Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 941

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Folate-mediated delivery of macromolecular anticancer therapeutic agents

Lu, Yingjuan, Low, Philip S·2002·Advanced Drug Delivery Reviews

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0169-409x(02)00042-x

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 91

  1. Netti, 1995, Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery, Cancer Res., 55, 5451
  2. Torchilin, 2000, Drug targeting, Eur. J. Pharm. Sci., 11, S81, 10.1016/S0928-0987(00)00166-4 · DOI · Paper page
  3. Nakashima-Matsushita, 1999, Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis, Arthritis Rheum., 42, 1609, 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L · DOI · Paper page
  4. M.J. Turk, G.J. Breur, W.R. Widmer, C.M. Paulos, L. Xu, L.A. Grote, P.S. Low, Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis, Arthritis Rheum., in press. · DOI · Paper page
  5. Antony, 1992, The biological chemistry of folate receptors, Blood, 79, 2807, 10.1182/blood.V79.11.2807.2807 · DOI · Paper page
  6. Garin-Chesa, 1993, Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein, Am. J. Pathol., 142, 557
  7. Toffoli, 1997, Overexpression of folate binding protein in ovarian cancers, Int. J. Cancer, 74, 193, 10.1002/(SICI)1097-0215(19970422)74:2<193::AID-IJC10>3.0.CO;2-F · DOI · Paper page
  8. Gruner, 1998, The folate receptor as a potential therapeutic anticancer target, Invest. New Drugs, 16, 205, 10.1023/A:1006147932159 · DOI
  9. Reddy, 1998, Folate-mediated targeting of therapeutic and imaging agents to cancers, Crit. Rev. Ther. Drug Carrier Syst., 15, 587, 10.1615/CritRevTherDrugCarrierSyst.v15.i6.20 · DOI · Paper page
  10. Sudimack, 2000, Targeted drug delivery via the folate receptor, Adv. Drug Deliv. Rev., 41, 147, 10.1016/S0169-409X(99)00062-9 · DOI · Paper page
  11. Shen, 1994, Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity, Biochemistry, 33, 1209, 10.1021/bi00171a021 · DOI · Paper page
  12. Wang, 1992, Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates, Biochem. Pharmacol., 44, 1898, 10.1016/0006-2952(92)90089-2 · DOI
  13. Kamen, 1986, Properties of a folate binding protein (FBP) isolated from porcine kidney, Biochem. Pharmacol., 35, 2323, 10.1016/0006-2952(86)90458-2 · DOI
  14. da Costa, 1996, Purification and characterization of folate binding proteins from rat placenta, Biochim. Biophys. Acta, 1292, 23, 10.1016/0167-4838(95)00180-8 · doi:10.1016/0167-4838(95)00180-8
  15. Shen, 1995, Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity, Biochemistry, 34, 5660, 10.1021/bi00016a042 · DOI · Paper page
  16. Spiegelstein, 2000, Identification of two putative novel folate receptor genes in humans and mouse, Gene, 258, 117, 10.1016/S0378-1119(00)00418-2 · doi:10.1016/s0378-1119(00)00418-2
  17. Ross, 1994, Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications, Cancer, 73, 2432, 10.1002/1097-0142(19940501)73:9<2432::AID-CNCR2820730929>3.0.CO;2-S · DOI · Paper page
  18. Wu, 1999, Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix, Cancer Epidemiol. Biomarkers Prev., 8, 775
  19. Weitman, 1994, The folate receptor in central nervous system malignancies of childhood, J. Neurooncol., 21, 107, 10.1007/BF01052894 · doi:10.1007/bf01052894
  20. Bueno, 2001, The alpha folate receptor is highly activated in malignant pleural mesothelioma, J. Thorac. Cardiovasc. Surg., 121, 225, 10.1067/mtc.2001.111176 · DOI
  21. Toffoli, 1998, Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer, Int. J. Cancer, 79, 121, 10.1002/(SICI)1097-0215(19980417)79:2<121::AID-IJC4>3.0.CO;2-V · DOI
  22. Ross, 1999, Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia, Cancer, 85, 348, 10.1002/(SICI)1097-0142(19990115)85:2<348::AID-CNCR12>3.0.CO;2-4 · doi:10.1002/(sici)1097-0142(19990115)85:2<348::aid-cncr12>3.0.co;2-4
  23. Reddy, 1999, Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells, Blood, 93, 3940, 10.1182/blood.V93.11.3940 · doi:10.1182/blood.v93.11.3940
  24. Weitman, 1992, Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis, Cancer Res., 52, 6708
  25. Patrick, 1997, Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice, J. Neurooncol., 32, 111, 10.1023/A:1005713115147 · doi:10.1023/a:1005713115147
  26. Birn, 1997, Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule, Am. J. Physiol., 272, F70
  27. Leamon, 1991, Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis, Proc. Natl. Acad. Sci. USA, 88, 5572, 10.1073/pnas.88.13.5572 · DOI · Paper page
  28. Turek, 1993, Endocytosis of folate–protein conjugates: ultrastructural localization in KB cells, J. Cell. Sci., 106, 423, 10.1242/jcs.106.1.423 · DOI · Paper page
  29. Rothberg, 1990, Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate, J. Cell Biol., 111, 2931, 10.1083/jcb.111.6.2931 · DOI · Paper page
  30. Mayor, 1994, Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking, Science, 264, 1948, 10.1126/science.7516582 · DOI · Paper page
  31. Rothberg, 1990, The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway, J. Cell Biol., 110, 637, 10.1083/jcb.110.3.637 · DOI · Paper page
  32. Anderson, 1992, Potocytosis: sequestration and transport of small molecules by caveolae, Science, 255, 410, 10.1126/science.1310359 · DOI · Paper page
  33. Wu, 1997, Clustering of GPI-anchored folate receptor independent of both cross-linking and association with caveolin, J. Membr. Biol., 159, 137, 10.1007/s002329900277 · DOI
  34. Varma, 1998, GPI-anchored proteins are organized in submicron domains at the cell surface, Nature, 394, 798, 10.1038/29563 · DOI · Paper page
  35. Kamen, 1986, Receptor-mediated folate accumulation is regulated by the cellular folate content, Proc. Natl. Acad. Sci. USA, 83, 5983, 10.1073/pnas.83.16.5983 · DOI · Paper page
  36. Lee, 1996, Measurement of endosome pH following folate receptor-mediated endocytosis, Biochim. Biophys. Acta, 1312, 237, 10.1016/0167-4889(96)00041-9 · DOI · Paper page
  37. Mathias, 1996, Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67–deferoxamine–folate, J. Nucl. Med., 37, 1003
  38. Mathias, 1998, Indium-111–DTPA–folate as a potential folate-receptor-targeted radiopharmaceutical, J. Nucl. Med., 39, 1579
  39. Guo, 1999, 99mTc–HYNIC–folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging, J. Nucl. Med., 40, 1563
  40. Leamon, 2001, Folate-mediated targeting: from diagnostics to drug and gene delivery, Drug Discov. Today, 6, 44, 10.1016/S1359-6446(00)01594-4 · DOI · Paper page
  41. Leamon, 1992, Cytotoxicity of momordin–folate conjugates in cultured human cells, J. Biol. Chem., 267, 24966, 10.1016/S0021-9258(19)73992-1 · DOI
  42. Leamon, 1993, Cytotoxicity of folate–Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain, J. Biol. Chem., 268, 24847, 10.1016/S0021-9258(19)74542-6 · DOI · Paper page
  43. Atkinson, 2001, Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells, J. Biol. Chem., 276, 27930, 10.1074/jbc.M102825200 · doi:10.1074/jbc.m102825200
  44. Lee, 1995, Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro, Biochim. Biophys. Acta, 1233, 134, 10.1016/0005-2736(94)00235-H · DOI · Paper page
  45. S.M. Stephenson, P.S. Low, R.J. Lee, Folate receptor mediated targeting of liposomal drugs to cancer cells, Methods Enzymol., in press. · DOI
  46. Goren, 2000, Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump, Clin. Cancer Res., 6, 1949
  47. Wang, 1995, Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol, Proc. Natl. Acad. Sci. USA, 92, 3318, 10.1073/pnas.92.8.3318 · DOI · Paper page
  48. Ginobbi, 1997, Folic acid–polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells, Anticancer Res., 17, 29
  49. Li, 1998, Folate-mediated targeting of antisense oligodeoxynucleotides to ovarian cancer cells, Pharm. Res., 15, 1540, 10.1023/A:1011946915209 · DOI
  50. Lee, 1996, Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer, J. Biol. Chem., 271, 8481, 10.1074/jbc.271.14.8481 · DOI · Paper page
  51. Douglas, 1996, Targeted gene delivery by tropism-modified adenoviral vectors, Nat. Biotechnol., 14, 1574, 10.1038/nbt1196-1574 · DOI
  52. Xu, 2001, Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy, J. Control. Release, 74, 115, 10.1016/S0168-3659(01)00324-8 · DOI
  53. Stella, 2000, Design of folic acid-conjugated nanoparticles for drug targeting, J. Pharm. Sci., 89, 1452, 10.1002/1520-6017(200011)89:11<1452::AID-JPS8>3.0.CO;2-P · DOI · Paper page
  54. Rihova, 1998, Receptor-mediated targeted drug or toxin delivery, Adv. Drug Deliv. Rev., 29, 273, 10.1016/S0169-409X(97)00084-7 · DOI
  55. Kataoka, 2001, Block copolymer micelles for drug delivery: design, characterization and biological significance, Adv. Drug Deliv. Rev., 47, 113, 10.1016/S0169-409X(00)00124-1 · DOI · Paper page
  56. Lu, 1999, Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug, J. Drug Target., 7, 43, 10.3109/10611869909085491 · DOI
  57. Kranz, 1995, Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis, Proc. Natl. Acad. Sci. USA, 92, 9057, 10.1073/pnas.92.20.9057 · DOI
  58. Lu, 2002, Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors, Cancer Immunol. Immunother., 51, 153, 10.1007/s00262-002-0266-6 · DOI · Paper page
  59. Leamon, 1994, Selective targeting of malignant cells with cytotoxin–folate conjugates, J. Drug Target., 2, 101, 10.3109/10611869409015898 · DOI
  60. Leamon, 1999, Folate-mediated drug delivery: effect of alternative conjugation chemistry, J. Drug Target., 7, 157, 10.3109/10611869909085499 · doi:10.3109/10611869909085499
  61. Shinoda, 1998, In vivo fate of folate-BSA in non-tumor- and tumor-bearing mice, J. Pharm. Sci., 87, 1521, 10.1021/js980215v · DOI
  62. Ward, 2000, Folic acid targeting of protein conjugates into ascites tumour cells from ovarian cancer patients, J. Drug Target., 8, 119, 10.3109/10611860008996857 · doi:10.3109/10611860008996857
  63. Drummond, 2000, Liposome targeting to tumors using vitamin and growth factor receptors, Vitam. Horm., 60, 285, 10.1016/S0083-6729(00)60022-5 · DOI
  64. Vyas, 2001, Ligand–receptor-mediated drug delivery: an emerging paradigm in cellular drug targeting, Crit. Rev. Ther. Drug Carrier Syst., 18, 1, 10.1615/CritRevTherDrugCarrierSyst.v18.i1.10 · DOI · Paper page
  65. Lee, 1994, Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis, J. Biol. Chem., 269, 3198, 10.1016/S0021-9258(17)41848-5 · DOI · Paper page
  66. Lee, 1998, The effects of pH and intraliposomal buffer strength on the rate of liposome content release and intracellular drug delivery, Biosci. Rep., 18, 69, 10.1023/A:1020132226113 · DOI
  67. Gabizon, 1999, Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies, Bioconjug. Chem., 10, 289, 10.1021/bc9801124 · DOI · Paper page
  68. Woodle, 1992, Sterically stabilized liposomes, Biochim. Biophys. Acta, 1113, 171, 10.1016/0304-4157(92)90038-C · DOI · Paper page
  69. Papahadjopoulos, 1990, Liposomes designed to avoid the reticuloendothelial system, Prog. Clin. Biol. Res., 343, 85
  70. Vogel, 1996, Peptide-mediated release of folate-targeted liposome contents from endosomal compartments, J. Am. Chem. Soc., 118, 1581, 10.1021/ja952725m · DOI
  71. Rui, 1998, Diplasmenylcholine–folate liposomes: an efficient vehicle for intracellular drug delivery, J. Am. Chem. Soc., 120, 11213, 10.1021/ja9742949 · DOI
  72. Qualls, 2001, Chloroaluminum phthalocyanine tetrasulfonate delivered via acid-labile diplasmenylcholine–folate liposomes: intracellular localization and synergistic phototoxicity, Int. J. Cancer, 93, 384, 10.1002/ijc.1339 · DOI
  73. Guo, 2000, Receptor-specific delivery of liposomes via folate–PEG-chol, J. Liposome Res., 10, 179, 10.3109/08982100009029385 · DOI
  74. Mellman, 1996, Endocytosis and molecular sorting, Annu. Rev. Cell Dev. Biol., 12, 575, 10.1146/annurev.cellbio.12.1.575 · DOI · Paper page
  75. Pouton, 1998, Polycation–DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids, J. Control. Release, 53, 289, 10.1016/S0168-3659(98)00015-7 · DOI · Paper page
  76. Reddy, 1999, Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy, J. Pharm. Sci., 88, 1112, 10.1021/js990169e · DOI
  77. Turk, 2002, Characterization of a novel pH-sensitive peptide that enhances drug release from folate targeted liposomes at endosomal pHs, Biochim. Biophys. Acta, 1559, 56, 10.1016/S0005-2736(01)00441-2 · DOI
  78. Reddy, 2000, Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation, J. Control. Release, 64, 27, 10.1016/S0168-3659(99)00135-2 · DOI
  79. Kirpotin, 1997, Targeting of liposomes to solid tumors: the case of sterically stabilized anti-HER2 immunoliposomes, J. Liposome Res., 7, 391, 10.3109/08982109709035509 · DOI
  80. Pizzato, 2001, Evidence for nonspecific adsorption of targeted retrovirus vector particles to cells, Gene Ther., 8, 1088, 10.1038/sj.gt.3301494 · DOI
  81. Reddy, 2001, Retargeting of viral vectors to the folate receptor endocytic pathway, J. Control. Release, 74, 77, 10.1016/S0168-3659(01)00316-9 · doi:10.1016/s0168-3659(01)00316-9
  82. Mislick, 1995, Transfection of folate–polylysine DNA complexes: evidence for lysosomal delivery, Bioconjug. Chem., 6, 512, 10.1021/bc00035a002 · DOI
  83. Leamon, 1999, Folate copolymer-mediated transfection of cultured cells, Bioconjug. Chem., 10, 947, 10.1021/bc990066n · DOI
  84. Guo, 1999, Receptor-targeted gene delivery via folate-conjugated polyethylenimine, AAPS PharmSci., 1, E19, 10.1208/ps010419 · DOI
  85. Leong, 1998, DNA-polycation nanospheres as non-viral gene delivery vehicles, J. Control. Release, 53, 183, 10.1016/S0168-3659(97)00252-6 · DOI · Paper page
  86. Rihova, 1995, Antibody-targeted polymer-bound drugs, Folia Microbiol., 40, 367, 10.1007/BF02814745 · doi:10.1007/bf02814745
  87. Nishiyama, 2001, Cisplatin-loaded polymer–metal complex micelle with time-modulated decaying property as a novel drug delivery system, Pharm. Res., 18, 1035, 10.1023/A:1010908916184 · DOI · Paper page
  88. Springer, 1997, Antibody-directed enzyme prodrug therapy (ADEPT): a review, Adv. Drug Deliv. Rev., 26, 151, 10.1016/S0169-409X(97)00032-X · DOI
  89. Patrick, 1998, Intracerebral bispecific ligand–antibody conjugate increases survival of animals bearing endogenously arising brain tumors, Int. J. Cancer, 78, 470, 10.1002/(SICI)1097-0215(19981109)78:4<470::AID-IJC13>3.0.CO;2-A · doi:10.1002/(sici)1097-0215(19981109)78:4<470::aid-ijc13>3.0.co;2-a
  90. Roy, 1998, Targeting T cells against brain tumors with a bispecific ligand–antibody conjugate, Int. J. Cancer, 76, 761, 10.1002/(SICI)1097-0215(19980529)76:5<761::AID-IJC23>3.0.CO;2-5 · doi:10.1002/(sici)1097-0215(19980529)76:5<761::aid-ijc23>3.0.co;2-5
  91. Rund, 1999, Bispecific agents target endogenous murine T cells against human tumor xenografts, Int. J. Cancer, 83, 141, 10.1002/(SICI)1097-0215(19990924)83:1<141::AID-IJC24>3.0.CO;2-0 · doi:10.1002/(sici)1097-0215(19990924)83:1<141::aid-ijc24>3.0.co;2-0

Cited by

See all 941

Metadata

Authors
Lu, Y., & Low, P. S.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2002-09
Volume
54
Issue
5
Pages
675-693
ISSN
0169-409X (ISSN-L)
OpenAlex
W2104993716
Cited by
941
References
2
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Folate-mediated delivery of macromolecular anticancer therapeutic agents. https://app.cochat.ai/papers/10.1016/s0169-409x(02)00042-x
The paper
Lu, Y., & Low, P. S. (2002). Folate-mediated delivery of macromolecular anticancer therapeutic agents. Advanced Drug Delivery Reviews. https://doi.org/10.1016/s0169-409x(02)00042-x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.