Cited by 388Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

Lewis, D·1997·Neuropsychopharmacology

DOI 10.1016/s0893-133x(96)00277-1

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Abstract

Multiple lines of evidence suggest that the prefrontal cortex is a site of dysfunction in schizophrenia. In addition, one of the characteristics of this disorder is the tendency for clinical symptoms to appear first during late adolescence or early adulthood. Recent studies in nonhuman primates have shown that the connectivity of the prefrontal cortex is substantially refined during adolescence, suggesting that these developmental changes may be critical for the appearance of the clinical features of schizophrenia. This article reviews data demonstrating that these late developmental changes are selective for particular neural elements in the prefrontal cortex and that they are synaptically linked. It is suggested that these neural elements comprise a functional circuit that is likely to be especially vulnerable in schizophrenia, a hypothesis that can be directly tested in postmortem studies.

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Authors: Lewis, D.
Affiliations: University of Pittsburgh (US)
Corresponding author: Lewis, D
ORCID: Lewis, D
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1997-06
Volume: 16
Issue: 6
Pages: 385-398
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(96)00277-1
OpenAlex: W2013122647
Cited by: 388
References: 122
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 33 · 2014: 14 · 2013: 19 · 2012: 16
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service
National Institute of Mental Health (MH43784, MH-51234, MH 45156, R01MH051234, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: prefrontal cortex, adolescence, schizophrenia, synaptic refinement, cortical connectivity, non-human primates, postmortem studies
MeSH terms: Adolescent, Humans, Nerve Net, Schizophrenia, Synapses, Prefrontal Cortex

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Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

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