Cited by 3,638NF-κB Signaling PathwaysImmune Response and InflammationSignaling Pathways in Disease

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Missing Pieces in the NF-κB Puzzle

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Ghosh, Sankar, Karin, Michael·2002·Cell

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Abstract

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

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Crossref · 10.1016/s0092-8674(02)00703-1

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RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA
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Self-citation
Retracted
A Toll-like receptor recognizes bacterial DNA
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NF-κB at the crossroads of life and death
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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Influential
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Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-α with BCAR1 and Traf6
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“We next analysed the phosphorylated forms of the inhibitor of NF- B, which becomes degraded thereby releasing active NF- B (Ghosh and Karin 2002), and of the p65 subunit of NF- B, which is specifically induced by TNF (Ghosh and Karin, 2002) and associated with TNF-mediated neuroprotection…”
InfluentialSelf-citation
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“To examine whether ZnO stimula tion increased NFκB activity, we deter mined phosphorylation and degradation of the NFκB inhibitory protein κBα (IκBα), an event indicative of the canonical NFκB activating pathway (Ghosh and Karin 2002; Karin and BenNeriah 2000).”
Background
IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
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“The classical manner for NF-κB activation is mainly dependent on the IKKβ subunit induction (Ghosh and Karin, 2002; Hayden and Ghosh, 2004).”
Background
RETRACTED: Co-regulation of nuclear respiratory factor-1 by NFκB and CREB links LPS-induced inflammation to mitochondrial biogenesis
Suliman, H. B., Sweeney, T. E., Withers, C. M., & Piantadosi, C. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.064089 · Cited by 92
“An example is the full spectrum of processes involved in immunity, inflammation, proliferation and apoptosis that are activated by the pleiotropic transcription factor NFB and lead to a broad array of effects (Ghosh and Karin, 2002).”
Retracted

Authors: Ghosh, S., & Karin, M.
Affiliations: Howard Hughes Medical Institute (US)
University of California San Diego (US)
Corresponding author: Ghosh, Sankar
ORCID: Ghosh, Sankar
Karin, Michael
Venue: Cell
Publisher: Elsevier BV
Published: 2002-04
Volume: 109
Issue: 2
Pages: S81-S96
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00703-1
OpenAlex: W1976382352
Cited by: 3,638
References: 158
Citations by year: 2026: 29 · 2025: 65 · 2024: 66 · 2023: 49 · 2022: 66 · 2021: 94 · 2020: 100 · 2019: 84 · 2018: 103 · 2017: 111 · 2016: 122 · 2015: 141 · 2014: 134 · 2013: 144 · 2012: 189
FWCI: 19.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4125 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, IκB kinase complex, transcription factor regulation, transcriptional activity, IκB, signal transduction
MeSH terms: Animals, Cell Nucleus, Cytoplasm, Enzyme Activation, Gene Expression Regulation, Humans, Signal Transduction, NF-kappa B, Protein Serine-Threonine Kinases, Catalytic Domain, Active Transport, Cell Nucleus, I-kappa B Kinase

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Missing Pieces in the NF-κB Puzzle

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