Signal Transduction by the JNK Group of MAP Kinases

Cell Signaling by Receptor Tyrosine Kinases

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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

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Cell Signaling by Receptor Tyrosine Kinases

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BCL-2 family members and the mitochondria in apoptosisPreprint

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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

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The stress-activated protein kinase subfamily of c-Jun kinases

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Signaling Through Scaffold, Anchoring, and Adaptor Proteins

Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481

Phosphorylation of c-jun mediated by MAP kinases

Pulverer, B., Kyriakis, J. M., Avruch, J., Nikolakaki, E., & Woodgett, J. R. (1991) · Nature · doi:10.1038/353670a0 · Cited by 1,470

Selective interaction of JNK protein kinase isoforms with transcription factors.

Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,296

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,265

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138

Regulation of JNK signaling by GSTp

Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1321 · Cited by 1,105

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

Duesbery, N. S., Webb, C. P., Leppla, S. H., Gordon, V. M., Klimpel, K. R., Copeland, T. D., Ahn, N. G., Oskarsson, M. K., Fukasawa, K., Paull, K. D., et al. (1998) · Science · doi:10.1126/science.280.5364.734 · Cited by 1,007

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M

Yamamoto, K., Ichijo, H., & Korsmeyer, S. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8469 · Cited by 1,003

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Yeh, W., de la Pompa, J. L., McCurrach, M. E., Shu, H., Elia, A., Shahinian, A., Ng, M. S. W., Wakeham, A. C., Khoo, W., Mitchell, K., et al. (1998) · Science · doi:10.1126/science.279.5358.1954 · Cited by 890

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

Kuan, C.-Y., Yang, D. D., Roy, D. R. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80727-8 · Cited by 889

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesPreprint

Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kägi, D., Hakem, A., McCurrach, M. E., Khoo, W., Kaufman, S. A., et al. (1998) · Genes & Development · doi:10.1101/gad.12.6.806 · Cited by 835

A conserved docking motif in MAP kinases common to substrates, activators and regulators

Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

Keyse, S. M. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00075-7 · Cited by 808

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801

Ras and Rho GTPases

Bar‐Sagi, D., & Hall, A. (2000) · Cell · doi:10.1016/s0092-8674(00)00115-x · Cited by 800

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

Yeh, W., Shahinian, A., Speiser, D. E., Kraunus, J., Billia, F., Wakeham, A. C., de la Pompa, J. L., Ferrick, D. A., Hum, B., Iscove, N. N., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80391-x · Cited by 798

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

Takekawa, M., & Saito, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81619-0 · Cited by 746

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

Arias, J., Alberts, A. S., Brindle, P. K., Claret, F. X., Smeal, T., Karin, M., Feramisco, J. R., & Montminy, M. (1994) · Nature · doi:10.1038/370226a0 · Cited by 726

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

Behrens, A., Sibilia, M. C., & Wagner, E. F. (1999) · Nature Genetics · doi:10.1038/6854 · Cited by 677

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., & Ichijo, H. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80283-x · Cited by 647

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642

TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

Takaesu, G., Kishida, S., Hiyama, A., Yamaguchi, T., Shibuyà, H., Irie, K., Ninomiya‐Tsuji, J., & Matsumoto, K. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80244-0 · Cited by 615

Defective T Cell Differentiation in the Absence of Jnk1

Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., & Flavell, R. A. (1998) · Science · doi:10.1126/science.282.5396.2092 · Cited by 579

Control of cell cycle progression by c-Jun is p53 dependentPreprint

Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., & Wagner, E. F. (1999) · Genes & Development · doi:10.1101/gad.13.5.607 · Cited by 576

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

Liu, H., Nishitoh, H., Ichijo, H., & Kyriakis, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2198-2208.2000 · Cited by 545

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

Ito, T., Deng, X., Carr, B. K., & May, W. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.11671 · Cited by 541

c-Jun is essential for normal mouse development and hepatogenesis

Hilberg, F., Aguzzi, A., Howells, N., & Wagner, E. F. (1993) · Nature · doi:10.1038/365179a0 · Cited by 539

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Leppä, S., & Bohmann, D. (1999) · Oncogene · doi:10.1038/sj.onc.1203173 · Cited by 522

MEKK1/JNK signaling stabilizes and activates p53

Fuchs, S. Y., Adler, V., Pincus, M. R., & Ronai, Z. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10541 · Cited by 521

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80849-1 · Cited by 509

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

Schaeffer, H. J., Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A., & Weber, M. J. (1998) · Science · doi:10.1126/science.281.5383.1668 · Cited by 472

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainPreprint

Baud, V., Liu, Z.-G., Bennett, B. L., Suzuki, N., Xia, Y., & Karin, M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1297 · Cited by 464

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458

Signal Transduction by Tumor Necrosis Factor Mediated by JNK Protein Kinases

Sluss, H. K., Barrett, T., Dérijard, B., & Davis, R. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8376 · Cited by 457

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

Yang, D. D., Conze, D. B., Whitmarsh, A. J., Barrett, T., Davis, R. J., Rincón, M., & Flavell, R. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80640-8 · Cited by 453

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000955200 · Cited by 450

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.Preprint

Sluss, H. K., Han, Z., Barrett, T., Davis, R. J., & Ip, Y. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2745 · Cited by 412

Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector

Orth, K., Palmer, L. E., Bao, Z., Stewart, S., Rudolph, A. E., Bliska, J. B., & Dixon, J. E. (1999) · Science · doi:10.1126/science.285.5435.1920 · Cited by 402

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

Maundrell, K., Antonsson, B. E., Magnenat, E. M., Camps, M., Muda, M., Chabert, C., Gilliéron, C., Boschert, U., Vial-Knecht, E., Martinou, J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25238 · Cited by 396

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway

Yamaguchi, K., Nagai, S., Ninomiya‐Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H., & Matsumoto, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.179 · Cited by 395

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

Whitmarsh, A. J., & Davis, R. J. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01309-7 · Cited by 387

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activationPreprint

Chen, C., Gherzi, R., Andersen, J., Gaietta, G. M., Jürchott, K., Royer, H. D., Mann, M., & Karin, M. (2000) · Genes & Development · doi:10.1101/gad.14.10.1236 · Cited by 380

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

Sabapathy, K., Jochum, W., Hochedlinger, K., Chang, L., Karin, M., & Wagner, E. F. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00213-0 · Cited by 359

Matrix Survival Signaling

Almeida, E. A. C., Ilić, D., Han, Q., Hauck, C. R., Jin, F., Kawakatsu, H., Schlaepfer, D. D., & Damsky, C. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.741 · Cited by 358

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

Gotoh, Y., & Cooper, J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17477 · Cited by 355

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

Wang, Y., Su, B., Sah, V. P., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5423 · Cited by 340

JNK targets p53 ubiquitination and degradation in nonstressed cellsPreprint

Fuchs, S. Y., Adler, V., Buschmann, T., Yin, Z., Wu, X., Jones, S. N., & Ronai, Z. A. (1998) · Genes & Development · doi:10.1101/gad.12.17.2658 · Cited by 338

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., & Ghosh, S. (1999) · Genes & Development · doi:10.1101/gad.13.16.2059 · Cited by 334

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., & Takeda, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003412200 · Cited by 332

JNK is required for effector T-cell function but not for T-cell activation

Dong, C., Yang, D. D., Tournier, C., Whitmarsh, A. J., Xu, J., Davis, R. J., & Flavell, R. A. (2000) · Nature · doi:10.1038/35011091 · Cited by 328

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

Yujiri, T. (1998) · Science · doi:10.1126/science.282.5395.1911 · Cited by 326

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

Nishina, H., Fischer, K., Radvanyi, L. G., Shahinian, A., Hakem, R., Rubie, E. A., Bernstein, A., Mak, T. W., Woodgett, J. R., & Penninger, J. M. (1997) · Nature · doi:10.1038/385350a0 · Cited by 323

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

Breitschopf, K., Haendeler, J., Malchow, P., Zeiher, A. M., & Dimmeler, S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1886-1896.2000 · Cited by 319

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.Preprint

Riesgo‐Escovar, J. R., Jenni, M., Fritz, A. L., & Hafen, E. (1996) · Genes & Development · doi:10.1101/gad.10.21.2759 · Cited by 313

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

Sabapathy, K., Hu, Y., Kallunki, T., Schreiber, M., David, J., Jochum, W., Wagner, E. F., & Karin, M. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80065-7 · Cited by 302

Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

Adachi‐Yamada, T., Fujimura‐Kamada, K., Nishida, Y., & Matsumoto, K. (1999) · Nature · doi:10.1038/22112 · Cited by 298

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

Kawasaki, H., Schiltz, L., Chiu, R., Itakura, K., Taira, K., Nakatani, Y., & Yokoyama, K. K. (2000) · Nature · doi:10.1038/35012097 · Cited by 288

High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH 2 -Terminal Kinase and Caspase-3

Ho, F. M., Liu, S., Liau, C. S., Huang, P. J., & Lin‐Shiau, S. Y. (2000) · Circulation · doi:10.1161/01.cir.101.22.2618 · Cited by 288

Protein phosphatase 2Cα inhibits the human stress‐responsive p38 and JNK MAPK pathways

Takekawa, M., Maeda, T., & Saito, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4744 · Cited by 286

Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

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Tumor necrosis factor α‐induced activation of c‐jun N‐terminal kinase is mediated by TRAF2

Reinhard, C., Shamoon, B., Shyamala, V., & Williams, L. T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1080 · Cited by 277

TAK1 Mitogen-activated Protein Kinase Kinase Kinase Is Activated by Autophosphorylation within Its Activation Loop

Kishimoto, K., Matsumoto, K., & Ninomiya‐Tsuji, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7359 · Cited by 274

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH 2 -terminal kinase activation, and defects in AP-1 transcriptional activity

Yang, D., Tournier, C., Wysk, M., Lu, H., Xu, J., Davis, R. J., & Flavell, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3004 · Cited by 271

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

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p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

Milne, D., Campbell, L. E., Campbell, D. G., & Meek, D. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5511 · Cited by 257

Mekk3 is essential for early embryonic cardiovascular development

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The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

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The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

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Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

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Role of Gadd45 in apoptosis

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Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

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SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

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Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

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Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase

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The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

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The MKK7 Gene Encodes a Group of c-Jun NH 2 -Terminal Kinase Kinases

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Stress-activated kinases regulate protein stability

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Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4

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Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates

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The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells

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c-Jun NH 2 -Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

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Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner

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Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation

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Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2

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Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons

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IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells

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The Evi‐1 oncoprotein inhibits c‐Jun N‐terminal kinase and prevents stress‐induced cell death

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A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type‐D GABAergic motor neurons

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Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.

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An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

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The Mixed Lineage Kinase DLK Utilizes MKK7 and Not MKK4 as Substrate

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Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

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Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation

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Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation

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cDNA Cloning and Mapping of a Novel Islet-Brain/JNK-Interacting Protein

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SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development

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JNK1 Is Required for T Cell-Mediated Immunity Against Leishmania major Infection

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Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase

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Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells

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Signaling Networks and Cell Cycle Control

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Control of MAPK Signaling by Ste20- and Ste11-Like Kinases

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Nitric Oxide and Peroxynitrite in Health and Disease

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Cellular processing of platinum anticancer drugs

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A central role for JNK in obesity and insulin resistance

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Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

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Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

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Roles of mammalian sterile 20‐like kinase 2‐dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2‐related kinases

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Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

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