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Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse–glia affair

Göritz, Christian, Mauch, Daniela H, Nägler, Karl, Pfrieger, Frank W·2002·Journal of Physiology-Paris
DOI 10.1016/s0928-4257(02)00014-1
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Abstract

Brain development and function relies on the exchange of signals between neurons and glial cells. Here we review a series of recent studies on cultures of purified retinal ganglion cells (RGCs) that point to a new role of glial cells in the formation and plasticity of synaptic connections. The results suggest that neurons must import glia-derived cholesterol via lipoproteins to form numerous and efficient synaptic connections. This finding may explain why throughout the central nervous system (CNS) the main phase of synaptogenesis starts synchronously after glia differentiation and why astrocytes produce apolipoprotein E (apoE) and cholesterol-containing lipoproteins. Experimental tests of these hypotheses may further our understanding of the cholesterol metabolism in the brain and may help to explain neurologic symptoms resulting from defective cholesterol and lipoprotein metabolism.

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Research works printed but not linked: 38

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Metadata

Authors
Göritz, C., Mauch, D. H., Nägler, K., & Pfrieger, F. W.
Venue
Journal of Physiology-Paris
Publisher
Elsevier BV
Published
2002-05
Volume
96
Issue
3-4
Pages
257-263
ISSN
0928-4257
DOI
10.1016/s0928-4257(02)00014-1
Cited by
88
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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