Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease
Abstract
The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe. By yearly temporal-lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15.1% per year (95% CI 10.0, 20.2) in 20 patients with histopathologically, confirmed Alzheimer's disease and 1.5% (0.2, 2.8) in 47 healthy ageing controls. Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event, probably a pathological cascade process. Thus, Alzheimer's disease may not be due simply to an acceleration of normal ageing but, rather, is the consequence of a true disease process.
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This rate was also within the range described in another study (27) using MRI volumetrics, but less than described by a different group (28) who measured the change in thickness of the medial temporal lobe on CT.
“This rate was also within the range described in another study (27) using MRI volumetrics, but less than described by a different group (28) who measured the change in thickness of the medial temporal lobe on CT.”
From Rates of hippocampal atrophy correlate with change in clinical status in aging and AD (2000) · cites this paper as [28]
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- Authors
- Jobst, K. A., Smith, A. D., Szatmari, M., Esiri, M. M., Jaskowski, A., Hindley, N., McDonald, B., & Molyneux, A. J.
- Affiliations
- University of Oxford (GB)
- John Radcliffe Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 343
- Issue
- 8901
- Pages
- 829-830
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1964756042
- Cited by
- 215
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 1
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, medial temporal lobe atrophy, atrophy rate, computed tomography, neuronal loss, aging
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Cognition, Humans, Longitudinal Studies, Temporal Lobe, Tomography, X-Ray Computed
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