Aversive stimuli and loss in the mesocorticolimbic dopamine system
Abstract
There is mounting evidence that the mesolimbic dopamine system carries valuation signals not only for appetitive or gain-related stimuli, with which it is traditionally associated, but also for aversive and loss-related stimuli. Cellular-level studies demonstrate that the neuronal architecture to support aversive stimuli encoding in this system does exist. Both cellular-level and human neuroimaging research suggest the co-existence of appetitive and aversive prediction-error signals within the mesocorticolimbic system. These findings shift the view of the mesocorticolimbic system as a singular pathway for reward to a system with multiple signals across a wide range of domains that drive value-based decision making.
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The periaqueductal gray is a primary site for aversive prediction errors, contrary to previous theories that a single system drives appetitive and aversive prediction errors.
“Our data and connectivity models identify the PAG as a primary site for aversive PEs, in contrast to previous neuroimaging findings and theories that a single system drives appetitive and aversive PEs29.”
From Representation of aversive prediction errors in the human periaqueductal gray (2014) · cites this paper as [29]
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- Authors
- Brooks, A. M., & Berns, G. S.
- Affiliations
- Emory University (US)
- Corresponding author
- Berns, Gregory S.
- ORCID
- Berns, Gregory S.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 17
- Issue
- 6
- Pages
- 281-286
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W2045804286
- Cited by
- 85
- References
- 85
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 4
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- mesocorticolimbic dopamine system, aversive stimuli, loss, prediction error, reward valuation, value-based decision making, dopaminergic neurons, mesolimbic dopamine system
- MeSH terms
- Animals, Appetitive Behavior, Avoidance Learning, Cerebral Cortex, Decision Making, Dopamine, Humans, Limbic System, Neural Pathways, Neurons, Reward
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