Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
Abstract
Spirulina is an alga that has a high nutritional value and some of its biological activities are attributed to the presence of antioxidants. Oxidative stress is involved in Parkinson's disease. This study aims at evaluating the neuroprotective role of Spirulina maxima (Sp.) against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity, used as a model of Parkinson's disease. Ninety-six male C-57 black mice were pretreated with Spirulina for 14 days (25, 50, 100, 150 or 200 mg/kg, oral), followed by three MPTP administrations (30 mg/kg, intraperitoneal, i.p.). Animals were given Sp. for 8 additional days. After the treatment, the striatal dopamine (DA) content was analysed by high performance liquid chromatography, and lipid peroxidation was studied as an index of oxidative stress. Sp. pretreatment at 150 mg/kg partially prevented (51%) the DA-depleting effect of MPTP and blocked oxidative stress. Spirulina partially prevents MPTP neurotoxicity and oxidative stress, suggesting it could be a possible alternative in experimental therapy.
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Pretreatment with Spirulina did not completely prevent the dopamine-consumption effect of MPTP and did not arrest oxidative stress.
“pretreatment with Spirulina did not completely prevent the DA-consumption effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and arrest oxidative stress [90].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [90]
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- Authors
- Chamorro, G., Pérez-Albiter, M., Serrano-García, N., Mares-Sámano, J. J., & Rojas, P.
- Affiliations
- Instituto Politécnico Nacional (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- University of North Dakota (US)
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2006-10
- Volume
- 9
- Issue
- 5-6
- Pages
- 207-212
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W2005439083
- Cited by
- 50
- References
- 34
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Spirulina maxima, MPTP-induced neurotoxicity, Parkinson's disease, neuroprotection, oxidative stress, lipid peroxidation, striatal dopamine, antioxidants, dietary supplementation
- MeSH terms
- Animals, Brain, Dopamine, Male, Mice, Inbred C57BL, Serotonin, Triazines, Lipid Peroxidation, Parkinsonian Disorders, Mice, Spirulina
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