Alcohol and the prefrontal cortex

Abernathy, Kenneth; Chandler, L. Judson; Woodward, John J.

doi:10.1016/s0074-7742(10)91009-x

Cited by 196Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Alcohol and the prefrontal cortex

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Abernathy, Kenneth, Chandler, L. Judson, Woodward, John J.·2010·International Review of Neurobiology

DOI 10.1016/s0074-7742(10)91009-xPMC PMC3593065

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Abstract

The prefrontal cortex occupies the anterior portion of the frontal lobes and is thought to be one of the most complex anatomical and functional structures of the mammalian brain. Its major role is to integrate and interpret inputs from cortical and sub-cortical structures and use this information to develop purposeful responses that reflect both present and future circumstances. This includes both action-oriented sequences involved in obtaining rewards and inhibition of behaviors that pose undue risk or harm to the individual. Given the central role in initiating and regulating these often complex cognitive and behavioral responses, it is no surprise that alcohol has profound effects on the function of the prefrontal cortex. In this chapter, we review the basic anatomy and physiology of the prefrontal cortex and discuss what is known about the actions of alcohol on the function of this brain region. This includes a review of both the human and animal literature including information on the electrophysiological and behavioral effects that follow acute and chronic exposure to alcohol. The chapter concludes with a discussion of unanswered questions and areas needing further investigation.

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Authors: Abernathy, K., Chandler, L. J., & Woodward, J. J.
Affiliations: Medical University of South Carolina (US)
ORCID: Chandler, L. Judson
Woodward, John J.
Venue: International Review of Neurobiology
Publisher: Elsevier
Published: 2010
Volume: 91
Pages: 289-320
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/s0074-7742(10)91009-x
PMC: PMC3593065
OpenAlex: W1562441344
Cited by: 196
References: 124
Citations by year: 2026: 9 · 2025: 14 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 11 · 2020: 22 · 2019: 18 · 2018: 17 · 2017: 15 · 2016: 15 · 2015: 8 · 2014: 12 · 2013: 4 · 2012: 7
FWCI: 9.81
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R37AA009986, P50AA010761, T32AA007474)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: alcohol, prefrontal cortex, frontal lobe, acute alcohol exposure, chronic ethanol exposure, electrophysiological effects, behavioral effects, cognitive function, inhibition, reward processing
MeSH terms: Alcohols, Animals, Humans, Memory, Short-Term, Neurons, Prefrontal Cortex, Neurotransmitter Agents, Executive Function

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