The postsynaptic density at glutamatergic synapses

Kennedy, Mary B.

doi:10.1016/s0166-2236(96)01033-8

Cited by 475Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersReceptor Mechanisms and Signaling

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The postsynaptic density at glutamatergic synapses

Kennedy, Mary B.·1997·Trends in Neurosciences

DOI 10.1016/s0166-2236(96)01033-8

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Abstract

The postsynaptic density (PSD) is a tiny, amorphous structure located beneath the postsynaptic membrane of synapses in the CNS. Until recently, the molecular composition and function of the PSD were mostly matters of speculation. With the advent of powerful new microchemical tools and molecular-genetic methods, three new classes of proteins have been identified in the PSD at glutamatergic synapses: the PSD-95 family, the NR2B subunit of the NMDA-type glutamate receptor, and densin-180. The PSD-95 family is involved in clustering of NMDA receptors. NR2B is phosphorylated by Ca2(+)-calmodulin-dependent protein kinase type II, a prominent constituent of the PSD. Densin-180 might represent a new class of synaptic adhesion molecule. Study of these molecules is beginning to reveal the functional significance of the PSD.

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Other interactions may additionally contribute to linking proteins of the postsynaptic junction to F-actin.
“Other interactions may additionally contribute to linking proteins of the postsynaptic junction to F-actin (Kennedy, 1997).”
From Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin (1998) · cites this paper as Kennedy, 1997

Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study
Colonnier, M. (1968) · Brain Research · doi:10.1016/0006-8993(68)90234-5 · Cited by 946

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Authors: Kennedy, M. B.
Affiliations: California Institute of Technology (US)
Corresponding author: Kennedy, Mary B.
ORCID: Kennedy, Mary B.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1997-06
Volume: 20
Issue: 6
Pages: 264-268
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/s0166-2236(96)01033-8
OpenAlex: W1991004364
Cited by: 475
References: 1
Citations by year: 2026: 1 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 16 · 2013: 8 · 2012: 12
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: postsynaptic density, glutamatergic synapses, PSD-95, NR2B subunit, calcium/calmodulin-dependent protein kinase II, receptor phosphorylation, synaptic adhesion molecules
MeSH terms: Animals, Nerve Tissue Proteins, Sialoglycoproteins, Receptors, N-Methyl-D-Aspartate, Presynaptic Terminals

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The postsynaptic density at glutamatergic synapses

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