Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 605

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Bioactive peptides derived from bovine whey proteins

Pihlanto-Leppälä, Anne·2000·Trends in Food Science & Technology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0924-2244(01)00003-6

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 81

  1. Tome, 1998, Physiological Effects of Milk Protein Components, International Dairy Journal, 8, 383, 10.1016/S0958-6946(98)00061-2 · doi:10.1016/s0958-6946(98)00061-2
  2. Mellander, 1950, The Physiological Importance of the Casein Phosphopeptide Calcium Salts. 11. Peroral calcium dosage of infants, Acta Society Medicine Uppsala, 55, 247
  3. Brantl, 1979, Novel Opioid Peptides Derived from Casein (β-Casomorphins) I. Isolation from Bovine Casein Peptone, Hoppe-Seyler's Z. Physiological Chemistry, 360, 1211, 10.1515/bchm2.1979.360.2.1211 · DOI · Paper page
  4. Zioudrou, 1979, Opioid Peptides Derived from Food Proteins, Journal of Biological Chemistry, 254, 2446, 10.1016/S0021-9258(17)30243-0 · DOI · Paper page
  5. Jolles, 1979, Immunostimulating Substances from Human Casein, Journal of Pharmacology, 3, 363
  6. Maruyama, 1982, A Peptide Inhibitor of Angiotensin I-converting Enzyme in the Tryptic Hydrolysate of Casein, Agricultural and Biological Chemistry, 46, 1393, 10.1271/bbb1961.46.1393 · DOI
  7. Yoshikawa, 1986, Opioid Peptides from Milk Proteins, Agricultural and Biological Chemistry, 50, 2419, 10.1271/bbb1961.50.2419 · DOI
  8. Jolles, 1986, Analogy between fibrinogen and casein. Effect of an Undecapeptide Isolated from κ-casein on Platelet Function, European Journal of Biochemistry, 158, 379, 10.1111/j.1432-1033.1986.tb09764.x · DOI · Paper page
  9. Tomita, 1991, Potent Antibacterial Peptides Generated by Pepsin Digestion of Bovine Lactoferrin, Journal of Dairy Science, 74, 4137, 10.3168/jds.S0022-0302(91)78608-6 · DOI · Paper page
  10. Mullally, 1996, Synthetic Peptides Corresponding to α-lactalbumin and β-lactoglobulin Sequences with Angiotensin-I-converting Enzyme Inhibitory Activity, Biological Chemistry Hoppe-Seyler, 377, 259
  11. Antila, 1991, Opioid Peptides Derived from In Vitro Proteolysis of Bovine Whey Proteins, International Dairy Journal, 1, 215, 10.1016/0958-6946(91)90015-Z · DOI
  12. Pihlanto-Leppälä, 1996, Opioid Whey Protein Peptides Obtained by Membrane Filtration, IDF Bulletin, 311, 36
  13. Pihlanto-Leppälä, 1997, Bioactive Peptide Derived from In Vitro Proteolysis of Bovine β-lactoglobulin and its Effect on Smooth Muscle, Journal of Dairy Research, 64, 149, 10.1017/S0022029996001926 · DOI
  14. Pihlanto-Leppälä, 1998, Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins, International Dairy Journal, 8, 325, 10.1016/S0958-6946(98)00048-X · DOI · Paper page
  15. Pihlanto-Leppälä, 2000, Angiotensin I-converting Enzyme Inhibitory Properties of Whey Protein Digest, Journal of Dairy Research, 67, 53, 10.1017/S0022029999003982 · DOI · Paper page
  16. Höllt, 1983, Multiple Endogenous Opioid Peptides, Trends in Neuroscience, 6, 24, 10.1016/0166-2236(83)90010-3 · DOI · Paper page
  17. Paroli, 1988, Opioid Peptides from Food (the Exorphins), World Review of Nutrition and Diets, 55, 58, 10.1159/000415559 · DOI
  18. Teschemacher, 1994, Milk Protein Derived Atypical Opioid Peptides and Related Compounds with Opioid Antagonist Activity (Review), 3
  19. Koch, 1988, Human β-casomorphin-8 immunoreactive material in the plasma of women during pregnancy and after delivery, Regulatory Peptides, 20, 107, 10.1016/0167-0115(88)90044-4 · doi:10.1016/0167-0115(88)90044-4
  20. Meisel, 1986, Chemical Characterization and Opioid Activity of an Exorphin Isolated from In Vivo Digests of Casein, FEBS Letters, 196, 223, 10.1016/0014-5793(86)80251-4 · DOI
  21. Petrillo, 1982, Angiotensin Converting Enzyme Inhibitors, Medical Research Reviews, 2, 1, 10.1002/med.2610020103 · DOI · Paper page
  22. Ondetti, 1971, Angiotensin-converting enzyme inhibitors from the Venom of Bothrops jararaca. Isolation, Elucidation of Structure and Synthesis, Biochemistry, 19, 4033, 10.1021/bi00798a004 · DOI · Paper page
  23. Ariyoshi, 1993, Angiotensin-converting Enzyme Inhibitors Derived from Food Proteins, Trends in Food Science and Technology, 4, 139, 10.1016/0924-2244(93)90033-7 · DOI · Paper page
  24. Yamamoto, 1997, Antihypertensive Peptides Derived from Food Proteins, Biopolymers, 43, 129, 10.1002/(SICI)1097-0282(1997)43:2<129::AID-BIP5>3.0.CO;2-X · DOI · Paper page
  25. Nurminen, 2000, α-Lactorphin Lowers Blood Pressure via Radiotelemetry in Normotensive and Spontaneuously Hypertensive Rats, Life Sciences, 66, 1535, 10.1016/S0024-3205(00)00471-9 · DOI · Paper page
  26. Mullally, 1997, Identification of a Novel Angiotensin-I-converting Enzyme Inhibitory Peptide Corresponding to a Tryptic Fragment of Bovine Beta-lactoglobulin, FEBS Letters, 402, 99, 10.1016/S0014-5793(96)01503-7 · DOI · Paper page
  27. Abubakar, 1998, Structural Analysis of New Antihypertensive Peptides Derived from Cheese Whey Protein by Proteinase K Digestion, Journal of Dairy Science, 81, 3131, 10.3168/jds.S0022-0302(98)75878-3 · DOI · Paper page
  28. Maeno, 1996, Isolation of an Antihypertensive Peptide from Casein Hydrolysate Produced by a Proteinase from Lactobacillus helveticus CP790, Journal of Dairy Science, 79, 1316, 10.3168/jds.S0022-0302(96)76487-1 · DOI · Paper page
  29. Bouhallab, 1995, Continuous Hydrolysis of Caseinomactopeptide in a Membrane Reactor, Lait, 75, 251, 10.1051/lait:1995317 · DOI
  30. Mullally, 1997, Angiotensin-I-converting Enzyme Inhibitory Activities of Gastric and Pancreatic Proteinase Digests of Whey Proteins, International Dairy Journal, 7, 299, 10.1016/S0958-6946(97)00018-6 · DOI · Paper page
  31. Bordenave, 1999, Continuous Hydrolysis of Goat Whey in an Ultrafiltration Reactor, Preparative Biochemistry and Biotechnology, 29, 189, 10.1080/10826069908544890 · doi:10.1080/10826069908544890
  32. Wijers, 1998, Use of Nanofiltration Membranes for the Desalting of Peptide Fractions from Whey Protein Enzymatic Hydrolysates, Lait, 78, 621, 10.1051/lait:1998655 · doi:10.1051/lait:1998655
  33. Recio, 1999, Two Ion-exchange Methods for the Isolation of Antibacterial Peptides from Lactoferrin — In Situ Enzymatic Hydrolysis on an Ion-exchange Membrane, Journal of Chromatography, 831, 191, 10.1016/S0021-9673(98)00950-9 · DOI
  34. van Beresteijn, 1994, Molecular Mass Distribution, Immunological Properties and Nutritive Value of Whey Protein Hydrolysates, Journal of Food Protection, 57, 619, 10.4315/0362-028X-57.7.619 · doi:10.4315/0362-028x-57.7.619
  35. Thomas, 1987, Proteolytic Enzymes of Dairy Starter Cultures, FEMS Microbiology Reviews, 46, 245, 10.1111/j.1574-6968.1987.tb02464.x · DOI · Paper page
  36. Poolman, 1995, The Proteolytic Pathway of Lactococcus lactis, Journal of Applied Bacteriology, 79, 65
  37. Roudot-Algaron, 1994, Phosphopeptides from Comté Cheese, Journal of Food Science, 59, 544, 10.1111/j.1365-2621.1994.tb05558.x · DOI
  38. Singh, 1997, Isolation and Identification of Further Peptides in the Diafiltration Retentate of the Water-soluble Fraction of Cheddar cheese, Journal of Dairy Research, 64, 433, 10.1017/S0022029997002227 · DOI · Paper page
  39. Meisel, 1997, ACE-inhibitory Activities in Milk Products, Milchwissenschaft, 52, 307
  40. Smacchi, 1998, Peptides from Several Italian Cheeses Inhibitory to Proteolytic Enzymes of Lactic Acid Bacteria, Pseudomonas fluorescens ATCC 948 and to the Angiotensin I-converting Enzyme, Enzyme and Microbial Technology, 22, 687, 10.1016/S0141-0229(97)00261-5 · DOI
  41. Ryhänen, E.-L., Pihlanto-Leppälä, A. and Pahkala, E. ‘Production of a New Type of Ripened Cheese with Bioactive Properties. in International Dairy Journal, submitted for publication
  42. Saito, 2000, Isolation and Structural Analysis of Antihypertensive Peptides that Exist Naturally in Gouda Cheese, Journal of Dairy Science, 83, 1434, 10.3168/jds.S0022-0302(00)75013-2 · DOI · Paper page
  43. Addeo, 1992, Characterization of the 12% Tricholoroacetic Acid-insoluble Oligopeptides of Parmigiano-Reggiano Cheese, Journal of Dairy Research, 59, 401, 10.1017/S0022029900030673 · DOI
  44. Nakamura, 1995, Purification and Characterization of Angiotensin I-converting Enzyme Inhibitors from Sour Milk, Journal of Dairy Science, 78, 777, 10.3168/jds.S0022-0302(95)76689-9 · DOI · Paper page
  45. Kahala, 1993, Peptides in Fermented Finnish Milk Products, Agricultural Science in Finland, 2, 379
  46. Gobbetti, 2000, Production of Angiotensin-I-converting-enzyme Inhibitory Peptides in Fermented Milks Started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4, Applied and Environmental Microbiology, 66, 3898, 10.1128/AEM.66.9.3898-3904.2000 · DOI · Paper page
  47. Sugai, 1998, ACE Inhibitors and Functional Foods, IDF Bulletin, 336, 17
  48. Petrilli, 1984, Does Casomorphins have a Functional Role?, FEBS Letters, 169, 53, 10.1016/0014-5793(84)80288-4 · DOI
  49. Chang, 1985, Isolation of a Specific μ-opiate Receptor Peptide, Morphiceptin, from an Enzymatic Digest of Milk Proteins, Journal of Biological Chemistry, 260, 9706, 10.1016/S0021-9258(17)39296-7 · DOI
  50. Naito, 1972, In Vivo Formation of Phosphopeptide with Calcium-binding Property in the Small Intestinal Tract of the Rat Fed on Casein, Agricultural and Biological Chemistry, 36, 409, 10.1271/bbb1961.36.409 · DOI
  51. Sato, 1983, The Necessity for the Phosphate Portion of Casein Molecules to Enhance Ca Absorption from the Small Intestine, Agricultural and Biological Chemistry, 47, 2415, 10.1271/bbb1961.47.2415 · DOI
  52. Meisel, 1989, Chemical Characterization of Bioactive Peptides from In-vivo Digestion of Casein, Journal of Dairy Research, 56, 343, 10.1017/S0022029900028788 · DOI
  53. Scanff, 1992, Characterization and Kinetics of Gastric Emptying of Peptides Derived from Milk Proteins in the Preruminant Calf, Journal of Dairy Research, 59, 437, 10.1017/S0022029900027102 · DOI
  54. Tomita, 1994, A Review, Acta Paediatrica Jponica, 36, 585, 10.1111/j.1442-200X.1994.tb03250.x · DOI · Paper page
  55. Kenny, 1982, Topology of Microvillar Membrane Hydrolases of Kidney and Intestine, Physiological Reviews, 62, 91, 10.1152/physrev.1982.62.1.91 · DOI
  56. Yoshioka, 1987, Role of Rat Intestinal Brush Border Membrane Angiotensin Converting Enzyme in Dietary Protein Digestion, American Journal of Physiology, 253, G781
  57. Erickson, 1989, Identification of Proline-specific Carboxypeptidase Localized to Brush Border Membrane of Rat Small Intestine and its Possible Role in Protein Digestion, Digestive Diseases and Sciences, 34, 400, 10.1007/BF01536262 · DOI
  58. Döring, 1998, Minimal Molecular Determinants of Substrates for Recognition by the Intestinal Peptide Transporter, The Journal of Biological Chemistry, 273, 23211, 10.1074/jbc.273.36.23211 · doi:10.1074/jbc.273.36.23211
  59. Kerchner, 1983, Studies on the Transport of Enkephalin-like Oligopeptides in Rat Intestinal Mucosa, Journal of Phamacology and Experimental Therapeutics, 226, 33
  60. Svedberg, 1985, Demonstration of a β-casomorphin Immunoreactive Material in In Vitro Digest of Bovine Milk and in Small Intestine Contents after Bovine Milk Ingestion in Adult Humans, Peptides, 6, 825, 10.1016/0196-9781(85)90308-0 · DOI · Paper page
  61. Tome, 1987, Opiate Activity and Transepithelial Passage of Intact β-casomorphins in Rabbit Ileum, American Journal of Physiology, 253, G737
  62. Mahé, 1989, Absorption of Intact β-casomorphins (β-cm) in Rabbit Ileum In Vitro, Reproduction, Nutrition, Development, 29, 725, 10.1051/rnd:19890611 · doi:10.1051/rnd:19890611
  63. Teschemacher, 1986, No Evidence for the Presence of β-casomorphins in Human Plasma after Ingestion of Cow's Milk or Milk Products, Journal of Dairy Research, 53, 135, 10.1017/S0022029900024730 · DOI
  64. Masuda, 1996, Antihypertensive Peptides are Present in Aorta after Oral Administration of Sour Milk Containing these Peptides to Spontaneously Hypertensive Rats, Journal of Nutrition, 126, 3063, 10.1093/jn/126.12.3063 · DOI · Paper page
  65. Teschemacher, 1997, Milk Protein-derived Opioid Receptor Ligands, Biopolymers, 43, 99, 10.1002/(SICI)1097-0282(1997)43:2<99::AID-BIP3>3.0.CO;2-V · DOI · Paper page
  66. Wüster, 1981, Multiple Opiate Receptors in Peripheral Tissue Preparations, Biochemical Pharmacology, 30, 1883, 10.1016/0006-2952(81)90194-5 · DOI
  67. Brantl, 1981, Opioid Activities of β-casomorphins, Life Sciences, 28, 1903, 10.1016/0024-3205(81)90297-6 · DOI · Paper page
  68. Grecksch, 1981, Evidence for Analgesic Activity of β-casomorphin in Rats, Neurosciece Letters, 27, 325, 10.1016/0304-3940(81)90451-1 · DOI
  69. Widy-Tyskiewicz, 1989, Analgesic activity of Morphiceptin, β-casomorphin-4, and Deltakephalin in Normotensive Wistar-Glaxo and Spontaneously Hypertensive Rats, Peptides, 10, 539, 10.1016/0196-9781(89)90139-3 · doi:10.1016/0196-9781(89)90139-3
  70. Hedner, 1987, beta-Casomorphins Induce Apnea and Irregular Breathing in Adult Rats and Newborn Rabbits, Life Sciences, 41, 2303, 10.1016/0024-3205(87)90543-1 · doi:10.1016/0024-3205(87)90543-1
  71. Taira, 1990, Effect of Beta-casomorphin on Neonatal Sleep in Rats, Peptides, 11, 1, 10.1016/0196-9781(90)90101-A · doi:10.1016/0196-9781(90)90101-a
  72. Blass, 1996, β-casomorphin Causes Hypoalgesia in 10-days old Rats, Pediatric Research, 39, 199, 10.1203/00006450-199602000-00002 · doi:10.1203/00006450-199602000-00002
  73. Daniel, 1991, Effect of casein and β-Casomorphins on Gastrointestinal Motility in Rats, Journal of Nutrition, 120, 252, 10.1093/jn/120.3.252 · DOI · Paper page
  74. Tome, 1988, Neuromediate Action of β-casomorphins on Ion Transport in Rabbit Ileum, Reproduction, Nutrition, Development, 28, 909, 10.1051/rnd:19880604 · doi:10.1051/rnd:19880604
  75. Binder, 1984, Role of Opiate Receptors in Regulation of Enkephalin Stimulation of Active Sodium and Chloride Absorption, American Journal of Physiology, 247, 432
  76. Wyvratt, 1985, Recent Developments in the Design of Angiotensin-converting Enzyme Inhibitors, Medical Research Reviews, 5, 485, 10.1002/med.2610050405 · DOI · Paper page
  77. Karaki, 1990, Antihypertensive Effect of Tryptic Hydrolysate of Milk Casein in Spontaneously Hypertensive Rats, Comparative Biochemistry and Physiology, 96C, 367
  78. Sekiya, 1992, Antihypertensive Effects of Tryptic Hydrolysate of Casein on Normotensive and Hypertensive Volunteers, J. Jpn. Soc. Nutr. Food Sci., 45, 513, 10.4327/jsnfs.45.513 · DOI
  79. Feuerstein, 1987, The Opioid Peptides. A Role in Hypertension, Hypertension, 9, 561, 10.1161/01.HYP.9.6.561 · DOI
  80. Wang, 1994, Cardiovascular Effects of Microinjection of Dynorphin-A(1–8) into the Hippocampus in Conscious, Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats, Clinical and Experimental Hypertension, 16, 229, 10.3109/10641969409067951 · doi:10.3109/10641969409067951
  81. Chu, 1999, Inhibition of Cardiovascular Activity Following Microinjection of Novel Opioid-like Neuropeptide Nociceptin (orphanin FQ) into the Rat Rostral Ventrolateral Medulla, Brain Research, 829, 134, 10.1016/S0006-8993(99)01357-8 · doi:10.1016/s0006-8993(99)01357-8

Cited by

See all 605

Metadata

Authors
Pihlanto-Leppälä, A.
Venue
Trends in Food Science & Technology
Publisher
Elsevier BV
Published
2000-09
Volume
11
Issue
9-10
Pages
347-356
ISSN
0924-2244 (ISSN-L)
OpenAlex
W17038625
Cited by
605
References
2
FWCI
0.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Bioactive peptides derived from bovine whey proteins. https://app.cochat.ai/papers/10.1016/s0924-2244(01)00003-6
The paper
Pihlanto-Leppälä, A. (2000). Bioactive peptides derived from bovine whey proteins. Trends in Food Science & Technology. https://doi.org/10.1016/s0924-2244(01)00003-6

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.