When mothering goes awry: challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving

Drury, Stacy S.; Sánchez, Mar M.; Gonzalez, Andrea

doi:10.1016/j.yhbeh.2015.10.007

Cited by 72Child Abuse and TraumaNeuroendocrine regulation and behaviorStress Responses and Cortisol

When mothering goes awry: challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving

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Drury, Stacy S., Sánchez, Mar M., Gonzalez, Andrea·2016·Hormones and Behavior

DOI 10.1016/j.yhbeh.2015.10.007PMC PMC4802164

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Abstract

This article is part of a Special Issue "Parental Care".Across mammalian species, mothers shape socio-emotional development and serve as essential external regulators of infant physiology, brain development, behavior patterns, and emotional regulation. Caregiving quality, consistency and predictability shape the infant's underlying neurobiological processes. Although the requirements for "optimal" caregiving differ across species, the negative long-term consequences of the absence of needed caregiving (e.g. neglect) or the presence of harmful/aversive caregiving (e.g. physical abuse), are translatable across species. Recognizing the significant potential of cross species comparisons in terms of defining underlying mechanisms, effective translation requires consideration of the evolutionary, ecological, and fundamental biological and developmental differences between and among species. This review provides both an overview of several success stories of cross-species translations in relation to negative caregiving and a template for future studies seeking to most effectively define the underlying biological processes and advance research dedicated to mitigating the lasting negative health consequences of child maltreatment.

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Studies in rodents, primates, and humans have identified a sensitive period in early life during which abusive care from an attachment figure interacts with heightened neural plasticity to program long-term impairments in social behavior through effects on amygdala development.
“Indeed, studies in rodents, primates, and humans have identified a sensitive period in early life during which abusive care from an attachment figure interacts with heightened neural plasticity to program long-term impairments in social behavior through effects on amygdala development (Opendak and Sullivan, 2016, Humphreys and Zeanah, 2015, Drury et al., 2015).”
From Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior (2017) · cites this paper as Drury et al., 2015

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Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats.
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Authors: Drury, S. S., Sánchez, M. M., & Gonzalez, A.
Affiliations: Tulane University (US)
Emory University (US)
Corresponding author: Drury, Stacy S.
ORCID: Drury, Stacy S.
Sánchez, Mar M.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2016-01
Volume: 77
Pages: 182-192
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2015.10.007
PMC: PMC4802164
OpenAlex: W2176484432
Cited by: 72
References: 188
Citations by year: 2025: 5 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 2
FWCI: 11.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes for Health Research (AG),
Brain and Behavior Research Foundation (R01 MH 101533)
Tulane University Oliver Fund
NIH (MH 078105)
NICHD (HD077623)
Yerkes National Primate Research Center – YNPRC – Base (P51OD11132)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: child abuse, child neglect, maternal care, cross-species translation, rodent models, non-human primates, human subjects research, social-emotional development, emotion regulation, infant development, translational research
MeSH terms: Animals, Child, Child Abuse, Child Development, Humans, Infant, Maternal Behavior, Mothers, Primates

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When mothering goes awry: challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving

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