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Gender differences in the responses to noxious stimuli

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The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man

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Sex differences in the perception of noxious heat stimuli

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Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence

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Evaluating psychosocial contributions to chronic pain outcomes

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A systematic literature review of 10 years of research on sex/gender and experimental pain perception – Part 1: Are there really differences between women and men?

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Sex, gender, and pain: women and men really are different

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Gender differences in pressure pain threshold in healthy humans

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A systematic literature review of 10 years of research on sex/gender and pain perception – Part 2: Do biopsychosocial factors alter pain sensitivity differently in women and men?

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The A118G single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans

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Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults

Edwards, R. R., Fillingim, R. B., & Ness, T. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00324-x · Cited by 356

Pain and Emotion: Effects of Affective Picture Modulation

Meagher, M. W., Arnau, R. C., & Rhudy, J. L. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200101000-00010 · Cited by 342

Wind‐up and the NMDA receptor complex from a clinical perspective

Eide, P. K. (2000) · European Journal of Pain · doi:10.1053/eujp.1999.0154 · Cited by 337

Gender differences in prevalence of upper extremity musculoskeletal disorders

Treaster, D. E., & Burr, D. C. (2004) · Ergonomics · doi:10.1080/00140130310001638171 · Cited by 291

Gender differences in pain

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Sex, Gender, and Pain

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Sex-Related Differences in Human Pain and Rat Afferent Discharge Evoked by Injection of Glutamate Into the Masseter Muscle

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Individual differences in pain responses

Fillingim, R. B. (2005) · Current Rheumatology Reports · doi:10.1007/s11926-005-0018-7 · Cited by 231

Peripheral and central components of habituation of heat pain perception and evoked potentials in humans

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Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia

Graven‐Nielsen, T. (2006) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740600865980 · Cited by 227

Reference values for quantitative sensory testing in children and adolescents: Developmental and gender differences of somatosensory perception

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Functional abdominal pain patient subtypes in childhood predict functional gastrointestinal disorders with chronic pain and psychiatric comorbidities in adolescence and adulthood

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Pain-related Catastrophizing in Healthy Women Is Associated With Greater Temporal Summation of and Reduced Habituation to Thermal Pain

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Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables

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Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones

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Race and Sex Differences in Cutaneous Pain Perception

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Pain Sensitivity Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case Control Study

Greenspan, J. D., Slade, G. D., Bair, E., Dubner, R. A., Fillingim, R. B., Ohrbach, R. K., Knott, C. E., Mulkey, F. A., Rothwell, R., & Maixner, W. D. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.08.006 · Cited by 204

Contact heat-evoked temporal summation: Tonic versus repetitive-phasic stimulation

Granot, M., Granovsky, Y., Sprecher, E., Nir, R., & Yarnitsky, D. (2006) · Pain · doi:10.1016/j.pain.2006.02.003 · Cited by 203

Glutamate-evoked pain and mechanical allodynia in the human masseter muscle

Svensson, P. J., Cairns, B. E., Wang, K., Hu, J. W., Graven‐Nielsen, T., Arendt‐Nielsen, L., & Sessle, B. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00079-9 · Cited by 195

Reference values of mechanical and thermal pain tests in a pain‐free population

Neziri, A. Y., Scaramozzino, P., Andersen, O. K., Dickensonl, A. H., Arendt‐Nielsen, L., & Curatolol, M. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.08.011 · Cited by 194

Influences of gender role and anxiety on sex differences in temporal summation of pain

Robinson, M. E., Wise, E. A., Gagnon, C., Fillingim, R. B., & Price, D. D. (2004) · The Journal of Pain · doi:10.1016/j.jpain.2003.11.004 · Cited by 193

Effects of age on temporal summation and habituation of thermal pain: Clinical relevance in healthy older and younger adults

Edwards, R. R., & Fillingim, R. B. (2001) · Journal of Pain · doi:10.1054/jpai.2001.25525 · Cited by 189

Bilateral Widespread Mechanical Pain Sensitivity in Women With Myofascial Temporomandibular Disorder: Evidence of Impairment in Central Nociceptive Processing

Fernández‐de‐las‐Peñas, C., Galán-del-Río, F., Fernández‐Carnero, J., Pesquera, J., Arendt‐Nielsen, L., & Svensson, P. J. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.04.017 · Cited by 187

Temporal Summation of Pain Evoked by Mechanical Stimulation in Deep and Superficial Tissue

Nie, H., Arendt‐Nielsen, L., Andersen, H., & Graven‐Nielsen, T. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.01.352 · Cited by 184

Impact of Age, Gender and Cognitive Functioning on Pain Perception

Pickering, G. P., Jourdan, D., Eschalier, A., & Dubray, C. (2002) · Gerontology · doi:10.1159/000048937 · Cited by 185

Chronic pain and sex-differences; women accept and move, while men feel blue

Rovner, G. S., Sunnerhagen, K. S., Björkdahl, A., Gerdle, B., Börsbo, B., Johansson, F., & Gillanders, D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175737 · Cited by 179

Gender differences in temporal summation of mechanically evoked pain

Sarlani, E., & Greenspan, J. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00015-5 · Cited by 171

Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia

Fernández‐Carnero, J., Fernández‐de‐las‐Peñas, C., De-la-Llave-Rincón, A. I., Ge, H., & Arendt‐Nielsen, L. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181a68a040 · Cited by 171

Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin

Frot, M., Feine, J. S., & Bushnell, C. M. (2004) · Pain · doi:10.1016/j.pain.2003.11.017 · Cited by 171

Morphine responses and experimental pain: Sex differences in side effects and cardiovascular responses but not analgesia

Fillingim, R. B., Ness, T. J., Glover, T. L., Campbell, C. M., Hastie, B. A., Price, D. D., & Staud, R. M. (2005) · Journal of Pain · doi:10.1016/j.jpain.2004.11.005 · Cited by 169

The role of gender in fibromyalgia syndrome

Yunus, M. B. (2001) · Current Rheumatology Reports · doi:10.1007/s11926-001-0008-3 · Cited by 166

Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects

Bhutta, A. T., Rovnaghi, C. R., Simpson, P. M., Gossett, J. M., Scalzo, F. M., & Anand, K. J. S. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00432-2 · Cited by 157

Mechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual model

Smith, M. T., Quartana, P. J., Okonkwo, R., & Nasir, A. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0073-2 · Cited by 152

Evidence for generalized hyperalgesia in temporomandibular disorders patients

Sarlani, E., & Greenspan, J. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00095-2 · Cited by 150

Why Look in the Brain for Answers to Temporomandibular Disorder Pain?

Sarlani, E., & Greenspan, J. D. (2005) · Cells Tissues Organs · doi:10.1159/000086200 · Cited by 145

Sex differences in temporal characteristics of descending inhibitory control: an evaluation using repeated bilateral experimental induction of muscle pain

Ge, H.-Y., Madeleine, P., & Arendt-Nielsen, L. (2004) · Pain · doi:10.1016/j.pain.2004.03.005 · Cited by 146

Sex differences and predictors of objective cough frequency in chronic cough

Kelsall, A., Decalmer, S., McGuinness, K., Woodcock, A. A., & Smith, J. A. (2009) · Thorax · doi:10.1136/thx.2008.106237 · Cited by 147

Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls

Smith, B. W., Tooley, E. M., Montague, E. Q., Robinson, A. E. R., Cosper, C. J., & Mullins, P. G. (2008) · Pain · doi:10.1016/j.pain.2008.09.018 · Cited by 145

White matter brain and trigeminal nerve abnormalities in temporomandibular disorder

Moayedi, M., Weissman-Fogel, I., Salomons, T. V., Crawley, A. P., Goldberg, M. B., Freeman, B. V., Tenenbaum, H. C., & Davis, K. D. (2012) · Pain · doi:10.1016/j.pain.2012.04.003 · Cited by 144

Distraction Analgesia in Chronic Pain Patients

Schreiber, K. L., Campbell, C. M., Martel, M. O., Greenbaum, S., Wasan, A. D., Borsook, D., Jamison, R. N., & Edwards, R. R. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000465 · Cited by 143

Thermal sensitivity to warmth during rest and exercise: a sex comparison

Gerrett, N., Ouzzahra, Y., Coleby, S., Hobbs, S., Redortier, B., Voelcker, T., & Havenith, G. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2875-0 · Cited by 145

Referred Pain from Muscle Trigger Points in the Masticatory and Neck-Shoulder Musculature in Women With Temporomandibular Disoders

Fernández‐de‐las‐Peñas, C., Galán-del-Río, F., Alonso‐Blanco, C., Jiménez‐García, R., Arendt‐Nielsen, L., & Svensson, P. J. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.005 · Cited by 138

Evidence for up-regulated central nociceptive processing in patients with masticatory myofascial pain.

Sarlani, E., Grace, E. G., Reynolds, M. A., & Greenspan, J. D. (2004) · PubMed · Cited by 136

Examining sex differences in knee pain: the Multicenter Osteoarthritis Study

Glass, N. A., Segal, N. A., Sluka, K. A., Torner, J. C., Nevitt, M. C., Felson, D. T., Bradley, L. A., Neogi, T., Lewis, C. E., & Frey‐Law, L. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.06.030 · Cited by 135

Sex and Pain-Related Psychological Variables Are Associated With Thermal Pain Sensitivity for Patients With Chronic Low Back Pain

George, S. Z., Wittmer, V. T., Fillingim, R. B., & Robinson, M. E. (2007) · Journal of Pain · doi:10.1016/j.jpain.2006.05.009 · Cited by 138

Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation

Sarlani, E., Grace, E. G., Reynolds, M. A., & Greenspan, J. D. (2004) · Pain · doi:10.1016/j.pain.2004.01.019 · Cited by 132

Shoulder Pain Following Laparoscopic Cholecystectomy: Factors Affecting the Incidence and Severity

Kandil, T. S., & Hefnawy, E. E. (2010) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/lap.2010.0112 · Cited by 127

Prolonged ovarian sex steroid treatment of male rats produces antinociception: identification of sex-based divergent analgesic mechanisms

Liu, N., & Gintzler, A. R. (2000) · Pain · doi:10.1016/s0304-3959(99)00278-x · Cited by 127

Gender and laterality differences in thermosensation throughout the perceptible range

Sarlani, E., Farooq, N. S., & Greenspan, J. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00211-2 · Cited by 125

Effects of the N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Temporal Summation of Pain are Similar in Fibromyalgia Patients and Normal Control Subjects

Staud, R. M., Vierck, C. J., Robinson, M. E., & Price, D. D. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.01.357 · Cited by 125

Fear of pain, not pain catastrophizing, predicts acute pain intensity, but neither factor predicts tolerance or blood pressure reactivity: An experimental investigation in pain‐free individuals

George, S. Z., Dannecker, E. A., & Robinson, M. E. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.007 · Cited by 131

Anticipated and experienced pain associated with endodontic therapy

Watkins, C. A., Logan, H. L., & Kirchner, H. L. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0020 · Cited by 125

Response of males and females to high-force eccentric exercise

Rinard, J., Clarkson, P. M., SMITH, L. L., & Grossman, M. (2000) · Journal of Sports Sciences · doi:10.1080/026404100364965 · Cited by 117

Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome

Chang, L., Mayer, E. A., Labus, J. S., Schmulson, M. J., Lee, O. Y., Olivas, T. I., Stains, J., & Naliboff, B. D. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00729.2005 · Cited by 116

Sex Differences in Opioid Analgesia and Addiction: Interactions among Opioid Receptors and Estrogen Receptors

Lee, C. W., & Ho, I.-K. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-45 · Cited by 109

Brain mechanisms of social touch-induced analgesia in females

López‐Solà, M., Geuter, S., Koban, L., Coan, J. A., & Wager, T. D. (2019) · Pain · doi:10.1097/j.pain.0000000000001599 · Cited by 110

Predicting, preventing and managing persistent pain after breast cancer surgery: the importance of psychosocial factors

Schreiber, K. L., Kehlet, H., Belfer, I., & Edwards, R. R. (2014) · Pain Management · doi:10.2217/pmt.14.33 · Cited by 106

Gender and Post–Dural Puncture Headache

Wu, C. L., Rowlingson, A. J., Cohen, S. R., Michaels, R. K., Courpas, G. E., Joe, E. M., & Liu, S. S. (2006) · Anesthesiology · doi:10.1097/00000542-200609000-00027 · Cited by 102

A quantitative somatosensory testing of pain threshold in individuals with mental retardation

Defrin, R., Pick, C. G., Peretz, C., & Carmeli, E. (2004) · Pain · doi:10.1016/j.pain.2003.12.003 · Cited by 102

Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain

Smith, M. T., Remeniuk, B., Finan, P. H., Speed, T. J., Tompkins, D. A., Robinson, M., Gonzalez, K., Bjurström, M. F., & Irwin, M. R. (2018) · SLEEP · doi:10.1093/sleep/zsy209 · Cited by 101

Risk Factors Predicting the Development of Widespread Pain From Chronic Back or Neck Pain

Kindler, L. L., Jones, K. D., Perrin, N., & Bennett, R. M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.007 · Cited by 99

Pain Characteristics after Total Laparoscopic Hysterectomy

Choi, J. B., Kang, K., Song, M. K., Seok, S., Kim, Y. H., & Kim, J. E. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.15875 · Cited by 98

Sex‐based differences in gastrointestinal pain

Mayer, E. A., Berman, S. M., Chang, L., & Naliboff, B. D. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.01.006 · Cited by 98

Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans

Frey‐Law, L., Sluka, K. A., McMullen, T., Lee, J., Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2008) · Pain · doi:10.1016/j.pain.2008.08.014 · Cited by 98

Sex and Race Differences in Pain Sensitization among Patients with Chronic Low Back Pain

Meints, S. M., Wang, V. C., & Edwards, R. R. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.07.001 · Cited by 101

Quantitative sensory testing: identifying pain characteristics in patients with osteoarthritis

Arant, K. R., Katz, J. N., & Neogi, T. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.09.011 · Cited by 95

Pain-Related Rumination, But Not Magnification or Helplessness, Mediates Race and Sex Differences in Experimental Pain

Meints, S. M., Stout, M. E., Abplanalp, S. J., & Hirsh, A. T. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.11.005 · Cited by 95

Sex differences and phases of the estrous cycle alter the response of spinal cord dynorphin neurons to peripheral inflammation and hyperalgesia

Bradshaw, H. B., Miller, J. E., Ling, Q., Malsnee, K., & Ruda, A. M. (2000) · Pain · doi:10.1016/s0304-3959(99)00253-5 · Cited by 93

Quantitative sensory testing in children with migraine: Preliminary evidence for enhanced sensitivity to painful stimuli especially in girls

Zohsel, K., Hohmeister, J., Oelkers‐Ax, R., Flor, H., & Hermann, C. (2006) · Pain · doi:10.1016/j.pain.2005.12.015 · Cited by 92

Quantitative Somatosensory Testing of Warm and Heat-Pain Thresholds: The Effect of Body Region and Testing Method

Defrin, R., Shachal-Shiffer, M., Hadgadg, M., & Peretz, C. (2006) · Clinical Journal of Pain · doi:10.1097/01.ajp.0000154048.68273.d8 · Cited by 92

Dispositional anxiety and the experience of pain: gender‐specific effects

Jones, A., Zachariae, R. H., & Arendt‐Nielsen, L. (2003) · European Journal of Pain · doi:10.1016/s1090-3801(02)00139-8 · Cited by 91

Hyperalgesia in an animal model of multiple sclerosis

Aicher, S. A., Silverman, M. B., Winkler, C. W., & Bebo, B. F. (2004) · Pain · doi:10.1016/j.pain.2004.03.025 · Cited by 91

Low intensity vagal nerve stimulation lowers human thermal pain thresholds

Ness, T. J., Fillingim, R. B., Randich, A., Backensto, E. M., & Faught, E. (2000) · Pain · doi:10.1016/s0304-3959(00)00237-2 · Cited by 90

Overview of orofacial pain: epidemiology and gender differences in orofacial pain

Shinal, R. M., & Fillingim, R. B. (2007) · Dental Clinics of North America · doi:10.1016/j.cden.2006.09.004 · Cited by 80

A Search for Sex Differences in Response to Analgesia

Averbuch, M., & Katzper, M. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.22.3424 · Cited by 86

Studies of pain in human subjects

Gracely, R. H. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50022-9 · Cited by 86

Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine

Fillingim, R. B., Hastie, B. A., Ness, T. J., Glover, T. L., Campbell, C. M., & Staud, R. M. (2004) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.008 · Cited by 88

The Association of Greater Dispositional Optimism With Less Endogenous Pain Facilitation Is Indirectly Transmitted Through Lower Levels of Pain Catastrophizing

Goodin, B. R., Glover, T. L., Sotolongo, A. S., King, C. D., Sibille, K. T., Herbert, M. S., Cruz‐Almeida, Y., Sanden, S. H., Staud, R. M., Redden, D. T., et al. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.007 · Cited by 89

Gender differences in pain modulation evoked by repeated injections of glutamate into the human trapezius muscle

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Female thermal sensitivity to hot and cold during rest and exercise.

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