Cited by 347Healthcare Decision-Making and RestraintsPsychiatric care and mental health servicesSchizophrenia research and treatment

Community treatment orders for patients with psychosis (OCTET): a randomised controlled trial

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Burns, Tom, Rugkåsa, Jorun, Molodynski, Andrew, Dawson, John, Yeeles, Ksenija, Vazquez-Montes, Maria, Voysey, Merryn, Sinclair, Julia +1 more·2013·The Lancet

Abstract

Background Compulsory supervision outside hospital has been developed internationally for the treatment of mentally ill people following widespread deinstitutionalisation but its efficacy has not yet been proven. Community treatment orders (CTOs) for psychiatric patients became available in England and Wales in 2008. We tested whether CTOs reduce admissions compared with use of Section 17 leave when patients in both groups receive equivalent levels of clinical contact but different lengths of compulsory supervision.Methods OCTET is a non-blinded, parallel-arm randomised controlled trial. We postulated that patients with a diagnosis of psychosis discharged from hospital on CTOs would have a lower rate of readmission over 12 months than those discharged on the pre-existing Section 17 leave of absence. Eligible patients were those involuntarily admitted to hospital with a diagnosis of psychosis, aged 18-65 years, who were deemed suitable for supervised outpatient care by their clinicians. Consenting patients were randomly assigned (1:1 ratio) to be discharged from hospital either on CTO or Section 17 leave. Randomisation used random permuted blocks with lengths of two, four, and six, and stratified for sex, schizophrenic diagnosis, and duration of illness. Research assistants, treating clinicians, and patients were aware of assignment to randomisation group. The primary outcome measure was whether or not the patient was admitted to hospital during the 12-month follow-up period, analysed with a log-binomial regression model adjusted for stratification factors. We did all analyses by intention to treat. This trial is registered, number ISRCTN73110773.Findings Of 442 patients assessed, 336 patients were randomly assigned to be discharged from hospital either on CTO (167 patients) or Section 17 leave (169 patients). One patient withdrew directly after randomisation and two were ineligible, giving a total sample of 333 patients (166 in the CTO group and 167 in the Section 17 group). At 12 months, despite the fact that the length of initial compulsory outpatient treatment differed significantly between the two groups (median 183 days CTO group vs 8 days Section 17 group, p<0·001) the number of patients readmitted did not differ between groups (59 [36%] of 166 patients in the CTO group vs 60 [36%] of 167 patients in the Section 17 group; adjusted relative risk 1·0 [95% CI 0·75-1·33]).Interpretation In well coordinated mental health services the imposition of compulsory supervision does not reduce the rate of readmission of psychotic patients. We found no support in terms of any reduction in overall hospital admission to justify the significant curtailment of patients' personal liberty.Funding National Institute of Health Research.

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  • Only one study reported on outcomes at 36 months' follow-up.

    “Only one study reported on outcomes at 36 months' follow-up (Burns 2013)”

    From Compulsory community and involuntary outpatient treatment for people with severe mental disorders. (2017) · cites this paper as Burns 2013

    The Statistical analysis section defines the trial’s follow-up period as 12 months, and the Results report outcomes at 12 months. The cited paper therefore reports 12-month outcomes, not outcomes at the claimed 36-month follow-up; it also cannot establish how many other studies reported 36-month outcomes. Page numbers were not available in our copy. (LLM, conf=0.88)

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  • In Burns 2013's non-randomised comparison, participants who were on CTOs for between six and 12 months did better than participants with other durations of CTOs (less than six months, 12 to 24 months and 24 to 36 months).

    “although participants who were on CTOs for between six and 12 months did better than participants with other durations of CTOs (less than six months, 12 to 24 months and 24 to 36 months).”

    From Compulsory community and involuntary outpatient treatment for people with severe mental disorders. (2017) · cites this paper as Burns 2013

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  • Burns 2013 followed up all but three people included in their original intention-to-treat analysis (total n = 330).

    “The authors were able to follow-up all but three people who had been included in their original intention-to-treat analysis (total n = 330).”

    From Compulsory community and involuntary outpatient treatment for people with severe mental disorders. (2017) · cites this paper as Burns 2013

    The Results (page not available in our copy) say that one person withdrew and two were found ineligible immediately after randomisation. The intention-to-treat analysis included 333 people, and primary-outcome data were available for all 333—not 330 of them. (LLM, conf=0.90)

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  • In Burns 2013's non-randomised comparison at 36-month follow-up, people who had experienced a CTO had significantly more readmissions than those who had not (IDR 1.39, 95% CI 1.07 to 1.79).

    “People who had experienced a CTO had significantly more readmissions than those who had not (IDR 1.39, 95% CI 1.07 to 1.79) but otherwise there were no clear differences between groups in readmission rates, duration of readmission or time to first readmission.”

    From Compulsory community and involuntary outpatient treatment for people with severe mental disorders. (2017) · cites this paper as Burns 2013

    The Results and Statistical analysis sections describe a randomised trial with 12-month follow-up, not a non-randomised comparison at 36 months. The outcomes table reports no significant difference in the number of readmissions (IDR 0.82, 95% CI 0.58–1.16), contrary to the attributed IDR of 1.39. Page numbers are not available in our copy. (LLM, conf=0.89)

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  • In Burns 2013's non-randomised comparison, there was no linear relationship between readmission outcomes and duration of CTO.

    “In addition, they did not identify a linear relationship between readmission outcomes and duration of CTO although participants who were on CTOs for between six and 12 months did better than participants with other durations of CTOs (less than six months, 12 to 24 months and 24 to 36 months).”

    From Compulsory community and involuntary outpatient treatment for people with severe mental disorders. (2017) · cites this paper as Burns 2013

    The Results describe a randomised comparison of CTO and Section 17 groups, contrary to the claim that Burns 2013 made a non-randomised comparison. The Statistical analysis section specifies 12-month follow-up, and the reported results do not compare readmissions across CTO-duration categories or assess a linear relationship with duration; they cannot establish the claimed six-to-12-month advantage over categories extending to 36 months. Page numbers are not available in our copy. (LLM, conf=0.84)

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Cites

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Research works printed but not linked: 1

  1. Lukoff D, Nuechterlein K, Ventura J. Manual for expanded brief psychiatric rating scale (BPRS). Schizophr Bull 1986; 12: 594-602.

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Authors
Burns, T., Rugkåsa, J., Molodynski, A., Dawson, J., Yeeles, K., Vazquez-Montes, M., Voysey, M., Sinclair, J., & Priebe, S.
Affiliations
  • University of Oxford (GB)
  • Akershus University Hospital (NO)
  • Oxford Health NHS Foundation Trust (GB)
  • University of Otago (NZ)
  • University of Southampton (GB)
  • Queen Mary University of London (GB)
Corresponding author
Burns, Tom
Venue
The Lancet
Publisher
Elsevier BV
Published
2013-05
Volume
381
Issue
9878
Pages
1627-1633
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2142344992
Cited by
347
References
20
Citations by year
2026: 8 · 2025: 17 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 14 · 2020: 19 · 2019: 28 · 2018: 47 · 2017: 39 · 2016: 41 · 2015: 36 · 2014: 45 · 2013: 29
FWCI
56.00
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders
National Institute for Health and Care Research (RP-PG-0606-1006)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Healthcare Decision-Making and Restraints
  • Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
community treatment orders, psychosis, hospital readmission, involuntary psychiatric admission, deinstitutionalization, schizophrenia, involuntary treatment, mental health law, community mental health
MeSH terms
Adolescent, Adult, Aged, Community Mental Health Services, Female, United Kingdom, Hospitalization, Humans, Male, Middle Aged, Patient Readmission, Psychotic Disorders, State Medicine, Linear Models, Treatment Outcome, Statistics, Nonparametric

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