Cited by 134Protein Kinase Regulation and GTPase SignalingProtein Tyrosine PhosphatasesMelanoma and MAPK Pathways

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Docking interactions in the mitogen-activated protein kinase cascades

Tanoue, Takuji, Nishida, Eisuke·2002·Pharmacology & Therapeutics

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Abstract

Regulation of cellular functions and responses utilizes a number of the signal transduction pathways. Each pathway should transduce signals with high efficiency and fidelity to avoid unnecessary crosstalks. The mitogen-activated protein kinase (MAPK) cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. MAPK is activated by MAPK kinase; phosphorylates various targets, including transcription factors and MAPK-activated protein kinases; and is inactivated by several phosphatases. Recent studies have provided a cue to understand the molecular mechanism underlying the signal transduction through the MAPK cascades. In the MAPK cascades, docking interactions, which are achieved through a site outside the catalytic domain of MAPKs, regulate the efficiency and specificity of the enzymatic reactions. The docking interaction is different from a transient enzyme-substrate interaction through the active center. It has been shown that activators, substrates, and inactivators of MAPKs utilize a common site on MAPKs in the docking interaction. Then, the docking interaction may regulate not only the efficiency and specificity of the cascades, but also the ordered and integrated signaling.

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Authors: Tanoue, T., & Nishida, E.
Affiliations: Kyoto University (JP)
Corresponding author: Nishida, Eisuke
ORCID: Nishida, Eisuke
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2002-02
Volume: 93
Issue: 2-3
Pages: 193-202
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/s0163-7258(02)00188-2
OpenAlex: W1992023215
Cited by: 134
References: 57
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 5
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: mitogen-activated protein kinase, MAPK signaling, MAPK kinase, signal transduction, enzyme regulation, signaling specificity, signaling crosstalk, MAPK phosphorylation
MeSH terms: Animals, Humans, Membrane Proteins, Molecular Biology, Phosphorylation, Signal Transduction, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

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Docking interactions in the mitogen-activated protein kinase cascades

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