α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

Paylor, Richard; Nguyen, Michelle; Crawley, Jacqueline N.; Patrick, James; Beaudet, Arthur; Orr-Urtreger, Avi

doi:10.1101/lm.5.4.302

PreprintCited by 298Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

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Paylor, Richard, Nguyen, Michelle, Crawley, Jacqueline N., Patrick, James, Beaudet, Arthur, Orr-Urtreger, Avi·1998·Learning & Memory

DOI 10.1101/lm.5.4.302PMC PMC311270

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Abstract

The alpha7 nicotinic acetylcholine receptor (nAChR) subunit is abundantly expressed in the hippocampus and contributes to hippocampal cholinergic synaptic transmission suggesting that it may contribute to learning and memory. There is also evidence for an association between levels of alpha7 nAChR and in sensorimotor gating impairments. To examine the role of alpha7 nAChRs in learning and memory and sensorimotor gating, Acra7 homozygous mutant mice and their wild-type littermates were tested in a Pavlovian conditioned fear test, for spatial learning in the Morris water task, and in the prepulse inhibition paradigm. Exploratory activity, motor coordination, and startle habituation were also evaluated. Acra7 mutant mice displayed the same levels of contextual and auditory-cue condition fear as wild-type mice. Similarly, there were no differences in spatial learning performance between mutant and wild-type mice. Finally, Acra7 mutant and wild-type mice displayed similar levels of prepulse inhibition. Other behavioral responses in Acra7 mutant mice were also normal, except for an anxiety-related behavior in the open-field test. The results of this study show that the absence of alpha7 nAChRs has little impact on normal, base-line behavioral responses. Future studies will examine the contribution of alpha7 nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments.

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α7 nAChR-lacking knockout mice show decreased levels of anxiety in the elevated plus maze.
“Paylor et al. (1998) showed that α7 nAChR-lacking KO mice show decreased levels of anxiety in the EPM paradigm”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Paylor et al. (1998)
a7 nAChRs have not been implicated directly in anxiety.
“Furthermore, although a7 nAChRs have not been implicated directly in anxiety (Paylor et al., 1998;Vicens et al., 2011) they are necessary in the ventral tegmental area for the expression of withdrawal from nicotine, suggesting that targeting of the a7 subtype may also relieve nicotine withdrawal symptoms (Nomikos et al., 1999).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Paylor et al., 1998

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Authors: Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A.
Affiliations: National Institutes of Health (US)
Howard Hughes Medical Institute (US)
ORCID: Crawley, Jacqueline N.
Beaudet, Arthur
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 1998-09-01
Volume: 5
Issue: 4
Pages: 302-316
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.5.4.302
PMC: PMC311270
OpenAlex: W2140474257
Cited by: 298
References: 59
Citations by year: 2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 18 · 2014: 16 · 2013: 12 · 2012: 13
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: alpha7 nicotinic acetylcholine receptor, hippocampus-dependent learning, spatial learning, fear conditioning, sensorimotor gating, prepulse inhibition, anxiety-like behavior, cholinergic neurotransmission, hippocampus
MeSH terms: Animals, Conditioning, Classical, Darkness, Exploratory Behavior, Fear, Hippocampus, Homozygote, Learning, Light, Motor Activity, Synaptic Transmission, Pain, Psychomotor Performance, Receptors, Nicotinic, Reflex, Startle, Mice, Knockout, Mice, alpha7 Nicotinic Acetylcholine Receptor

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α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

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