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Cited by 176Treatment of Major DepressionChild and Adolescent Psychosocial and Emotional DevelopmentPsychological Treatments and Disorders

Treatment of depression in children and adolescents

Ryan, Neal D·2005·The Lancet
DOI 10.1016/s0140-6736(05)67321-7
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Abstract

Depressive disorders during youth occur frequently, are chronic and recurrent, and are associated with significant functional impairment, morbidity, and mortality. Two psychotherapeutic approaches-cognitive behavioural therapy and interpersonal therapy-are each better than wait-list or treatment-as-usual approaches. Several antidepressants have proven efficacious compared with placebo; however, more than half the studies comparing antidepressant treatment with placebo in children and adolescents with depression have not shown any benefit of the active compounds. Suicide rates are decreasing overall in adolescents, and there seems to be a correlation between the use of selective serotonin reuptake inhibitors (SSRIs) and a decrease in completed suicide. However, there was a signal for increase in suicide attempts and suicidal ideation in patients on acute antidepressant treatment when all antidepressants were assessed as a single group. Thus, there is substantial debate about the best approach to treat this serious disorder. Here, we discuss the treatment options for depression in children and adolescents.

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Crossref · 10.1016/s0140-6736(05)67321-7

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  • Adolescent depression is characterized by chronicity and high recurrence, often accompanied by severe functional impairment and increased risks of self-harm and suicide.

    “Adolescent depression is characterized by chronicity and high recurrence, often accompanied by severe functional impairment and increased risks of self-harm and suicide (3, 4).”

    From Recent developments in bibliotherapy for adolescent depression (2025) · cites this paper as [3]

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Authors
Ryan, N. D.
Affiliations
University of Pittsburgh Medical Center (US)
Corresponding author
Ryan, Neal D
ORCID
Ryan, Neal D
Venue
The Lancet
Publisher
Elsevier BV
Published
2005-09
Volume
366
Issue
9489
Pages
933-940
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(05)67321-7
OpenAlex
W2153849975
Cited by
176
References
13
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 10
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
childhood depression, adolescent depression, cognitive behavioral therapy, interpersonal psychotherapy, antidepressants, selective serotonin reuptake inhibitors, suicide, suicidal ideation, suicide attempts, psychotherapy, treatment efficacy
MeSH terms
Adolescent, Antidepressive Agents, Child, Depressive Disorder, Humans, Psychotherapy, Suicide

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