Recruitment of Progenitor Cells by an Extracellular Matrix Cryptic Peptide in a Mouse Model of Digit Amputation
Open accessAbstract
Biologic scaffolds composed of extracellular matrix (ECM) have been used successfully in preclinical models and humans for constructive remodeling of functional, site-appropriate tissue after injury. The mechanisms underlying ECM-mediated constructive remodeling are not completely understood, but scaffold degradation and site-directed recruitment of both differentiated and progenitor cells are thought to play critical roles. Previous studies have shown that degradation products of ECM scaffolds can recruit a population of progenitor cells both in vitro and in vivo. The present study identified a single cryptic peptide derived from the α subunit of the collagen III molecule that is chemotactic for a well-characterized perivascular stem cell in vitro and causes the site-directed accumulation of progenitor cells in vivo. The oligopeptide was additionally chemotactic for human cortical neural stem cells, rat adipocyte stem cells, C2C12 myoblast cells, and rat Schwann cells in vitro. In an adult murine model of digit amputation, treatment with this peptide after mid-second phalanx amputation resulted in a greater number of Sox2+ and Sca1+,Lin- cells at the site of injury compared to controls. Since progenitor cell activation and recruitment are key prerequisites for epimorphic regeneration in adult mammalian tissues, endogenous site-directed recruitment of such cells has the potential to alter the default wound healing response from scar tissue toward regeneration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Following implantation, natural ECM scaffolds undergo degradation, releasing matricryptic peptides and growth factors, which triggers a shift in macrophage polarization from pro-inflammatory M1 to anti-inflammatory regenerative M2, promoting angiogenesis and recruiting stem/progenitor cells for constructive remodeling.
“Following implantation, these natural ECM scaffolds undergo a degree of degradation, releasing matricryptic peptides and growth factors. This process triggers a shift in macrophage polarization from pro-inflammatory (M1) phenotype to an anti-inflammatory regenerative phenotype (M2 macrophages), promoting angiogenesis and recruiting stem/progenitor cell toward the implanted tissue for constructive”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [57]
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486 · see citing works
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · see citing works
Self-citationAn overview of tissue and whole organ decellularization processes
Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.057 · Cited by 3,591 · see citing works
Self-citationDefensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066 · see citing works
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650 · see citing works
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314 · see citing works
Uygun, B. E., Soto-Gutierrez, A., Yagi, H., Izamis, M.-L., Guzzardi, M. A., Shulman, C., Milwid, J., Kobayashi, N., Tilles, A., Berthiaume, F., et al. (2010) · Nature Medicine · doi:10.1038/nm.2170 · Cited by 1,370 · see citing works
Regeneration and orthotopic transplantation of a bioartificial lung
Ott, H. C., Clippinger, B., Conrad, C., Schuetz, C., Pomerantseva, I., Ikonomou, L., Kotton, D., & Vacanti, J. P. (2010) · Nature Medicine · doi:10.1038/nm.2193 · Cited by 1,090 · see citing works
Cells keep a memory of their tissue origin during axolotl limb regeneration
Kragl, M., Knapp, D., Nacu, E., Khattak, S., Maden, M., Epperlein, H. H., & Tanaka, E. M. (2009) · Nature · doi:10.1038/nature08152 · Cited by 854 · see citing works
The extracellular matrix as a scaffold for tissue reconstruction
Badylak, S. F. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084952102000940 · Cited by 819 · see citing works
Self-citationLee, C. H., Cook, J. L., Mendelson, A., Moioli, E. K., Yao, H., & Mao, J. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60668-x · Cited by 614 · see citing works
Small intestinal submucosa as a large diameter vascular graft in the dog
Badylak, S. F., Lantz, G. C., Coffey, A. C., & Geddes, L. A. (1989) · Journal of Surgical Research · doi:10.1016/0022-4804(89)90050-4 · Cited by 613 · see citing works
Self-citationHistone H3 phosphorylation and cell division
Hans, F., & Dimitrov, S. I. (2001) · Oncogene · doi:10.1038/sj.onc.1204326 · Cited by 519 · see citing works
Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate
Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcı́a, A., & Brockes, J. P. (2007) · Science · doi:10.1126/science.1147710 · Cited by 487 · see citing works
Davis, G. E., Bayless, K. J., Davis, M. J., & Meininger, G. A. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65020-1 · Cited by 452 · see citing works
Anti-angiogenic cues from vascular basement membrane collagen.
Colorado, P. C., Torre, A., Kamphaus, G. D., Maeshima, Y., Hopfer, H., Takahashi, K., Volk, R., Zamborsky, E. D., Herman, S., Sarkar, P. K., et al. (2000) · PubMed · Cited by 421 · see citing works
EXTRACELLULAR MATRIX BIOSCAFFOLDS FOR ORTHOPAEDIC APPLICATIONS
Valentin, J. E., Badylak, J. S., McCabe, G. P., & Badylak, S. F. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.e.01008 · Cited by 410 · see citing works
Self-citationDegradation Products of Extracellular Matrix Affect Cell Migration and Proliferation
Reing, J. E., Zhang, L., Myers-Irvin, J., Cordero, K. E., Freytes, D. O., Heber-Katz, E., Bedelbaeva, K., McIntosh, D., Dewilde, A., Braunhut, S. J., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0425 · Cited by 387 · see citing works
Self-citationRegeneration of Dental-Pulp-like Tissue by Chemotaxis-Induced Cell Homing
Kim, J. Y., Xin, X., Moioli, E. K., Chung, J., Lee, C., Chen, M., Fu, S. Y., Koch, P. D., & Mao, J. J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0181 · Cited by 363 · see citing works
Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds
Valentin, J. E., Stewart-Akers, A. M., Gilbert, T. W., & Badylak, S. F. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0419 · Cited by 356 · see citing works
Self-citationMicroarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
Monaghan, J. R., EPP, L. G., Putta, S., Page, R. B., Walker, J. A., Beachy, C. K., Zhu, W. Z., Pao, G. M., Verma, I. M., Hunter, T. R., et al. (2009) · BMC Biology · doi:10.1186/1741-7007-7-1 · Cited by 309 · see citing works
Mase, V. J., Hsu, J. R., Wolf, S. E., Wenke, J. C., Baer, D. G., Owens, J. G., Badylak, S. F., & Walters, J. (2010) · Orthopedics · doi:10.3928/01477447-20100526-24 · Cited by 291 · see citing works
Self-citationEsophageal Reconstruction with ECM and Muscle Tissue in a Dog Model
Badylak, S. F., Vorp, D. A., Spievack, A. R., Simmons-Byrd, A., Hanke, J., Freytes, D. O., Thapa, A., Gilbert, T. W., & Nieponice, A. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.03.002 · Cited by 291 · see citing works
Self-citationAntiangiogenic Activity of Restin, NC10 Domain of Human Collagen XV: Comparison to Endostatin
Ramchandran, R., Dhanabal, M., Volk, R., Waterman, M. J. F., Segal, M. S., Lu, H. A. J., Knebelmann, B., & Sukhatme, V. P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0248 · Cited by 290 · see citing works
Resorbable bioscaffold for esophageal repair in a dog model
Badylak, S. F., Meurling, S., Chen, M., Spievack, A. R., & Simmons-Byrd, A. (2000) · Journal of Pediatric Surgery · doi:10.1053/jpsu.2000.7834 · Cited by 277 · see citing works
Self-citationBiaxial strength of multilaminated extracellular matrix scaffolds
Freytes, D. O., Badylak, S. F., Webster, T. J., Geddes, L. A., & Rundell, A. E. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.015 · Cited by 235 · see citing works
Self-citationChemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds
Beattie, A. J., Gilbert, T. W., Guyot, J. P., Yates, A. J., & Badylak, S. F. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0162 · Cited by 218 · see citing works
Self-citationSellaro, T. L., Ravindra, A. K., Stolz, D. B., & Badylak, S. F. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0437 · Cited by 214 · see citing works
Self-citationSmall Intestinal Submucosa as a Small-Diameter Arterial Graft in the Dog
Lantz, G. C., Badylak, S. F., Coffey, A. C., Geddes, L. A., & Blevins, W. E. (1990) · Journal of Investigative Surgery · doi:10.3109/08941939009140351 · Cited by 210 · see citing works
Self-citationAntimicrobial activity of cecropins
Moore, A., Beazley, W. D., Bibby, M. C., & DeVine, D. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/37.6.1077 · Cited by 206 · see citing works
Extracellular matrix scaffold devices for rotator cuff repair
Derwin, K. A., Badylak, S. F., Steinmann, S. P., & Iannotti, J. P. (2010) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2009.10.020 · Cited by 205 · see citing works
Self-citationLi, F., Li, W., Johnson, S. A., Ingram, D. A., Yöder, M. C., & Badylak, S. F. (2004) · Endothelium · doi:10.1080/10623320490512390 · Cited by 197 · see citing works
Self-citationAksu, A. E., Rubin, J. P., Dudas, J. R., & Marra, K. G. (2008) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e3180621ff0 · Cited by 196 · see citing works
Zantop, T., Gilbert, T. W., Yöder, M. C., & Badylak, S. F. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20071 · Cited by 186 · see citing works
Self-citationMarrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix
Badylak, S. F., Park, K., Peppas, N. A., McCabe, G. P., & Yöder, M. C. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00729-9 · Cited by 176 · see citing works
Self-citationBone Metabolism Markers in Sports Medicine
Banfi, G., Lombardi, G., Colombini, A., & Lippi, G. (2010) · Sports Medicine · doi:10.2165/11533090-000000000-00000 · Cited by 175 · see citing works
An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR
Nieponice, A., McGrath, K., Qureshi, I. R., Beckman, E. J., Luketich, J. D., Gilbert, T. W., & Badylak, S. F. (2008) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2008.04.022 · Cited by 171 · see citing works
Self-citationKochupura, P. V., Azeloglu, E. U., Kelly, D. J., Doronin, S. V., Badylak, S. F., Krukenkamp, I. B., Cohen, I. S., & Gaudette, G. R. (2005) · Circulation · doi:10.1161/circulationaha.104.524355 · Cited by 168 · see citing works
Self-citationPreliminary experimental anticancer activity of cecropins.
Moore, A., Devine, D., & Bibby, M. C. (1994) · PubMed · Cited by 165 · see citing works
Lewis, J. P., & Trobaugh, F. E. (1964) · Nature · doi:10.1038/204589a0 · Cited by 161 · see citing works
Epimorphic regeneration approach to tissue replacement in adult mammals
Agrawal, V., Johnson, S. A., Reing, J. E., Zhang, L., Tottey, S., Wang, G., Hirschi, K. K., Braunhut, S. J., Gudas, L. J., & Badylak, S. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905851106 · Cited by 160 · see citing works
Self-citationMelman, L. M., Jenkins, E. D., Hamilton, N. A., Bender, L. C., Brodt, M. D., Deeken, C. R., Greco, S., Frisella, M. M., & Matthews, B. D. (2011) · Hernia · doi:10.1007/s10029-010-0770-0 · Cited by 127 · see citing works
Brennan-Pierce, E. P., Tang, X., Stewart‐Akers, A. M., Gudas, L. J., & Badylak, S. F. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.123 · Cited by 125 · see citing works
Self-citationHistology after dural grafting with small intestinal submucosa
Cobb, M. A., Badylak, S. F., Janas, W., & Boop, F. A. (1996) · Surgical Neurology · doi:10.1016/s0090-3019(96)00202-9 · Cited by 119 · see citing works
Self-citationZalavras, C. G., Gardocki, R., Huang, E. Y., Stevanovic, M. V., Hedman, T., & Tibone, J. E. (2006) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2005.06.007 · Cited by 106 · see citing works
Surgical technique for xenograft (SIS) augmentation of rotator-cuff repairs
Metcalf, M. H., Savoie, F. H. “., & Kellum, B. (2002) · Operative Techniques in Orthopaedics · doi:10.1053/otor.2002.36298 · Cited by 103 · see citing works
Magainins: A new family of membrane-active host defense peptides
Berkowitz, B. A., Bevins, C. L., & ZASLOFF, M. A. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90138-b · Cited by 102 · see citing works
Tottey, S., Corselli, M., Jeffries, E. M., Londoño, R., Péault, B., & Badylak, S. F. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0188 · Cited by 101 · see citing works
Self-citationAgrawal, V., Brown, B. N., Beattie, A. J., Gilbert, T. W., & Badylak, S. F. (2009) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.200 · Cited by 99 · see citing works
Self-citationReinforcement of Esophageal Anastomoses With an Extracellular Matrix Scaffold in a Canine Model
Nieponice, A., Gilbert, T. W., & Badylak, S. F. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.06.036 · Cited by 95 · see citing works
Self-citationMorphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model
Gilbert, T. W., Gilbert, S., Madden, M., Reynolds, S. D., & Badylak, S. F. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.04.071 · Cited by 80 · see citing works
Self-citationHodde, J. P., Badylak, S. F., & Shelbourne, K. D. (1997) · Tissue Engineering · doi:10.1089/ten.1997.3.27 · Cited by 78 · see citing works
Self-citationRepair of the tympanic membrane with urinary bladder matrix
Parekh, A., Mantle, B. A., Banks, J. M., Swarts, J. D., Badylak, S. F., Dohar, J. E., & Hebda, P. A. (2009) · The Laryngoscope · doi:10.1002/lary.20233 · Cited by 76 · see citing works
Self-citationBoruch, A. V., Nieponice, A., Qureshi, I. R., Gilbert, T. W., & Badylak, S. F. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.02.014 · Cited by 74 · see citing works
Self-citationBarth, D., Kyrieleis, O. J. P., Frank, S., Renner, C., & Moroder, L. (2003) · Chemistry - A European Journal · doi:10.1002/chem.200304918 · Cited by 71 · see citing works
KANOUPAKIS, E. M., Manios, E. G., Kallergis, E. M., Mavrakis, H. E., Goudis, C. A., Saloustros, I. G., Milathianaki, M. E., CHLOUVERAKIS, G. I., & Vardas, P. E. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.040 · Cited by 62 · see citing works
In vivo bladder regeneration using small intestinal submucosa: experimental study
Caione, P., Capozza, N., Zavaglia, D., Palombaro, G., & Boldrini, R. (2006) · Pediatric Surgery International · doi:10.1007/s00383-006-1705-9 · Cited by 60 · see citing works
Kelly, D. J., Rosen, A. B., Schuldt, A. J. T., Kochupura, P. V., Doronin, S. V., Potapova, I. A., Azeloglu, E. U., Badylak, S. F., Brink, P. R., Cohen, I. S., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0430 · Cited by 51 · see citing works
Self-citationKitahara, T., Takeishi, Y., Arimoto, T., Niizeki, T., Koyama, Y., Sasaki, T., Suzuki, S., Nozaki, N., Hirono, O., Nitobe, J., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.929 · Cited by 36 · see citing works
WOUND HEALING PROCESSES IN AMPUTATED MOUSE DIGITS
Schotté, O. E., & Smith, C. B. (1959) · Biological Bulletin · doi:10.2307/1538866 · Cited by 35 · see citing works
Davis, N. F., Callanan, A., McGuire, B. B., Mooney, R., Flood, H. D., & McGloughlin, T. M. (2010) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2010.11.005 · Cited by 23 · see citing works
Witteman, B. P. L., Foxwell, T. J., Monsheimer, S., Gelrud, A., Eid, G. M., Nieponice, A., O’Rourke, R. W., Hoppo, T., Bouvy, N. D., Badylak, S. F., et al. (2009) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-009-1053-x · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works
Self-citationExtracellular matrix hydrogels from decellularized tissues: Structure and function
Saldin, L. T., Cramer, M. C., Velankar, S., White, L. J., & Badylak, S. F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.068 · Cited by 818 · see citing works
Self-citationZhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Extracellular matrix as an inductive scaffold for functional tissue reconstruction
Brown, B. N., & Badylak, S. F. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.003 · Cited by 518 · see citing works
Self-citationSicari, B. M., Rubin, J. P., Dearth, C. L., Wolf, M. T., Ambrosio, F., Boninger, M. L., Turner, N. J., Weber, D. J., Simpson, T. W., Wyse, A. J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008085 · Cited by 490 · see citing works
Self-citationA hydrogel derived from decellularized dermal extracellular matrix
Wolf, M. T., Daly, K. A., Brennan-Pierce, E. P., Johnson, S. A., Carruthers, C. A., D'Amore, A., Nagarkar, S. P., Velankar, S. S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.051 · Cited by 482 · see citing works
Self-citationKim, B. S., Das, S., Jang, J., & Cho, D.-W. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00808 · Cited by 465 · see citing works
RETRACTED: Engineered whole organs and complex tissues
Badylak, S. F., Weiss, D. J., Caplan, A., & Macchiarini, P. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60073-7 · Cited by 417 · see citing works
Self-citationRetractedMatrix-bound nanovesicles within ECM bioscaffolds
Huleihel, L., Hussey, G. S., Naranjo, J. D., Zhang, L., Dziki, J. L., Turner, N. J., Stolz, D. B., & Badylak, S. F. (2016) · Science Advances · doi:10.1126/sciadv.1600502 · Cited by 387 · see citing works
Self-citationDecellularized matrices in regenerative medicine
Taylor, D. A., Sampaio, L. C., Ferdous, Z., Gobin, A. S., & Taite, L. J. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.044 · Cited by 335 · see citing works
Hydrogels derived from central nervous system extracellular matrix
Medberry, C. J., Crapo, P. M., Siu, B. F., Carruthers, C. A., Wolf, M. T., Nagarkar, S. P., Agrawal, V., Jones, K. E., Kelly, J., Johnson, S. A., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.062 · Cited by 278 · see citing works
Self-citationFunctional Biomaterials for Bone Regeneration: A Lesson in Complex Biology
Armiento, A. R., Hatt, L. P., Rosenberg, G. S., Thompson, K., & Stoddart, M. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909874 · Cited by 275 · see citing works
Biologic scaffolds composed of central nervous system extracellular matrix
Crapo, P. M., Medberry, C. J., Reing, J. E., Tottey, S., van der Merwe, Y., Jones, K. E., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.044 · Cited by 263 · see citing works
Self-citationThe promotion of a constructive macrophage phenotype by solubilized extracellular matrix
Sicari, B. M., Dziki, J. L., Siu, B. F., Medberry, C. J., Dearth, C. L., & Badylak, S. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.060 · Cited by 255 · see citing works
Self-citationDziki, J., Badylak, S., Yabroudi, M., Sicari, B., Ambrosio, F., Stearns, K., Turner, N., Wyse, A., Boninger, M. L., Brown, E. H. P., et al. (2016) · npj Regenerative Medicine · doi:10.1038/npjregenmed.2016.8 · Cited by 219 · see citing works
Self-citationBiocompatibility evaluation of tissue-engineered decellularized scaffolds for biomedical application
Hussein, K. H., Park, K.-M., Kang, K.-S., & Woo, H.-M. (2016) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.05.068 · Cited by 218 · see citing works
Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis
Swinehart, I. T., & Badylak, S. F. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24379 · Cited by 208 · see citing works
Self-citationDziki, J. L., Wang, D. S., Pineda, C., Sicari, B. M., Rausch, T., & Badylak, S. F. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35894 · Cited by 201 · see citing works
Self-citationCorona, B. T., Wu, X., Ward, C. L., McDaniel, J. S., Rathbone, C. R., & Walters, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.061 · Cited by 201 · see citing works
Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior
Cramer, M. C., & Badylak, S. F. (2020) · Annals of Biomedical Engineering · doi:10.1007/s10439-019-02408-9 · Cited by 196 · see citing works
Self-citationAn injectable extracellular matrix derived hydrogel for meniscus repair and regeneration
Wu, J., Ding, Q., Dutta, A., Wang, Y., Huang, Y.-H., Weng, H., Tang, L., & Hong, Y. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.027 · Cited by 194 · see citing works
Lin, H., Yang, G., Tan, J., & Tuan, R. S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.012 · Cited by 193 · see citing works
A Murine Model of Volumetric Muscle Loss and a Regenerative Medicine Approach for Tissue Replacement
Sicari, B. M., Agrawal, V., Siu, B. F., Medberry, C. J., Dearth, C. L., Turner, N. J., & Badylak, S. F. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0475 · Cited by 176 · see citing works
Self-citationThe host response to naturally-derived extracellular matrix biomaterials
Morris, A. H., Stamer, D. K., & Kyriakides, T. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.01.002 · Cited by 180 · see citing works
Bible, E., Dell’Acqua, F., Solanky, B., Balducci, A., Crapo, P. M., Badylak, S. F., Ahrens, E. T., & Modo, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.033 · Cited by 170 · see citing works
Self-citationPacelli, S., Basu, S., Whitlow, J., Chakravarti, A. R., Acosta, F. M., Varshney, A., Modaresi, S., Berkland, C. J., & Paul, A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.011 · Cited by 166 · see citing works
MSCs: The Sentinel and Safe-Guards of Injury
Caplan, A. I. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25255 · Cited by 163 · see citing works
Massensini, A. R., Ghuman, H., Saldin, L. T., Medberry, C. J., Keane, T. J., Nicholls, F. J., Velankar, S., Badylak, S. F., & Modo, M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.040 · Cited by 152 · see citing works
Self-citationPreparation and Use of Decellularized Extracellular Matrix for Tissue Engineering
McInnes, A. D., Moser, M., & Chen, D. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13040240 · Cited by 141 · see citing works
Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair
Keane, T. J., Horejs, C., & Stevens, M. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.02.002 · Cited by 142 · see citing works
Costa, A., Naranjo, J. D., Londono, R., & Badylak, S. F. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025676 · Cited by 135 · see citing works
Self-citationLiao, J., Xu, B., Zhang, R., Fan, Y., Xie, H., & Li, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01534b · Cited by 129 · see citing works
Matrix-bound nanovesicles recapitulate extracellular matrix effects on macrophage phenotype
Huleihel, L., Bartolacci, J. G., Dziki, J. L., Vorobyov, T., Arnold, B., Scarritt, M. E., Pineda Molina, C., LoPresti, S. T., Brown, B. N., Naranjo, J. D., et al. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0102 · Cited by 116 · see citing works
Self-citationFaulk, D. M., Wildemann, J. D., & Badylak, S. F. (2015) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2014.03.043 · Cited by 108 · see citing works
Self-citationPorcine Lung-Derived Extracellular Matrix Hydrogel Properties Are Dependent on Pepsin Digestion Time
Pouliot, R. A., Young, B. M., Link, P. A., Park, H. E., Kahn, A. R., Shankar, K., Schneck, M. B., Weiss, D. J., & Heise, R. L. (2020) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0042 · Cited by 106 · see citing works
Peptides for bone tissue engineering
Visser, R., Rico-Llanos, G., Pulkkinen, H. J., & Becerra, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.024 · Cited by 104 · see citing works
Effects of Biologic Scaffolds on Human Stem Cells and Implications for CNS Tissue Engineering
Crapo, P. M., Tottey, S., Slivka, P. F., & Badylak, S. F. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0186 · Cited by 103 · see citing works
Self-citationThe MSC curtain that stops the immune system
Caplan, A. I., & Sorrell, J. M. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.005 · Cited by 96 · see citing works
Fercana, G., Yerneni, S. S., Billaud, M., Hill, J. C., VanRyzin, P., Richards, T. D., Sicari, B. M., Johnson, S. A., Badylak, S. F., Campbell, P. G., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.037 · Cited by 95 · see citing works
Self-citationPreparation and characterization of pro-angiogenic gel derived from small intestinal submucosa
Wang, W., Zhang, X., Chao, N., Qin, T., Ding, W., Zhang, Y., Sang, J., & Luo, J. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.013 · Cited by 95 · see citing works
Patch Esophagoplasty: Esophageal Reconstruction Using Biologic Scaffolds
Nieponice, A., Ciotola, F. F., Nachman, F. D., Jobe, B. A., Hoppo, T., Londoño, R., Badylak, S. F., & Badaloni, A. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.08.011 · Cited by 93 · see citing works
Self-citationThe extracellular matrix of the gastrointestinal tract: a regenerative medicine platform
Hussey, G. S., Keane, T. J., & Badylak, S. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.76 · Cited by 88 · see citing works
Self-citationSicari, B. M., Dearth, C. L., & Badylak, S. F. (2013) · The Anatomical Record · doi:10.1002/ar.22794 · Cited by 88 · see citing works
Self-citationNative extracellular matrix: a new scaffolding platform for repair of damaged muscle
Teodori, L., Costa, A., Marzio, R., Perniconi, B., Coletti, D., Adamo, S., Gupta, B., & Tarnok, A. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00218 · Cited by 84 · see citing works
Agrawal, V., Kelly, J., Tottey, S., Daly, K. A., Johnson, S. A., Siu, B. F., Reing, J. E., & Badylak, S. F. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0257 · Cited by 81 · see citing works
Self-citationGranulation tissue formation and remodeling
Häkkinen, L., Larjava, H., & Koivisto, L. (2011) · Endodontic Topics · doi:10.1111/etp.12008 · Cited by 81 · see citing works
Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration
Badylak, S. F., Dziki, J. L., Sicari, B. M., Ambrosio, F., & Boninger, M. L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.047 · Cited by 75 · see citing works
Self-citationWu, Y., Wang, J., Shi, Y., Pu, H., Leak, R. K., Liou, A. K. F., Badylak, S. F., Liu, Z., Zhang, J., Chen, J., et al. (2017) · Cell Transplantation · doi:10.1177/0963689717714090 · Cited by 74 · see citing works
Self-citationDziki, J. L., Sicari, B. M., Wolf, M. T., Cramer, M. C., & Badylak, S. (2016) · Tissue Engineering. Part A · doi:10.1089/ten.tea.2016.0340 · Cited by 70 · see citing works
Self-citationZhou, C., Zhou, L., Liu, J., Xu, L., Xu, Z., Chen, Z., Ge, Y., Zhao, F., Wu, R., Wang, X., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.07.056 · Cited by 71 · see citing works
Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
Hussey, G. S., Cramer, M. C., & Badylak, S. F. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.09.004 · Cited by 69 · see citing works
Self-citationDigit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine
Dolan, C. P., Dawson, L., & Muneoka, K. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0236 · Cited by 67 · see citing works
Hussein, K. H., Saleh, T., Ahmed, E., Kwak, H., Park, K., Yang, S., Kang, B., Choi, K., Kang, K., & Woo, H. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36407 · Cited by 67 · see citing works
Body Management: Mesenchymal Stem Cells Control the Internal Regenerator
Caplan, A. I., & HARIRI, R. J. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0291 · Cited by 64 · see citing works
Prest, T. A., Yeager, E. A., LoPresti, S. T., Žygelytė, E., Martin, M. J., Dong, L., Gibson, A., Olutoye, O. O., Brown, B. N., & Cheetham, J. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36235 · Cited by 64 · see citing works
López-Martínez, S., Campo, H., de Miguel–Gómez, L., Faus, A., Navarro, A. T., Díaz, A., Pellicer, A., Ferrero, H., & Cervelló, I. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.639688 · Cited by 61 · see citing works
Liguori, G. R., Liguori, T. T. A., de Moraes, S. R., Sinkunas, V., Terlizzi, V., van Dongen, J. A., Sharma, P. K., Moreira, L. F. P., & Harmsen, M. C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00520 · Cited by 55 · see citing works
Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
Aulino, P., Costa, A., Chiaravalloti, E., Perniconi, B., Adamo, S., Coletti, D., Marrelli, M., Tatullo, M., & Teodori, L. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.10761 · Cited by 54 · see citing works
Biologic Scaffold for CNS Repair
Meng, F., Modo, M., & Badylak, S. F. (2014) · Regenerative Medicine · doi:10.2217/rme.14.9 · Cited by 54 · see citing works
Self-citationBiological Scaffolds for Abdominal Wall Repair: Future in Clinical Application?
Costa, A., Adamo, S., Gossetti, F., D’Amore, L., Ceci, F., Negro, P., & Bruzzone, P. (2019) · Materials · doi:10.3390/ma12152375 · Cited by 53 · see citing works
Faust, A. E., Kandakatla, A., van der Merwe, Y., Ren, T., Huleihel, L., Hussey, G. S., Naranjo, J. D., Johnson, S. A., Badylak, S. F., & Steketee, M. B. (2017) · Journal of Biomaterials Applications · doi:10.1177/0885328217698062 · Cited by 50 · see citing works
Self-citationHuman Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro
Murdock, M. H., David, S., Swinehart, I. T., Reing, J. E., Tran, K., Gassei, K., Orwig, K. E., & Badylak, S. F. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0147 · Cited by 50 · see citing works
Self-citationThe biomimetic extracellular matrix: a therapeutic tool for breast cancer research
Tamayo-Angorrilla, M., de Andrés, J. L., Jiménez, G., & Marchal, J. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.11.008 · Cited by 49 · see citing works
Extracellular matrix remodeling in 3D: implications in tissue homeostasis and disease progression
Ford, A. J., & Rajagopalan, P. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1503 · Cited by 51 · see citing works
Kim, J. S., Choi, J. S., & Cho, Y. W. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16783 · Cited by 47 · see citing works
Morris, A. H., Lee, H., Xing, H., Stamer, D. K., Tan, M., & Kyriakides, T. R. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08920 · Cited by 46 · see citing works
Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing
Wang, X., Chung, L., Hooks, J. S. T., Maestas, D. R., Lebid, A., Andorko, J. I., Huleihel, L., Chin, A. F., Wolf, M. T., Remlinger, N. T., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe2635 · Cited by 44 · see citing works
Equine cellular therapy—from stall to bench to bedside?
Burk, J., Badylak, S. F., Kelly, J., & Brehm, W. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22216 · Cited by 42 · see citing works
Self-citationGreco, K. V., Francis, L., Somasundaram, M., Greco, G. N., English, N. R., Roether, J. A., Boccaccini, A. R., Sibbons, P. D., & Ansari, T. (2015) · Journal of Biomaterials Applications · doi:10.1177/0885328215578638 · Cited by 42 · see citing works
Dawson, L., Yu, L., Yan, M., Marrero, L., Schanes, P. P., Dolan, C. P., Pela, M., Petersen, B., Han, M., & Muneoka, K. (2017) · Regeneration · doi:10.1002/reg2.81 · Cited by 42 · see citing works
Bioactive peptides for boosting stem cell culture platform: Methods and applications
Dayem, A. A., Lee, S. B., Lim, K. M., Kim, A., Shin, H. J., Vellingiri, B., Kim, Y. B., & Cho, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114376 · Cited by 40 · see citing works
Costa, A., Naranjo, J. D., Turner, N. J., Swinehart, I. T., Kolich, B., Shaffiey, S. A., Londoño, R., Keane, T. J., Reing, J. E., Johnson, S. A., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.053 · Cited by 39 · see citing works
Self-citationMatrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function
Quijano, L. M., Naranjo, J. D., El-Mossier, S. O., Turner, N. J., Pineda Molina, C., Bartolacci, J., Zhang, L., White, L., Li, H., & Badylak, S. F. (2020) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2020.0243 · Cited by 38 · see citing works
Self-citationBiologic properties of surgical scaffold materials derived from dermal ECM
Kulig, K. M., Luo, X., Finkelstein, E. B., Liu, X., Goldman, S., Sundback, C. A., Vacanti, J. P., & Neville, C. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.055 · Cited by 37 · see citing works
Dawson, L., Simkin, J., Sauque, M., Pela, M., Palkowski, T., & Muneoka, K. (2016) · Regeneration · doi:10.1002/reg2.51 · Cited by 37 · see citing works
Ning, L., Zhang, Y., Zhang, Y., Zhu, M., Ding, W., Jiang, Y., Zhang, Y., Luo, J., & Qin, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651583 · Cited by 34 · see citing works
Effect of source animal age upon macrophage response to extracellular matrix biomaterials
LoPresti, S. T., & Brown, B. N. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.03.004 · Cited by 33 · see citing works
Kim, B. S., Kim, J., Lee, J. W., Ryu, K. M., Kim, S., & Hwang, N. S.-Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.02.017 · Cited by 33 · see citing works
Partial Characterization of the Sox2+ Cell Population in an Adult Murine Model of Digit Amputation
Agrawal, V., Siu, B. F., Chao, H., Hirschi, K. K., Raborn, E., Johnson, S. A., Tottey, S., Hurley, K. B., Medberry, C. J., & Badylak, S. F. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0550 · Cited by 33 · see citing works
Self-citationNieponice, A., Gilbert, T. W., Johnson, S. A., Turner, N. J., & Badylak, S. F. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.09.029 · Cited by 33 · see citing works
Self-citationLin, M., Ge, J.-B., Wang, X., Dong, Z.-Q., Xing, M., Lu, F., & He, Y.-F. (2019) · Journal of Tissue Engineering · doi:10.1177/2041731419888168 · Cited by 30 · see citing works
Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury
Ren, T., van der Merwe, Y., & Steketee, M. B. (2015) · eNeuro · doi:10.1523/eneuro.0077-15.2015 · Cited by 29 · see citing works
Liang, R., Yang, G., Kim, K. E., D’Amore, A., Pickering, A. N., Zhang, C., & Woo, S. L. (2015) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2015.05.001 · Cited by 29 · see citing works
A clinical‐grade acellular matrix for esophageal replacement
Arakélian, L., Caille, C., Faivre, L., Corté, L., Bruneval, P., Shamdani, S., Flageollet, C., Albanese, P., Domet, T., Jarraya, M., et al. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2983 · Cited by 28 · see citing works
Decellularization of mammalian tissues
Keane, T. J., Saldin, L. T., & Badylak, S. F. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-087-3.00004-3 · Cited by 28 · see citing works
Self-citationHussein, K. H., Ahmadzada, B., Correa, J. C., Sultan, A., Wilken, S., Amiot, B., & Nyberg, S. L. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.001 · Cited by 28 · see citing works
“This process triggers a shift in macrophage polarization from pro-inflammatory (M1) phenotype to an anti-inflammatory regenerative phenotype (M2 macrophages), promoting angiogenesis and recruiting stem/progenitor cell toward the implanted tissue for constructive remodeling [5,57,58].”
BackgroundYazdanpanah, G., Jiang, Y., Rabiee, B., Omidi, M., Rosenblatt, M. I., Shokuhfar, T., Pan, Y., Naba, A., & Djalilian, A. R. (2021) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2021.0011 · Cited by 27 · see citing works
Greco, K. V., Francis, L., Huang, H., Ploeg, R. J., Boccaccini, A. R., & Ansari, T. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2338 · Cited by 27 · see citing works
Mechanisms underlying heterologous skin scaffold-mediated tissue remodeling
Mimura, K. K., Moraes, A. R., Miranda, A. C., Greco, R., Ansari, T., Sibbons, P., Greco, K. V., & Oliani, S. M. (2016) · Scientific Reports · doi:10.1038/srep35074 · Cited by 25 · see citing works
Extracellular Matrix for Myocardial Repair
Dziki, J. L., & Badylak, S. F. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-97421-7_8 · Cited by 25 · see citing works
Self-citationTowards rebuilding vaginal support utilizing an extracellular matrix bioscaffold
Liang, R., Knight, K. M., Easley, D. C., Palcsey, S. L., Abramowitch, S. D., & Moalli, P. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.015 · Cited by 25 · see citing works
Azadi, S., Yazdanpanah, M. A., Afshari, A., Alahdad, N., Chegeni, S., Angaji, A., Rezayat, S. M., & Tavakol, S. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241303818 · Cited by 24 · see citing works
Host Response to Naturally Derived Biomaterials
Lopresti, S. T., & Brown, B. N. (2015) · Host Response to Biomaterials · doi:10.1016/b978-0-12-800196-7.00004-9 · Cited by 24 · see citing works
Dempsey, S. G., Miller, C. H., Schüler, J. B., Veale, R. W. F., Day, D. J., & May, B. C. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235784 · Cited by 24 · see citing works
Lund, D. K., Mouly, V., & Cornelison, D. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00032.2014 · Cited by 23 · see citing works
Chen, Y., Xu, H., & Lin, G. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.46 · Cited by 23 · see citing works
The impact of sterilization upon extracellular matrix hydrogel structure and function
White, L. J., Keane, T. J., Smoulder, A. L., Zhang, L., Castleton, A. A., Reing, J. E., Turner, N. J., Dearth, C. L., & Badylak, S. F. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.04.001 · Cited by 23 · see citing works
Self-citationHost Response to Implanted Materials and Devices: An Overview
Scarritt, M. E., Londoño, R., & Badylak, S. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-45433-7_1 · Cited by 21 · see citing works
Self-citationOsteogenic differentiation of 3D cultured mesenchymal stem cells induced by bioactive peptides
Lukášová, V., Buzgo, M., Sovková, V., Daňková, J., Rampichová, M., & Amler, E. (2017) · Cell Proliferation · doi:10.1111/cpr.12357 · Cited by 22 · see citing works
Wang, Y., Papagerakis, S. M., Faulk, D. M., Badylak, S. F., Zhao, Y., Ge, L., Qin, M., & Papagerakis, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00942 · Cited by 22 · see citing works
Self-citation
- Authors
- Agrawal, V., Tottey, S., Johnson, S. A., Freund, J. M., Siu, B. F., & Badylak, S. F.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Badylak, Stephen F.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2011-10
- Volume
- 17
- Issue
- 19-20
- Pages
- 2435-2443
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- PMC
- PMC3179613
- OpenAlex
- W2169478984
- Cited by
- 180
- References
- 63
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 3 · 2021: 12 · 2020: 16 · 2019: 7 · 2018: 16 · 2017: 20 · 2016: 18 · 2015: 17 · 2014: 14 · 2013: 10 · 2012: 13
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Tissue Engineering Part A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (W81XWH, W81XWH-08-2-0032)
- National Heart, Lung, and Blood Institute (1F30-HL102990, F30HL102990)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- extracellular matrix, cryptic peptides, type III collagen, progenitor cell recruitment, chemotaxis, digit amputation, epimorphic regeneration, perivascular stem cells, neural stem cells, Schwann cells, myoblasts, scaffold degradation, wound healing, scar tissue, tissue engineering scaffolds
- MeSH terms
- Amputation, Surgical, Animals, Cell Count, Cell Separation, Chemotaxis, Disease Models, Animal, Extracellular Matrix, Forelimb, Humans, Peptides, Stem Cells, Toes, Reproducibility of Results, Sus scrofa, Cell Proliferation, Mice, Rats, SOXB1 Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
