The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.
Abstract
Although antioxidant systems help control the level of reactive oxygen species they may be overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress components as well as inflammatory mediators may be involved in the pathogenesis of vascular disorders, where localized markers of oxidative damage have been found. In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Polyphenols from both berries were able to localize into endothelial cells subsequently reducing endothelial cells vulnerability to increased oxidative stress at both the membrane and cytosol level. Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. In conclusion, polyphenols isolated from both blueberry and cranberry were able to afford protection to endothelial cells against stressor induced up-regulation of oxidative and inflammatory insults. This may have beneficial actions against the initiation and development of vascular diseases and be a contributing factor in the reduction of age-related deficits in neurological impairments previously reported by us.
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“Anthocyanins from berries commonly consumed in the United States, such as blueberries and cranberries, have been reported to reduce TNF-α induced upregulation of inflammatory mediators in human microvascular endothelial cells.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [63]
In the citing paper
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [63]
Citations
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Tavares, F. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Vaccinium macrocarpon (American Cranberry)
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“Anthocyanins help in the recruitment of leukocytes to sites of damage or inflammation along the endothelium (Youdim et al. 2002).”
Metadata
- Authors
- Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A.
- Affiliations
- Tufts University (US)
- Agriculture and Agri-Food Canada (CA)
- Corresponding author
- Youdim, Kuresh A.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 13
- Issue
- 5
- Pages
- 282-288
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W1868361743
- Cited by
- 319
- References
- 40
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 31 · 2012: 20
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Cranberry Institute
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- dietary flavonoids, blueberry polyphenols, cranberry polyphenols, anthocyanins, hydroxycinnamic acids, microvascular endothelial cells, oxidative stress, TNF-α, inflammation, antioxidant activity, interleukin-8, MCP-1, ICAM-1, vascular disease
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