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Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications
Open accessAbstract
Nicotinic acetylcholine receptors (nAChRs) in the muscle, autonomic ganglia, and brain are targets for pharmacologically administered nicotine. Several of the subunits that combine to form neuronal nicotinic receptors have been deleted by knockout or mutated by knockin in mice using homologous recombination. We will review the biochemical, pharmacological, anatomical, physiological, and behavioral phenotypes of mice with genetically altered neuronal nAChR subunits. Clinically relevant mutations in nAChR genes will also be discussed. In addition, some of the signal transduction pathways activated through nAChRs will be described in order to delineate the longer-term changes that might result from persistent activation or inactivation of nAChRs. Genetically manipulated mice have greatly increased our understanding of the subunit composition and physiological properties of nAChRs in vivo. In addition, these mice have provided a model system to determine the molecular basis for many of the pharmacological actions of nicotine on neurotransmitter release and behavior. Genetic manipulations in mice have also elucidated the role of nAChR subunits in various disease states, and suggest several avenues for drug development.
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“Nicotinic receptors function as non-selective, excitatory cation channels (Changeux et al., 1998; Picciotto et al., 2001) and occur as homomeric or heteromeric assemblies of a large family of α- and β-subunits (α2-α7 and β2-β4; reviewed in (Picciotto et al., 2000)).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Picciotto et al., 2001
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Cites
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Self-citationLinkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.587 · Cited by 1,141
Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., & Berkovic, S. F. (1995) · Nature Genetics · doi:10.1038/ng1095-201 · Cited by 1,134
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044
Acetylcholine receptor channel imaged in the open state
Unwin, P. N. T. (1995) · Nature · doi:10.1038/373037a0 · Cited by 1,000
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829
Freedman, R., Hall, M., Adler, L. E., & Leonard, S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00252-x · Cited by 678
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674
Elgoyhen, A. B., Vetter, D. E., Katz, E., Rothlin, C. V., Heinemann, S. F., & Boulter, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051622798 · Cited by 673
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668
Self-citationToward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
Karlin, A., & Akabas, M. H. (1995) · Neuron · doi:10.1016/0896-6273(95)90004-7 · Cited by 622
Luetje, C., & Patrick, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00837.1991 · Cited by 558
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
Marubio, L. M., Jiménez, M. D. M. A., Cordero‐Erausquin, M., Léna, C., Novère, N. G. L., d’Exaerde, A. D. K., Huchet, M., Damaj, M. I., & Changeux, J. (1999) · Nature · doi:10.1038/19756 · Cited by 538
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
Revah, F., Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M., & Changeux, J. (1991) · Nature · doi:10.1038/353846a0 · Cited by 524
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494
Jones, G., Sahakian, B. J., Levy, R., Warburton, D. M., & Gray, J. A. (1992) · Psychopharmacology · doi:10.1007/bf02247426 · Cited by 476
Schoepfer, R., Conroy, W. G., Whiting, P. J., Gore, M., & Lindstrom, J. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90031-a · Cited by 473
The nicotinic receptor β2 subunit is mutant in nocturnal frontal lobe epilepsy
Fusco, M. D., Becchetti, A., Patrignani, A., Annesi, G., Gambardella, A., Quattrone, A., Ballabio, A., Wanke, E., & Casari, G. (2000) · Nature Genetics · doi:10.1038/81566 · Cited by 447
Novère, N. L., & Changeux, J. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00167110 · Cited by 429
Kao, P. N., Dwork, A. J., Kaldany, R.-R., Silver, M. L., Wideman, J., Stein, S., & Karlin, A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71257-3 · Cited by 409
Claudio, T., Ballivet, M., Patrick, J., & Heinemann, S. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.4.1111 · Cited by 409
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 404
Self-citationFunctional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 395
Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Bertrand, S., & Changeux, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6971 · Cited by 390
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387
Self-citationPerry, E. K., Morris, C. M., COURT, J. A., Cheng, A. V., FAIRBAIRN, A. F., McKeith, I. G., Irving, D., Brown, A. J., & Perry, R. H. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00410-7 · Cited by 386
Le Novere, N., Zoli, M., & Changeux, J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01206.x · Cited by 385
Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor
Leonard, R. J., Labarca, C. G., Charnet, P., Davidson, N., & Lester, H. A. (1988) · Science · doi:10.1126/science.2462281 · Cited by 370
Cigarette smoking and protection from Parkinson's disease
Morens, D. M., Grandinetti, A., REED, D. M., White, L. R., & Ross, G. W. (1995) · Neurology · doi:10.1212/wnl.45.6.1041 · Cited by 368
Steinlein, O. K., Magnússon, A., Stoodt, J., Bertrand, S., Weiland, S., Berkovic, S. F., Nakken, K. O., Propping, P., & Bertrand, D. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.943 · Cited by 356
Nicotinic receptors in the brain. Links between molecular biology and behavior
Picciotto, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00146-3 · Cited by 354
Self-citationBansal, A., Singer, J. H., Hwang, B. J., Xu, W., Beaudet, A., & Feller, M. B. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07672.2000 · Cited by 350
Grady, S., Marks, M. J., Wonnacott, S., & Collins, A. C. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08322.x · Cited by 350
Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine
Pich, E. M., Pagliusi, S. R., Tessari, M., Talabot‐Ayer, D., van Huijsduijnen, R. H., & Chiamulera, C. (1997) · Science · doi:10.1126/science.275.5296.83 · Cited by 347
Zoli, M., Novère, N. G. L., Hill, J. A., & Changeux, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01912.1995 · Cited by 337
Phillips, H. A., Favre, I., Kirkpatrick, M., Zuberi, S. M., Goudie, D. R., Heron, S. E., Scheffer, I. E., Sutherland, G. R., Berkovic, S. F., Bertrand, D., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316946 · Cited by 320
Labarca, C. G., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., & Lester, H. A. (1995) · Nature · doi:10.1038/376514a0 · Cited by 302
Giraudat, J., Dennis, M., Heidmann, T., Chang, J. Y., & Changeux, J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2719 · Cited by 300
3 Regulation of ligand-gated ion channels by protein phosphorylation
Swope, S. L., Moss, S. J., Raymond, L. A., & Huganir, R. L. (1999) · Advances in second messenger and phosphoprotein research · doi:10.1016/s1040-7952(99)80005-6 · Cited by 299
Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A. (1998) · Learning & Memory · doi:10.1101/lm.5.4.302 · Cited by 298
Vetter, D. E., Liberman, M. C., Mann, J. R., Barhanin, J., Boulter, J., Brown, M. C., Saffiote-Kolman, J., Heinemann, S. F., & Elgoyhen, A. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)80756-4 · Cited by 296
Cigarette smoking and Parkinson's disease
Baron, J. A. (1986) · Neurology · doi:10.1212/wnl.36.11.1490 · Cited by 295
Xu, W., Gelber, S. E., Orr‐Urtreger, A., Armstrong, D. L., Lewis, R. A., Ou, C., Patrick, J. W., Role, L. W., Biasi, M. D., & Beaudet, A. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5746 · Cited by 289
lynx1, an Endogenous Toxin-like Modulator of Nicotinic Acetylcholine Receptors in the Mammalian CNS
Miwa, J. M., Ibáñez-Tallon, I., Crabtree, G. W., Sánchez, R., Šali, A., Role, L. W., & Heintz, N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80757-6 · Cited by 287
Xu, W., Orr‐Urtreger, A., Nigro, F., Gelber, S. E., Sutcliffe, C. B., Armstrong, D. L., Patrick, J. W., Role, L. W., Beaudet, A. L., & Biasi, M. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09298.1999 · Cited by 283
Kaufmann, C. A., Suarez, B. K., Malaspina, D., Pepple, J. R., Švrakić, D. M., Markel, P. D., Meyer, J. M., Zambuto, C. T., Schmitt, K., Matise, T. C., et al. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980710)81:4 · Cited by 266
Nicotinic Receptor Function in Schizophrenia
Leonard, S. S., Adams, C., Breese, C. R., Adler, L. E., Bickford, P. C., Byerley, W., Coon, H. H., Griffith, J. M., Miller, C., Myles‐Worsley, M., et al. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.3.431 · Cited by 263
Selective Excitation of Subtypes of Neocortical Interneurons by Nicotinic Receptors
Porter, J. T., Cauli, B., Tsuzuki, K., Lambolez, B., Rossier, J., & Audinat, E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05228.1999 · Cited by 262
Wada, E., McKinnon, D. H., Heinemann, S., Patrick, J., & Swanson, L. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90248-a · Cited by 254
Rossi, F., Pizzorusso, T., Porciatti, V., Marubio, L. M., Maffei, L., & Changeux, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101120998 · Cited by 252
Galzi, J., Revah, F., Black, D. M., Goeldner, M. P., HIRTH, C. G., & Changeux, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86964-2 · Cited by 248
Gault, J., Robinson, M., Berger, R., Drebing, C. J., Logel, J., Hopkins, J., Moore, T., Jacobs, S., Meriwether, J., Choi, M. J., et al. (1998) · Genomics · doi:10.1006/geno.1998.5363 · Cited by 245
β3: A New Member of Nicotinic Acetylcholine Receptor Gene Family Is Expressed in Brain
Deneris, E. S., Boulter, J., Swanson, L. W., Patrick, J., & Heinemann, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83343-9 · Cited by 225
Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses
Kuryatov, A., Olale, F., Cooper, J., Choi, C. H., & Lindstrom, J. M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00144-1 · Cited by 224
Role of Ca2+Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus
Léna, C., & Changeux, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00576.1997 · Cited by 218
Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
Brioni, J. D., O'Neill, A. B., Kim, D. J. B., & Decker, M. W. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90498-7 · Cited by 216
Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors
Zoli, M., Picciotto, M. R., Ferrari, R., Cocchi, D., & Changeux, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1235 · Cited by 208
Self-citationRoss, S. A., Wong, J. Y. F., Clifford, J. J., Kinsella, A., Massalas, J. S., Horne, M. K., Scheffer, I. E., Kola, I., Waddington, J. L., Berkovic, S. F., et al. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06431.2000 · Cited by 204
Fenster, C. P., Whitworth, T. L., Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04804.1999 · Cited by 204
Stevens, K. E. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00178-g · Cited by 203
Mulle, C., Vidal, C., Benoit, P., & Changeux, J. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02588.1991 · Cited by 200
Relation between nicotine intake and Alzheimer's disease.
van Duijn, C. M., & Hofman, A. (1991) · BMJ · doi:10.1136/bmj.302.6791.1491 · Cited by 198
The Location of the Gate in the Acetylcholine Receptor Channel
Wilson, G. G., & Karlin, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80506-1 · Cited by 195
Dineley‐Miller, K., & Patrick, J. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90244-6 · Cited by 194
A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy
Hirose, S., Iwata, H., Akiyoshi, H., Kobayashi, K., Ito, M., Wada, K., Kaneko, S., & Mitsudome, A. (1999) · Neurology · doi:10.1212/wnl.53.8.1749 · Cited by 194
Arias, H. R. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00154-0 · Cited by 193
Ryan, R. E., Ross, S. A., Drago, J., & Loiacono, R. E. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703989 · Cited by 188
The actions of nicotine and cocaine in a mouse model of anxiety
Costall, B., Elizabeth Kelly, M., Naylor, R. J., & Onaivi, E. S. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90450-4 · Cited by 186
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons
Léna, C., d’Exaerde, A. D. K., Cordero‐Erausquin, M., Novère, N. G. L., Jiménez, M. D. M. A., & Changeux, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12126 · Cited by 181
Changeux, J., Galzi, J., Devillers‐Thiéry, A., & Bertrand, D. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500004352 · Cited by 179
Smoking and schizophrenia: abnormal nicotinic receptor expression
Leonard, S., Breese, C., Adams, C., Benhammou, K., Gault, J., Stevens, K., Lee, M., Adler, L., Olincy, A., Ross, R., et al. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00035-2 · Cited by 177
Labarca, C., Schwarz, J., Deshpande, P., Schwarz, S., Nowak, M. W., Fonck, C., Nashmi, R., Kofuji, P., Dang, H., Shi, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041582598 · Cited by 177
Flores, C. M., DeCamp, R. M., Kilo, S., Rogers, S. W., & Hargreaves, K. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-07892.1996 · Cited by 177
5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors
Mukhin, A. G., Gündisch, D., Horti, A. G., Koren, A. O., Tamagnan, G., Kimes, A. S., Chambers, J., Vaupel, D. B., King, S. L., Picciotto, M. R., et al. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.3.642 · Cited by 173
Self-citationGalzi, J., Bertrand, D., Devillers‐Thiéry, A., Revah, F., Bertrand, S., & Changeux, J. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80668-s · Cited by 171
Genetic influences on nicotine responses
Marks, M. J., Stitzel, J. A., & Collins, A. C. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90406-1 · Cited by 170
Sines, S. M., Kreienkamp, H., BREN, N. D., Maeda, R. K., & Taylor, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90077-2 · Cited by 166
Grady, S. R., Meinerz, N. M., Cao, J., Reynolds, A. M., Picciotto, M. R., Changeux, J., McIntosh, J. M., Marks, M. J., & Collins, A. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00019.x · Cited by 156
Self-citationEpibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains
Berglund, U. W., & Nordberg, A. K. (1995) · Neuroreport · doi:10.1097/00001756-199511270-00033 · Cited by 148
Corringer, P., Galzi, J., Eiselé, J.-L., Bertrand, S., Changeux, J., & Bertrand, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11749 · Cited by 147
A discrete site for general anesthetics on a postsynaptic receptor.
Forman, S. A., Miller, K. W., & Yellen, G. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10508-7 · Cited by 143
Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C.
Fenster, C. P., Beckman, M. L., Parker, J. C., Sheffield, E. B., Whitworth, T. L., Quick, M. W., & Lester, R. A. J. (1999) · PubMed · Cited by 143
Clarke, P. B. S., Jakubovič, A., & Fibiger, H. C. (1988) · Psychopharmacology · doi:10.1007/bf02180033 · Cited by 140
Williams, B. M., Temburni, M. K., Levey, M. S., Bertrand, S., Bertrand, D., & Jacob, M. H. (1998) · Nature Neuroscience · doi:10.1038/2792 · Cited by 131
Lü, Y., Grady, S. R., Marks, M. J., Picciotto, M. R., Changeux, J., & Collins, A. C. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37839-5 · Cited by 129
Self-citationOrr‐Urtreger, A., Broide, R. S., Kasten, M. R., Dang, H., Dani, J. A., Beaudet, A. L., & Patrick, J. W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742154.x · Cited by 129
Gopalakrishnan, M., Molinari, E. J., & Sullivan, J. P. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.3.524 · Cited by 127
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (1999) · PubMed · Cited by 126
Self-citationBertrand, S., Weiland, S., Berkovic, S. F., Steinlein, O. K., & Bertrand, D. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702154 · Cited by 126
Czajkowski, C., Kaufmann, C. M., & Karlin, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6285 · Cited by 122
Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine
Zachariou, V. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00224-4 · Cited by 117
Self-citationNeuronal nicotinic acetylcholine receptors: from the gene to the disease
Weiland, S., Bertrand, D., & Leonard, S. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00199-6 · Cited by 117
Determinants of Specificity for α-Conotoxin MII on α3β2 Neuronal Nicotinic Receptors
Harvey, S. C., McIntosh, J. M., Cartier, G. E., Maddox, F. N., & Luetje, C. W. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.2.336 · Cited by 116
Functional α6-Containing Nicotinic Receptors Are Present in Chick Retina
Vailati, S., Hanke, W. R. L., Bejan, A., Barabino, B., Longhi, R., Balestra, B., Moretti, M., Clementi, F., & Gotti, C. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.1.11 · Cited by 111
Rust, G., Burgunder, J., Lauterburg, T., & Cachelin, A. B. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00290.x · Cited by 109
The Cognitive Psychopharmacology of Alzheimer's Disease: Focus on Cholinergic Systems
Lawrence, A. D., & Sahakian, B. J. (1998) · Neurochemical Research · doi:10.1023/a:1022419712453 · Cited by 105
Schuller, H. M., Jull, B. A., Sheppard, B. J., & Plummer, H. K. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00094-7 · Cited by 105
Tsuneki, H., Klink, R., Léna, C., Korn, H., & Changeux, J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00138.x · Cited by 100
Structure of the Nicotinic Receptor Acetylcholine-binding Site
Czajkowski, C., & Karlin, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3160 · Cited by 99
The Nicotinic Acetylcholine Receptor of theTorpedoElectric Ray
Unwin, N. C. (1998) · Journal of Structural Biology · doi:10.1006/jsbi.1997.3949 · Cited by 96
Richardson, C., Morgan, J. M., Jasani, B., Green, J. T., Rhodes, J., Williams, G. T., Lindstrom, J. M., Wonnacott, S., Thomas, G. A. O., & Smith, V. V. (2001) · Gastroenterology · doi:10.1053/gast.2001.26320 · Cited by 96
Chiara, D. C., & Cohen, J. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32940 · Cited by 95
Acute and Chronic Nicotine Exposures Modulate the Immune System through Different Pathways
Singh, M., Kalra, R., Puttfarcken, P. S., Kozak, A., Tesfaigzi, Y., & Sopori, M. L. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8897 · Cited by 91
Epping-Jordan, M. P., Picciotto, M. R., Changeux, J.-P., & Pich, E. M. (1999) · Psychopharmacology · doi:10.1007/s002130051135 · Cited by 86
Self-citationNovère, N. G. L., Zoli, M., Léna, C., Ferrari, R., Picciotto, M. R., Merlo‐Pich, E., & Changeux, J. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00012 · Cited by 86
Self-citationSteinlein, O. K., Stoodt, J., Mulley, J. C., Berkovic, S. F., Scheffer, I. E., & Brodtkorb, E. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00205.x · Cited by 84
Sáenz, A., Galán, J., Caloustian, C., Lorenzo, F., Márquez, C., Rodríguez, N., Jiménez, M. D., Poza, J. J., Cobo, A. M., Grid, D., et al. (1999) · Archives of Neurology · doi:10.1001/archneur.56.8.1004 · Cited by 83
Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
Bitner, R. S., Nikkel, A. L., Curzon, P., Donnelly‐Roberts, D. L., Puttfarcken, P. S., Namovic, M. T., Jacobs, I. C., Meyer, M. D., & Decker, M. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02442-2 · Cited by 82
Hellström‐Lindahl, E., Moore, H., & Nordberg, A. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740777.x · Cited by 81
Cucina, A., Corvino, V., Sapienza, P., Borrelli, V., Lucarelli, M., Scarpa, S., Ström, R., Santoro-D'Angelo, L., & Cavallaro, A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0478 · Cited by 80
Czajkowski, C., & Karlin, A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54614-7 · Cited by 79
Tsigelny, I. F., Sugiyama, N., Sine, S. M., & Taylor, P. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78047-0 · Cited by 79
Boorman, J. P., Groot‐Kormelink, P. J., & Sivilotti, L. G. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00565.x · Cited by 77
A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber
Cao, W., Burkholder, T., Wilkins, L. H., & Collins, A. C. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90124-c · Cited by 76
Caldarone, B. J., Duman, C. H., & Picciotto, M. R. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00137-4 · Cited by 75
Self-citationPairwise Interactions between Neuronal α7Acetylcholine Receptors and α-Conotoxin PnIB
Quiram, P. A., McIntosh, J. M., & Sine, S. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4889 · Cited by 73
Khiroug, L., Sokolova, E., Giniatullin, R. A., Afzalov, R., & Nistri, A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02458.1998 · Cited by 73
Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells
Messing, R. O., Stevens, A., Kiyasu, E., & Sneade, A. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-02-00507.1989 · Cited by 72
Eilers, H., Schaeffer, E., Bickler, P. E., & Forsayeth, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1105 · Cited by 71
Altered baroreflex responses in α7 deficient mice
Franceschini, D., Orr‐Urtreger, A., Yu, W., Mackey, L. Y., Bond, R. A., Armstrong, D. L., Patrick, J. W., Beaudet, A. L., & Biasi, M. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00195-9 · Cited by 68
Pairwise Interactions between Neuronal α7Acetylcholine Receptors and α-Conotoxin ImI
Quiram, P. A., Jones, J. J., & Sine, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19517 · Cited by 68
Tang, K., Wu, H., Mahata, S. K., & O’Connor, D. T. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.59 · Cited by 65
Quiram, P. A., & Sine, S. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11001 · Cited by 64
Phosphorylation of the Nicotinic Acetylcholine Receptor by Protein Tyrosine Kinasesa
Swope, S. L., Qu, Z., & Huganir, R. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17476.x · Cited by 59
Levandoski, M. M., Lin, Y., Moise, L., McLaughlin, J. T., Cooper, E., & Hawrot, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26113 · Cited by 56
Sine, S. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23521 · Cited by 55
Papke, R. L., Duvoisin, R. M., & Heinemann, S. F. (1993) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1993.0058 · Cited by 54
Pharmacological and null mutation approaches reveal nicotinic receptor diversity
Whiteaker, P., Marks, M. J., Grady, S. R., Lü, Y., Picciotto, M. R., Changeux, J., & Collins, A. C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00052-2 · Cited by 51
Self-citationLi, M. D., Kane, J. K., Matta, S. G., Blaner, W. S., & Sharp, B. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01318.2000 · Cited by 50
Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula.
Connolly, J. G., Gibb, A. J., & Colquhoun, D. M. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020650 · Cited by 48
Hsu, Y., Edwards, S. C., & Wecker, L. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062427.x · Cited by 47
Cox, M., Ely, C. M., Catling, A. D., Weber, M. J., & Parsons, S. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031103.x · Cited by 46
Stitzel, J. A., Blanchette, J., & Collins, A. C. (1998) · PubMed · Cited by 46
Long‐Term Activation of Protein Kinase C by Nicotine in Bovine Adrenal Chromaffin Cells
Tuominen, R. K., McMillian, M., Ye, H., Stachowiak, M. K., Hudson, P. M., & Hong, J. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10037.x · Cited by 44
Stitzel, J. A., Jimenez, M., Marks, M. J., Tritto, T., & Collins, A. C. (2000) · PubMed · Cited by 43
Damaj, M. I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00579-3 · Cited by 41
Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation
Kuryatov, A., Olale, F., Choi, C. H., & Lindstrom, J. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00027-3 · Cited by 40
β3 subunit is present in different nicotinic receptor subtypes in chick retina
Vailati, S., Moretti, M., Balestra, B., McIntosh, M., Clementi, F., & Gotti, C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00067-4 · Cited by 39
Schoepfer, R., Halvorsen, S. W., Conroy, W. G., Whiting, P. J., & Lindstrom, J. M. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81580-7 · Cited by 38
Stitzel, J. A., Lü, Y., Jimenez, M., Tritto, T., & Collins, A. C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00200-x · Cited by 37
Stitzel, J. A., Farnham, D. A., & Collins, A. C. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00149-0 · Cited by 36
Liu, Q., & Berg, D. K. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.3.1124 · Cited by 35
Picciotto, M. R., Zoli, M., Zachariou, V., & Changeux, J. (1997) · Biochemical Society Transactions · doi:10.1042/bst0250824 · Cited by 35
Self-citationHiel, H., Luebke, A. E., & Fuchs, P. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01947-8 · Cited by 32
Rovira, J. C., Ballesta, J. J., Vicente‐Agulló, F., Campos‐Caro, A., Criado, M., Sala, F., & Sala, S. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00889-8 · Cited by 31
Blum, M., Wu, G., Mudò, G., Belluardo, N., Andersson, K., Agnati, L. F., & Fuxé, K. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00364-o · Cited by 30
Faiman, C. P., de Erausquin, G. A., & Baratti, C. M. (1991) · Behavioral and Neural Biology · doi:10.1016/0163-1047(91)90592-e · Cited by 28
Chick Optic Lobe Contains a Developmentally Regulated α2α5β2 Nicotinic Receptor Subtype
Balestra, B., Vailati, S., Moretti, M., Hanke, W., Clementi, F., & Gotti, C. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.2.300 · Cited by 28
Marks, M. J., Stitzel, J. A., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00115-5 · Cited by 24
Self-citationMadhok, T. C., Matta, S. G., & Sharp, B. M. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00073-2 · Cited by 24
McLaughlin, J. T., Hawrot, E., & Yellen, G. (1995) · Biochemical Journal · doi:10.1042/bj3100765 · Cited by 23
Daubas, P., Salmon, A., Zoli, M., Geoffroy, B., Devillers‐Thiéry, A., Bessis, A., Médevielle, F., & Changeux, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2237 · Cited by 21
Sala, S., Rovira, J. C., Vicente‐Agulló, F., Campos‐Caro, A., Criado, M., Sala, F., & Ballesta, J. J. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900209 · Cited by 21
The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo
Viseshakul, N., Figl, A., Lytle, C. Y., & Cohen, B. N. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00128-4 · Cited by 19
Rovira, J. C., Vicente‐Agulló, F., Campos‐Caro, A., Criado, M., Sala, F., Sala, S., & Ballesta, J. J. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240051131 · Cited by 19
Luetje, C. W., Maddox, F. N., & Harvey, S. C. (1998) · PubMed · Cited by 17
Bunnemann, B., Terron, A., Zantedeschi, V., Pich, E. M., & Chiamulera, C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00104-7 · Cited by 16
Lentz, T. L., Chaturvedi, V., & Conti‐Fine, B. M. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00474-7 · Cited by 7
Pandey, S. C. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12817-2 · Cited by 6
Wang, Z. Z., Fuhrer, C., Shtrom, S., Sugiyama, J. E., Ferns, M., & Hall, Z. W. (1996) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1996.061.01.039 · Cited by 6
Lentz, T. L. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2155 · Cited by 4
Mutations Affecting Local Anesthetic Block of the Nicotinic Acetylcholine Receptor Ion Channel
Leonard, R. J., Charnet, P., Labarca, C. G., Vogelaar, N. J., Czyzyk, L., Gouin, A., Davidson, N., & Lester, H. A. (1991) · PsycEXTRA Dataset · doi:10.1037/e496192006-005 · Cited by 1
Young (2000) · doi:10.1002/1096-8628(20001009)96:5
Khan (2000) · doi:10.1002/1531-8249(200008)48:2
Research works printed but not linked: 7
- Booker, 2000, Analysis of nicotinic receptors containing beta3 subunits in the regulation of anxiety using the beta3 null mutant mice, Soc Neurosci Abstr, 26, 1405
- Grady, 2000, Characterization of dopamine release mediated by the nicotinic acetylcholine receptor inhibited by α-conotoxin MII, Soc Neurosci Abstr, 26, 901
- Leonard, 1998, Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative, Am J Med Genet, 81, 308, 10.1002/(SICI)1096-8628(19980710)81:4<308::AID-AJMG6>3.0.CO;2-P · DOI
- Luo, 2000, α3β2β3 Nicotinic acetylcholine receptors, Soc Neurosci Abstr, 26, 22
- Riley, 1997, Further suggestive evidence for involvement of the α7-nicotinic cholinergic receptor gene on chromosome 15q13-q14 in schizophrenia, Am J Hum Genet, 61, A402
- Rollins, 1993, Reduction in auditory gating following intra-cerebroventricular application of α-bungarotoxin binding site ligands and α-7 antisense oligonucleotides, Soc Neurosci Abstr, 19, 837
- Xu, 1997, Gene targeting of the α7 and β2 subunits and the β4, α3, and α5 cluster of neuronal nicotine acetylcholine receptors, Soc Neurosci Abstr, 23, 391
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Metadata
- Authors
- Picciotto, M. R., Caldarone, B. J., Brunzell, D. H., Zachariou, V., Stevens, T. R., & King, S. L.
- Affiliations
- Yale University (US)
- Corresponding author
- Picciotto, Marina R
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 92
- Issue
- 2-3
- Pages
- 89-108
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2053266420
- Cited by
- 221
- References
- 176
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 11 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 14 · 2013: 2 · 2012: 17
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA 10455, DA84733, DA 00436)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- neuronal nicotinic acetylcholine receptors, nicotine pharmacology, signal transduction, neurotransmitter release, behavioral phenotypes, physiological phenotypes, drug development
- MeSH terms
- Animals, Anxiety, Electrophysiology, Learning, Memory, Neurons, Nicotine, Phenotype, Receptors, Nicotinic, Signal Transduction, Point Mutation, Mice, Knockout, Nicotinic Agonists, Mice
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