Characterization of the Shank Family of Synaptic Proteins
Open accessAbstract
Shank1, Shank2, and Shank3 constitute a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank directly interacts with GKAP and Homer, thus potentially bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex in synapses (Naisbitt, S., Kim, E., Tu, J. C. , Xiao, B., Sala, S., Valtschanoff, J., Weinberg, R. J., Worley, P. F., and Sheng, M. (1999) Neuron 23, 569-582; Tu, J. C., Xiao, B., Naisbitt, S., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., and Worley, P. F. (1999) Neuron 23, 583-592). Shank contains multiple domains for protein-protein interaction including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. By characterizing Shank cDNA clones and RT-PCR products, we found that there are four sites for alternative splicing in Shank1 and another four sites in Shank2, some of which result in deletion of specific domains of the Shank protein. In addition, the expression of the splice variants is differentially regulated in different regions of rat brain during development. Immunoblot analysis of Shank proteins in rat brain using five different Shank antibodies reveals marked heterogeneity in size (120-240 kDa) and differential spatiotemporal expression. Shank1 immunoreactivity is concentrated at excitatory synaptic sites in adult brain, and the punctate staining of Shank1 is seen in developing rat brains as early as postnatal day 7. These results suggest that alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SHANK genes have complex transcriptional regulation with multiple intragenic promoters and extensive alternatively spliced exons in both humans and mice.
“SHANK genes display a complex transcriptional regulation with multiple intragenic promoters and extensive alternatively spliced exons both in humans and mice (Leblond et al., 2012; Lim et al., 1999; Maunakea et al., 2010; McWilliams et al., 2004; Redecker et al., 2006; Wang et al., 2011; Wilson et al., 2003).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Lim et al., 1999
Expression of Shank3 isoforms is cell type-specific and developmentally regulated.
“The expression of Shank3 isoforms is cell type-specific and developmentally regulated (Lim et al., 1999; Maunakea et al., 2010).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Lim et al., 1999
Differences in SHANK2 exon numbering across organisms in other reports likely reflect uncharacterized exons or alternative splicing.
“The difference in exon numbering for SHANK2 in different organisms in other reports is likely due to the pattern of uncharacterized exons or alternative splicing (Leblond et al., 2012; Lim et al., 1999; McWilliams et al., 2004).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Lim et al., 1999
Alternative splicing of exons 19-20 and isoforms of SHANK2E, SHANK2A, and SHANK2B are conserved in mice, but the status of SHANK2C and other spliced exons has not been confirmed.
“The alternative splicing of exons 19-20 and isoforms of SHANK2E (Jiang, unpublished data), SHANK2A, and SHANK2B (Lim et al., 1999) were conserved in mice but the status of SHANK2C and other spliced exons has not been confirmed.”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Lim et al., 1999
Cites
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256 · see citing works
Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,882 · see citing works
Brenman, J. E., Chao, D. S., Gee, S., McGee, A. W., Craven, S. E., Santillano, D. R., Wu, Z., Huang, F., Xia, H., Peters, M. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81053-3 · Cited by 1,596 · see citing works
Cho, K.-O., Hunt, C. A., & Kennedy, M. B. (1992) · Neuron · doi:10.1016/0896-6273(92)90245-9 · Cited by 1,193 · see citing works
Golub, T. R., Barker, G. F., Lovett, M., & Gilliland, D. G. (1994) · Cell · doi:10.1016/0092-8674(94)90322-0 · Cited by 1,154 · see citing works
Homer: a protein that selectively binds metabotropic glutamate receptors
Brakeman, P., Lanahan, A. A., O’Brien, R., Roche, K. W., Barnes, C. A., Huganir, R. L., & Worley, P. F. (1997) · Nature · doi:10.1038/386284a0 · Cited by 1,115 · see citing works
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,047 · see citing works
Self-citationNaisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works
Self-citationGRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
Dong, H., O’Brien, R., Fung, E. T., Lanahan, A. A., Worley, P. F., & Huganir, R. L. (1997) · Nature · doi:10.1038/386279a0 · Cited by 871 · see citing works
Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works
Niethammer, M., Kim, E., & Sheng, M. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02157.1996 · Cited by 750 · see citing works
Self-citationXiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A. M., Lanahan, A. A., Wenthold, R. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80588-7 · Cited by 649 · see citing works
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634 · see citing works
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590 · see citing works
Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2
Gorina, S. S., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.1001 · Cited by 571 · see citing works
Kim, E., Cho, K.-O., Rothschild, A., & Sheng, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80284-6 · Cited by 558 · see citing works
Self-citationKim, E., Naisbitt, S., Hsueh, Y.-P., Rao, A., Rothschild, A., Craig, A. M., & Sheng, M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.3.669 · Cited by 516 · see citing works
Self-citationActivity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
Rao, A., & Craig, A. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80962-9 · Cited by 492 · see citing works
PDZ Proteins Organize Synaptic Signaling Pathways
Craven, S. E., & Bredt, D. S. (1998) · Cell · doi:10.1016/s0092-8674(00)81179-4 · Cited by 491 · see citing works
The postsynaptic density at glutamatergic synapses
Kennedy, M. B. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01033-8 · Cited by 475 · see citing works
A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene
Hirai, H., Maru, Y., Hagiwara, K., Nishida, J., & Takaku, F. (1987) · Science · doi:10.1126/science.2825356 · Cited by 441 · see citing works
SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.
Müller, B., Kistner, U., Kindler, S., Chung, W. J., Kuhlendahl, S., Fenster, S. D., Lau, L.-F., Veh, R., Huganir, R., Gundelfinger, E., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80157-9 · Cited by 435 · see citing works
Stein, E., Lane, A. A., Cerretti, D. P., Schoecklmann, H. O., Schroff, A. D., Etten, R. L. V., & Daniel, T. O. (1998) · Genes & Development · doi:10.1101/gad.12.5.667 · Cited by 424 · see citing works
Kistner, U., Wenzel, B., Veh, R. W., Cases-Langhoff, C., Garner, A. M., APPELTAUER, U., Voss, B., Gundelfinger, E. D., & Garner, C. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53433-5 · Cited by 414 · see citing works
Enlightening the Postsynaptic Density
Ziff, E. B. (1997) · Neuron · doi:10.1016/s0896-6273(00)80409-2 · Cited by 381 · see citing works
Muller, B., Kistner, U., Veh, R. W., Cases-Langhoff, C., Becker, B., Gundelfinger, E., & Garner, C. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02354.1995 · Cited by 381 · see citing works
Tezuka, T., Umemori, H., Akiyama, T., Nakanishi, S., & Yamamoto, T. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.435 · Cited by 377 · see citing works
Takeuchi, M., Hata, Y., Hirao, K., Toyoda, A., Irie, M., & Takai, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.11943 · Cited by 359 · see citing works
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP
Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G. J., States, B. A., Daly, C., deSouza, S., Abagyan, R. A., Valtschanoff, J. G., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80568-1 · Cited by 357 · see citing works
Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein
Brenman, J. E., Christopherson, K. S., Craven, S. E., McGee, A. W., & Bredt, D. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07407.1996 · Cited by 333 · see citing works
PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects
Sheng, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80190-7 · Cited by 324 · see citing works
Self-citationSerra‐Pagès, C., Kedersha, N. L., Fazikas, L., Medley, Q., Debant, A., & Streuli, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07282.x · Cited by 321 · see citing works
CRIPT, a Novel Postsynaptic Protein that Binds to the Third PDZ Domain of PSD-95/SAP90
Niethammer, M., Valtschanoff, J. G., Kapoor, T. M., Allison, D. W., Weinberg, R. J., Craig, A. M., & Sheng, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)81009-0 · Cited by 303 · see citing works
Self-citationTu, Y., Li, F., Goicoechea, S. M., & Wu, C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2425 · Cited by 303 · see citing works
SAM as a protein interaction domain involved in developmental regulation
Schultz, J., Peer Bork, B., Ponting, C. P., & Hofmann, K. (1997) · Protein Science · doi:10.1002/pro.5560060128 · Cited by 300 · see citing works
Watanabe, M., Fukaya, M., Sakimura, K., Manabe, T., Mishina, M., & Inoue, Y. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00063.x · Cited by 292 · see citing works
Novel Members of the Vesl/Homer Family of PDZ Proteins That Bind Metabotropic Glutamate Receptors
Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H., & Inokuchi, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23969 · Cited by 280 · see citing works
Molecular mechanisms of glutamate receptor clustering at excitatory synapses
O’Brien, R., Lau, L., & Huganir, R. L. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80062-7 · Cited by 270 · see citing works
Du, Y., Weed, S. A., Xiong, W.-C., Marshall, T. D., & Parsons, J. T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5838 · Cited by 254 · see citing works
Oligomeric Structure of the Human EphB2 Receptor SAM Domain
Thanos, C. D., Goodwill, K. E., & Bowie, J. U. (1999) · Science · doi:10.1126/science.283.5403.833 · Cited by 235 · see citing works
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Sicheri, F., Stapleton, D., Balan, I., & Pawson, T. J. (1999) · Nature Structural Biology · doi:10.1038/4917 · Cited by 230 · see citing works
Gesemann, M., Cavalli, V., Denzer, A. J., Brancaccio, A., Schumacher, B., & Rüegg, M. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80096-3 · Cited by 227 · see citing works
Jousset, C., Carron, C., Boureux, A., Quang, C. T., Oury, C., Dusanter‐Fourt, I., Charon, M., Levin, J., Bernard, O., & Ghysdael, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.1.69 · Cited by 207 · see citing works
Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
Alagarsamy, S., Marino, M. J., Rouse, S. T., Gereau, R. W., Heinemann, S. F., & Conn, P. J. (1999) · Nature Neuroscience · doi:10.1038/6338 · Cited by 200 · see citing works
Lau, L., Mammen, A. L., Ehlers, M., Kindler, S., Chung, W. J., Garner, C. C., & Huganir, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21622 · Cited by 177 · see citing works
SAM: A novel motif in yeast sterile anddrosophilapolyhomeotic proteins
Ponting, C. P. (1995) · Protein Science · doi:10.1002/pro.5560040927 · Cited by 152 · see citing works
Stein, E., Cerretti, D. P., & Daniel, T. O. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23588 · Cited by 141 · see citing works
DAP‐1, a novel protein that interacts with the guanylate kinase‐like domains of hDLG and PSD‐95
Satoh, K., Yanai, H., Senda, T., Kohu, K., Nakamura, T., Okumura, N., Matsumine, A., Kobayashi, S., Toyoshima, K., & Akiyama, T. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1310329.x · Cited by 122 · see citing works
Masuko, N., Makino, K., Kuwahara, H., Fukunaga, K., Sudo, T., Araki, N., Yamamoto, H., Yamada, Y., Miyamoto, E., & Saya, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5782 · Cited by 88 · see citing works
Barr, M. M., Tu, H., Aelst, L. V., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5597 · Cited by 80 · see citing works
O'Toole, J. J., Deyst, K. A., Bowe, M. A., Nastuk, M. A., McKechnie, B. A., & Fallon, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7369 · Cited by 78 · see citing works
Campanelli, J. T., Gayer, G. G., & Scheller, R. H. (1996) · Development · doi:10.1242/dev.122.5.1663 · Cited by 74 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Self-citationBozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works
The Shank family of scaffold proteins
Sheng, M., & Kim, E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1851 · Cited by 578 · see citing works
Self-citationSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Wang, X., McCoy, P. A., Rodriguiz, R. M., Pan, Y., Je, H. S., Roberts, A. C., Kim, C. J., Berrios, J., Colvin, J. S., Bousquet-Moore, D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr212 · Cited by 537 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
Leblond, C. S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., Konyukh, M., Chaste, P., Ey, E., Rastam, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002521 · Cited by 429 · see citing works
Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory
Lee, S.-H., Choi, J.-H., Lee, N., Lee, H.-R., Kim, J.-I., Yu, N.-K., Choi, S.-L., Lee, S.-H., Kim, H., & Kaang, B.-K. (2008) · Science · doi:10.1126/science.1150541 · Cited by 409 · see citing works
Wilson, H. L., Wong, A. C. C., Shaw, S. R., Tse, W.-Y., Stapleton, G. A., Phelan, M. C., Hu, S., Marshall, J., & McDermid, H. E. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.575 · Cited by 377 · see citing works
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
Self-citationBoeckers, T. M., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00931.x · Cited by 349 · see citing works
Bonaglia, M. C., Giorda, R., Borgatti, R., Felisari, G., Gagliardi, C., Selicorni, A., & Zuffardi, O. (2001) · The American Journal of Human Genetics · doi:10.1086/321293 · Cited by 309 · see citing works
Zhou, Y., Kaiser, T., Monteiro, P., Zhang, X., Van der Goes, M. S., Wang, D., Barak, B., Zeng, M., Li, C., Lu, C., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.023 · Cited by 325 · see citing works
Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
Roussignol, G., Ango, F., Romorini, S., Tu, J. C., Sala, C., Worley, P. F., Bockaert, J., & Fagni, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4354-04.2005 · Cited by 293 · see citing works
Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288 · see citing works
Self-citationAn Architectural Framework That May Lie at the Core of the Postsynaptic Density
Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292 · see citing works
The emerging role of <i>SHANK</i> genes in neuropsychiatric disorders
Guilmatre, A., Huguet, G., Delorme, R., & Bourgeron, T. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22128 · Cited by 237 · see citing works
Ontogeny of postsynaptic density proteins at glutamatergic synapses
Petralia, R. S., Sans, N., Wang, Y.-X., & Wenthold, R. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.013 · Cited by 236 · see citing works
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
Grabrucker, A. M., Schmeisser, M. J., Schoen, M., & Boeckers, T. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.003 · Cited by 233 · see citing works
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Grabrucker, A. M., Knight, M. J., Proepper, C., Bockmann, J., Joubert, M., Rowan, M., Nienhaus, G. U., Garner, C. C., Bowie, J. U., Kreutz, M. R., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.336 · Cited by 228 · see citing works
Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020631 · Cited by 220 · see citing works
Self-citationSociability and motor functions in Shank1 mutant mice
Silverman, J. L., Turner, S. M., Barkan, C. L., Tolu, S. S., Saxena, R., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.026 · Cited by 218 · see citing works
Self-citationPark, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works
Self-citationSHANK3 as an autism spectrum disorder-associated gene
Uchino, S., & Waga, C. (2013) · Brain and Development · doi:10.1016/j.braindev.2012.05.013 · Cited by 176 · see citing works
The genetics of child psychiatric disorders: focus on autism and Tourette syndrome
State, M. W. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.004 · Cited by 162 · see citing works
Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., & Kim, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0940 · Cited by 151 · see citing works
Self-citationSynaptic Scaffolding Proteins in Rat Brain
Böckers, T. M., Mameza, M. G., Kreutz, M. R., Bockmann, J., Weise, C., Buck, F., Richter, D., Gundelfinger, E. D., & Kreienkamp, H.-J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102454200 · Cited by 137 · see citing works
GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
Shin, S. M., Zhang, N., Hansen, J., Gerges, N. Z., Pak, D. T. S., Sheng, M., & Lee, S. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3259 · Cited by 126 · see citing works
Self-citationBoeckers, T. M., Liedtke, T., Spilker, C., Dresbach, T., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02910.x · Cited by 113 · see citing works
Hung, A. Y., Sung, C. C., Brito, I. L., & Sheng, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009842 · Cited by 106 · see citing works
Self-citationScaffolding proteins at the postsynaptic density: shank as the architectural framework
Kreienkamp, H. J. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_15 · Cited by 105 · see citing works
Uchino, S., Wada, H., Honda, S., Nakamura, Y., Ondo, Y., Uchiyama, T., Tsutsumi, M., Suzuki, E., Hirasawa, T., & Kohsaka, S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03831.x · Cited by 95 · see citing works
DNA methylation regulates tissue‐specific expression of Shank3
Beri, S., Tonna, N., Menozzi, G., Bonaglia, M. C., Sala, C., & Giorda, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04539.x · Cited by 74 · see citing works
Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells
McWILLIAMS, R. R., GIDEY, E., FOUASSIER, L., WEED, S. A., & DOCTOR, R. B. (2004) · Biochemical Journal · doi:10.1042/bj20031577 · Cited by 63 · see citing works
A new synaptic player leading to autism risk: Met receptor tyrosine kinase
Judson, M. C., Eagleson, K. L., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9081-8 · Cited by 43 · see citing works
Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
Jacot-Descombes, S., Keshav, N. U., Dickstein, D. L., Wicinski, B., Janssen, W. G. M., Hiester, L. L., Sarfo, E. K., Warda, T., Fam, M. M., Harony-Nicolas, H., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00393-8 · Cited by 41 · see citing works
Howell, B. W., & Smith, K. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.019 · Cited by 35 · see citing works
- Authors
- Lim, S., Naisbitt, S., Yoon, J., Hwang, J.-I., Suh, P.-G., Sheng, M., & Kim, E.
- Affiliations
- Pusan National University (KR)
- Howard Hughes Medical Institute (US)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Kim, Eunjoon
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 274
- Issue
- 41
- Pages
- 29510-29518
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2084494997
- Cited by
- 295
- References
- 52
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 22 · 2023: 15 · 2022: 12 · 2021: 15 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 10 · 2013: 12 · 2012: 26
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 35050, R01NS035050)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- Shank1, Shank2, SHANK3, postsynaptic density, alternative splicing, splice variants, GKAP, Homer, NMDA receptor, metabotropic glutamate receptors, ankyrin repeats, SH3 domain, sterile alpha motif domain, proline-rich region, synaptic proteins, brain development, excitatory synapses, spatiotemporal expression
- MeSH terms
- Amino Acid Sequence, Animals, Brain, Carrier Proteins, Cloning, Molecular, Fluorescent Antibody Technique, Molecular Sequence Data, Nerve Tissue Proteins, Synaptic Transmission, RNA, Messenger, Sequence Homology, Amino Acid, Alternative Splicing, Gene Expression Regulation, Developmental, COS Cells, Reverse Transcriptase Polymerase Chain Reaction, Adaptor Proteins, Signal Transducing, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
