Early-life handling stimulation and environmental enrichment

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Psychobiology of novelty seeking and drug seeking behavior

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Infantile Experience and Resistance to Physiological Stress

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Do early‐life events permanently alter behavioral and hormonal responses to stressors?

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Effects of environmental enrichment on gene expression in the brain

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Physiological and behavioral effects of infantile stimulation

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Heritable variation for aggression as a reflection of individual coping strategies

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Insensitivity of the analysis of variance to heredity-environment interaction

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Novelty-Seeking in Rats-Biobehavioral Characteristics and Possible Relationship with the Sensation-Seeking Trait in Man

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Infantile Stimulation Induces Brain Lateralization in Rats

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Enriched and impoverished environments: Effects on brain and behavior

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Effects of enriched and restricted early environments on the learning ability of bright and dull rats.

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Relations between brain chemistry and problem-solving among rats raised in enriched and impoverished environments.

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Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects

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Enriched and Impoverished Environments

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Factor Analysis Shows That Female Rat Behaviour Is Characterized Primarily by Activity, Male Rats Are Driven by Sex and Anxiety

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The effects of experimental variations on problem solving in the rat.

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Enrichment-dependent differences in novelty exploration in rats can be explained by habituation.

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Enriching heredity: the impact of the environment on the anatomy of the brain

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Inbred Roman High- and Low-Avoidance Rats

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A Further Study of Infantile Handling and Adult Avoidance Learning1

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Neonatal Handling and Environmental Enrichment Effects on Emotionality, Novelty/Reward Seeking, and Age-Related Cognitive and Hippocampal Impairments: Focus on the Roman Rat Lines

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The nature of the effect of free-environmental experience in the rat.

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The Effects of Early Shock and Handling on Later Avoidance Learning1

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Psychological stress and environmental adaptation in enriched vs. impoverished housed rats

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Environmental influences on the central nervous system and their implications for the aging rat

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Genetic and experiential manipulation of fear-related behavior in Japanese quail chicks (Coturnix coturnix japonica).

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Environmental enrichment in BALB/c mice

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The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors

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EARLY STIMULATION OF RODENTS: A CRITICAL REVIEW OF PRESENT INTERPRETATIONS

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Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro

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Environments as Therapy for Brain Dysfunction

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Environmental influence on behaviour and nerve growth factor in the brain

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Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats

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Differential rearing experience, gender, and radial maze performance

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The Role and Mechanisms of Action of Glucocorticoid Involvement in Memory Storage

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Sex differences in emotional behaviour in the rat: Correlation between open-field defecation and active avoidance

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Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment

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Genetic Selection and Differential Stress Responses: The Roman Lines/Strains of Rats

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Development and evolution of brain size : behavioral implications

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Effects of early experience on adrenocortical reactivity

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Nesting Material as Environmental Enrichment Has No Adverse Effects on Behavior and Physiology of Laboratory Mice

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Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

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Molecular Approaches to Learning and Memory

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Genetic and ontogenetic determinants of adult behavior in the rat.

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Effects of Postnatal Handling of Rats on Emotional, HPA-Axis, and Prolactin Reactivity to Novelty and Conflict

Núñez, J. F., Ferré, P., Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00225-9 · Cited by 127 · see citing works

The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: Psychopharmacological validation

Fernández‐Teruel, A., Escorihuela, R. M., Núñez, J. F., Zapata, A., Boix, F., Salazar, W., & Tobeña, A. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90205-x · Cited by 126 · see citing works

Early childhood : the development of self-regulatory mechanisms

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Effects of fear conditioning on subsequent avoidance behavior and movement.

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EFFECTS OF HANDLING IN INFANCY UPON ADULT BEHAVIOR AND ADRENOCORTICAL ACTIVITY: SUGGESTIONS FOR A NEUROENDOCRINE MECHANISM

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Brief exposure to an enriched environment improves performance on the Morris water task and increases hippocampal cytosolic protein kinase C activity in young rats

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Effects of environmental complexity and social groupings upon modification of emotional behavior.

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Object interactions in juvenile rats (Rattus norvegicus): Effects of different experiential histories.

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Infantile Experience and the Maturation of the Pituitary Adrenal Axis

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Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional (Roman high-avoidance) and hyperemotional (Roman low-avoidance) rats.Preprint

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Early stimulation effects on novelty-induced behavior in two psychogenetically-selected rat lines with divergent emotionality profiles

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Early handling increases hippocampal long-term potentiation in young rats

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Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain

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Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats

Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90157-0 · Cited by 94 · see citing works

Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor

Pham, T. M., Söderström, S., Henriksson, B. G., & Mohammed, A. H. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02252-8 · Cited by 86 · see citing works

Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats

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Effects of early experiences on emotional and physiological reactivity in the rat.

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Crucial periods for free-environmental experience in the rat.

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Influence of environmental enrichment and sex on predator stress response in rats

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Effects of early protein malnutrition and environmental stimulation upon the reactivity to diazepam in two animal models of anxiety

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Infantile (handling) stimulation and behavior in young Roman high- and low-avoidance rats

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Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: Toward overcoming a genetic deficit

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Effects of environmental enrichment on open-field activity and Hebb-Williams problem solving in rats.

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Restricted daily exposure to environmental enrichment increases the diversity of exploration

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Long‐term behavioural and neuroendocrine changes in roman HIGH‐(RHA/Verh) and LOW‐(RLA‐Verh) avoidance rats following neonatal handling

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Genetic determinants of individual differences in avoidance learning: Behavioral and endocrine characteristics

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Learned fear, emotional reactivity and fear of heights: a factor analytic map from a large F2 intercross of Roman rat strains

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Gender and early environmental influences on activity, overresponsiveness, and exploration

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Long-term effects of preweaning and postweaning free-environment experience on rats' problem-solving behavior.

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Genetic learning deficiency does not hinder environment-dependent brain growth

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Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System

Escorihuela, R. M., Fernández‐Teruel, A., Tobeña, A., Vivas, N. M., Màrmol, F., Badı́a, A., & Dierssen, M. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.1043 · Cited by 63 · see citing works

The anxiolytic action of benzodiazepines is not present in handling-habituated rats

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Experience-dependent changes in exploratory behavior in the adult rat (Rattus norvegicus): Overall activity level and interactions with objects.

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Infantile experiences, strain differences, and avoidance learning.

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Postnatal handling reduces anxiety as measured by emotionality rating and hyponeophagia tests in female rats

Ferré, P., Núñez, J. F., García, E., Tobeña, A., Escorihuela, R. M., & Fernández‐Teruel, A. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00419-j · Cited by 59 · see citing works

Infantile stimulation and adult exploratory behavior: Effects of handling upon tactual variation seeking.

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Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats

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Experience-dependent changes in exploratory behavior in the adult rat (Rattus norvegicus): Overall activity level and interactions with objects.

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Handling in infancy, brain laterality and muricide in rats

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Neonatal Nonhandling andIn UteroPrenatal Stress Reduce the Density of NADPH-Diaphorase-Reactive Neurons in the Fascia Dentata and Ammon’s Horn of Rats

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Environmental manipulation differentially alters c-Fos expression in amygdaloid nuclei following aversive conditioning

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Effects of aging on environmental modulation of hippocampal evoked responses.

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Differential effects of early stimulation and/or perinatal flumazenil treatment in young Roman low- and high-avoidance rats

Fernández‐Teruel, A., Escorihuela, R. M., Driscoll, P., Tobeña, A., & Bättig, K. (1992) · Psychopharmacology · doi:10.1007/bf02245303 · Cited by 43 · see citing works

Effects of preweaning and postweaning manipulations upon problem-solving behavior.

Denenberg, V. H., & Morton, J. (1962) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0042528 · Cited by 41 · see citing works

Pre-weaning non-handling of rats disrupts latent inhibition in males, and results in persisting sex-and area-dependent increases in dopamine and serotonin turnover

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Different effects of acute neonatal stressors and long-term postnatal handling on stress-induced changes in behavior and in ornithine decarboxylase activity of adult rats

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Behavioral effects of environmental enrichment in randomly bred mice.

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Fernández‐Teruel, A., & Tobeña, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.014 · Cited by 43 · see citing works

Progressive habituation to separation alleviates the negative effects of weaning in the mother and foal

Lansade, L., Foury, A., Reigner, F., Vidament, M., Guettier, E., Bouvet, G., Soulet, D., Parias, C., Ruet, A., Mach, N., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.005 · Cited by 43 · see citing works

DARPP‐32 in the orchestration of responses to positive natural stimuli

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Bizarre behaviors and risk assessment in 3xTg-AD mice at early stages of the disease

Baeta-Corral, R., & Giménez‐Llort, L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.017 · Cited by 39 · see citing works

Behavioral differences of male Wistar rats from different vendors in vulnerability and resilience to chronic mild stress are reflected in epigenetic regulation and expression of p11

Theilmann, W., Kleimann, A., Rhein, M., Bleich, S., Frieling, H., Löscher, W., & Brandt, C. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.041 · Cited by 39 · see citing works

Cellular mechanisms underlying an effect of “early handling” on pCREB and BDNF in the neonatal rat hippocampus

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Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats

Antoniazzi, C. T. D. D., Metz, V. G., Roversi, K., de Freitas, D. L., Vey, L. T., Dias, V. T., Segat, H. J., Duarte, M. M. M. F., & Bürger, M. E. (2016) · Hippocampus · doi:10.1002/hipo.22686 · Cited by 38 · see citing works

Volumetric brain differences between the Roman rat strains: Neonatal handling effects, sensorimotor gating and working memory

Río-Álamos, C., Piludu, M. A., Gerbolés, C., Barroso, D., Oliveras, I., Sánchez-González, A., Cañete, T., Tapias-Espinosa, C., Sampedro-Viana, D., Torrúbia, R., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.033 · Cited by 38 · see citing works

Neonatal handling decreases unconditioned anxiety, conditioned fear, and improves two-way avoidance acquisition: a study with the inbred Roman high (RHA-I)- and low-avoidance (RLA-I) rats of both sexes

Río-Álamos, C., Oliveras, I., Cañete, T., Blázquez, G., Martínez-Membrives, E., Tobeña, A., & Fernández‐Teruel, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00174 · Cited by 36 · see citing works

Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II

Costa, R., Tamascia, M. L., Sanches, A., Moreira, R. P., Cunha, T. S., Nogueira, M. D., Casarini, D. E., & Marcondes, F. K. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112250 · Cited by 36 · see citing works

Physiological and behavioural consequences of long-term moderate treadmill exercise

Lalanza, J. F., Sanchez‐Roige, S., Gagliano, H., Fuentes, S., Bayod, S., Camins, A., Pallàs, M., Armario, A., & Escorihuela, R. M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.008 · Cited by 36 · see citing works

Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation

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Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation

Godar, S. C., Mosher, L. J., Scheggi, S., Devoto, P., Moench, K. M., Strathman, H. J., Jones, C. M., Frau, R., Melis, M., Gambarana, C., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.028 · Cited by 33 · see citing works

Neonatal handling enduringly decreases anxiety and stress responses and reduces hippocampus and amygdala volume in a genetic model of differential anxiety: Behavioral-volumetric associations in the Roman rat strains

Río-Álamos, C., Oliveras, I., Piludu, M. A., Gerbolés, C., Cañete, T., Blázquez, G., Lope‐Piedrafita, S., Martínez-Membrives, E., Torrúbia, R., Tobeña, A., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.12.003 · Cited by 34 · see citing works

Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling

Muntsant-Soria, A., Shrivastava, K., Recasens, M., & Giménez‐Llort, L. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00007 · Cited by 34 · see citing works

The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies

Macrı̀, S., Ceci, C., Altabella, L., Canese, R., & Giovanni Laviola, A. (2013) · Scientific Reports · doi:10.1038/srep02380 · Cited by 31 · see citing works

Environmental enrichment impacts discrimination between familiar and unfamiliar human odours in snakes (Pantherophis guttata)

Nagabaskaran, G., Burman, O. H. P., Hoehfurtner, T., & Wilkinson, A. (2021) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2021.105278 · Cited by 30 · see citing works

Environmental Enrichment Increases Glucocorticoid Receptors and Decreases GluA2 and Protein Kinase M Zeta (PKMζ) Trafficking During Chronic Stress: A Protective Mechanism?

Zanca, R. M., Braren, S. H., Maloney, B., Schrott, L. M., Luine, V. N., & Serrano, P. A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00303 · Cited by 30 · see citing works

Prenatal ethanol exposure increases risk of psychostimulant addiction

Wang, R., Shen, Y.-L., Hausknecht, K. A., Chang, L., Haj‐Dahmane, S., Vezina, P., & Shen, R. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.030 · Cited by 30 · see citing works

Environmental enrichment during rearing alters corticosterone levels, thymocyte numbers, and aggression in female BALB/c mice.

Hutchinson, E. K., Avery, A. C., & VandeWoude, S. (2012) · PubMed Central · Cited by 30 · see citing works

Sexually dimorphic long-term effects of an early life experience on AMPA receptor subunit expression in rat brain

Katsouli, S., Stamatakis, A., Giompres, P., Kouvelas, E. D., Stylianopoulou, F., & Mitsacos, A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.073 · Cited by 29 · see citing works

Marble-burying is enhanced in 3xTg-AD mice, can be reversed by risperidone and it is modulable by handling

Torres–Lista, V., Pousa, S. L., & Giménez‐Llort, L. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.05.001 · Cited by 29 · see citing works

Effects of neonatal handling on playfulness by means of reversal of the desire to play in rats (Rattus norvegicus).

Aguilar, R., Caramés, J. M., & Espinet, A. (2009) · Journal of comparative psychology · doi:10.1037/a0016437 · Cited by 29 · see citing works

Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood

Aghaie, C. I., Hausknecht, K. A., Wang, R., Dezfuli, P. H., Haj‐Dahmane, S., Kane, C. J. M., Sigurdson, W. J., & Shen, R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14275 · Cited by 29 · see citing works

Perceptual context-dependent remodeling of the forepaw map in the SI cortex of rats trained on tactile discrimination

Xerri, C., Bourgeon, S., & Coq, J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.003 · Cited by 29 · see citing works

Neonatal Handling and Gender Modulate Brain Monoamines and Plasma Corticosterone Levels following Repeated Stressors in Adulthood

Panagiotaropoulos, T. I., Pondiki, S., Papaioannou, A., Alikaridis, F., Stamatakis, A., Gerozissis, K., & Stylianopoulou, F. (2004) · Neuroendocrinology · doi:10.1159/000082516 · Cited by 28 · see citing works

Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age

Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.016 · Cited by 27 · see citing works

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

Wang, R., Hausknecht, K. A., Shen, Y.-L., Haj‐Dahmane, S., Vezina, P., & Shen, R. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.07.013 · Cited by 27 · see citing works

Physical training in developing rats does not influence the kindling development in the adult life

Arida, R. M., Scorza, F. A., de Lacerda, A. F. S., da Silva, S. G., & Cavalheiro, É. A. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.11.016 · Cited by 27 · see citing works

Are the effects of enrichment due to the presence of multiple items or a particular item in the cages of laboratory rat?

Abou-Ismail, U. A. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.06.007 · Cited by 26 · see citing works

Effects of rat odour and shelter on maternal behaviour in C57BL/6 dams and on fear and stress responses in their adult offspring

Coutellier, L. D., Friedrich, A.-C., Failing, K., Marashi, V., & Würbel, H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.02.006 · Cited by 26 · see citing works

Abilities in tactile discrimination of textures in adult rats exposed to enriched or impoverished environments

Bourgeon, S., Xerri, C., & Coq, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.002 · Cited by 26 · see citing works

Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats

Fernández‐Teruel, A., Oliveras, I., Cañete, T., Río-Álamos, C., Tapias-Espinosa, C., Sampedro-Viana, D., Sánchez-González, A., Sanna, F., Torrúbia, R., González‐Maeso, J., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.042 · Cited by 24 · see citing works

Effect of neonatal handling on serotonin 1A sub-type receptors in the rat hippocampus

Stamatakis, A., Mantelas, A., Papaioannou, A., Pondiki, S., Fameli, M., & Stylianopoulou, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.035 · Cited by 24 · see citing works

Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat

Simpson, J., Bree, D., & Kelly, J. P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.008 · Cited by 23 · see citing works

Long‐term effects of neonatal handling on mu‐opioid receptor levels in the brain of the offspring

Kiosterakis, G., Stamatakis, A., Diamantopoulou, A., Fameli, M., & Stylianopoulou, F. (2009) · Developmental Psychobiology · doi:10.1002/dev.20383 · Cited by 23 · see citing works

Selective effects of neonatal handling on rat brain N-methyl-d-aspartate receptors

Stamatakis, A., Toutountzi, E., Fragioudaki, K., Kouvelas, E. D., Stylianopoulou, F., & Mitsacos, A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.032 · Cited by 23 · see citing works

The power of “touch” and early enriched stimulation: neuroplasticity effects in rodents and preterm infants

Fernández‐Teruel, A. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327336 · Cited by 11 · see citing works

Neuroprotection and recovery from early-life adversity: considerations for environmental enrichment

Kentner, A. C. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.165315 · Cited by 17 · see citing works

Early behavioural enrichment in the form of handling renders mouse pups unresponsive to anxiolytic drugs and increases NGF levels in the hippocampus

Cirulli, F., Capone, F. T., Bonsignore, L. T., Aloe, L., & Alleva, E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.018 · Cited by 26 · see citing works

Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats

Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90157-0 · Cited by 94 · see citing works

Effects of environmental enrichment on the prevention or reversal of behavioral and neurobiological changes induced by early life stress

de Sá, N. V. A. C. (2023) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)