Cited by 319Phytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

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Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Youdim, Kuresh A., McDonald, Jane, Kalt, Wilhemina, Joseph, James A.·2002·The Journal of Nutritional Biochemistry

DOI 10.1016/s0955-2863(01)00221-2

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Abstract

Although antioxidant systems help control the level of reactive oxygen species they may be overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress components as well as inflammatory mediators may be involved in the pathogenesis of vascular disorders, where localized markers of oxidative damage have been found. In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Polyphenols from both berries were able to localize into endothelial cells subsequently reducing endothelial cells vulnerability to increased oxidative stress at both the membrane and cytosol level. Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. In conclusion, polyphenols isolated from both blueberry and cranberry were able to afford protection to endothelial cells against stressor induced up-regulation of oxidative and inflammatory insults. This may have beneficial actions against the initiation and development of vascular diseases and be a contributing factor in the reduction of age-related deficits in neurological impairments previously reported by us.

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“따라서 ROS를 제거할 수 있는 항산화제의 섭취는 산화적 스트레스 를 감소시켜 만성적인 염증반응을 억제할 수 있는 것으로 보고되고 있으며(1,7), 플라보노이드와 폴리페놀은 LPS로 자극한 대식세포가 생성한 ROS를 제거할 뿐만 아니라 ROS 의 발생 또한 조절하여 산화적 스트레스를 효과적으로 억제 할 수 있음이 보고되었다(8-10).”
Oxidative Stress and the Lung in Diabetes
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Does strawberry supplementation ameliorate markers of cardiovascular and metabolic health? A systematic review and meta-analysis
Mousavi, R., Arab‐Zozani, M., Foroumandi, E., Karandish, M., Maghsoumi‐Norouzabad, L., Mansoori, A., & Moludi, J. (2021) · Nutrition & Food Science · doi:10.1108/nfs-10-2021-0295 · Cited by 2
Dietary Antioxidants in Mitigating Oxidative Stress in Cardiovascular Diseases
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Raspberries and Human Health: A Clinical Perspective on the Bioavailability and Bioactivity of Red Raspberry Antioxidants
Snyder, D. M. (2010) · Cited by 2
Qualitative analysis of phytochemicals and anti-bacterial screening using ZnS/Mn nanoparticles encapsulated with ethanolic extract of Nyctanthes arbor-tristis Linn.
Soubhagya, K. B., & Anilkumar, M. (2020) · Materials Today Proceedings · doi:10.1016/j.matpr.2020.03.146 · Cited by 1
Pomegranate (Punica Granatum L): Beneficial Impacts, Health Benefits and Uses in Poultry Nutrition
Attia, Y. A., Taha, A. E.-S., El-Hack, M. E. A., Abdo, M., Abo‐Ahmed, A. I., Emam, M. A., El‐Naggar, K., Abdel-Latif, M. A., Abdelsalam, N. R., & Alagawany, M. M. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815049015122010009 · Cited by 1
Rapid recovery of homozygous Pr gene introgression lines in Indian tropical cauliflower backgrounds through combined use of morphological and molecular markers
Singh, S., Kumar, S., & Verma, V. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1609917 · Cited by 1
Fungal Solid-State and Submerged Fermentation of Blueberry Bagasse: Extraction Strategies, Phenolic Profiling, and Cellular Immunomodulation
Hurtado‐Romero, A., Luzardo-Ocampo, I., Antunes‐Ricardo, M., López‐Pacheco, F., García-Amezquita, L. E., Carrillo-Nieves, D., & García‐Cayuela, T. (2026) · Fermentation · doi:10.3390/fermentation12030128 · Cited by 1
“In addition, TNF-α is released early after LPS stimulation, whereas iNOS expression and NO accumulation peak after 12–24 h, so asynchronous kinetics can produce divergent patterns between NO and cytokine readouts [52,53].”
Feed supplements to maintain performance and health
McKeever, K. H. (2011) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-740-0_11 · Cited by 1
EFFECT OF COMPOSITE EDIBLE COATINGS AND ABIOTIC STRESS ON POST HARVEST QUALITY OF FRUITS
Narayanapurapu, P. T. R., Narayanapurapu, & de Bellevue, S. A. (2012) · Cited by 1
Vaccinium macrocarpon Ait. and urinary tract infections
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Bioactive Nutraceuticals for Amyotrophic Lateral Sclerosis
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Wild Blueberries (Vaccinium angustifolium): Modulators of Vascular Function, Structure, and Metabolism
Klimis‐Zacas, D. J., & Kristo, A. S. (2012) · ACS symposium series · doi:10.1021/bk-2012-1093.ch009 · Cited by 1
Characterization and stability study of cranberry flavonoids in lipid liquid crystalline systems
Linkevičiūtė, A., Būdienė, J., Naujalis, E., Katelnikovas, A., & Barauskas, J. (2016) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201600373 · Cited by 1
Effect of Purple Sweet Potato Extract (Ipomoea batatas L) on Zebrafish (Danio rerio) By Diet Induced Obesity
Nur, A., Riskawati, Y. K., Widodo, E., Ratnawati, R., Firdausy, A., Dewi, L. K., & Karina, M. (2019) · Research Journal of Life Science · doi:10.21776/ub.rjls.2019.006.02.2 · Cited by 1
“Anthocyanin itself has several biological activities, for example as antioxidants (Kähkönen & Heinonen, 2003), anti-inflammatory (Wang & Mazza, 2002; Youdim et al., 2002), antiatherosclerosis (Fuhrman et al., 2005; Xia et al., 2005), anti-diabetic (Grace et al., 2009; Nizamutdinova et al., 2009;…”
Background
Vaccinium macrocarpon (Cranberry)
Torkos, S., Dorren, R., & Murray, M. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00121-7 · Cited by 1
The E ffec t of Whole Wild Blueberries on Endothelial Function of the Sprague-Dawley Rat as Related to Cardiovascular Disease
Norton, C. A. (2003) · DigitalCommons (California Polytechnic State University) · Cited by 1
Modulation of autophagy enhances the apoptotic cell death in human T lymphoma cells treated with Anthocyanin
El‐Sokkary, G. H., Sayed, D. M., Fuad, S., & Shakor, A. B. A. (2013) · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology · doi:10.21608/eajbsc.2013.16098 · Cited by 1
“…studies have shown that anthocyanins display a wide range of biological activities (Mazza, 2000; Kong et al., 2003) including antioxidant (Wang et al., 1997; Tsuda et al., 1998; Fukumoto and Mazza, 2000; Mazza et al., 2002), and anti inflammatory (Wang and Mazza, 2002; Youdim et al., 2002).”
Background
The protective effect of ascorbate and catechin against myocardial ischemia-reperfusion injury in an isolated rat heart model
Hadeed, A. A. (2014) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Potential influence of blueberry and black raspberry pomace phenolics on inflammatory cytokines in coronary cells
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Inhibitory effects of berry anthocyanins on palmitic acid- or lipopolysaccharide- induced inflammation in human preadipocytes
Gao, C. (2011) · Louisiana State University · doi:10.31390/gradschool_theses.1569 · Cited by 1
“Anthocyanin and hydroxycinnamic acids from blueberry and cranberry protected endothelial cells against TNF-α induced inflammatory responses (Youdim et al., 2002).”
BackgroundInfluential
The model system C. elegans demonstrates the health benefits of legumes and the potential benefits of legume consumption
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Characterisation of phenolic antioxidants in fruits and vegetables : bioavailability of raspberry phenolics in humans and rats
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Licciardello, C. (2008) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/1958
“They may reduce the risk of coronary heart disease (Renaud and de Lorgeril, 1992), the inflammatory insult (Youdim et al., 2002), they may modulate the immune response (Wang and Mazza, 2002) and exert anti-carcinogenic activities in vitro (Fimognari et al.”
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The Effect of Wild Blueberry Consumption on the Inflammatory Response, Oxidative Stress and DNA Damage Associated with Exercise
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Effects of Hibiscus Sabdariffa Extracts on 2, 4-Dinitrophenylhydrazine-induced Cytotoxicity in Rabbits
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Activités antidiabétiques et neuroprotectrices du jus de bleuet biostransformé
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Extração, micronização e estabilização de pigmentos funcionais = construção de uma unidade multipropósito para desenvolvimento de processos com fluídos pressurizados
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Anti-Leukopenic and Antioxidant Effects of Cranberry Extract in Benzene and Fluorouracil induced Leukopenia in Rats
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Anthocyanins and heart health
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Authors: Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A.
Affiliations: Tufts University (US)
Agriculture and Agri-Food Canada (CA)
Corresponding author: Youdim, Kuresh A.
ORCID: Youdim, Kuresh A.
Joseph, James A.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2002-05
Volume: 13
Issue: 5
Pages: 282-288
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/s0955-2863(01)00221-2
OpenAlex: W1868361743
Cited by: 319
References: 40
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 31 · 2012: 20
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Cranberry Institute
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: dietary flavonoids, blueberry polyphenols, cranberry polyphenols, anthocyanins, hydroxycinnamic acids, microvascular endothelial cells, oxidative stress, TNF-α, inflammation, antioxidant activity, interleukin-8, MCP-1, ICAM-1, vascular disease

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