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Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

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Jensen, Jimmy, McIntosh, Anthony R, Crawley, Adrian P, Mikulis, David J, Remington, Gary, Kapur, Shitij·2003·Neuron

DOI 10.1016/s0896-6273(03)00724-4

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Abstract

The brain "reward" system, centered on the limbic ventral striatum, plays a critical role in the response to pleasure and pain. The ventral striatum is activated in animal and human studies during anticipation of appetitive/pleasurable events, but its role in aversive/painful events is less clear. Here we present data from three human fMRI studies based on aversive conditioning using unpleasant cutaneous electrical stimulation and show that the ventral striatum is reliably activated. This activation is observed during anticipation and is not a consequence of relief after the aversive event. Further, the ventral striatum is activated in anticipation regardless of whether there is an opportunity to avoid the aversive stimulus or not. Our data suggest that the ventral striatum, a crucial element of the brain "reward" system, is directly activated in anticipation of aversive stimuli.

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Authors: Jensen, J., McIntosh, A. R., Crawley, A. P., Mikulis, D. J., Remington, G., & Kapur, S.
Affiliations: Centre for Addiction and Mental Health (CA)
University of Toronto (CA)
Corresponding author: Kapur, Shitij
ORCID: Jensen, Jimmy
McIntosh, Anthony R
Crawley, Adrian P
Mikulis, David J
Remington, Gary
Kapur, Shitij
Venue: Neuron
Publisher: Elsevier BV
Published: 2003-12
Volume: 40
Issue: 6
Pages: 1251-1257
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00724-4
OpenAlex: W1982327643
Cited by: 455
References: 53
Citations by year: 2026: 6 · 2025: 10 · 2024: 5 · 2023: 41 · 2022: 8 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 21 · 2017: 15 · 2016: 19 · 2015: 27 · 2014: 32 · 2013: 25 · 2012: 34
FWCI: 6.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3547 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: ventral striatum, aversive stimuli, anticipation, aversive conditioning, cutaneous electrical stimulation, reward systems, pain, avoidance, limbic system
MeSH terms: Adult, Avoidance Learning, Basal Ganglia, Electric Stimulation, Female, Humans, Magnetic Resonance Imaging, Male, Pain Measurement, Reward

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Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

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