The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Direct and Long-Range Action of a Wingless Morphogen Gradient
Open accessAbstract
Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form of Wg, and (iii) a constitutively active form of the cytosolic protein Armadillo (Arm), which normally acts to transduce Wg, and we compare them with the effects of removing endogenous Wg or Arm activity. Our results indicate that wild-type Wg acts at long range, up-regulating the transcription of particular target genes as a function of concentration and distance from secreting cells. In contrast, tethered Wg and Arm have only short-range or autonomous effects, respectively, on the transcription of these genes. We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Cited by
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Self-citationBänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Self-citationRyoo, H. D., Gorenc, T., & Steller, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.019 · Cited by 624
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M. (2006) · Cell · doi:10.1016/j.cell.2006.04.009 · Cited by 580
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M., et al. (2016) · Nature · doi:10.1038/nature16937 · Cited by 525
Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493
Self-citationHarterink, M., Port, F., Lorenowicz, M. J., McGough, I. J., Silhankova, M., Betist, M. C., van Weering, J. R. T., van Heesbeen, R. G. H. P., Middelkoop, T. C., Basler, K., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2281 · Cited by 327
Self-citationSelf-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients
Eldar, A., Rosin, D., Shilo, B.-Z., & Barkai, N. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00292-2 · Cited by 289
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B., & Jiang, J. (2002) · Nature · doi:10.1038/nature733 · Cited by 288
Active endocannabinoids are secreted on extracellular membrane vesicles
Gabrielli, M., Battista, N., Riganti, L., Prada, I., Antonucci, F., Cantone, L., Matteoli, M., Maccarrone, M., & Verderio, C. (2015) · The EMBO Reports · doi:10.15252/embr.201439668 · Cited by 231
Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development
Tallquist, M. D., French, W. J., & Soriano, P. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000052 · Cited by 192
Zecca, M., & Struhl, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000386 · Cited by 148
Self-citationHelping Wingless take flight: how WNT proteins are secreted
Hausmann, G., Bänziger, C., & Basler, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2141 · Cited by 147
Self-citationFeinbaum, R., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9272 · Cited by 148
Culi, J., & Mann, R. S. (2003) · Cell · doi:10.1016/s0092-8674(02)01279-5 · Cited by 119
Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
Zeng, Y. A., & Verheyen, E. M. (2004) · Development · doi:10.1242/dev.01177 · Cited by 60
An anteroposterior Dorsal gradient in the Drosophila embryo
Huang, A. M., Rusch, J., & Levine, M. (1997) · Genes & Development · doi:10.1101/gad.11.15.1963 · Cited by 59
Lovick, J. K., Ngo, K. T., Omoto, J. J., Wong, D. C., Nguyen, J. D., & Hartenstein, V. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.07.008 · Cited by 48
Wong, D. C., Lovick, J. K., Ngo, K. T., Borisuthirattana, W., Omoto, J. J., & Hartenstein, V. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.07.009 · Cited by 46
Metadata
- Authors
- Zecca, M., Basler, K., & Struhl, G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 87
- Issue
- 5
- Pages
- 833-844
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2029307548
- Cited by
- 731
- References
- 1
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
