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Cited by 22Regulation of Appetite and ObesityMuscle metabolism and nutritionAmino Acid Enzymes and Metabolism

Dietary branched-chain amino acids and protein selection by rats

Anderson, Sheila A., Tews, Jean K., Harper, Alfred E.·1990·The Journal of Nutrition
DOI 10.1093/jn/120.1.52
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Abstract

Consumption by rats of high protein diets is associated with elevated plasma and brain concentrations of branched-chain amino acids (BCAA). We examined the possibility that changes in BCAA concentrations in blood and brain might serve as modulators of protein consumption. After young rats had adjusted to selecting between a 10% or 25% casein diet and a 50% casein diet, a mixture of BCAA was included in the diet containing the lower amount of protein (10% + BCAA, 25% + BCAA). Supplementation of the 10% or 25% casein diets with BCAA and subsequent elevation of BCAA concentrations in plasma and brain were associated with increased selection of protein in rats given the 10% + BCAA/50% casein diet choice, but not in rats offered the 25% + BCAA/50% casein diets. When no alternative diet was available, addition of BCAA to a 15% casein diet depressed food intake, and rats given a choice between a 15% casein diet with or without added BCAA selected almost exclusively the diet without added BCAA. Although BCAA concentrations were high in plasma and brain in all experiments, concentrations of methionine, tyrosine, phenylalanine, tryptophan and histidine were low in brain in experiments in which rats altered their diet or protein selection after BCAA addition. High concentrations of BCAA in plasma and brain were not consistently associated with changes in protein selection.

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Crossref · 10.1093/jn/120.1.52

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  • When given a choice, a wide range of species will self-select between diets that are high and low in protein in order to maintain protein intake.

    “When given a choice, a wide range of species will self-select between diets that are high and low in protein in order to maintain protein intake”

    From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [83]

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Authors
Anderson, S. A., Tews, J. K., & Harper, A. E.
Affiliations
University of Wisconsin–Madison (US)
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
1990-01
Volume
120
Issue
1
Pages
52-63
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/120.1.52
OpenAlex
W1565357502
Cited by
22
References
34
Citations by year
2024: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk010747-22, 5r01am010747-19, AM10747)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK10747)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
branched-chain amino acids, protein selection, protein intake, casein diet, amino acid supplementation, plasma amino acids, brain amino acids, food choice, dietary intake, rats
MeSH terms
Amino Acids, Amino Acids, Branched-Chain, Analysis of Variance, Animals, Brain, Dietary Proteins, Eating, Food Preferences, Male, Rats

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