Cited by 3,638NF-κB Signaling PathwaysImmune Response and InflammationSignaling Pathways in Disease

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Missing Pieces in the NF-κB Puzzle

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Ghosh, Sankar, Karin, Michael·2002·Cell

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Abstract

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

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Crossref · 10.1016/s0092-8674(02)00703-1

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RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA
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Self-citation
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A Toll-like receptor recognizes bacterial DNA
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Self-citation
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
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NF-κB at the crossroads of life and death
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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Self-citation
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Background
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Background
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Background
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Self-citation
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Background
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Influential
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Self-citation
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Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor‐independent mechanisms
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“…internalized oATP might target the IkB-kinase complex that facilitates the British Journal of Pharmacology vol 140 (3) dissociation of cytosolic p50/p65/IkB complexes, rapid degradation of IkB, and consequent nuclear accumulation of transcriptionally active NF-kB subunits (Ghosh & Karin, 2002).”

Authors: Ghosh, S., & Karin, M.
Affiliations: Howard Hughes Medical Institute (US)
University of California San Diego (US)
Corresponding author: Ghosh, Sankar
ORCID: Ghosh, Sankar
Karin, Michael
Venue: Cell
Publisher: Elsevier BV
Published: 2002-04
Volume: 109
Issue: 2
Pages: S81-S96
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00703-1
OpenAlex: W1976382352
Cited by: 3,638
References: 158
Citations by year: 2026: 29 · 2025: 65 · 2024: 66 · 2023: 49 · 2022: 66 · 2021: 94 · 2020: 100 · 2019: 84 · 2018: 103 · 2017: 111 · 2016: 122 · 2015: 141 · 2014: 134 · 2013: 144 · 2012: 189
FWCI: 19.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4125 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, IκB kinase complex, transcription factor regulation, transcriptional activity, IκB, signal transduction
MeSH terms: Animals, Cell Nucleus, Cytoplasm, Enzyme Activation, Gene Expression Regulation, Humans, Signal Transduction, NF-kappa B, Protein Serine-Threonine Kinases, Catalytic Domain, Active Transport, Cell Nucleus, I-kappa B Kinase

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Missing Pieces in the NF-κB Puzzle

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