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Dynamic Statistical Parametric Mapping
Open accessAbstract
Functional magnetic resonance imaging (fMRI) can provide maps of brain activation with millimeter spatial resolution but is limited in its temporal resolution to the order of seconds. Here, we describe a technique that combines structural and functional MRI with magnetoencephalography (MEG) to obtain spatiotemporal maps of human brain activity with millisecond temporal resolution. This new technique was used to obtain dynamic statistical parametric maps of cortical activity during semantic processing of visually presented words. An initial wave of activity was found to spread rapidly from occipital visual cortex to temporal, parietal, and frontal areas within 185 ms, with a high degree of temporal overlap between different areas. Repetition effects were observed in many of the same areas following this initial wave of activation, providing evidence for the involvement of feedback mechanisms in repetition priming.
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“such algorithms all share and utilize a common assumption that EEG/MEG sources are more likely to occur at where fMRI views as activated.”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [149]
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Metadata
- Authors
- Dale, A. M., Liu, A. K., Fischl, B. R., Buckner, R. L., Belliveau, J. W., Lewine, J. D., & Halgren, E.
- Affiliations
- Massachusetts General Hospital (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- Inserm (FR)
- Corresponding author
- Dale, Anders M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 26
- Issue
- 1
- Pages
- 55-67
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2013150886
- Cited by
- 1,787
- References
- 84
- Citations by year
- 2026: 77 · 2025: 99 · 2024: 90 · 2023: 89 · 2022: 98 · 2021: 83 · 2020: 94 · 2019: 91 · 2018: 83 · 2017: 66 · 2016: 64 · 2015: 71 · 2014: 70 · 2013: 70 · 2012: 66
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS18741, R01NS018741)
- National Center for Research Resources (R01RR013609, R01-RR13609)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- spatiotemporal mapping, semantic processing, word recognition, visual word processing, repetition priming, feedback mechanisms, multimodal neuroimaging, magnetoencephalography
- MeSH terms
- Brain, Brain Mapping, Cerebral Cortex, Cognition, Humans, Magnetic Resonance Imaging, Magnetoencephalography
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