Stability of the memory of eye position in a recurrent network of conductance-based model neurons
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Studies of the neural correlates of short-term memory in a wide variety of brain areas have found that transient inputs can cause persistent changes in rates of action potential firing, through a mechanism that remains unknown. In a premotor area that is responsible for holding the eyes still during fixation, persistent neural firing encodes the angular position of the eyes in a characteristic manner: below a threshold position the neuron is silent, and above it the firing rate is linearly related to position. Both the threshold and linear slope vary from neuron to neuron. We have reproduced this behavior in a biophysically plausible network model. Persistence depends on precise tuning of the strength of synaptic feedback, and a relatively long synaptic time constant improves the robustness to mistuning.
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Miller et al. showed that fine-tuning of connectivity in the somatosensory discrimination model yields a line attractor capable of parametric working memory.
“Miller et al. (Miller et al., 2003) showed that fine-tuning of connectivity in this model yields a line attractor capable of parametric working memory, similar to the one in the gaze-control system (Seung et al., 2000).”
From Decision Making in Recurrent Neuronal Circuits (2008) · cites this paper as Seung et al., 2000
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“Miller et al. (Miller et al., 2003) showed that fine-tuning of connectivity in this model yields a line attractor capable of parametric working memory, similar to the one in the gazecontrol system (Seung et al., 2000).”
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- Authors
- Seung, H. S., Lee, D. D., Reis, B. Y., & Tank, D. W.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Seung, H.Sebastian
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 26
- Issue
- 1
- Pages
- 259-271
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2052296894
- Cited by
- 339
- References
- 65
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 15 · 2017: 14 · 2016: 11 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 13
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- short-term memory, eye position, eye fixations, recurrent neural networks, synaptic time constants, persistent firing, premotor neurons, memory stability
- MeSH terms
- Animals, Electric Conductivity, Eye Movements, Goldfish, Membrane Potentials, Memory, Short-Term, Oculomotor Muscles, Oculomotor Nerve, Neural Networks, Computer
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