Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies

Dickson, D.W

doi:10.1016/s0197-4580(97)00065-1

Cited by 169Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies

Dickson, D.W·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00065-1

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Abstract

Alzheimer's disease (AD) is the most common cause of primary progressive dementia. It is defined by its pathological features, because the clinical syndrome of dementia lacks specificity. Although the brain in AD has many structural alterations, the two cardinal pathological features and sine qua non of AD are senile plaques and neurofibrillary degeneration. The latter takes the form of neurofibrillary tangles composed of paired helical filaments, as well as degenerating neurites within the neuropil ("neuropil threads") and within a diagnostically significant subset of SP, referred to as "neuritic plaques." All SP contain amyloid, but not all have pair helical filament-type neurites. The presence of even a small number of plaques with paired helical filament-type neurites in the neocortex is associated with cognitive impairment, and this lesion may be the most specific histopathological feature of AD. Although these observations suggest that the major difference between SP in aging and AD relate to differences in neuritic degeneration, more recent studies have also indicated that amyloid deposits are biochemically heterogenous and that amyloid deposits in aging may be different from those in AD. As more specific markers become available for recognizing AD-specific structural lesions, refined neuropathological diagnostic criteria will evolve. In the meantime, a practical neuropathological approach to the diagnosis of AD requires both widespread neocortical SP and an advanced stage of neurofibrillary degeneration. Using these criteria, it is very unlikely that AD will be diagnosed in an individual who was not demented in life. The rationale for adopting this conservative approach is that our knowledge is incomplete with respect to fundamental differences between the lesions in aging and AD.

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Subsequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse AβPs.
“Subsequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse AβPs (45, 98, 106, 154, 189, 261).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [45]

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
Self-citation
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921 · see citing works
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774 · see citing works
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
Goedert, M., Jakes, R., Spillantini, M. G., Hasegawa, M., Smith, M. J., & Crowther, R. A. (1996) · Nature · doi:10.1038/383550a0 · Cited by 1,036 · see citing works
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.
Roher, A. E., Lowenson, J. D., Clarke, S., Wolkow, C., Wang, R., Cotter, R. J., Reardon, I. M., Zürcher-Neely, H. A., Heinrikson, R. L., & Ball, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53661-9 · Cited by 799 · see citing works
Alzheimer's Disease: A Central Role for Amyloid
Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works
Self-citation
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease
Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works
Correlations of synaptic and pathological markers with cognition of the elderly
Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410 · see citing works
Self-citation
Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease
Masliah, E., Sisk, A., Mallory, M. E., Mucke, L., Schenk, D., & Games, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05795.1996 · Cited by 387 · see citing works
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.
Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383 · see citing works
Self-citation
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease
Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R. N., Simms, G., Beyreuther, K. T., & Masters, C. L. (1988) · Neurology · doi:10.1212/wnl.38.11.1688 · Cited by 369 · see citing works
Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients.
Bancher, C., Braak, H., Fischer, P., & Jellinger, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90590-h · Cited by 314 · see citing works
Research advances in Alzheimer's disease and related disorders
Iqbal, K., & Disorders, R. (1995) · Wiley eBooks · Cited by 228 · see citing works
Plaque-Only Alzheimer Disease is Usually the Lewy Body Variant, and Vice Versa
Hansen, L. A., Masliah, E., Galasko, D., & Terry, R. D. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199311000-00012 · Cited by 227 · see citing works
Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease
Gowing, E., Roher, A. E., Woods, A. S., Cotter, R. J., Chaney, M., Little, S. P., & Ball, M. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78080-6 · Cited by 223 · see citing works
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques
Dickson, D. W., Crystal, H., Mattiace, L. A., Kress, Y., Schwagerl, A. L., Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1989) · Acta Neuropathologica · doi:10.1007/bf00691284 · Cited by 203 · see citing works
Self-citation
Diffuse Lewy body disease
Dickson, D. W., Davies, P., Mayeux, R. P., Crystal, H., Horoupian, D. S., Thompson, A. J., & Goldman, J. E. (1987) · Acta Neuropathologica · doi:10.1007/bf00686786 · Cited by 203 · see citing works
Self-citation
Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects.
Dickson, D. W., Wertkin, A. M., Kress, Y., Ksiȩżak-Reding, H., & Yen, S.-H. (1990) · PubMed · Cited by 169 · see citing works
Self-citation
Pathological markers associated with normal aging and dementia in the elderly
Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks‐Nelson, H., & Antis, P. (1993) · Annals of Neurology · doi:10.1002/ana.410340410 · Cited by 161 · see citing works
Self-citation
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.
Arai, H., Lee, V. M., Otvos, L. P., Greenberg, B., Lowery, D. E., Sharma, S., Schmidt, M. L., & Trojanowski, J. Q. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2249 · Cited by 155 · see citing works
βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians
Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90096-t · Cited by 149 · see citing works
Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.
Liu, W.-K., Williams, R. T., Hall, F. L., Dickson, D. W., & Yen, S.-H. C. (1995) · PubMed Central · Cited by 78 · see citing works
Self-citation
Glycation and Microglial Reaction in Lesions of Alzheimer's Disease
Dickson, D. W., Sinicropi, S., Yen, S.-H. C., Ko, L., Mattiace, L. A., Bucala, R., & Vlassara, H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00116-9 · Cited by 76 · see citing works
Self-citation
Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex
Probst, A., Anderton, B. H., Brion, J., & ULRICH, J. (1989) · Acta Neuropathologica · doi:10.1007/bf00687379 · Cited by 67 · see citing works
Qualitative and Quantitative Differences in Senile Plaque Dystrophie Neurites of Alzheimerʼs Disease and Normal Aged Brain
WANG, D., & Muñoz, D. G. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199507000-00009 · Cited by 62 · see citing works
FORM AND DISTRIBUTION OF SENILE PLAQUES SEEN IN SILVER IMPREGNATED SECTIONS IN THE BRAINS OF INTELLECTUALLY NORMAL ELDERLY PEOPLE AND PEOPLE WITH ALZHEIMER‐TYPE DEMENTIA
Gibson, P. H. (1983) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1983.tb00123.x · Cited by 59 · see citing works
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease.
Shin, R., Ogomori, K., Kitamoto, T., & Tateishi, J. (1989) · Europe PMC (PubMed Central) · Cited by 58 · see citing works
Alzheimer neurofibrillary lesions: Molecular nature and potential roles of different components
Yen, S.-H. C., Liu, W.-K., Hall, F. L., Yan, S., Stern, D. M., & Dickson, D. W. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00022-7 · Cited by 53 · see citing works
Self-citation
Two distinct ubiquitin immunoreactive senile plaques in Alzheimer's disease: relationship with the intellectual status in 29 cases
He, Y., Delaère, P., Duyckaerts, C. J., Wąsowicz, M., Piette, F., & Hauw, J. (1993) · Acta Neuropathologica · doi:10.1007/bf00454909 · Cited by 33 · see citing works
Associations of Status and Change Measures of Neuropsychological Function With Pathologic Changes in Elderly, Originally Nondemented Subjects
Crystal, H., Dickson, D. W., Sliwinski, M. J., Masur, D., Blau, A. D., & Lipton, R. B. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550010102023 · Cited by 23 · see citing works
Self-citation
Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?
Dickson, D. W., & Yen, S.-H. C. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90075-4 · Cited by 19 · see citing works
Self-citation
UBIQUITIN IMMUNOREACTIVE STRUCTURES IN NORMAL BRAINS
Dickson, D. W., Wertkin, A. M., Kress, Y., Ksiszek-Reding, H., & Yen, S. H. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199005000-00135 · Cited by 11 · see citing works
Self-citation

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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“The dense core can display radiating Aβ fibrils, and it is in these peripheral zones of the plaque where dystrophic neurites and activated microglia are concentrated, that lends credence to the hypothesis that Aβ drives neuronal degeneration and cognitive decline in AD [18, 39].”
BackgroundSelf-citation
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
“Sub-sequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse A A Ps (45, 98, 106, 154, 189, 261).”
Background
Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease
Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., & Rumbaugh, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.197 · Cited by 727 · see citing works
Binding Characteristics of Radiofluorinated 6-Dialkylamino-2-Naphthylethylidene Derivatives as Positron Emission Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer's Disease
Agdeppa, E. D., Kepe, V., Liu, J., Flores-Torres, S., Satyamurthy, N., Petrič, A., Cole, G. M., Small, G. W., Huang, S., & Barrio, J. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-j0004.2001 · Cited by 421 · see citing works
Emerging role of the cannabinoid receptor CB <sub>2</sub> in immune regulation: therapeutic prospects for neuroinflammation
Cabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408 · see citing works
18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease
Fodero‐Tavoletti, M. T., Okamura, N., Furumoto, S., Mulligan, R. S., Connor, A. R., McLean, C., Cao, D., Rigopoulos, A., Cartwright, G. A., O'Keefe, G. J., et al. (2011) · Brain · doi:10.1093/brain/awr038 · Cited by 329 · see citing works
Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 280 · see citing works
Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression
Tolar, M., Hey, J., Power, A., & Abushakra, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126355 · Cited by 246 · see citing works
Quinoline and Benzimidazole Derivatives: Candidate Probes forIn VivoImaging of Tau Pathology in Alzheimer's Disease
Okamura, N., Suemoto, T., Furumoto, S., Suzuki, M., Shimadzu, H., Akatsu, H., Yamamoto, T., Fujiwara, H., Nemoto, M., Maruyama, M., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1738-05.2005 · Cited by 212 · see citing works
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
Haroutunian, V., Purohit, D. P., Perl, D. P., Marin, D., Khan, K., Lantz, M., Davis, K. L., & Mohs, R. C. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.713 · Cited by 201 · see citing works
Regional protein expression in human Alzheimer’s brain correlates with disease severity
Xu, J., Patassini, S., Rustogi, N., Riba‐Garcia, I., Hale, B. D., Phillips, A. M., Waldvogel, H. J., Haines, R., Bradbury, P., Stevens, A., et al. (2019) · Communications Biology · doi:10.1038/s42003-018-0254-9 · Cited by 182 · see citing works
Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease
Beauquis, J., Pavía, P., Pomilio, C. J., Vinuesa, Á., Podlutskaya, N., Galván, V., & Saravia, F. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.009 · Cited by 177 · see citing works
Diagnosis of Parkinson's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera
Han, M. C., Nagele, E. P., DeMarshall, C. A., Acharya, N. K., & Nagele, R. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032383 · Cited by 175 · see citing works
Precortical Phase of Alzheimer's Disease ( AD )‐Related Tau Cytoskeletal Pathology
Stratmann, K., Heinsen, H., Korf, H., Turco, D. D., Ghebremedhin, E., Seidel, K., Bouzrou, M., Grinberg, L. T., Böhl, J., Wharton, S. B., et al. (2015) · Brain Pathology · doi:10.1111/bpa.12289 · Cited by 174 · see citing works
Glutamate–glutamine cycling in Alzheimer's disease
WALTON, H., & DODD, P. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2006.10.007 · Cited by 174 · see citing works
Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
Zatti, G., Burgo, A., Giacomello, M., Barbiero, L., Ghidoni, R., Sinigaglia, G., Florean, C., Bagnoli, S., Binetti, G. G., Sorbi, S., et al. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.03.002 · Cited by 151 · see citing works
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques
Bacskai, B. J., Skoch, J. M., Hickey, G. A., Allen, R., & Hyman, B. T. (2003) · Journal of Biomedical Optics · doi:10.1117/1.1584442 · Cited by 150 · see citing works
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
Žilka, N., Kazmerova, Z., Jadhav, S., Neradil, P., Maďari, A., Obetkova, D., Bugos, O., & Novák, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-47 · Cited by 147 · see citing works
Fibrillar β-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease
Matsuoka, Y., Picciano, M., LaFrancois, J. J., & Duff, K. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00115-4 · Cited by 147 · see citing works
Diagnosis of Alzheimer's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera
Nagele, E. P., Han, M. C., DeMarshall, C. A., Belinka, B. A., & Nagele, R. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023112 · Cited by 146 · see citing works
Diabetes and Hypercholesterolemia Increase Blood-Brain Barrier Permeability and Brain Amyloid Deposition: Beneficial Effects of the LpPLA2 Inhibitor Darapladib
Acharya, N. K., Levin, E. C., Clifford, P. M., Han, M. C., Tourtellotte, R., Chamberlain, D., Pollaro, M., Coretti, N. J., Kosciuk, M. C., Nagele, E. P., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122254 · Cited by 140 · see citing works
Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina
Gramlich, O. W., Gehrke-Beck, S., Hohenstein-Blaul, N. V. T. U., Boehm, N., Ziegler, A., Vetter, J. M., Pfeiffer, N., & Grus, F. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057557 · Cited by 132 · see citing works
Aβ peptides can enter the brain through a defective blood–brain barrier and bind selectively to neurons
Clifford, P. M., Zarrabi, S., Siu, G., Kinsler, K., Kosciuk, M. C., Venkataraman, V., D’Andrea, M. R., Dinsmore, S. T., & Nagele, R. G. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.070 · Cited by 127 · see citing works
Is synaptic loss a unique hallmark of Alzheimer’s disease?
Scheff, S. W., Neltner, J. H., & Nelson, P. T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.028 · Cited by 118 · see citing works
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
Sağlık, B. N., Ilgın, S., & Özkay, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.10.042 · Cited by 116 · see citing works
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Altschul, D., Dickson, D. W., Lipton, R. B., Katz, M. J., Derby, C. A., Lee, S. H., Wang, C., & Verghese, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.011 · Cited by 114 · see citing works
Self-citation
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Wang, Y., Lv, M.-N., & Zhao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102035 · Cited by 117 · see citing works
Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease
Thomas, P., Hecker, J. R., Faunt, J., & Fenech, M. F. (2007) · Mutagenesis · doi:10.1093/mutage/gem029 · Cited by 114 · see citing works
2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease
Agdeppa, E. D. (2003) · Molecular Imaging and Biology · doi:10.1016/j.mibio.2003.09.010 · Cited by 113 · see citing works
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Pathological Substrates of Cognitive Decline in Alzheimer&rsquo;s Disease
Giannakopoulos, P., Kövari, E., Gold, G., von Gunten, A., Hof, P. R., & Bouras, C. (2009) · Frontiers of Neurology and Neuroscience · doi:10.1159/000197881 · Cited by 101 · see citing works
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain
Ercan-Herbst, E., Ehrig, J., Schöndorf, D. C., Behrendt, A., Klaus, B., Gomez Ramos, B., Prat Oriol, N., Weber, C., & Ehrnhoefer, D. E. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0823-2 · Cited by 101 · see citing works
Origin of metastable oligomers and their effects on amyloid fibril self-assembly
Hasecke, F., Miti, T., Perez, C., Barton, J., Schölzel, D., Gremer, L., Grüning, C. S. R., Matthews, G., Meisl, G., Knowles, T. P. J., et al. (2018) · Chemical Science · doi:10.1039/c8sc01479e · Cited by 100 · see citing works
Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
Giannakopoulos, P., Gold, G., Kövari, E., von Gunten, A., Imhof, A., Bouras, C., & Hof, P. R. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0144-y · Cited by 95 · see citing works
The Challenges of Tau Imaging
Villemagne, V. L., Furumoto, S., Fodero‐Tavoletti, M. T., Harada, R., Mulligan, R. S., Kudo, Y., Masters, C. L., Yanai, K., Cc, R., & Okamura, N. (2012) · Future Neurology · doi:10.2217/fnl.12.34 · Cited by 98 · see citing works
In vivo tau imaging: Obstacles and progress
Villemagne, V. L., & Okamura, N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.013 · Cited by 96 · see citing works
Natural history of Alzheimer’s disease
Honig, L. S., & Mayeux, R. P. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351476 · Cited by 96 · see citing works
Oxidative Damage, Protein Synthesis, and Protein Degradation in Alzheimers Disease
Ding, Q., Dimayuga, E. R., & Keller, J. N. (2007) · Current Alzheimer Research · doi:10.2174/156720507779939788 · Cited by 95 · see citing works
Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes
Wang, Q., Li, W.-X., Dai, S.-X., Guo, Y.-C., Han, F.-F., Zheng, J.-J., Li, G.-H., & Huang, J.-F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161032 · Cited by 88 · see citing works
The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits
Ye, X., Tai, W., & Zhang, D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.004 · Cited by 88 · see citing works
Test-retest reproducibility for the tau PET imaging agent flortaucipir F 18.
Devous, M. D., Joshi, A. D., Navitsky, M., Southekal, S., Pontecorvo, M. J., Shen, H., Lu, M., Shankle, W. R., Seibyl, J. P., Marek, K., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.200691 · Cited by 79 · see citing works
The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship
Knight, S. D., Presto, J., Linse, S. S., & Johansson, J. (2013) · Biochemistry · doi:10.1021/bi400908x · Cited by 77 · see citing works
CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease
Koppel, J. L., Vingtdeux, V., Marambaud, P., d’Abramo, C., Jimenez, H. T., Stauber, M., Friedman, R., & Davies, P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00140.revised · Cited by 74 · see citing works
Apolipoprotein E ε4 Is a Determinant for Alzheimer-Type Pathologic Features in Tauopathies, Synucleinopathies, and Frontotemporal Degeneration
Josephs, K. A., Tsuboi, Y., Cookson, N., Watt, H., & Dickson, D. W. (2004) · Archives of Neurology · doi:10.1001/archneur.61.10.1579 · Cited by 70 · see citing works
Self-citation
Sleep disorders in neurodegenerative diseases
Raggi, A., & Ferri, R. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03034.x · Cited by 68 · see citing works
18F-florbetaben Aβ imaging in mild cognitive impairment
Ong, K. T., Villemagne, V. L., Bahar‐Fuchs, A., Lamb, F., Chételat, G., Raniga, P., Mulligan, R. S., Salvado, O., Pütz, B., Roth, K. S., et al. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt158 · Cited by 64 · see citing works
The Role of Cholesterol and Statins in Alzheimer's Disease
Miller, L. J., & Chacko, R. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d104 · Cited by 63 · see citing works
Dementia with Lewy Bodies
Ferman, T. J., & Boeve, B. F. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.03.001 · Cited by 63 · see citing works
Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution
Rui, Y., Gu, J., Yu, K., Hartzell, H. C., & Zheng, J. Q. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-10 · Cited by 61 · see citing works
Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
Cabral, G. A., & Griffin-Thomas, L. (2008) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153008785700118 · Cited by 60 · see citing works
A Dominant Role for FE65 (APBB1) in Nuclear Signaling
Yang, Z., Cool, B. H., Martin, G. M., & Hu, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508445200 · Cited by 59 · see citing works
1H NMR Metabolomic Signatures in Five Brain Regions of the AβPPswe Tg2576 Mouse Model of Alzheimer's Disease at Four Ages
Lalande-Martin, J., Halley, H., Balayssac, S., Gilard, V., Dejean, S., Martino, R., Francès, B., Lassalle, J., & Malet‐Martino, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130023 · Cited by 58 · see citing works
Identification of non-alkaloid natural compounds of Angelica purpurascens (Avé-Lall.) Gilli. (Apiaceae) with cholinesterase and carbonic anhydrase inhibition potential
Karakaya, S., Bingöl, Z., Koca, M., Dagoglu, S., Pınar, N. M., Demırcı, B., Gülçın, İ., Brestič, M., & Sytar, O. (2019) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2019.11.001 · Cited by 57 · see citing works
Molecular Docking Studies of Coumarins Isolated from Extracts and Essential Oils of Zosima absinthifolia Link as Potential Inhibitors for Alzheimer’s Disease
Karakaya, S., Koca, M., Yılmaz, S. V., Yıldırım, K., Pınar, N. M., Demırcı, B., Brestic, M., & Sytar, O. (2019) · Molecules · doi:10.3390/molecules24040722 · Cited by 57 · see citing works
Progression of neurofibrillary changes and PHF-τ in end-stage Alzheimer’s disease is different from plaque and cortical microglial pathology
Thal, D. R., Arendt, T., Waldmann, G., Holzer, M., Zedlick, D., Rüb, U., & Schober, R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00090-6 · Cited by 53 · see citing works
In Vivo Brain Imaging of Tangle Burden in Humans
Small, G. W., Agdeppa, E. D., Kepe, V., Satyamurthy, N., Huang, S., & Barrio, J. R. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:19:3:321 · Cited by 52 · see citing works
Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function
Wasik, U., Schneider, G., Mietelska‐Porowska, A., Mazurkiewicz, M., Fabczak, H., Weis, S., Zabke, C., Harrington, C. R., Filipek, A., & Niewiadomska, G. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.007 · Cited by 51 · see citing works
Revision of the criteria for Alzheimer's disease: A symposium
DeKosky, S. T., Carrillo, M. C., Phelps, C. H., Knopman, D. S., Petersen, R. C., Frank, R., Schenk, D., Masterman, D. M., Siemers, E., Cedarbaum, J. M., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.12.007 · Cited by 50 · see citing works
In vivo amyloid imaging in Alzheimer?s disease
Sair, H. I., Doraiswamy, P. M., & Petrella, J. R. (2004) · Neuroradiology · doi:10.1007/s00234-003-1034-9 · Cited by 50 · see citing works
NPT088 reduces both amyloid‐β and tau pathologies in transgenic mice
Levenson, J. M., Schroeter, S., Carroll, J. C., Cullen, V., Asp, E., Proschitsky, M., Chung, C. H. ‐., Gilead, S., Nadeem, M., Dodiya, H. B., et al. (2016) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.06.004 · Cited by 47 · see citing works
Tissue transglutaminase, protein cross-linking and Alzheimer's disease: review and views.
Wang, D., Dickson, D. W., & Malter, J. S. (2008) · PubMed Central · Cited by 47 · see citing works
Self-citation
Activation of Human Macrophages by Amyloid-β Is Attenuated by Astrocytes
Smits, H. A., van Beelen, A. J., Vos, N., Rijsmus, A., van der Bruggen, T., Verhoef, J., Muiswinkel, F. L. V., & Nottet, H. S. L. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6869 · Cited by 46 · see citing works
BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide
Zhang, J., Zhu, D., Sheng, R., Wu, H., Hu, Y., Wang, F., Cai, T., Yang, B., & He, Q. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.054 · Cited by 45 · see citing works
Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents
Karakaya, S., Koca, M., Sytar, O., Dursunoglu, B., Özbek, H., Duman, H., Güvenalp, Z., & Kılıç, C. S. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.01.020 · Cited by 44 · see citing works
APOE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy
Tsuboi, Y., Josephs, K., Cookson, N., & Dickson, D. (2003) · Neurology · doi:10.1212/01.wnl.0000044340.37138.a9 · Cited by 46 · see citing works
Self-citation
Alzheimer's Disease and Down Syndrome: From Meiosis to Dementia
Petronis, A. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7128 · Cited by 44 · see citing works
Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases
DeMarshall, C. A., Sarkar, A., Nagele, E. P., Goldwaser, E. L., Godsey, G. A., Acharya, N. K., & Nagele, R. G. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.05.005 · Cited by 42 · see citing works
Iodinated tracers for imaging amyloid plaques in the brain
Kung, H. F. (2003) · Molecular Imaging and Biology · doi:10.1016/j.mibio.2003.09.003 · Cited by 39 · see citing works
Repair and regeneration: ferroptosis in the process of remodeling and fibrosis in impaired organs
Yin, J., Xu, X., Guo, Y., Sun, C., Yang, Y., Liu, H., Yu, P., Wu, T. S., & Song, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02181-2 · Cited by 38 · see citing works
NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
Companys‐Alemany, J., Turcu, A. L., Schneider, M., Müller, C. E., Vázquez, S., Griñán‐Ferré, C., & Pallàs, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04438-4 · Cited by 38 · see citing works
Can insulin signaling pathways be targeted to transport Aβ out of the brain?
Vandal, M., Bourassa, P., & Calon, F. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00114 · Cited by 37 · see citing works
Rosiglitazone prevents the memory deficits induced by amyloid-beta oligomers via inhibition of inflammatory responses
Xu, S., Guan, Q., Wang, C., Wei, X., Chen, X., Zheng, B., An, P., Zhang, J., Chang, L. Y., Zhou, W., et al. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.06.010 · Cited by 36 · see citing works
Randomization of Amyloid‐β‐Peptide(1‐42) Conformation by Sulfonated and Sulfated Nanoparticles Reduces Aggregation and Cytotoxicity
Saraiva, A. M., Cardoso, I., Saraiva, M. J., Tauer, K., Pereira, M. D. C., Coelho, M. A. N., Möhwald, H., & Brezesinski, G. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.200900448 · Cited by 35 · see citing works
Antioxidant and anticholinesterase activities of Ferulago syriaca Boiss. and F. isaurica Peșmen growing in Turkey
Karakaya, S., Koca, M., Kılıç, C. S., & Çoşkun, M. (2018) · Medicinal Chemistry Research · doi:10.1007/s00044-018-2196-7 · Cited by 33 · see citing works
Synthesis and preliminary evaluation of 2‐arylhydroxyquinoline derivatives for tau imaging
Tago, T., Furumoto, S., Okamura, N., Harada, R., Ishikawa, Y., Arai, H., Yanai, K., Iwata, R., & Kudo, Y. (2013) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3133 · Cited by 32 · see citing works
Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta‐amyloid peptide(1‐42) and fed a high‐cholesterol diet
Liu, R., Gu, R., Qi, X., Zhang, T., Zhao, Y. D., He, Y., Pei, J.-J., & Guan, Z. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21463 · Cited by 31 · see citing works
Systematic review of the efficacy of statins for the treatment of Alzheimer’s disease
Mejías-Trueba, M., Pérez-Moreno, M. A., & Fernández-Arche, M. Á. (2018) · Clinical Medicine · doi:10.7861/clinmedicine.18-1-54 · Cited by 31 · see citing works
Effects of statins on α7 nicotinic receptor, cholinesterase and α-form of secreted amyloid precursor peptide in SH-SY5Y cells
ROENSCH, J., Crisby, M., Nordberg, A. K., XIAO, Y., ZHANG, L., & GUAN, Z. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.02.001 · Cited by 31 · see citing works
Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer’s Disease Brain
Cai, L., Qu, B., Hurtle, B. T., Dadiboyena, S., Diaz-Arrastia, R. R., & Pike, V. W. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00051 · Cited by 30 · see citing works
Histamine Induces Alzheimer’s Disease-Like Blood Brain Barrier Breach and Local Cellular Responses in Mouse Brain Organotypic Cultures
Sedeyn, J. C., Wu, H., Hobbs, R. D., Levin, E. C., Nagele, R. G., & Venkataraman, V. (2015) · BioMed Research International · doi:10.1155/2015/937148 · Cited by 30 · see citing works
Imaging Brain Metabolism and Pathology in Alzheimer ’s Disease with Positron Emission Tomography
D, R. W. C. (2014) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000143 · Cited by 29 · see citing works
APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks
Röskam, S., Neff, F., Schwarting, R. K. W., Bacher, M., & Dodel, R. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.006 · Cited by 28 · see citing works
NetDecoder: a network biology platform that decodes context-specific biological networks and gene activities
da Rocha, E. L., Ung, C. Y., McGehee, C. D., Correia, C., & Li, H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw166 · Cited by 27 · see citing works
CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease
Koppel, J. L., Vingtdeux, V., Marambaud, P., d’Abramo, C., Jimenez, H. T., Stauber, M., Friedman, R., & Davies, P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00140 · Cited by 27 · see citing works
Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer’s Disease and APPswe/PS1dE9 Double Transgenic Mice Brains
Zhang, J., Wang, S., Huang, W. C., Bennett, D. A., Dickson, D. W., Wang, D., & Wang, R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9413-x · Cited by 26 · see citing works
Self-citation
Dioscin Protects against Aβ1–42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy
Zhang, Z., Han, K., Wang, C., Sun, C., & Jia, N. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00046 · Cited by 24 · see citing works
Lovastatin stimulates up-regulation of α7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the α-form of secreted amyloid precursor protein
Xiu, J., Nordberg, A. K., Shan, K.-R., Yu, W., Olsson, J. M., Nordman, T., Mousavi, M. T., & Guan, Z. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20658 · Cited by 24 · see citing works
Copper–amyloid-β complex may catalyze peroxynitrite production in brain: evidence from molecular modeling
Giacovazzi, R., Ciofini, I., Rao, L., Amatore, C. A., & Adamo, C. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp54839b · Cited by 23 · see citing works
Evidence that Brain-Reactive Autoantibodies Contribute to Chronic Neuronal Internalization of Exogenous Amyloid-β1-42 and Key Cell Surface Proteins During Alzheimer’s Disease Pathogenesis
Goldwaser, E. L., Acharya, N. K., Wu, H., Godsey, G. A., Sarkar, A., DeMarshall, C. A., Kosciuk, M. C., & Nagele, R. G. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190962 · Cited by 22 · see citing works
Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
Koutarapu, S., Ge, J., Dulewicz, M., Srikrishna, M., Szadziewska, A., Wood, J. I., Blennow, K., Zetterberg, H., Michno, W., Ryan, N. S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59085-7 · Cited by 21 · see citing works
Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy
Bosch-Morató, M., Iriondo, C., Guivernau, B., Valls-Comamala, V., Vidal, N., Olivé, M., Querfurth, H. W., & Muñoz, F. J. (2016) · Oncotarget · doi:10.18632/oncotarget.7997 · Cited by 21 · see citing works
Immunological Aspects of Alzheimer??s Disease
Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Eikelenboom, P. (2001) · BioDrugs · doi:10.2165/00063030-200115050-00004 · Cited by 21 · see citing works
CD45RB Is a Novel Molecular Therapeutic Target to Inhibit Aβ Peptide-Induced Microglial MAPK Activation
Zhu, Y., Hou, H., Nikolic, W. V., Ehrhart, J. C., Rrapo, E., Bickford, P. C., Giunta, B. N., & Tan, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002135 · Cited by 21 · see citing works
Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides
Goldblatt, G., Matos, J. O., Gornto, J., & Tatulian, S. A. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp03343h · Cited by 20 · see citing works
Intracellular pathways involved in TNF-α and superoxide anion release by Aβ(1–42)-stimulated primary human macrophages
Smits, H. A., Vos, N., Wat, J. W. Y., van der Bruggen, T., Verhoef, J., & Nottet, H. S. L. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00254-5 · Cited by 19 · see citing works
Modulating Metals As A Therapeutic Strategy For Alzheimer’s Disease
Hung, L. W., & Barnham, K. J. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.32 · Cited by 18 · see citing works
Structure and permeability changes of the blood-brain barrier in APP/PS1 mice: an Alzheimer’s disease animal model
Wang, Y., Liu, J., Zhang, Z., Wang, X., & Zhang, C. (2011) · Neurochemical Journal · doi:10.1134/s1819712411030135 · Cited by 16 · see citing works
Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation
Bao, L., Hao, S., Xi, S., Yan, X., Zhang, H., Shen, R., & Gu, Z. (2018) · Chemical Communications · doi:10.1039/c8cc04913k · Cited by 16 · see citing works
Chemical Composition, Antioxidant and Anticholinesterase Activities of the Essential oil of Origanum rotundifolium Boiss. from Turkey
Özbek, H., Güvenalp, Z., Özek, T., Sevindik, H. G., Yuca, H., Yerdelen, K. Ö., & Demirezer, L. Ö. (2017) · Records of Natural Products · doi:10.25135/rnp.62.16.05.040 · Cited by 15 · see citing works

Neuropathology of Alzheimer's Disease
Castellani, R. J., Peclovits, A., & Perry, G. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.04604-9 · Cited by 8 · see citing works
The neuropathological diagnosis of Alzheimer disease
Jellinger, K. A. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_9 · Cited by 97 · see citing works
Neuropathology of Alzheimer’s disease: a critical update
Jellinger, K. A., & Bancher, C. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-7508-8_8 · Cited by 231 · see citing works
Diagnostic criteria for the neuropathologic assessment of Alzheimer's disease.
Powers, J. M. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00070-5 · Cited by 214 · see citing works
Strategies for Improving the Postmortem Neuropathological Diagnosis of Alzheimer’s Disease
Trojanowski, J. Q., Clark, C. M., Schmidt, M. L., Arnold, S. E., & LEE, V. M. ‐. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00075-4 · Cited by 39 · see citing works

Authors: Dickson, D. W.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Dickson, D.W
ORCID: Dickson, D.W
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-07
Volume: 18
Issue: 4
Pages: S21-S26
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00065-1
OpenAlex: W2011769584
Cited by: 168
References: 44
Citations by year: 2026: 4 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 11 · 2018: 15 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 12
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ag006803-11)
U.S. Public Health Service (NIA 03949)
National Institute on Aging (AG-06803)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, neuropathological diagnosis, amyloid plaques, neurofibrillary degeneration, paired helical filaments, neuritic plaques, amyloid deposits, neuropil threads, dementia, clinicopathological correlation, diagnostic criteria
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cell Count, Diagnosis, Differential, Humans, Longitudinal Studies, Middle Aged, Parkinson Disease, Prospective Studies, Severity of Illness Index, Neurofibrillary Tangles, Neuropil Threads, Plaque, Amyloid

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Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies

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