Strategies of protein selection by weanling and adult rats
Abstract
Weanling and adult male rats were offered pairs of diets containing either 0 and 20%, 0 and 40%, 0 and 60%, or 10 and 40% casein. Initially they preferred the lower protein diets, and then after one to ten days abruptly switched to adequate levels of protein choice. After 14 days, the diets were changed so that the first group received 10 and 40%, the second 20 and 60%, the third 10 and 40%, and the fourth 0 and 60% casein. Following the change, all weanling rats showed significant and systematic shifts in percentage of total energy chosen as protein (%P-E); most adults did not. Within each group, the variability in %P-E selected between different rats was higher than the day-to-day variability of individuals. In the adults no significant correlations were observed between protein selection and brain serotonin metabolism. We conclude that protein intake in rats is regulated in the sense that all animals learnt to eat sufficient protein to maintain growth, and most animals ate a constant amount of protein each day. On the other hand, the range of protein intake between individuals, and the shifts in selection among the weanlings when diet choices were changed seem to preclude the existence of a mechanism which precisely regulates protein intake.
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When given a choice, a wide range of species will self-select between diets that are high and low in protein in order to maintain protein intake.
“When given a choice, a wide range of species will self-select between diets that are high and low in protein in order to maintain protein intake”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [87]
Cites
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,755 · see citing works
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
Fernstrom, J. D., & Wurtman, R. J. (1972) · Science · doi:10.1126/science.178.4059.414 · Cited by 1,166 · see citing works
The Selection of Foods by Rats, Humans, and Other Animals
Rozin, P. N. (1976) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60081-9 · Cited by 476 · see citing works
NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION1
Fernstrom, J. D., & Faller, D. V. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb10489.x · Cited by 425 · see citing works
The body weight regulatory system: normal and disturbed mechanisms.
CIOFFI, L. A., James, W. P. T., & Itallie, T. B. V. (1981) · Raven Press eBooks · Cited by 347 · see citing works
Wurtman, J. J., & Wurtman, R. J. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90339-4 · Cited by 247 · see citing works
Food intake regulation in the weanling rat: self-selection of protein and energy
Musten, B., Peace, D., & Anderson, G. H. (1974) · The Journal of Nutrition · doi:10.1093/jn/104.5.563 · Cited by 189 · see citing works
Control of protein and energy intake: Role of plasma amino acids and brain neurotransmitters
Anderson, G. H. (1979) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y79-158 · Cited by 156 · see citing works
Ashley, D. V. M., & Anderson, G. H. (1975) · Journal of Nutrition · doi:10.1093/jn/105.11.1412 · Cited by 126 · see citing works
Self-citationChanges in brain serotonin metabolism associated with fasting and satiation in rats
Pérez-Cruet, J., Tagliamonte, A., Tagliamonte, P., & Gessa, G. L. (1972) · Life Sciences · doi:10.1016/0024-3205(72)90149-x · Cited by 106 · see citing works
Food Preferences Acquired by Association with Variations in Amino Acid Nutrition
Booth, D., & Simson, P. C. (1971) · Quarterly Journal of Experimental Psychology · doi:10.1080/00335557143000149 · Cited by 83 · see citing works
Plasma amino acid responses in humans to evening meals of differing nutritional composition
Ashley, D., Barclay, D., Chauffard-Alboucq, F. A., Moënnoz, D., & Leathwood, P. D. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.1.143 · Cited by 82 · see citing works
Self-citationSelective decrease in protein intake following brain serotonin depletion
Ashley, D. V. M., Coscina, D. V., & Anderson, G. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90315-1 · Cited by 66 · see citing works
Self-citationBlundell, J. E., Latham, C. J., Moniz, E., et al. (1979) · Current Medical Research and Opinion · doi:10.1185/03007997909117490 · Cited by 53 · see citing works
Short-Term Zinc Deficiency in the Rat and Self-Selection of Dietary Protein Level
Reeves, P. G., & O’Dell, B. L. (1981) · Journal of Nutrition · doi:10.1093/jn/111.2.375 · Cited by 52 · see citing works
Protein and energy consumption, plasma amino acid ratios, and brain neurotransmitter concentrations
Peters, J. C., & Harper, A. E. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90271-7 · Cited by 52 · see citing works
Diabetes, dietary tryptophan, and protein intake regulation in weanling rats
Woodger, T. L., Sirek, A., & Anderson, G. H. (1979) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1979.236.5.r307 · Cited by 34 · see citing works
Peng, Y., Meliza, L. L., Vavich, M. G., & Kemmerer, A. R. (1975) · Journal of Nutrition · doi:10.1093/jn/105.11.1395 · Cited by 29 · see citing works
Anderson, G. H., & Ashley, D. V. M. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90002-9 · Cited by 25 · see citing works
Self-citationNutrition in transition. Proceedings, Western Hemisphere Nutrition Congress V.
White, P. L., & Selvey, N. (1978) · Cited by 10 · see citing works
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Peters, J. C., & Harper, A. E. (1985) · The Journal of Nutrition · doi:10.1093/jn/115.3.382 · Cited by 163 · see citing works
Homeostatic regulation of protein intake: in search of a mechanism
Morrison, C. D., Reed, S. D., & Henagan, T. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00609.2011 · Cited by 99 · see citing works
FGF21 and the physiological regulation of macronutrient preference
Hill, C. M., Qualls-Creekmore, E., Berthoud, H.-R., Soto, P., Yu, S., McDougal, D. H., Münzberg, H., & Morrison, C. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa019 · Cited by 99 · see citing works
PETERS, J., & HARPER, A. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90048-9 · Cited by 52 · see citing works
Murphy, M., Peters, K. Z., Denton, B. S., Lee, K. A., Chadchankar, H., & McCutcheon, J. E. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.011 · Cited by 42 · see citing works
Protein selection by rats adapted to high or moderately low levels of dietary protein
Tews, J. K., Repa, J. J., & Harper, A. E. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90105-b · Cited by 28 · see citing works
Dietary branched-chain amino acids and protein selection by rats
Anderson, S. A., Tews, J. K., & Harper, A. E. (1990) · The Journal of Nutrition · doi:10.1093/jn/120.1.52 · Cited by 22 · see citing works
- Authors
- Leathwood, P. D., & Ashley, D. V. M.
- Affiliations
- Nestlé (Switzerland) (CH)
- Corresponding author
- Leathwood, Peter D.
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 4
- Issue
- 2
- Pages
- 97-112
- ISSN
- 0195-6663 (ISSN-L)
- OpenAlex
- W2086855877
- Cited by
- 64
- References
- 20
- Citations by year
- 2025: 2 · 2024: 1 · 2020: 2 · 2017: 2 · 2016: 1 · 2012: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- casein, weanling rats, adult rats, food choice, serotonin metabolism, energy allocation
- MeSH terms
- Animals, Brain Chemistry, Caseins, Dietary Proteins, Food Preferences, Hydroxyindoleacetic Acid, Male, Nutritional Requirements, Rats, Inbred Strains, Serotonin, Time Factors, Tryptophan, Rats
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