GABAergic Cerebellar System In Autism: A Neuropathological And Developmental Perspective
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GABAergic dysfunction in the cerebellum in autism has been demonstrated repeatedly.
“GABAergic dysfunction in the cerebellum in autism has been demonstrated repeatedly [70, 124, 261].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [261]
The loss of Purkinje cells in ASD despite normal innervating interneurons is interpreted as a neurodevelopmental process with Purkinje cells initially normal but degenerating later, probably between 32 weeks of gestation and early postnatal life.
“The loss of Purkinje cells in subjects with ASD, despite a normal amount of innervating interneurons, was interpreted as a neurodevelopmental process with Purkinje cells present initially in normal numbers and distribution but degenerating later, probably between 32 weeks of gestation and early postnatal life [35].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [35]
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- Authors
- Blatt, G. J.
- Affiliations
- Boston University (US)
- Corresponding author
- Blatt, Gene J.
- ORCID
- Blatt, Gene J.
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2005
- Volume
- 71
- Pages
- 167-178
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W1583256392
- Cited by
- 56
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 6.90
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hussman Foundation
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD039459, HD39459-04)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, cerebellum, GABAergic system, Purkinje cells, excitation-inhibition balance, developmental cognitive neuroscience, glutamic acid decarboxylase, GABA receptors, motor coordination, stereotyped movements, autism severity
- MeSH terms
- Animals, Autistic Disorder, Cerebellum, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Humans, Purkinje Cells
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