Cited by 85Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Aversive stimuli and loss in the mesocorticolimbic dopamine system

Brooks, Andrew M., Berns, Gregory S.·2013·Trends in Cognitive Sciences

Abstract

There is mounting evidence that the mesolimbic dopamine system carries valuation signals not only for appetitive or gain-related stimuli, with which it is traditionally associated, but also for aversive and loss-related stimuli. Cellular-level studies demonstrate that the neuronal architecture to support aversive stimuli encoding in this system does exist. Both cellular-level and human neuroimaging research suggest the co-existence of appetitive and aversive prediction-error signals within the mesocorticolimbic system. These findings shift the view of the mesocorticolimbic system as a singular pathway for reward to a system with multiple signals across a wide range of domains that drive value-based decision making.

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Crossref · 10.1016/j.tics.2013.04.001

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85 of 85 references verified0 citation errors · 0 not checkable

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  • The periaqueductal gray is a primary site for aversive prediction errors, contrary to previous theories that a single system drives appetitive and aversive prediction errors.

    “Our data and connectivity models identify the PAG as a primary site for aversive PEs, in contrast to previous neuroimaging findings and theories that a single system drives appetitive and aversive PEs29.”

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Authors
Brooks, A. M., & Berns, G. S.
Affiliations
Emory University (US)
Corresponding author
Berns, Gregory S.
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2013-06
Volume
17
Issue
6
Pages
281-286
ISSN
1364-6613 (ISSN-L)
OpenAlex
W2045804286
Cited by
85
References
85
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 4
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
mesocorticolimbic dopamine system, aversive stimuli, loss, prediction error, reward valuation, value-based decision making, dopaminergic neurons, mesolimbic dopamine system
MeSH terms
Animals, Appetitive Behavior, Avoidance Learning, Cerebral Cortex, Decision Making, Dopamine, Humans, Limbic System, Neural Pathways, Neurons, Reward

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