Gut feelings: a randomised, triple-blind, placebo-controlled trial of probiotics for depressive symptoms
Open accessAbstract
BACKGROUND: Depression is the leading cause of disability worldwide; with evidence suggesting that decreased gut barrier function and inflammation are correlated with depressive symptoms. We conducted a clinical trial to determine the effect of consumption of probiotic supplements (Winclove's Ecologic® Barrier) on depressive symptoms in a sample of participants with mild to severe depression. METHOD: 71 participants were randomly allocated to either probiotic or placebo, which was, consumed daily over eight weeks. Pre- and post-intervention measures of symptoms and vulnerability markers of depression as well as gut microbiota composition were compared. Clinical trial participants were also compared on psychological variables and gut microbiota composition to a non-depressed group (n = 20). RESULTS: All clinical trial participants demonstrated improvement in symptoms, suggesting non-specific therapeutic effects associated with weekly monitoring visits. Participants in the probiotic group demonstrated a significantly greater reduction in cognitive reactivity compared with the placebo group, particularly in the mild/moderate subgroup. Probiotics did not significantly alter the microbiota of depressed individuals, however, a significant correlation was found between Ruminococcus gnavus and one depression metric. LIMITATIONS: There was a high attrition rate, which may be attributed to weekly monitoring visits. Additionally, modulation of the gut microbiota may need more specific testing to distinguish subtle changes. CONCLUSIONS: While microbiota composition was similar between all groups, probiotics did affect a psychological variable associated with susceptibility to depression. Further research is needed to investigate how probiotics can be utilised to modify mental wellbeing, and whether they can act as an adjunct to existing treatments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Casertano et al. (2024) and Chahwan et al. (2019) reported reductions in maladaptive cognitive reactivity and rumination without broad mood changes.
“Casertano et al. (2024) and Chahwan et al. (2019) reported reductions in maladaptive cognitive reactivity and rumination without broad mood changes”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Chahwan et al. (2019)
The Secondary outcomes section reports lower cognitive reactivity after probiotics than after placebo, particularly among participants with mild or moderate depression, but not those with severe depression. The Discussion reports no greater reduction in depressive symptoms, anxiety, or stress than with placebo. The paper does not report a reduction in rumination; rumination appears only in a cited reference title. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn that trial, probiotics did not significantly alter microbiota composition in depressed participants, though a correlation was found between Ruminococcus gnavus and one depression metric.
“However, probiotics did not significantly alter the microbiota composition in the depressed participants, though a correlation was found between Ruminococcus gnavus and one depression metric.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Chahwan et al., 2019
Psychobiotics can positively affect psychological variables related to depression susceptibility.
“Despite a high attrition rate and the need for more specific microbiota analysis, the study suggests that psychobiotics can positively affect psychological variables related to depression susceptibility.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Chahwan et al., 2019
In a clinical trial of Ecologic® BARRIER in individuals with mild to severe depression, those in the psychobiotic group experienced a significantly greater reduction in cognitive reactivity, particularly in those with mild to moderate depression.
“While all participants showed some improvement, those in the psychobiotic group experienced a significantly greater reduction in cognitive reactivity, particularly in those with mild to moderate depression.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Chahwan et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,013 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Lovibond, P. F., & Lovibond, S. H. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)00075-u · Cited by 14,523 · see citing works
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447 · see citing works
A new method for non-parametric multivariate analysis of variance
Anderson, M. J. (2001) · Austral Ecology · doi:10.1111/j.1442-9993.2001.01070.pp.x · Cited by 13,828 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · cited 1× · see citing works
“Multiple causes of depression have been identified, including genetic, neurological, inflammatory, personality, cognitive, and environmental factors (Beck and Bredemeier, 2016; Disner et al., 2011; Miller and Raison, 2016; Sullivan et al., 2000; Wohleb et al., 2016).”
BackgroundBravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
dplyr: A Grammar of Data Manipulation
Wickham, H., François, R., Henry, L., Müller, K., & Vaughan, D. (2014) · doi:10.32614/cran.package.dplyr · Cited by 3,457 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Assessing the quality of controlled clinical trials
Jüni, P., Altman, D. G., & Egger, M. (2001) · BMJ · doi:10.1136/bmj.323.7303.42 · Cited by 3,309 · cited 1× · see citing works
“In the current study, weekly visits were implemented due to ethics board requirements for weekly participant safety monitoring, with utilisation of intention-to-treat analysis to diminish attrition bias (Jüni et al., 2001; May et al., 1981; Sackett and Gent, 1979).”
MethodGut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
UniFrac: an effective distance metric for microbial community comparison
Lozupone, C., Lladser, M. E., Knights, D., Stombaugh, J., & Knight, R. (2011) · The ISME Journal · doi:10.1038/ismej.2010.133 · Cited by 2,825 · see citing works
The Epidemiology of Depression Across Cultures
Kessler, R. C., & Bromet, E. J. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114409 · Cited by 2,657 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Grand challenges in global mental health
Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., et al. (2011) · Nature · doi:10.1038/475027a · Cited by 2,043 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Dimidjian, S., Hollon, S. D., Dobson, K. S., Schmaling, K. B., Kohlenberg, R. J., Addis, M. E., Gallop, R., McGlinchey, J. B., Markley, D. K., Gollan, J. K., et al. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.4.658 · Cited by 1,607 · cited 1× · see citing works
“on similar studies using BDI scores as a primary outcome for treatment of depression (Dimidjian et al., 2006; Titov et al., 2011).”
MethodPsychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Behavioral activation treatments of depression: a meta-analysis.
Cuijpers, P., van Straten, A., & Warmerdam, L. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.11.001 · Cited by 1,144 · see citing works
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut · doi:10.1136/gut.2010.223263 · Cited by 1,063 · see citing works
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
Gut microbes and the brain: paradigm shift in neuroscience
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3299-14.2014 · Cited by 1,033 · see citing works
Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Probiotics and the gut microbiota in intestinal health and disease
Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907 · see citing works
Treatment-resistant depression: therapeutic trends, challenges, and future directions
Al-harbi (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s29716 · Cited by 796 · cited 1× · see citing works
“Research indicates that these treatments are effective in reducing depressive symptoms, with approximately 60–70% of patients responding to treatment (Al-Harbi, 2012).”
BackgroundAkkasheh, G., Kashani-Poor, Z., Tajabadi-Ebrahimi, M., Jafari, P., Akbari, H., Taghizadeh, M., Memarzadeh, M. R., Asemi, Z., & Esmaillzadeh, A. (2016) · Nutrition · doi:10.1016/j.nut.2015.09.003 · Cited by 767 · cited 1× · see citing works
“Akkasheh and colleagues identified that consumption of probiotics containing Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium bifidum over an eight-week period led to a significant reduction in depressive symptoms (Akkasheh et al., 2016).”
BackgroundCytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · cited 5× · see citing works
“which is a vulnerability marker of depression (Kruijt et al., 2013; Steenbergen et al., 2015; Van der Does, 2005).”
BackgroundResultInfluentialIntegrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Alterations in intestinal permeability
Arrieta, M., Bistritz, L., & Meddings, J. B. (2006) · Gut · doi:10.1136/gut.2005.085373 · Cited by 634 · see citing works
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622 · see citing works
Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-6 · Cited by 577 · see citing works
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · see citing works
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554 · see citing works
Beck, A. T., & Bredemeier, K. (2016) · Clinical Psychological Science · doi:10.1177/2167702616628523 · Cited by 510 · see citing works
The effects of probiotics on depressive symptoms in humans: a systematic review
Wallace, C. J. K., & Milev, R. (2017) · Annals of General Psychiatry · doi:10.1186/s12991-017-0138-2 · Cited by 471 · see citing works
Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446 · see citing works
Treatment resistant depression: methodological overview and operational criteria
Souery, D., Amsterdam, J. D., de Montigny, C., Lecrubier, Y., Montgomery, S., Lipp, O., Racagni, G., Zohar, J., & Mendlewicz, J. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00004-2 · Cited by 443 · see citing works
Microbes and mental health: A review
Rieder, R., Wisniewski, P. J., Alderman, B. L., & Campbell, S. C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.016 · Cited by 429 · see citing works
Immune–neural connections: how the immune system’s response to infectious agents influences behavior
McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works
Controversy in Counting and Attributing Events in Clinical Trials
Sackett, D. L., & Gent, M. (1979) · New England Journal of Medicine · doi:10.1056/nejm197912273012602 · Cited by 413 · see citing works
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 362 · see citing works
From depressive symptoms to depressive disorders: the relevance of thresholds
Ayuso‐Mateos, J. L., Nuevo, R., Verdes, E., Naidoo, N., & Chatterji, S. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.071191 · Cited by 348 · see citing works
Major Depressive Disorder Treatment Guidelines in America and Europe
Davidson, J. R. T. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.9058se1c.04gry · Cited by 344 · see citing works
LYTE, M., LI, W., OPITZ, N., GAYKEMA, R., & GOEHLER, L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.06.019 · Cited by 334 · see citing works
De Palma, G., Nadal, I., Medina, M., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-63 · Cited by 330 · see citing works
Scanlan, P. D., Shanahan, F., O'Mahony, C., & Marchesi, J. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00312-06 · Cited by 330 · see citing works
Romijn, A. R., Rucklidge, J. J., Kuijer, R. G., & Frampton, C. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416686694 · Cited by 323 · see citing works
Lin, P., Ding, B., Feng, C., Yin, S., Zhang, T., Qi, X., Lv, H., Guo, X., Dong, K., Zhu, Y., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.051 · Cited by 311 · see citing works
Transdiagnostic internet treatment for anxiety and depression: a randomised controlled trial
Titov, N., Dear, B. F., Schwencke, G., Andrews, G., Johnston, L., Craske, M. G., & McEvoy, P. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.03.007 · Cited by 285 · cited 1× · see citing works
“on similar studies using BDI scores as a primary outcome for treatment of depression (Dimidjian et al., 2006; Titov et al., 2011).”
MethodBehavioural activation for depression
Veale, D. (2008) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.107.004051 · Cited by 282 · see citing works
Major depressive disorder: probiotics may be an adjuvant therapy.
Logan, A., & Katzman, M. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.019 · Cited by 277 · see citing works
Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications
Rao, R. K., & Samak, G. (2013) · Current Nutrition & Food Science · doi:10.2174/1573401311309020004 · Cited by 266 · see citing works
Antimicrobial activity of psychotropic drugs
Munoz-Bellido, J. L., Munoz-Criado, S., & Garcı̀a-Rodrı̀guez, J. A. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00154-5 · Cited by 249 · see citing works
Ki Cha, B., Mun Jung, S., Hwan Choi, C., Song, I.-D., Woong Lee, H., Joon Kim, H., Hyuk, J., Kyung Chang, S., Kim, K., Chung, W.-S., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823712b1 · Cited by 216 · see citing works
Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease
Lyte, M., & Cryan, J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4 · Cited by 212 · see citing works
Cizza, G., Marques, A. H., Eskandari, F., Christie, I. C., Torvik, S., Silverman, M. N., Phillips, T. M., & Sternberg, E. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.035 · Cited by 208 · see citing works
Probiotic treatment reduces depressive-like behaviour in rats independently of diet
Abildgaard, A., Elfving, B., Hokland, M., Wegener, G., & Lund, S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.014 · Cited by 196 · see citing works
Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172 · see citing works
Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption
Eloe-Fadrosh, E. A., Brady, A., Crabtree, J., Drabek, E. F., Ma, B., Mahurkar, A., Ravel, J., Haverkamp, M., Fiorino, A.-M., Botelho, C., et al. (2015) · mBio · doi:10.1128/mbio.00231-15 · Cited by 160 · see citing works
Beaud, D., Tailliez, P., & Anba-Mondoloni, J. (2005) · Microbiology · doi:10.1099/mic.0.27712-0 · Cited by 160 · see citing works
IL-10 modulates depressive-like behavior.
Mesquita, A., Correia-Neves, M., Roque, S., Castro, A. G., Vieira, P., Pedrosa, J., Palha, J., & Sousa, N. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.02.004 · Cited by 153 · see citing works
The randomized clinical trial: bias in analysis.
May, G. S., DeMets, D. L., Friedman, L. M., Furberg, C. D., & Passamani, E. R. (1981) · Circulation · doi:10.1161/01.cir.64.4.669 · Cited by 152 · see citing works
Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance
Ayaz, M., Subhan, F., Ahmed, J., Khan, A.-U., Ullah, F., Ullah, I., Ali, G., Syed, N.-I.-H., & Hussain, S. (2015) · Journal of Biological Research-Thessaloniki · doi:10.1186/s40709-015-0028-1 · Cited by 147 · see citing works
Psychobiotics and the gut–brain axis: in the pursuit of happiness
Foster, J. A., & Zhou, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s61997 · Cited by 137 · see citing works
Goehler, L. E., Lyte, M., & Gaykema, R. P. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.02.005 · Cited by 127 · see citing works
Stress matters: randomized controlled trial on the effect of probiotics on neurocognition
Papalini, S., Michels, F., Kohn, N., Wegman, J., van Hemert, S., Roelofs, K., Arias-Vasquez, A., & Aarts, E. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100141 · Cited by 123 · see citing works
Saxelin, M., Pessi, T., & Salminen, S. (1995) · International Journal of Food Microbiology · doi:10.1016/0168-1605(94)00091-j · Cited by 123 · see citing works
Pedicord, V. A., Lockhart, A. A. K., Rangan, K. J., Craig, J. W., Loschko, J., Rogoz, A., Hang, H. C., & Mucida, D. (2016) · Science Immunology · doi:10.1126/sciimmunol.aai7732 · Cited by 97 · see citing works
Thought suppression and cognitive vulnerability to depression
van der Does, W. A. J. (2005) · British Journal of Clinical Psychology · doi:10.1348/014466504x19442 · Cited by 81 · see citing works
Cognitive reactivity: Investigation of a potentially treatable marker of suicide risk in depression
Antypa, N., van der Does, W. A. J., & Penninx, B. W. J. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.013 · Cited by 78 · see citing works
An Investigation of the Relationship Between Cognitive Reactivity and Rumination
Moulds, M. L., Kandris, E., Williams, A. D., Lang, T., Yap, C. S. L., & Hoffmeister, K. (2007) · Behavior Therapy · doi:10.1016/j.beth.2007.05.001 · Cited by 69 · see citing works
The immunostimulating and antimicrobial properties of lithium and antidepressants
Lieb, J. (2004) · Journal of Infection · doi:10.1016/j.jinf.2004.03.006 · Cited by 59 · see citing works
Kruijt, A.-W., Antypa, N., Booij, L., de Jong, P. J., Glashouwer, K., Penninx, B. W. J. H., & Van der Does, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070245 · Cited by 49 · see citing works
Abildgaard, A. M., Elfving, B., Hokland, M., Lund, S. A., & Wegener, G. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.017 · Cited by 45 · see citing works
Less Is More in Antidepressant Clinical Trials
Rutherford, B. R., Cooper, T. M., Persaud, A., Brown, P. J., Sneed, J. R., & Roose, S. P. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r08267 · Cited by 40 · see citing works
The antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues.
Kristiansen, J. E. (1990) · PubMed · Cited by 39 · see citing works
Prescription drugs obscure microbiome analyses
Devkota, S. (2016) · Science · doi:10.1126/science.aaf1353 · Cited by 36 · see citing works
Examination of antimicrobial activity of selected non-antibiotic medicinal preparations.
Kruszewska, H., Zaręba, T., & Tyski, S. S. (2013) · PubMed · Cited by 36 · see citing works
(2009) · PubMed · Cited by 27 · see citing works
van Hemert, S., & Ormel, G. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.518187 · Cited by 20 · see citing works
Figueroa, C. A., Mocking, R. J. T., Mahmoud, G. A., Koeter, M. W. J., Bockting, C., van der Does, W. A. J., Ruhé, H. G., & Schene, A. H. (2018) · British Journal of Clinical Psychology · doi:10.1111/bjc.12175 · Cited by 15 · see citing works
Flagged first, then by citations
2 of the 106 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The gut microbiota in anxiety and depression—A systematic review
Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912 · see citing works
Engineered living biomaterials
Rodrigo-Navarro, A., Sankaran, S., Dalby, M., del Campo, A., & Salmerón-Sánchez, M. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00350-8 · Cited by 419 · see citing works
Probiotics and the microbiota-gut-brain axis: Focus on psychiatry
Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00313-5 · Cited by 337 · see citing works
<i>Ruminococcus gnavus</i> : friend or foe for human health
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad014 · Cited by 335 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Schaub, A.-C., Schneider, E., Vázquez-Castellanos, J. F., Schweinfurth, N., Kettelhack, C., Doll, J. P. K., Yamanbaeva, G., Mählmann, L., Brand, S., Beglinger, C., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01977-z · Cited by 273 · see citing works
The microbiota-immune axis as a central mediator of gut-brain communication
Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 228 · see citing works
Sources, formulations, advanced delivery and health benefits of probiotics
Roobab, U., Batool, Z., Manzoor, M. F., Shabbir, M. A., Khan, M. R., & Aadil, R. M. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2020.01.003 · Cited by 216 · see citing works
Alli, S. R., Gorbovskaya, I., Liu, J. C. W., Kolla, N. J., Brown, L., & Müller, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094494 · Cited by 202 · see citing works
The gut microbiota and mental health in adults
Järbrink‐Sehgal, E., & Andréasson, A. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.01.016 · Cited by 176 · see citing works
Snigdha, S., Ha, K., Tsai, P., Dinan, T. G., Bartos, J. D., & Shahid, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107978 · Cited by 171 · see citing works
Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works
The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 153 · see citing works
Barrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143 · see citing works
Gao, M., Wang, J., Liu, P., Tu, H., Zhang, R., Zhang, Y., Sun, N., & Zhang, K. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02670-5 · Cited by 149 · see citing works
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127 · see citing works
Wallace, C. J. K., & Milev, R. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.618279 · Cited by 120 · see citing works
Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders
Verma, A., Inslicht, S. S., & Bhargava, A. (2024) · Cells · doi:10.3390/cells13171436 · Cited by 133 · see citing works
Knuesel, T., & Mohajeri, M. (2021) · Nutrients · doi:10.3390/nu14010037 · Cited by 109 · see citing works
Nikolova, V., Cleare, A., Young, A., & Stone, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040647 · Cited by 106 · see citing works
Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis
Zhang, Q., Chen, B., Zhang, J., Dong, J., Ma, J., Zhang, Y., Jin, K., & Lü, J. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04963-x · Cited by 114 · see citing works
Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation
Kvaková, M., Bertková, I., Štofilová, J., & Savidge, T. (2021) · Foods · doi:10.3390/foods10061297 · Cited by 100 · see citing works
Kim, C.-S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.10.008 · Cited by 104 · see citing works
Knudsen, J. K., Michaelsen, T. Y., Bundgaard‐Nielsen, C., Nielsen, R. E., Hjerrild, S., Leutscher, P. D. C., Wegener, G., & Sørensen, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-01248-9 · Cited by 95 · see citing works
Ng, Q. X., Lim, Y. L., Yaow, C. Y. L., Ng, W., Thumboo, J., & Liew, T. M. (2023) · Nutrients · doi:10.3390/nu15061351 · Cited by 93 · see citing works
Liśkiewicz, P., Kaczmarczyk, M., Misiak, B., Wroński, M., Bąba-Kubiś, A., Skonieczna‐Żydecka, K., Marlicz, W. M., Bieńkowski, P., Misera, A., Pełka-Wysiecka, J., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110076 · Cited by 90 · see citing works
Tang, W., Meng, Z., Li, N., Liu, Y., Li, L., Chen, D., & Yang, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.611014 · Cited by 89 · see citing works
Merkouris, E., Mavroudi, T., Miliotas, D., Tsiptsios, D., Serdari, A., Christidi, F., Doskas, T. K., Mueller, C., & Tsamakis, K. (2024) · Microorganisms · doi:10.3390/microorganisms12020411 · Cited by 88 · see citing works
The Development of High-Quality Multispecies Probiotic Formulations: From Bench to Market
Grumet, L., Tromp, Y., & Stiegelbauer, V. (2020) · Nutrients · doi:10.3390/nu12082453 · Cited by 90 · see citing works
The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches
Varesi, A., Campagnoli, L. I. M., Chirumbolo, S., Candiano, B., Carrara, A., Ricevuti, G., Esposito, C., & Pascale, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106799 · Cited by 85 · see citing works
Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
Naveed, M., Zhou, Q.-G., Chu, X., Taleb, A., Meng, F. J., Ahmed, B., Zhang, Y., Fukunaga, K., & Han, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110051 · Cited by 81 · see citing works
Gut microbiome in serious mental illnesses: A systematic review and critical evaluation
Nguyen, T. T., Hathaway, H., Kościółek, T., Knight, R. D., & Jeste, D. V. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.08.026 · Cited by 78 · see citing works
El Dib, R., Periyasamy, A. G., de Barros, J. L., França, C. G., Senefonte, F. L., Vesentini, G., Alves, M. G. O., Rodrigues, J. V. D. S., Gomaa, H., Gomes Júnior, J. R., et al. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.027 · Cited by 75 · see citing works
Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75 · see citing works
Zuffa, S., Schimmel, P., Gonzalez-Santana, A., Belzer, C., Knol, J., Bölte, S., Falck‐Ytter, T., Forssberg, H., Swann, J. R., & Heijtz, R. D. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02556-6 · Cited by 73 · see citing works
Probiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 78 · see citing works
Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review
Smith, K. S., Greene, M. W., Babu, J. R., & Frugé, A. D. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1701220 · Cited by 71 · see citing works
Mathee, K., Cickovski, T., Deoraj, A., Stollstorff, M., & Narasimhan, G. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001112 · Cited by 68 · see citing works
New hope for Parkinson’s disease treatment: Targeting gut microbiota
Fan, H., Sheng, S., & Zhang, F. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13916 · Cited by 66 · see citing works
Role of Probiotics and Diet in the Management of Neurological Diseases and Mood States: A Review
Thangaleela, S., Sivamaruthi, B. S., Kesika, P., & Chaiyasut, C. (2022) · Microorganisms · doi:10.3390/microorganisms10112268 · Cited by 73 · see citing works
Probiotics for the treatment of depression and its comorbidities: A systemic review
Gao, J., Zhao, N., Cheng, Y., Lei, W., Wang, Y., Liu, X., Zheng, N., Shao, L., Chen, X., Sun, Y., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1167116 · Cited by 75 · see citing works
Feng, L., Zhou, N., Li, Z., Fu, D., Guo, Y., Gao, X., & Liu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202101088rrr · Cited by 67 · see citing works
Asad, A., Kirk, M., Zhu, S., Dong, X. Z., & Gao, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae177 · Cited by 70 · see citing works
Dong, Z., Shen, X., Hao, Y., Li, J., Li, H., Xu, H., Li, Y., & Kuang, W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.651536 · Cited by 66 · see citing works
The Role of Probiotics and Their Metabolites in the Treatment of Depression
Jach, M. E., Serefko, A., Szopa, A., Sajnaga, E., Golczyk, H., Santos, L. S., Borowicz, K. K., & Sieniawska, E. (2023) · Molecules · doi:10.3390/molecules28073213 · Cited by 70 · see citing works
Li, S., Yang, D., Zhou, C., Chen, L., Liu, L., Lin, R., Li, X., Liu, Y., Qiu, H., Cao, H., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14497 · Cited by 71 · see citing works
Ferrari, S., Mulè, S., Parini, F., Galla, R., Ruga, S., Rosso, G., Brovero, A., Molinari, C. G., & Uberti, F. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.03.011 · Cited by 68 · see citing works
Browne, P. D., Bolte, A. C., der Vaart, I. B.-V., Claassen, E., & de Weerth, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-81204-9 · Cited by 65 · see citing works
Microbiota-targeted interventions for mental health
Berding, K., & Cryan, J. F. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000758 · Cited by 68 · see citing works
Kovtun, A. S., Averina, O. V., Angelova, I. Y., Yunes, R. А., Zorkina, Y., Morozova, A. Y., Pavlichenko, A. V., Syunyakov, T., Karpenko, O., Kostyuk, G. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092162 · Cited by 67 · see citing works
Mosquera, F. E. C., Martinez, S. L., & Liscano, Y. (2024) · Nutrients · doi:10.3390/nu16091352 · Cited by 62 · see citing works
Major Depressive Disorder and gut microbiota – Association not causation. A scoping review
Łoniewski, I., Misera, A., Skonieczna‐Żydecka, K., Kaczmarczyk, M., Kaźmierczak-Siedlecka, K., Misiak, B., Marlicz, W. M., & Samochowiec, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110111 · Cited by 63 · see citing works
Baião, R., Capitão, L. P., Higgins, C., Browning, M., Harmer, C. J., & Burnet, P. W. J. (2022) · Psychological Medicine · doi:10.1017/s003329172100550x · Cited by 66 · see citing works
Xia, J., Gu, L., Guo, Y., Feng, H., Chen, S., Jurat, J., Fu, W., & Zhang, D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.627608 · Cited by 59 · see citing works
Ross, K. (2023) · EXPLORE · doi:10.1016/j.explore.2023.02.007 · Cited by 59 · see citing works
Gut microbiome predicts cognitive function and depressive symptoms in late life
Kolobaric, A., Andreescu, C., Jašarević, E., Hong, C. H., Roh, H., Cheong, J. Y., Kim, Y., Shin, T. S., Kang, C. S., Kwon, C. O., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02551-3 · Cited by 62 · see citing works
Bioque, M., González-Rodríguez, A., García‐Rizo, C., Cobo, J., Monreal, J. A., Usall, J., Soria, V., & Labad, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110130 · Cited by 58 · see citing works
de Oliveira, F. L., Salgaço, M. K., de Oliveira, M. T., Mesa, V., Sartoratto, A., da Silva, A. M. P., Ramos, W. S., & Sivieri, K. (2023) · Nutrients · doi:10.3390/nu15061521 · Cited by 57 · see citing works
Strain-specific effects of probiotics on depression and anxiety: a meta-analysis
Rahmannia, M., Poudineh, M., Mirzaei, R., Aalipour, M. A., Bonjar, A. H. S., Goudarzi, M., Kheradmand, A., Aslani, H. R., Sadeghian, M., Nasiri, M. J., et al. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00634-8 · Cited by 66 · see citing works
Hofmeister, M., Clement, F. M., Patten, S. B., Li, J., Dowsett, L. E., Farkas, B., Mastikhina, L., Egunsola, O., Diaz, R., Cooke, N. C. A., et al. (2021) · CMAJ Open · doi:10.9778/cmajo.20200283 · Cited by 56 · see citing works
Patterson, E., Griffin, S. M., Ibarra, A., Ellsiepen, E., & Hellhammer, D. H. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100277 · Cited by 53 · see citing works
Alam, Z., Shang, X., Effat, K., Kanwal, F., He, X., Li, Y., Xu, C., Niu, W., War, A. R., & Zhang, Y. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14302 · Cited by 53 · see citing works
Gut feelings: the relations between depression, anxiety, psychotropic drugs and the gut microbiome
Brushett, S., Gaćeša, R., Vila, A. V., Gois, M. F. B., Andreu‐Sánchez, S., Swarte, J. C., Klaassen, M. A. Y., Collij, V., Sinha, T., Bolte, L. A., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2281360 · Cited by 54 · see citing works
Sun, Y., Cheng, L., Zeng, X., Zhang, X., Liu, Y., Wu, Z., & Weng, P. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.164 · Cited by 50 · see citing works
Coletto, E., Latousakis, D., Pontifex, M. G., Crost, E. H., Vaux, L., Santamarina, E. P., Goldson, A. J., Brion, A., Hajihosseini, M. K., Vauzour, D., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2073784 · Cited by 49 · see citing works
Wilmes, L., Collins, J. M., O’Riordan, K. J., O’Mahony, S. M., Cryan, J. F., & Clarke, G. A. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14095 · Cited by 49 · see citing works
Ağagündüz, D., Çelik, E., Cemali, Ö., Bingöl, F. G., Özenir, Ç., Özoğul, F., & Capasso, R. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10092-4 · Cited by 47 · see citing works
Skowron, K., Budzyńska, A., Wiktorczyk-Kapischke, N., Chomacka, K., Grudlewska‐Buda, K., Wilk, M., Wałecka-Zacharska, E., Andrzejewska, M., & Gospodarek-Komkowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147820 · Cited by 47 · see citing works
Vasiliu, O. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1074736 · Cited by 42 · see citing works
Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109489 · Cited by 42 · see citing works
Rewiring the Brain Through the Gut: Insights into Microbiota–Nervous System Interactions
Săvulescu-Fiedler, I., Benea, S. N., Căruntu, C., Nancoff, A.-S., Homentcovschi, C., & Bucurica, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070489 · Cited by 45 · see citing works
Ullah, H., Khan, A., Rengasamy, K. R. R., Minno, A. D., Sacchi, R., & Daglia, M. (2022) · Nutrients · doi:10.3390/nu14132751 · Cited by 44 · see citing works
Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation
Methiwala, H. N., Vaidya, B., Addanki, V. K., Bishnoi, M., Sharma, S. S., & Kondepudi, K. K. (2021) · Food & Function · doi:10.1039/d0fo02855j · Cited by 38 · see citing works
Kaczmarczyk, M., Szulińska, M., Łoniewski, I., Kręgielska-Narożna, M., Skonieczna‐Żydecka, K., Kościółek, T., Bezshapkin, V., & Bogdański, P. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.815798 · Cited by 40 · see citing works
Zandifar, A., Badrfam, R., Mohammaditabar, M., Kargar, B., Goodarzi, S., Hajialigol, A., Ketabforoush, S., Heidari, A., Fathi, H., Shafiee, A., et al. (2025) · Brain and Behavior · doi:10.1002/brb3.70401 · Cited by 46 · see citing works
Lee, D.-S., Kim, M., Nam, S., Kang, M., & Lee, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031143 · Cited by 37 · see citing works
The Effect of a Probiotic Complex on the Gut-Brain Axis: A Translational Study
Nobile, V., Giardina, S., & Puoci, F. (2021) · Neuropsychobiology · doi:10.1159/000518385 · Cited by 40 · see citing works
Stress, inflammation, microbiome and depression
Medina-Rodriguez, E. M., Cruz, A. A., Abreu, J. C. D., & Beurel, E. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173561 · Cited by 37 · see citing works
Misera, A., Liśkiewicz, P., Łoniewski, I., Skonieczna-Żydecka, K., & Samochowiec, J. (2021) · Pharmaceuticals · doi:10.3390/ph14100952 · Cited by 34 · see citing works
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health
Bhatia, N. Y., Jalgaonkar, M. P., Hargude, A. B., Sherje, A. P., Oza, M. J., & Doshi, G. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220822172039 · Cited by 37 · see citing works
Association of dietary live microbe intake with frailty in US adults: evidence from NHANES
Huo, X., Jia, S., Sun, L., Yao, Y., Liao, H., & Chen, X. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100171 · Cited by 33 · see citing works
Balta, I., Butucel, E., Mohylyuk, V., Criste, A. D., Dezmirean, D. S., Ştef, L., Peț, I., & Corcionivoschi, N. (2021) · Diseases · doi:10.3390/diseases9030060 · Cited by 35 · see citing works
The Many Ages of Microbiome–Gut–Brain Axis
Ratto, D., Roda, E., Romeo, M., Venuti, M. T., Desiderio, A., Lupo, G., Capelli, E., Sandionigi, A., & Rossi, P. (2022) · Nutrients · doi:10.3390/nu14142937 · Cited by 31 · see citing works
Sempach, L., Doll, J. P. K., Limbach, V., Marzetta, F., Schaub, A.-C., Schneider, E., Kettelhack, C., Mählmann, L., Schweinfurth, N., Ibberson, M. R., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03030-7 · Cited by 33 · see citing works
Mirashrafi, S., Taghanaki, S. Z. H., Sarlak, F., Moravejolahkami, A. R., Kermani, M. A. H., & Haratian, M. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14724 · Cited by 31 · see citing works
Dao, H. V., Hoang, L. B., Trinh, T. O., Tran, T. T. T., & Dao, L. V. (2021) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s312316 · Cited by 30 · see citing works
A psychobiotic approach to the treatment of depression: A systematic review and meta-analysis
Zhu, H., Tian, P., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104999 · Cited by 30 · see citing works
Gut Biome and Mental Health: Do Probiotics Work?
Madabushi, J. S., Khurana, P., Gupta, N., & Gupta, M. (2023) · Cureus · doi:10.7759/cureus.40293 · Cited by 31 · see citing works
Moshfeghinia, R., Nemati, H., Ebrahimi, A., Shekouh, D., Karami, S., Eraghi, M. M., Mohagheghzadeh, H., Hunter, J., & Pasalar, M. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.05.053 · Cited by 32 · see citing works
Rupp, S. K., & Stengel, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.844564 · Cited by 28 · see citing works
Karczewski, J., Zielińska, A., Staszewski, R., Eder, P., Dobrowolska, A., & Souto, E. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116145 · Cited by 27 · see citing works
Li, Y., Yu, Z., Li, A., & Ren, Z. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i28.3555 · Cited by 27 · see citing works
Lai, Y. R., Yu, H., Deng, H., Fang, Q., Lei, H., Liu, L., Wu, N., Guo, X., & Song, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.911140 · Cited by 27 · see citing works
The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions
Martínez‐Guardado, I., Arboleya, S., Pérez, F. J. G., Kaliszewska, A., Gueimonde, M., & Arias, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073610 · Cited by 26 · see citing works
Nutraceuticals in Psychiatric Disorders: A Systematic Review
Bozzatello, P., Novelli, R., Montemagni, C., Rocca, P., & Bellino, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094824 · Cited by 28 · see citing works
PRO-DEMET Randomized Controlled Trial on Probiotics in Depression—Pilot Study Results
Gawlik-Kotelnicka, O., Margulska, A., Skowrońska, A., & Strzelecki, D. (2023) · Nutrients · doi:10.3390/nu15061400 · Cited by 25 · see citing works
Dalziel, J. E., Zobel, G., Dewhurst, H., Hurst, C., Olson, T., Rodriguez-Sanchez, R., Mace, L. J., Parkar, N., Thum, C., Hannaford, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310433 · Cited by 25 · see citing works
Márquez-Morales, L., El-Kassis, E. G., Cavazos‐Arroyo, J., Rocha–Rocha, V. M., Martínez‐Gutiérrez, F., & Pérez‐Armendáriz, B. (2021) · Nutrients · doi:10.3390/nu13051551 · Cited by 26 · see citing works
Psychobiotics as a novel strategy for alleviating anxiety and depression
Zou, R., Tian, P., Xu, M., Zhu, H., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104718 · Cited by 23 · see citing works
Komorniak, N., Kaczmarczyk, M., Łoniewski, I., Kley, A. M., Nalian, A. G., Wroński, M., Kaseja, K., Kowalewski, B., Folwarski, M., & Stachowska, E. (2023) · Nutrients · doi:10.3390/nu15234905 · Cited by 22 · see citing works
- Authors
- Chahwan, B., Kwan, S., Isik, A., van Hemert, S., Burke, C., & Roberts, L.
- Affiliations
- University of Technology Sydney (AU)
- Corresponding author
- Burke, Catherine
- Roberts, Lynette
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 253
- Pages
- 317-326
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2944223773
- Cited by
- 256
- References
- 106
- Citations by year
- 2026: 18 · 2025: 41 · 2024: 43 · 2023: 49 · 2022: 39 · 2021: 43 · 2020: 18 · 2019: 4 · 2017: 1
- FWCI
- 20.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- probiotics, depressive symptoms, depression, gut microbiota, Ruminococcus gnavus, cognitive reactivity, intestinal barrier, inflammation, gut-brain axis
- MeSH terms
- Gastrointestinal Microbiome, Adult, Depression, Female, Humans, Male, Placebos, Research Design, Dietary Supplements, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
