Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998

The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737

A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations

Weigle, D. S., Breen, P. A., Matthys, C. C., Callahan, H. S., Meeuws, K. E., Burden, V. R., & Purnell, J. Q. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.41 · Cited by 774

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

Havel, P. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00132.x · Cited by 607

The role of insulin receptor signaling in the brain

Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604

Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552

Leptin targets in the mouse brain

Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22025 · Cited by 484

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476

Insulin signaling in the central nervous system: Learning to survive

van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444

Central effects of estradiol in the regulation of food intake, body weight, and adiposity

Brown, L. M., & Clegg, D. J. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.005 · Cited by 331

Insulin and Leptin as Adiposity Signals

Benoit, S. C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.267 · Cited by 266

Sexual differences in the control of energy homeostasis

Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

Neumann, K., Rojo, L., Navarrete, L., Farias, G., Reyes, P., & Maccioni, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908919 · Cited by 236

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

Carvalheira, J. B. C., Ribeiro, E. B., Ara�jo, E. P., Guimar�es, R. B., Telles, M. M., Torsoni, M., Gontijo, J. A. R., Velloso, L. A., & Saad, M. J. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1246-x · Cited by 176

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation

Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C., & Ashford, M. L. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-54 · Cited by 173

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

Park, C. J., Zhao, Z., Glidewell-Kenney, C., Lazic, M., Chambon, P., Krust, A., Weiss, J., Clegg, D. J., Dunaif, A., Jameson, J. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41702 · Cited by 162

Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis

Rahmouni, K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.00920 · Cited by 150

Signals that influence food intake and body weight

WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.060 · Cited by 131

The role of hypothalamic estrogen receptors in metabolic regulation

Frank, A., Brown, L. M., & Clegg, D. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.002 · Cited by 128

Leptin and the Cardiovascular System

Rahmouni, K. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.225 · Cited by 110

Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus

Fekete, C., Singru, P. S., Sanchez, E., Sarkar, S., Christoffolete, M. A., Riberio, R. S., Rand, W. M., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2006) · Endocrinology · doi:10.1210/en.2005-0956 · Cited by 97

Obesity-Related Hypertension and the Role of Insulin and Leptin in High-Fat–Fed Rabbits

Lim, K., Burke, S. L., & Head, G. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00705 · Cited by 95

Adiposity Signaling and Biological Defense Against Weight Gain: Absence of Protection or Central Hormone Resistance?

Schwartz, M. W., & Niswender, K. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0906 · Cited by 93

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86

Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis

Shi, H., Strader, A. D., Sorrell, J. E., Chambers, J. B., Woods, S. C., & Seeley, R. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00704.2007 · Cited by 85

Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism

Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71

Obesity-related hypertension: Is there a role for selective leptin resistance?

Correia, M. L. G., & Haynes, W. G. (2004) · Current Hypertension Reports · doi:10.1007/s11906-004-0074-9 · Cited by 46

Leptin Deficiency Per Se Dictates Body Composition and Insulin Action in ob/ob Mice

Van Den Hoek, A. M., Teusink, B., Voshol, P. J., Havekes, L. M., Romijn, J. A., & Pijl, H. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01626.x · Cited by 34

The Brain-Gut-Islet Connection

Woods, S. C., Benoit, S. C., & Clegg, D. J. (2006) · Diabetes · doi:10.2337/db06-s015 · Cited by 30

Cardiovascular and Sympathetic Effects of Disrupting Tyrosine 985 of the Leptin Receptor

Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L., & Rahmouni, K. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.166538 · Cited by 24

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

Dornellas, A. P. S., Watanabe, R. L. H., Pimentel, G. D., Boldarine, V. T., Nascimento, C. M. O., Oyama, L. M., Ghebremeskel, K., Wang, Y., Bueno, A. A., & Ribeiro, E. B. (2015) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.003 · Cited by 18

Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis

Shaheen, N., Shaheen, A., Diab, R. A., Saad, A. M., Abdelwahab, O. A., Soliman, S., Hefnawy, M. T., Ramadan, A., Meshref, M., & Nashwan, A. J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1296764 · Cited by 7