Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
Abstract
The Ts65Dn mouse is segmentally trisomic for a part of mouse chromosome 16 and is a genetic model for Down syndrome and Alzheimer's disease. Although many studies have examined the learning and memory processes in Ts65Dn mice, it has yet to be determined if Ts65Dn mice are specifically impaired in learning tasks that require an intact hippocampus. Context discrimination learning is dependent on the dorsal hippocampus in mice. In this task, mice learn to discriminate two similar contexts, one of which is associated with foot shock. In the current study, Ts65Dn mice learned almost identically to what has been reported for mice with dorsal hippocampal lesions, while controls behaved similarly to sham lesioned mice. Therefore, Ts65Dn mice have learning deficits in a hippocampal dependent task that may be related to the loss of cholinergic input to the hippocampus, which occurs after 6 months of age.
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Mouse models of DS have elucidated specific defects in neurogenesis, neuronal differentiation, and impaired synaptic plasticity and learning.
“Mouse models have provided additional insights into the developmental progression of DS, elucidating specific defects in neurogenesis, neuronal differentiation, and impaired synaptic plasticity and learning (Chakrabarti et al., 2007, 2010; Hyde et al., 2001; Kleschevnikov et al., 2004; Siarey et al., 1997, 1999; Tyler and Haydar, 2013; Wang et al., 2013).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Hyde et al., 2001
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- Authors
- Hyde, L. A., Frisone, D. F., & Crnic, L. S.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Hyde, Lynn A
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 118
- Issue
- 1
- Pages
- 53-60
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1987268303
- Cited by
- 108
- References
- 36
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 9
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ag005866-02)
- National Institute on Aging (AG05866)
- National Institute of Mental Health (MH 15442, T32MH015442)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04024, P30HD004024, HD17449, P01HD017449)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Ts65Dn mouse model, Down syndrome, hippocampus, dorsal hippocampus, hippocampus-dependent learning, Alzheimer's disease, trisomy, learning deficits
- MeSH terms
- Age Factors, Animals, Discrimination Learning, Disease Models, Animal, Down Syndrome, Fear, Genotype, Hippocampus, Male, Mice, Neurologic Mutants, Mice
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