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Cited by 86Menstrual Health and DisordersMaternal Mental Health During Pregnancy and PostpartumCircadian rhythm and melatonin

A controlled study of light therapy in women with late luteal phase dysphoric disorder

Lam, Raymond W., Carter, Diana, Misri, Shaila, Kuan, Annie J., Yatham, Lakshmi N., Zis, Athanasios P.·1999·Psychiatry Research
DOI 10.1016/s0165-1781(99)00043-8
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Abstract

Previous studies suggest that light therapy, as used to treat seasonal affective disorder, may be beneficial for pre-menstrual depressive disorders. We conducted a six-menstrual cycle randomized, double-blind, counter-balanced, crossover study of dim vs. bright light therapy in women with late luteal phase dysphoric disorder (LLPDD). Fourteen women who met DSM-III-R criteria for LLPDD completed two menstrual cycles of prospective baseline monitoring of pre-menstrual symptoms, followed by two cycles of each treatment. During the 2-week luteal phase of each treatment cycle, patients were randomized to receive 30 min of evening light therapy using: (1) 10000 lx cool-white fluorescent light (active condition); or (2) 500 lx red fluorescent light (placebo condition), administered by a light box at their homes. After two menstrual cycles of treatment, patients were immediately crossed over to the other condition for another two cycles. Outcome measures were assessed at the mid-follicular and luteal phases of each cycle. Results showed that the active bright white light condition significantly reduced depression and pre-menstrual tension scores during the symptomatic luteal phase, compared to baseline, while the placebo dim red light condition did not. These results suggest that bright light therapy is an effective treatment for LLPDD.

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Authors
Lam, R. W., Carter, D., Misri, S., Kuan, A. J., Yatham, L. N., & Zis, A. P.
Affiliations
  • University of British Columbia Hospital (CA)
  • University of British Columbia (CA)
Corresponding author
Lam, Raymond W.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1999-06
Volume
86
Issue
3
Pages
185-192
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/s0165-1781(99)00043-8
OpenAlex
W2024539602
Cited by
85
References
48
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 5
FWCI
5.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
phototherapy, late luteal phase dysphoric disorder, premenstrual dysphoric disorder, dim red light, premenstrual depression, premenstrual syndrome, luteal phase
MeSH terms
Adult, Circadian Rhythm, Double-Blind Method, Female, Humans, Luteal Phase, Phototherapy, Premenstrual Syndrome, Psychiatric Status Rating Scales, Treatment Outcome, Cross-Over Studies, Chronotherapy

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