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Cited by 274Stress Responses and CortisolAdrenal Hormones and DisordersNeuroendocrine regulation and behavior

Stress and the developing limbic-hypothalamic-pituitary-adrenal axis

M. Vázquez, Delia·1998·Psychoneuroendocrinology
DOI 10.1016/s0306-4530(98)00029-8
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Abstract

The postnatal limbic-hypothalamic-pituitary-adrenal (LHPA) axis in the rodent is remarkably different from the adult, both in structure and function. The first 2 weeks postnatally are characterized by a 'silent period' during which the developing animal is hyporesponsive to stress (stress hyporesponsive period-SHRP), followed by a new and unique phase of stress responsiveness when the animal fails to swiftly terminate glucocorticoid secretion. In this review, we summarize our work which focuses on the regulatory biology of the components of the LHPA system and the consequences of its disruption on the adaptive responses of the developing organism. We find that the animal during the first 2 weeks of life responds to an intermittent chronic challenge increasing anterior pituitary POMC post-translational events, while the adult increases genomic events. The result for both the mature and the developing animal is the same, an increase in corticosterone (CS) levels. In addition, we have found evidence of impaired rate sensitive feedback in the weanling animal, as well as changes in ACTH clearance. Similar to the young animal emerging from SHRP, maternally deprived pups during the first week of life exhibit a substantial and sustained ACTH and CS response to stress. In the deprived animal these changes are accompanied by decreases in mineralocorticoid receptor gene expression in the hippocampus, suggesting that changes in mineralocorticoid to glucocorticoid receptor ratios may be important in this phenomena. What has become evident from our studies is that mechanisms underlying normal LHPA development are dynamic, age dependent and distinct to the strategies used by the mature organism to cope with stress.

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  • The pubertal/adolescent transition in humans and laboratory animals is generally associated with increased ANS and stress hormone reactivity to stressors, and slower post-stress hormonal recovery relative to adults.

    “the pubertal/adolescent transition in humans and laboratory animals has generally been reported to be associated with increased ANS and stress hormone reactivity to stressors (e.g., Vázquez, 1998; Walker et al, 2004; Gunnar et al, 2009; Stroud et al, 2009), along with slower post-stress hormonal recovery relative to adults (Romeo & McEwen, 2006).”

    From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Vázquez, 1998

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Authors
M. Vázquez, D.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1998-10
Volume
23
Issue
7
Pages
663-700
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/s0306-4530(98)00029-8
OpenAlex
W1980057501
Cited by
274
References
90
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 11 · 2015: 13 · 2014: 20 · 2013: 6 · 2012: 9
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32mh009720-02, 5r01da002265-19)
  • National Institute of Mental Health (MH09720)
  • National Institute on Drug Abuse (DA02265, DA00250)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
stress hyporesponsive period, postnatal development, corticosterone, proopiomelanocortin, glucocorticoid negative feedback, mineralocorticoid receptor, hippocampus, maternal deprivation, stress responsiveness
MeSH terms
Adaptation, Psychological, Adrenocorticotropic Hormone, Age Factors, Animals, Animals, Newborn, Arousal, Brain Mapping, Corticosterone, Feedback, Female, Hippocampus, Hypothalamo-Hypophyseal System, Limbic System, Maternal Deprivation, Pituitary-Adrenal System, Pregnancy, Pro-Opiomelanocortin, RNA, Messenger, Gene Expression, Receptors, Mineralocorticoid, Rats

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