Ahn, 2000, Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation, Cancer Res., 60, 5934
  3. Alfa, 1989, Fission yeast cyclin: Subcellular localisation and cell cycle regulation, J. Cell Sci. Suppl., 12, 9, 10.1242/jcs.1989.Supplement_12.2 · DOI
  4. Alfa, 1990, Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast, Nature, 347, 680, 10.1038/347680a0 · DOI
  5. Al-Khodairy, 1992, DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe, EMBO J., 11, 1343, 10.1002/j.1460-2075.1992.tb05179.x · DOI
  6. Al-Khodairy, 1994, Identification and characterisation of new elements involved in checkpoint and feedback controls in fission yeast, Mol. Biol. Cell, 5, 147, 10.1091/mbc.5.2.147 · DOI
  7. Allen, 1994, The SADI/Rad53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast, Genes Dev., 8, 2416, 10.1101/gad.8.20.2401 · DOI
  8. Bailly, 1992, Cytoplasmic accumulation of cyclin B1 in human cells: Association with a detergent-resistant compartment and with the centrosome, J. Cell Sci., 101, 529, 10.1242/jcs.101.3.529 · DOI
  9. Ball, 2001, The structural maintenance of chromosomes (SMC) family of proteins in mammals, Chromosome Res., 9, 85, 10.1023/A:1009287518015 · DOI
  10. Banin, 1988, Enhanced phosphorylation of p53 by ATM in response to DNA damage, Science, 281, 1674, 10.1126/science.281.5383.1674 · DOI · Paper page
  11. Bao, 2001, ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses, Nature, 411, 969, 10.1038/35082110 · DOI
  12. Barbet, 1993, Fission yeast weel protein kinase is not required for DNA damage-dependent mitotic arrest, Nature, 364, 824, 10.1038/364824a0 · DOI
  13. Bartek, 2001, Mammalian G1- and S-phase checkpoints in response to DNA damage, Curr. Opin. Cell Biol., 13, 738, 10.1016/S0955-0674(00)00280-5 · DOI
  14. Bartek, 2001, Pathways governing GUS transition and their response to DNA damage, FEBS Lett., 490, 117, 10.1016/S0014-5793(01)02114-7 · DOI
  15. Bartkova, 1997, Aberrations of the Gl- and G1/S-regulating genes in human cancer, Prog. Cell Cycle Res., 3, 211, 10.1007/978-1-4615-5371-7_16 · DOI
  16. Beach, 1982, Functionally homologous cell cycle control genes in budding and fission yeast, Nature, 300, 706, 10.1038/300706a0 · DOI
  17. Bentley, 1996, The Schizosaccharomyces pombe rad3 checkpoint gene, EMBO J., 15, 6641, 10.1002/j.1460-2075.1996.tb01054.x · DOI
  18. Blasina, 1999, A human homologue of the checkpoint kinase Cds 1 directly inhibits Cdc25 phosphatase, Curr Biol., 9, 1, 10.1016/S0960-9822(99)80041-4 · DOI
  19. Boddy, 1999, DNA replication checkpoint control, Front. Biosci., 4, D841, 10.2741/Boddy · DOI
  20. Boddy, 1998, Replication checkpoint enforced by kinases Cds1 and Chk1, Science, 280, 909, 10.1126/science.280.5365.909 · DOI · Paper page
  21. Brondello, 1999, Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases, Mol. Cell. Biol., 19, 4262, 10.1128/MCB.19.6.4262 · DOI
  22. Burtelow, 2000, Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage, J. Biol. Chem., 275, 26343, 10.1074/jbc.M001244200 · DOI
  23. Burtelow, 2001, Reconstitution and molecular analysis of the hRad9-hHusI-hRad1 (9-1-1) DNA damage responsive checkpoint complex, J. Biol. Chem., 276, 25903, 10.1074/jbc.M102946200 · DOI
  24. Busby, 2000, The radiosensitizing agent 7-hydroxystaurosporine (UCN-O1) inhibits the DNA damage checkpoint kinase hChk 1, Cancer Res., 60, 2108
  25. Callebaut, 1997, From BRCAI to RAPT: A widespread BRCT module closely associated with DNA repair, FEBS Lett., 400, 25, 10.1016/S0014-5793(96)01312-9 · DOI
  26. Canman, 1998, Activation of the ATM kinase by ionizing radiation and phosphorylation of p53, Science, 281, 1677, 10.1126/science.281.5383.1677 · DOI · Paper page
  27. Caspari, 2000, Characterisation of Schizosaccharomyces pombe Husl: A PCNA related protein that associates with Radl and Rad9, Mol. Cell. Biol., 20, 1254, 10.1128/MCB.20.4.1254-1262.2000 · DOI
  28. Chan, 2000, Cooperative effects of genes controlling the G(2)/M checkpoint, Genes Dev., 14, 1584, 10.1101/gad.14.13.1584 · DOI
  29. Chang, 1993, Finishing the cell cycle: Control of mitosis and cytokinesis in fission yeast, Trends Genet., 9, 333, 10.1016/0168-9525(93)90022-A · DOI
  30. Chen, 1999, Association of Chk 1 with 14-3-3 proteins is stimulated by DNA damage, Genes Dev., 13, 675, 10.1101/gad.13.6.675 · DOI
  31. Chen, 2001, ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation, J. Biol. Chem., 276, 16580, 10.1074/jbc.M008871200 · DOI
  32. Chen, 2001, Absence of apparent phenotype in mice lacking cdc25c protein phosphatase, Mol. Cell. Biol., 21, 3853, 10.1128/MCB.21.12.3853-3861.2001 · DOI
  33. Chen, 1999, Emerging roles of BRCAI in transcriptional regulation and DNA repair, J. Cell. Physiol., 181, 385, 10.1002/(SICI)1097-4652(199912)181:3<385::AID-JCP2>3.0.CO;2-4 · DOI
  34. Cliby, 1998, Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints, EMBO J., 17, 159, 10.1093/emboj/17.1.159 · DOI
  35. Clute, 1999, Temporal and spatial control of cyclin B 1 destruction in metaphase, Nat. Cell Biol., 1, 82, 10.1038/10049 · DOI
  36. Creanor, 1996, The kinetics of the B cyclin p56cdcl3 and the phosphatase p80cdc25 during the cell cycle of the fission yeast Schizosaccharomyces pombe, J. Cell Sci., 109, 1647, 10.1242/jcs.109.6.1647 · DOI
  37. Cressman, 1999, Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice, Mol. Cell. Biol., 19, 7061, 10.1128/MCB.19.10.7061 · DOI
  38. Cullmann, 1995, Characterization of the five replication factor C genes of Saccharomyces cerevisiae, Mol. Cell. Biol., 15, 4661, 10.1128/MCB.15.9.4661 · DOI
  39. Curman, 2001, Inhibition of the G2 DNA damage checkpoint and of protein kinases Chkl and Chk2 by the marine sponge alkaloid debromohymenialdisine, J. Biol. Chem., 276, 17914, 10.1074/jbc.M100728200 · DOI
  40. Dahlen, 1998, Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe, Mol Biol. Cell, 9, 611, 10.1091/mbc.9.3.611 · DOI
  41. Dalal, 1999, Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site, Mol. Cell. Biol., 19, 4465, 10.1128/MCB.19.6.4465 · DOI
  42. Davezac, 2000, Regulation of CDC25B phosphatases subcellular localization, Oncogene, 19, 2179, 10.1038/sj.onc.1203545 · DOI
  43. De Souza, 1999, Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans, Mol. Biol. Cell, 10, 3661, 10.1091/mbc.10.11.3661 · DOI
  44. Ducommun, 1990, Fission yeast cdc25 is a cell-cycle regulated protein, Biochem. Biophys. Res. Commun., 167, 301, 10.1016/0006-291X(90)91765-K · DOI
  45. Ducommun, 1991, cdc2 phosphorylation is required for its interaction with cyclin, EMBO J., 10, 3311, 10.1002/j.1460-2075.1991.tb04895.x · DOI
  46. Dunphy, 1991, The cdc25 protein contains an intrinsic phosphatase activity, Cell, 67, 189, 10.1016/0092-8674(91)90582-J · DOI
  47. D'Urso, 1995, DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast, J. Cell Sci., 108, 3109, 10.1242/jcs.108.9.3109 · DOI
  48. Edwards, 1999, A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins, Nat. Cell Biol., 1, 393, 10.1038/15623 · DOI
  49. El-Deity, 1993, WAFT, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016/0092-8674(93)90500-P · DOI · Paper page
  50. Evan, 2001, Proliferation, cell cycle and apoptosis in cancer, Nature, 411, 342, 10.1038/35077213 · DOI
  51. Evans, 1983, Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division, Cell, 33, 389, 10.1016/0092-8674(83)90420-8 · DOI
  52. Fanes, 1977, Control of cell size and cycle time in Schizosaccharomyces pombe, J. Cell Sci., 24, 51, 10.1242/jcs.24.1.51 · DOI
  53. Ferrell, 1999, Xenopus oocyte maturation: New lessons from a good egg, Bioessays, 21, 833, 10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P · DOI
  54. Fletcher, 2002, Abolishment of the Tyr-15 inhibitory phosphorylation site on cdc2 reduces the radiation-induced G(2) delay, revealing a potential checkpoint in early mitosis, Cancer Res., 62, 241
  55. Fogarty, 1994, The Drosophila maternal-effect mutation grapes causes a metaphase arrest at nuclear cycle 13, Development, 120, 2131, 10.1242/dev.120.8.2131 · DOI
  56. Fogarty, 1997, The Drosophila grapes gene is related to checkpoint gene chkl/rad27 and is required for late syncytial division fidelity, Curr. Biol., 7, 418, 10.1016/S0960-9822(06)00189-8 · DOI
  57. Frankish, 2001, BRCA1 has a pivotal role in repairing DNA, Lancet, 357, 1678, 10.1016/S0140-6736(00)04864-9 · DOI
  58. Furnari, 1997, Cdc25 mitotic inducer targeted by chkl DNA damage checkpoint kinase, Science, 277, 1495, 10.1126/science.277.5331.1495 · DOI
  59. Gabrielli, 1996, Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells, J. Cell Sci., 109, 1081, 10.1242/jcs.109.5.1081 · DOI
  60. Galaktionov, 1991, Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins, Cell, 67, 1181, 10.1016/0092-8674(91)90294-9 · DOI
  61. Gallant, 1992, Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells, J. Cell Biol., 117, 213, 10.1083/jcb.117.1.213 · DOI
  62. Gardner, 2000, The spindle checkpoint: Two transitions, two pathways, Trends Cell Biol., 10, 154, 10.1016/S0962-8924(00)01727-X · DOI
  63. Gatei, 2000, Role for ATM in DNA damage-induced phosphorylation of BRCAI, Cancer Res., 60, 3299
  64. Gautier, 1991, cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2, Cell, 67, 197, 10.1016/0092-8674(91)90583-K · DOI
  65. Gilbert, 2001, Budding yeast Rad9 is an ATP-dependent Rad53 activating machine, Mol. Cell, 8, 129, 10.1016/S1097-2765(01)00267-2 · DOI · Paper page
  66. Girard, 1991, Cyclin-A is required for the onset of DNA-replication in mammalian fibroblasts, Cell, 67, 1169, 10.1016/0092-8674(91)90293-8 · DOI
  67. Gottlieb, 1996, p53 in growth control and neoplasia, Biochim. Biophys. Acta, 1287, 77
  68. Gould, 1989, Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis, Nature, 342, 39, 10.1038/342039a0 · DOI
  69. Gould, 1990, Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase, Science, 250, 1573, 10.1126/science.1703321 · DOI
  70. Gould, 1991, Phosphorylation at Thr 167 is required for fission yeast p34cdc2 function, EMBO J., 10, 3297, 10.1002/j.1460-2075.1991.tb04894.x · DOI
  71. Graves, 2000, The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01, J. Biol. Chem., 275, 5600, 10.1074/jbc.275.8.5600 · DOI
  72. Graves, 2001, Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding, Oncogene, 20, 1839, 10.1038/sj.onc.1204259 · DOI
  73. Greenwell, 1995, TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene, Cell, 82, 823, 10.1016/0092-8674(95)90479-4 · DOI
  74. Guo, 2000, Requirement for Art in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV damaged DNA in Xenopus egg extracts, Genes Dev., 14, 2745, 10.1101/gad.842500 · DOI · Paper page
  75. Hagting, 1998, MPF localization is controlled by nuclear export, EMBO J, 17, 4127, 10.1093/emboj/17.14.4127 · DOI
  76. Harper, 1993, The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases, Cell, 75, 805, 10.1016/0092-8674(93)90499-G · DOI · Paper page
  77. Hartwell, 1992, Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells, Cell, 71, 543, 10.1016/0092-8674(92)90586-2 · DOI
  78. Harvey, 2002, Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases, Genome Biol., 3, 3003, 10.1186/gb-2002-3-2-reviews3003 · DOI
  79. Hawley, 1996, Strange bedfellows in even stranger places: The role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53, Genes Dev., 10, 2383, 10.1101/gad.10.19.2383 · DOI
  80. Heald, 1993, Human weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase, Cell, 74, 463, 10.1016/0092-8674(93)80048-J · DOI
  81. Hebert, 1994, Candidate tumor-suppressor genes MTS 1 (pl6lNK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T but not from B-cell lineage acute lymphoblastic leukemias, Blood, 84, 4038, 10.1182/blood.V84.12.4038.bloodjournal84124038 · DOI
  82. Hermeking, 1997, 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression, Mol. Cell, 1, 3, 10.1016/S1097-2765(00)80002-7 · DOI · Paper page
  83. Hirao, 2000, DNA damage-induced activation of p53 by the checkpoint kinase Chk2, Science, 287, 1824, 10.1126/science.287.5459.1824 · DOI
  84. Hofmann, 1994, cdt1 is an essential target of the Cdcl0/Sctl transcription factor: Requirement for DNA replication and inhibition of mitosis, EMBO, 13, 425, 10.1002/j.1460-2075.1994.tb06277.x · DOI
  85. Honda, 1997, 14-3-3 ζ protein binds to the caboxyl half of mouse wee1 kinase, Biochem. Biophys. Res. Commun., 230, 262, 10.1006/bbrc.1996.5933 · DOI
  86. Hunter, 1995, When is a lipid kinase not a lipid kinase? When it is a protein kinase, Cell, 83, 1, 10.1016/0092-8674(95)90225-2 · DOI
  87. Hwang, 1998, Radiation and the G2 phase of the cell cycle, Radiat. Res., 150, S52, 10.2307/3579808 · DOI
  88. Jackson, 2000, An indolocarbazole inhibitor of human chkl abrogates cell cycle arrest caused by DNA damage, Cancer Res., 60, 566
  89. Jeffrey, 1995, Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex, Nature, 376, 313, 10.1038/376313a0 · DOI
  90. Jin, 1996, Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells, J. Cell Biol., 134, 963, 10.1083/jcb.134.4.963 · DOI
  91. Kai, 2001, Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures, Mol. Cell. Biol., 21, 3289, 10.1128/MCB.21.10.3289-3301.2001 · DOI
  92. Karlsson, 1999, Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis, J. Cell Biol., 146, 573, 10.1083/jcb.146.3.573 · DOI
  93. Kaur, 2001, Structure-function analysis of fission yeast husl-rad1-rad9 checkpoint complex, Mol. Biol. Cell, 12, 3744, 10.1091/mbc.12.12.3744 · DOI
  94. Kawakami, 1996, UCN-01, 7-hydroxylstaurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line, Biochem. Biophys. Res. Commun., 219, 778, 10.1006/bbrc.1996.0310 · DOI · Paper page
  95. Khanna, 2001, DNA double-strand breaks: Signaling, repair and the cancer connection, Nat. Genet., 27, 247, 10.1038/85798 · DOI · Paper page
  96. Kim, 2001, Rfc4 interacts with Rpal and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae, Mol. Cell. Biol., 21, 3725, 10.1128/MCB.21.11.3725-3737.2001 · DOI
  97. Ko, 1996, p53: Puzzle and paradigm, Genes Dev., 10, 1054, 10.1101/gad.10.9.1054 · DOI
  98. Koniaras, 2001, Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitises p53 mutant human cells, Oncogene, 20, 7453, 10.1038/sj.onc.1204942 · DOI
  99. Kostrub, 1998, Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad l p and is phosphorylated in response to DNA damage, EMBO J., 17, 2055, 10.1093/emboj/17.7.2055 · DOI
  100. Krause, 2001, Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants, Mol. Cell. Biol., 21, 5156, 10.1128/MCB.21.15.5156-5168.2001 · DOI
  101. Krek, 1991, Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites, EMBO J., 10, 305, 10.1002/j.1460-2075.1991.tb07951.x · DOI
  102. Kumagai, 1991, The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system, Cell, 64, 903, 10.1016/0092-8674(91)90315-P · DOI
  103. Kumagai, 1999, Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25, Genes Dev., 13, 1067, 10.1101/gad.13.9.1067 · DOI
  104. Kumagai, 2000, Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts, Mol. Cell, 6, 839, 10.1016/S1097-2765(05)00092-4 · DOI · Paper page
  105. Kumagai, 1998, The Xenopus chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts, J. Cell Biol., 142, 1559, 10.1083/jcb.142.6.1559 · DOI
  106. Lammer, 1998, The cdc25B phosphatase is essential for the G2/M phase transition in human cells, J. Cell Sci., 111, 2445, 10.1242/jcs.111.16.2445 · DOI
  107. Larson, 1997, A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells, Cancer Res., 57, 3351
  108. Lee, 2001, Positive regulation of Weel by Chkl and 14-3-3 proteins, Mol. Biol. Cell, 12, 551, 10.1091/mbc.12.3.551 · DOI
  109. Lehmann, 1995, The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair, Mol. Cell. Biol., 15, 7067, 10.1128/MCB.15.12.7067 · DOI
  110. Leu, 1999, The pachytene checkpoint in S. cerevisiae depends on Swelmediated phosphorylation of the cyclin-dependent kinase Cdc28, Mol. Cell, 4, 805, 10.1016/S1097-2765(00)80390-1 · DOI
  111. Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
  112. Li, 2002, Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor, Radiat. Res., 157, 322, 10.1667/0033-7587(2002)157[0322:WTTIGP]2.0.CO;2 · DOI
  113. Lim, 2000, ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway, Nature, 404, 613, 10.1038/35007091 · DOI · Paper page
  114. Lindsay, 1998, S-phase-specific activation of CdsI kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe, Genes Dev., 12, 382, 10.1101/gad.12.3.382 · DOI
  115. Liu, 1997, The human MytI kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex, Mol. Cell. Biol., 17, 571, 10.1128/MCB.17.2.571 · DOI
  116. Liu, 2000, Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint, Genes Dev., 14, 1448, 10.1101/gad.14.12.1448 · DOI · Paper page
  117. Lopez-Girona, 1999, Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein, Nature, 397, 172, 10.1038/16488 · DOI
  118. Lopez-Girona, 2001, Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast, Curr Biol., 11, 50, 10.1016/S0960-9822(00)00026-9 · DOI
  119. Lundgren, 1991, mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2, Cell, 64, 1111, 10.1016/0092-8674(91)90266-2 · DOI
  120. Martinho, 1998, Analysis of Rad3 and Chkl protein kinases defines different checkpoint responses, EMBO J., 17, 7239, 10.1093/emboj/17.24.7239 · DOI
  121. Matsuura, 1999, Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tell(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+), Genetics, 152, 1501, 10.1093/genetics/152.4.1501 · DOI
  122. McDonald, 2001, Checkpoint genes in cancer, Ann. Med., 33, 113, 10.3109/07853890109002066 · DOI
  123. McFarlane, 1997, Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: Dissection of DNA replication and G2 checkpoint control function, Mol. Gen. Genet., 255, 332, 10.1007/s004380050504 · DOI
  124. McGowan, 1993, Human weel kinase inhibits cell-division by phosphorylating p34(cdc2) exclusively on tyr15, EMBO, 12, 75, 10.1002/j.1460-2075.1993.tb05633.x · DOI
  125. Meijer, 1991, Cyclin B targets p34cdc2 for tyrosine phosphorylation, EMBO, 10, 1545, 10.1002/j.1460-2075.1991.tb07674.x · DOI
  126. Melchionna, 2000, Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1, Nat. Cell Biol., 2, 762, 10.1038/35036406 · DOI
  127. Melo, 2001, Two checkpoint complexes are independently recruited to sites of DNA damage in vivo, Genes Dev., 15, 2809, 10.1101/gad.903501 · DOI · Paper page
  128. Michael, 1998, Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1, Science, 282, 1886, 10.1126/science.282.5395.1886 · DOI
  129. Millar, 1991, p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast, EMBO J., 10, 4301, 10.1002/j.1460-2075.1991.tb05008.x · DOI
  130. Moreno, 1990, Substrates for p34cdc2: In vivo veritas?, Cell, 61, 549, 10.1016/0092-8674(90)90463-O · DOI
  131. Moreno, 1990, Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast, Nature, 344, 549, 10.1038/344549a0 · DOI
  132. Mossi, 1998, Clamping down on clamps and clamp loaders-the eukaryotic replication factor C, Eur. J. Biochem., 254, 209, 10.1046/j.1432-1327.1998.254209.x · DOI
  133. Murakami, 1995, A kinase from fission yeast responsible for blocking mitosis in S phase, Nature, 374, 817, 10.1038/374817a0 · DOI
  134. Nagata, 1991, An additional homolog of the fission yeast Cdc25+ gene occurs in humans and is highly expressed in some cancer cells, New Biol., 3, 959
  135. Naiki, 2000, Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae, Mol. Cell. Biol., 20, 5888, 10.1128/MCB.20.16.5888-5896.2000 · DOI
  136. Nasmyth, 1993, Control of the yeast cell cycle by the Cdc28 protein kinase, Curr. Biol., 5, 166, 10.1016/0955-0674(93)90099-C · DOI
  137. Nasmyth, 2001, A prize for proliferation, Cell, 107, 689, 10.1016/S0092-8674(01)00604-3 · DOI
  138. Nishijima, 1997, A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea, J. Cell Biol., 138, 1105, 10.1083/jcb.138.5.1105 · DOI
  139. Norbury, 1991, Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates, EMBO J., 10, 3321, 10.1002/j.1460-2075.1991.tb04896.x · DOI
  140. Nurse, 1975, Genetic control of cell size at cell division in yeast, Nature, 256, 547, 10.1038/256547a0 · DOI
  141. Nurse, 1990, Universal control mechanism regulating onset of M-phase, Nature, 344, 503, 10.1038/344503a0 · DOI
  142. Nurse, 2000, A long twentieth century of the cell cycle and beyond, Cell, 100, 71, 10.1016/S0092-8674(00)81684-0 · DOI
  143. Nurse, 1981, Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast, Nature, 292, 558, 10.1038/292558a0 · DOI
  144. Nurse, 1980, Regulatory genes controlling mitosis in the fission yeast. Schizosaccharomyces pombe, Genetics, 96, 627, 10.1093/genetics/96.3.627 · DOI
  145. O'Connell, 1997, Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation, EMBO J., 16, 545, 10.1093/emboj/16.3.545 · DOI
  146. O'Connor, 1997, Mammalian GI and G2 phase checkpoints, Cancer Sure, 29, 151
  147. O'Farrell, 1989, Directing cell division during development, Science, 246, 635, 10.1126/science.2683080 · DOI
  148. Ohi, 1999, Regulating the onset of mitosis, Curr. Opin. Cell Biol., 11, 267, 10.1016/S0955-0674(99)80036-2 · DOI
  149. Oren, 1999, Regulation of the p53 tumor suppressor protein, J. Biol. Chem., 274, 36031, 10.1074/jbc.274.51.36031 · DOI
  150. Paciotti, 1998, Mec1p is essential for phosphory lation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p, EMBO J., 17, 4199, 10.1093/emboj/17.14.4199 · DOI
  151. Pandita, 2000, Ionizing radiation activates the ATM kinase throughout the cell cycle, Oncogene, 19, 1386, 10.1038/sj.onc.1203444 · DOI
  152. Parker, 1992, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase, Science, 257, 1955, 10.1126/science.1384126 · DOI
  153. Parker, 1991, Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner, EMBO J., 10, 1255, 10.1002/j.1460-2075.1991.tb08067.x · DOI
  154. Paulovich, 1997, When checkpoints fail, Cell, 88, 315, 10.1016/S0092-8674(00)81870-X · DOI
  155. Pearson, 2002, Surviving a knockout blow, Nature, 415, 8, 10.1038/415008a · DOI
  156. Peng, 1997, Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216, Science, 277, 1501, 10.1126/science.277.5331.1501 · DOI · Paper page
  157. Pike, 2001, Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase, J. Biol. Chem., 276, 14019, 10.1074/jbc.M009558200 · DOI
  158. Pines, 1991, Human cyclin-A and cyclin-B1 are differentially located in the cell and undergo cell-cycle dependent nuclear transport, J. Cell Biol., 115, 1, 10.1083/jcb.115.1.1 · DOI
  159. Polyak, 1994, Cloning of p27Kip1 a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals, Cell, 78, 59, 10.1016/0092-8674(94)90572-X · DOI
  160. Price, 2000, Drosophila wee1 has an essential role in the nuclear divisions of earlyy embryogenesis, Genetics, 155, 159, 10.1093/genetics/155.1.159 · DOI
  161. Prives, 1999, The p53 pathway, J. Pathol., 187, 112, 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 · DOI
  162. Raleigh, 2000, The G(2) DNA damage checkpoint targets both Wee1 and Cdc25, J. Cell Sci., 113, 1727, 10.1242/jcs.113.10.1727 · DOI
  163. Rauen, 2000, The human checkpoint protein hRad 17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9, J. Biol. Chem., 275, 29767, 10.1074/jbc.M005782200 · DOI
  164. Rhind, 2000, Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways, J. Cell Sci., 113, 3889, 10.1242/jcs.113.22.3889 · DOI
  165. Rhind, 1997, Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast, Genes Dev., 11, 504, 10.1101/gad.11.4.504 · DOI
  166. Roberge, 1998, High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide, Cancer Res., 58, 5701
  167. Rouse, 2000, LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae, EMBO J., 19, 5801, 10.1093/emboj/19.21.5801 · DOI
  168. Roy, 1991, Activation of p34cdc2 kinase by cyclin-A, J. Cell Biol., 113, 507, 10.1083/jcb.113.3.507 · DOI
  169. Russell, 1986, cdc25+ functions as an inducer in the mitotic control of fission yeast, Cell, 45, 145, 10.1016/0092-8674(86)90546-5 · DOI
  170. Saka, 1993, Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+, Cell, 74, 383, 10.1016/0092-8674(93)90428-S · DOI
  171. Saka, 1997, Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1, Genes Dev., 11, 3387, 10.1101/gad.11.24.3387 · DOI
  172. Schmidt-Kastner, 1998, Absence of p53dependent cell cycle regulation in pluripotent mouse cell lines, Oncogene, 16, 3003, 10.1038/sj.onc.1201835 · DOI
  173. Scully, 1997, Dynamic changes of BRCA1 subnuclear location and phosphorylation state are intiated by DNA damage, Cell, 90, 425, 10.1016/S0092-8674(00)80503-6 · DOI · Paper page
  174. Sheldrick, 1993, Feedback controls and G2 checkpoints: Fission yeast as a model system, Bioessays, 15, 775, 10.1002/bies.950151202 · DOI
  175. Sherr, 1995, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev., 9, 1149, 10.1101/gad.9.10.1149 · DOI
  176. Sherr, 1999, CDK inhibitors: Positive and negative regulators of G1-phase progression, Genes Dev., 13, 1501, 10.1101/gad.13.12.1501 · DOI · Paper page
  177. Shimada, 1999, Replication factor C3 of Schisosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints, Mol. Biol. Cell, 10, 3991, 10.1091/mbc.10.12.3991 · DOI
  178. Sibon, 1999, The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition, Curr. Biol., 9, 302, 10.1016/S0960-9822(99)80138-9 · DOI
  179. Sidorova, 1997, Rad53-dependent phosphorylation of Swi6 and downregulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae, Genes Dev., 11, 3032, 10.1101/gad.11.22.3032 · DOI
  180. Smits, 2001, Checking out the G(2)/M transition, Biochim. Biophys. Acta, 1519, 1, 10.1016/S0167-4781(01)00204-4 · DOI
  181. Snaith, 2000, Schizosaccharomyces pombe Hsk1p is a potential cd1p target required for genome integrity, Mol. Cell. Biol., 20, 7922, 10.1128/MCB.20.21.7922-7932.2000 · DOI
  182. Soulier, 1999, The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage, Curr. Biol., 9, 551, 10.1016/S0960-9822(99)80242-5 · DOI
  183. St. Onge, 1999, The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1, Mol. Biol. Cell, 10, 1985, 10.1091/mbc.10.6.1985 · DOI
  184. Stillman, 1994, Smart machines at the DNA replication fork, Cell, 78, 725, 10.1016/S0092-8674(94)90362-X · DOI
  185. Strausfeld, 1991, Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein, Nature, 351, 242, 10.1038/351242a0 · DOI
  186. Strunnikov, 1998, SMC proteins and chromosome structure, Trends Cell Biol., 8, 454, 10.1016/S0962-8924(98)01370-1 · DOI
  187. Sun, 1998, Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint, Science, 281, 272, 10.1126/science.281.5374.272 · DOI
  188. Swenson, 1986, The clam embryo protein cyclin A induces entry into M phase and the resumption of mitosis in Xenopus oocytes, Cell, 47, 861, 10.1016/0092-8674(86)90801-9 · DOI
  189. Takai, 2000, Aberrant cell cycle checkpoint function and early embryonic death in Chkl(-/-) mice, Genes Dev., 14, 1439, 10.1101/gad.14.12.1439 · DOI
  190. Takizawa, 2000, Control of mitosis by changes in the subcellular location of cyclin-B1-Cdkl and Cdc25C, Curr Opin. Cell Biol., 12, 658, 10.1016/S0955-0674(00)00149-6 · DOI
  191. Taylor, 2001, Regulation of the G21M transition by p53, Oncogene, 20, 1803, 10.1038/sj.onc.1204252 · DOI
  192. Thelen, 1999, A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins, Cell, 96, 769, 10.1016/S0092-8674(00)80587-5 · DOI
  193. Tibbetts, 2000, Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress, Genes Dev., 14, 2989, 10.1101/gad.851000 · DOI · Paper page
  194. Toyoshima, 1998, Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint, EMBO J., 17, 2728, 10.1093/emboj/17.10.2728 · DOI
  195. Tzivion, 2002, 14-3-3 proteins: Active cofactors in cellular regulation by swine/threonine phosphorylation, J. Biol. Chem., 277, 3061, 10.1074/jbc.R100059200 · DOI
  196. Tzivion, 2001, 14-3-3 proteins; bringing new definitions to scaffolding, Oncogene, 20, 6331, 10.1038/sj.onc.1204777 · DOI · Paper page
  197. Vahteristo, 2001, p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: Further evidence of CHK2 in inherited prediposition, Cancer Res., 61, 5718
  198. Venclovas, 2000, Structure-based predictions of Radl, Rad9, Husl and Rad17 participation in sliding clamp and clamp-loading complexes, Nucleic Acids Res., 28, 2481, 10.1093/nar/28.13.2481 · DOI
  199. Verkade, 1998, Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast, Mol. Gen. Genet., 260, 426, 10.1007/s004380050913 · DOI
  200. Verkade, 1999, Rad18 is required for DNA repair and checkpoint responses in fission yeast, Mol. Biol. Cell, 10, 2905, 10.1091/mbc.10.9.2905 · DOI

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Metadata

Authors
Cuddihy, A. R., & O'Connell, M. J.
Venue
International Review of Cytology
Publisher
Elsevier
Published
2003
Pages
99-140
ISSN
0074-7696
DOI
10.1016/s0074-7696(02)22013-6
Cited by
89
References
12
Language
en

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