Cited by 319Phytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Youdim, Kuresh A., McDonald, Jane, Kalt, Wilhemina, Joseph, James A.·2002·The Journal of Nutritional Biochemistry

DOI 10.1016/s0955-2863(01)00221-2

Open this paper in CoChat — free account

Abstract

Although antioxidant systems help control the level of reactive oxygen species they may be overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress components as well as inflammatory mediators may be involved in the pathogenesis of vascular disorders, where localized markers of oxidative damage have been found. In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Polyphenols from both berries were able to localize into endothelial cells subsequently reducing endothelial cells vulnerability to increased oxidative stress at both the membrane and cytosol level. Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. In conclusion, polyphenols isolated from both blueberry and cranberry were able to afford protection to endothelial cells against stressor induced up-regulation of oxidative and inflammatory insults. This may have beneficial actions against the initiation and development of vascular diseases and be a contributing factor in the reduction of age-related deficits in neurological impairments previously reported by us.

Integrity signals

Registry

Crossref · 10.1016/s0955-2863(01)00221-2

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287
Effect of Plant Flavonoids on Immune and Inflammatory Cell Function
Middleton, E. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5335-9_13 · Cited by 735
Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase
Cho, H. P., Nakamura, M., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.471 · Cited by 639
Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries
Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y.-C., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999) · Journal of Natural Products · doi:10.1021/np990184z · Cited by 633
Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease
Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S. E., & Folts, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.10.1050 · Cited by 579
Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries
Wang, H., Nair, M. G., Strasburg, G. M., Chang, Y.-C., Booren, A. M., Gray, J. I., & DeWitt, D. L. (1999) · Journal of Natural Products · doi:10.1021/np980501m · Cited by 501

Show all 40 references

Research works printed but not linked: 1

Gerritsen, 1995, Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression, Am. J Pathol., 147, 278

Sorted by citations

Items 101–200 of 319

Concentrations of polyphenols from blueberry pomace extract using nanofiltration
Avram, A. M., Morin, P., Brownmiller, C., Howard, L. R., Sengupta, A., & Wickramasinghe, S. R. (2017) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2017.07.006 · Cited by 78
In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as anti‐obesity agents with α‐amylase and pancreatic lipase inhibitory activities
Marrelli, M., Loizzo, M. R., Nicoletti, M., Menichini, F., & Conforti, F. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6544 · Cited by 76
Some commonly fed herbs and other functional foods in equine nutrition: A review
Williams, C. A., & Lamprecht, E. D. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.06.004 · Cited by 74
“Cranberry (Vaccinium macrocarpon) polyphenols have been shown to protect endothelial cells against stressinduced up-regulation of oxidative and inflammatory mediators (Youdim et al., 2002).”
Background
Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins
Tran, P. H. L., & Tran, T. T. D. (2021) · Biomolecules · doi:10.3390/biom11010102 · Cited by 73
“1 mg/mL ACNs were protected from TNFαinduced damage [35].”
BackgroundInfluential
Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome
Simão, T. N. C., Lozovoy, M. A. B., Simão, A. N. C., Oliveira, S. R., Venturini, D., Morimoto, H. K., Miglioranza, L. H. D. S., & Dichi, I. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001207 · Cited by 83
“In addition, cranberry flavonoids reduce the vulnerability of endothelial cells to increased oxidative stress((58)).”
Background
Arsenic and Heavy Metal (Cadmium, Lead, Mercury and Nickel) Contamination in Plant-Based Foods
Hussain, S., Rengel, Z., Qaswar, M., Amir, M., & Zafar-ul-Hye, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-03344-6_20 · Cited by 76
Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis
Yi, W., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2006) · Food Research International · doi:10.1016/j.foodres.2006.01.001 · Cited by 71
Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers
Ntemiri, A., Ghosh, T. S., Gheller, M. E., Tran, T. T. T., Blum, J., Pellanda, P., Vlčková, K., Neto, M. C., Howell, A. B., Thalacker‐Mercer, A. E., et al. (2020) · Nutrients · doi:10.3390/nu12092800 · Cited by 74
Absorption and metabolism of red orange juice anthocyanins in rats
Felgines, C., Talavéra, S., Texier, O., Besson, C., Fogliano, V., Lamaison, J., Fauci, L. L., Galvano, G., Rémésy, C., & Galvano, F. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061728 · Cited by 69
“They may reduce the risk of coronary heart disease (Renaud & de Lorgeril, 1992), reduce inﬂammatory insult (Youdim et al. 2002), modulate the immune response (Wang & Mazza, 2002) and exert anticarcinogenic activities in vitro (Fimognari et al. 2004).”
Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats
Felgines, C., Texier, O., Besson, C., Lyan, B., Lamaison, J., & Scalbert, A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764772 · Cited by 70
Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model
Pereira, S. R., Pereira, R. D. C. A., Figueiredo, I. V., de Freitas, V. A. P., Dinis, T. C. P., & Almeida, L. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174116 · Cited by 69
The Effects of Blueberry Phytochemicals on Cell Models of Inflammation and Oxidative Stress
Lavefve, L., Howard, L. R., Adams, S. H., & Baum, J. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab137 · Cited by 71
Prevention and treatment effects of edible berries for three deadly diseases: Cardiovascular disease, cancer and diabetes
Yang, H., Tian, T., Wu, D., Dejun, G., & Lu, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1432562 · Cited by 65
“So blueberry, cranberry and sea buckthorn berries have a protective effect on endothelial cells (Youdim et al. 2002).”
Background
The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits
Rafieian‐Kopaei, M., Asgary, S., Adelnia, A., Setorki, M., Khazaei, M., Kazemi, S., & Shamsi, F. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9001202 · Cited by 64
Anthocyanins Inhibit Lipogenesis During Adipocyte Differentiation of 3T3-L1 Preadipocytes
Lee, B., Lee, M., Lefevre, M., & Kim, H. (2014) · Plant Foods for Human Nutrition · doi:10.1007/s11130-014-0407-z · Cited by 64
“A wide range of biological activities has been reported in animal studies of anthocyanins, including antioxidant [13], anti-inflammatory [14, 15], antiatherosclerosis [16, 17], and anti-hyperglycemic activities in mice [18] and streptozotocin-induced diabetic rats [19].”
Background
Fruits and leaves from wild blueberry plants contain diverse polyphenols and decrease neuroinflammatory responses in microglia
Debnath-Canning, M., Unruh, S., Vyas, P., Daneshtalab, N., Igamberdiev, A. U., & Weber, J. T. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103906 · Cited by 69
Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats
Shukitt‐Hale, B., Kalt, W., Carey, A. N., Vinqvist, M. R., McDonald, J. E., & Joseph, J. A. (2008) · Nutrition · doi:10.1016/j.nut.2008.10.018 · Cited by 63
Vascular Reactivity Is Affected by Dietary Consumption of Wild Blueberries in the Sprague-Dawley Rat
Kalea, A. Z., Clark, K., Schuschke, D. A., & Klimis‐Zacas, D. J. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0078 · Cited by 63
Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C
McAnulty, S. R., McAnulty, L. S., Nieman, D. C., Dumke, C. L., Morrow, J. D., Utter, A. C., Henson, D. A., Proulx, W. R., & George, G. L. (2004) · Nutrition Research · doi:10.1016/j.nutres.2003.10.003 · Cited by 63
A comprehensive review on medicinal plants possessing antioxidant potential
Zafar, F., Asif, H. M., Shaheen, G., Ghauri, A. O., Rajpoot, S. R., Tasleem, M. W., Shamim, T., Hadi, F., Noor, R., Ali, T., et al. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13743 · Cited by 62
“macrocarpon inhibits low density lipoproteins oxidation,(43,44) oxidative damage to neurons during ischaemia(45) and inflammatory damage to vascular endothelium.(46)”
Background
Comparison of the activities of hydrophilic anthocyanins and lipophilic tocols in black rice bran against lipid oxidation
Zhang, X., Shen, Y., Prinyawiwatkul, W., King, J. M., & Xu, Z. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.034 · Cited by 60
Confidence Intervals for Modeling Anthocyanin Retention in Grape Pomace during Nonisothermal Heating
Mishra, D. K., Dolan, K. D., & Yang, L. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00598.x · Cited by 60
Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea
Paik, S.-S., Jeong, E., Jung, S. W., Ha, T. J., Kang, S., Sim, S., Jeon, J. H., Chun, M., & Kim, I. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.02.010 · Cited by 58
Mechanisms of endothelial cell protection by hydroxycinnamic acids
Eduardo Fuentes, Q., & Palomo, I. F. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.10.006 · Cited by 58
Bioavailability of a bilberry anthocyanin extract and its impact on plasma antioxidant capacity in rats
Talavéra, S., Felgines, C., Texier, O., Besson, C., Mazur, A., Lamaison, J., & Rémésy, C. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2327 · Cited by 58
Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review
Drețcanu, G., Ştirbu, I., Leoplold, N., Cruceriu, D., Danciu, C., Stănilă, A., Fărcaș, A. C., Borda, I. M., Iuhas, C. I., & Diaconeasa, Z. M. (2022) · Plants · doi:10.3390/plants11091117 · Cited by 54
“A good example is cranberry extract, which is found to inhibit low-density lipoproteins (LDL) oxidation [79], carcinogenesis [80] and oxidative damage of the vascular endothelium [81], with potential in cancer prevention and therapy.”
Background
Identification and Characterization of Anthocyanins in Yard-Long Beans (Vigna unguiculata ssp. sesquipedalis L.) by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization/Mass Spectrometry (HPLC−DAD−ESI/MS) Analysis
Ha, T. J., Lee, M.-H., Park, C., Pae, S.-B., Shim, K.-B., Ko, J., Shin, S., Baek, I.-Y., & Park, K.-Y. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903883e · Cited by 53
Les flavonoïdes: structure, propriétés biologiques, rôle prophylactique et emplois en thérapeutique
Ghedira, K. (2005) · Phytothérapie · doi:10.1007/s10298-005-0096-8 · Cited by 50
“Cette activité intervient dans le maintien d’une perméabilité vasculaire normale [71, 93].”
Background
Analysis of phenolic compounds in wild populations of bilberry (Vaccinium myrtillus L.) from Montenegro
Jovanevi, M., Balijagi, J., Menkovi, N., Scaron, K., avikin, Zduni, G., Jankovi, T., & Deki-Ivankovi, M. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000080 · Cited by 53
“Flavonoids, including flavones, isoflavones, flavonones, anthocyanins, catechins, show various biological properties such as antibacterial, antioxidant, anti-inflammatory, anticarcenogenic activity (Shahidi and Naczk, 2004; Youdim et al., 2002; RiceEvans et al., 1997).”
Background
Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment
Bo’, C. D., Roursgaard, M., Porrini, M., Loft, S. H., Möller, P., & Riso, P. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600178 · Cited by 53
DNA stability and lipid peroxidation in vitamin E–deficient rats in vivo and colon cells in vitro
Duthie, S. J., Gardner, P., Morrice, P. C., Wood, S. G., Pirie, L. P., Bestwick, C., Milne, L., & Duthie, G. G. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0511-1 · Cited by 53
Biosynthesis and Characterization of 14C-Enriched Flavonoid Fractions from Plant Cell Suspension Cultures
Yousef, G. G., Seigler, D. S., Grusak, M. A., Rogers, R. B., Knight, C. T. G., Kraft, T. F. B., Erdman, J. W., & Lila, M. A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035371o · Cited by 51
Phytochemical screening, anthocyanins and antimicrobial activities in some berries fruits
Aly, A. A., Ali, H. G. M., & Eliwa, N. E. (2018) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-018-0005-0 · Cited by 50
A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice
Villegas, I., Alarcón‐de‐la‐Lastra, C., Orjales, A., & Casa, C. L. (2003) · International Immunopharmacology · doi:10.1016/j.intimp.2003.07.002 · Cited by 48
Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial
Mathison, B. D., Kimble, L. L., Kaspar, K. L., Khoo, C., & Chew, B. P. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.03.006 · Cited by 48
“mediators in human microvascular endothelial cells [25].”
Influence of Delphinidin-3-glucoside on Oxidized Low-Density Lipoprotein-Induced Oxidative Stress and Apoptosis in Cultured Endothelial Cells
Xie, X., Zhao, R., & Shen, G. X. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204461z · Cited by 47
LC-ESI/QTOF-MS Profiling of Chicory and Lucerne Polyphenols and Their Antioxidant Activities
Iqbal, Y., Ponnampalam, E. N., Suleria, H. A. R., Cottrell, J. J., & Dunshea, F. R. (2021) · Antioxidants · doi:10.3390/antiox10060932 · Cited by 47
Chemopreventive Potential of Wild Lowbush Blueberry Fruits in Multiple Stages of Carcinogenesis
Kraft, T. F. B., Schmidt, B. M., Yousef, G. G., Knight, C. T. G., Cuendet, M., Kang, Y., Pezzuto, J. M., Seigler, D. S., & Lila, M. A. (2005) · Journal of Food Science · doi:10.1111/j.1365-2621.2005.tb07151.x · Cited by 47
Protective effect of polyphenol-containing azuki bean (Vigna angularis) seed coats on the renal cortex in streptozotocin-induced diabetic rats
Sato, S., Yamate, J., Hori, Y., Hatai, A., Nozawa, M., & Sagai, M. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.02.003 · Cited by 47
“This hypothesis is also supported by reports that flavonoids found in berries and red wine inhibit MCP-1 expression in vitro and in vivo [31,32].”
Result
Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression
Murata, M., Nonaka, H., Komatsu, S., Goto, M., Morozumi, M., Yamada, S., Lin, I.-C., Yamashita, S., & Tachibana, H. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03661 · Cited by 47
Rapid screening for anthocyanins and anthocyanin dimers in crude grape extracts by high performance liquid chromatography coupled with diode array detection and tandem mass spectrometry
Pati, S., Liberatore, M. T., Gambacorta, G., Antonacci, D., & Notte, E. L. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.02.068 · Cited by 45
Anti-inflammatory and antinociceptive properties of blueberry extract(Vaccinium corymbosum)
Torri, E., Lemos, M., Caliari, V., Kassuya, C. A. L., Bastos, J. K., & de Andrade, S. F. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.4.0015 · Cited by 45
“These compounds are involved in a wide range of biological activity (Kong et al 2003), including antioxidant (Mazza et al 2002), anti-inflammatory (Youdim et al 2002) and anticarcinogenic (Katsube et al 2003).”
Background
Effects of Blueberry (Vaccinium ashei) on DNA Damage, Lipid Peroxidation, and Phase II Enzyme Activities in Rats
Dulebohn, R. V., Yi, W., Srivastava, A., Akoh, C. C., Krewer, G. W., & Fischer, J. G. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802405y · Cited by 44
Jabuticaba as a source of functional pigments.
dos Santos, D. T., & Meireles, M. A. A. (2009) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · Cited by 43
In-vitro antioxidant and in-vivo anti-inflammatory activities of aerial parts of Cassia species
Mehta, J. P., Parmar, P. H., Vadia, S. H., Patel, M. K., & Tripathi, C. B. (2013) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2013.06.010 · Cited by 43
CH 6 Dietary Flavonoids and Health — Broadening the Perspective
Andersen, O. M., & Markham, K. R. (2005) · CRC Press eBooks · doi:10.1201/9781420039443-10 · Cited by 43
Variation and correlation analysis of phenolic compounds in mungbean (Vigna radiata L.) varieties
Kim, J. K., Kim, E., Lee, O.-K., Park, S.-Y., Lee, B., Kim, S., Park, I., & Chung, I. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.05.060 · Cited by 42
Endoplasmic reticulum stress in diabetic mouse or glycated LDL-treated endothelial cells: protective effect of Saskatoon berry powder and cyanidin glycans
Zhao, R., Xie, X., Le, K., Li, W., Moghadasian, M. H., Trust Beta, & Shen, G. X. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.015 · Cited by 40
Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta
Kalea, A. Z., Lamari, F. N., Theocharis, A. D., Cordopatis, P. A., Schuschke, D. A., Karamanos, N. K., & Klimis‐Zacas, D. J. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.015 · Cited by 43
“have been reported to decrease the vulnerability of the vessels to oxidative stress and inflammatory insults [6–8].”
Dietary Flavonoids and Health — Broadening the Perspective
Clifford, M. N., & Brown, J. E. (2005) · CRC Press eBooks · doi:10.1201/9781420039443.ch6 · Cited by 40
Four-week ingestion of blood orange juice results in measurable anthocyanin urinary levels but does not affect cellular markers related to cardiovascular risk: a randomized cross-over study in healthy volunteers
Giordano, L., Coletta, W., Tamburrelli, C., D’Imperio, M., Crescente, M., Silvestri, C., Rapisarda, P., Recupero, G. R., Curtis, A. D., Iacoviello, L., et al. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0237-9 · Cited by 38
“They inhibit release of reactive oxygen species from activated human granulocytes [4], suppress free-radical-mediated lipid peroxidation and cell death in cultured aortic endothelial cells [5, 6] and reduce P-selectin expression in resting platelets [7].”
Background
Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3
Iwashima, T., Kudome, Y., Kishimoto, Y., Saita, E., Tanaka, M., Taguchi, C., Hirakawa, S., Mitani, N., Kondo, K. N., & Iida, K. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.3361 · Cited by 38
ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction
Kowalska, K., Dembczyński, R., Gołąbek-Grenda, A., Olkowicz, M., & Olejnik, A. M. (2021) · Nutrients · doi:10.3390/nu13030885 · Cited by 39
“ACNs and hydroxycinnamic acids present in blueberry and cranberry fruits reduced TNFα-induced upregulation of various inflammatory mediators (IL-8, MCP-1, and ICAM-1) in HUVECs [54].”
Background
Anthocyanins in cowpea [Vigna unguiculata (L.) Walp. ssp. unguiculata]
Ha, T. J., Lee, M.-H., Jeong, Y. N., Lee, J. H., Han, S., Park, C., Pae, S.-B., Hwang, C.-D., Baek, I.-Y., & Park, K.-Y. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0115-x · Cited by 37
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro
Deiana, M., Dessì, M., Ke, B., Liang, Y., Higa, T., Gilmour, P. S., Jen, L., Rahman, I., & Aruoma, O. I. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02061-2 · Cited by 37
Phytochemical profile and pro-healthy properties of berries
Ain, H. B. U., Tufail, T., Javed, M., Tufail, T., Arshad, M. U., Hussain, M., Khan, S. G., Bashir, S., Jbawi, E. M. A., & Saewan, S. A. (2022) · International Journal of Food Properties · doi:10.1080/10942912.2022.2096062 · Cited by 43
“obesity and consumption of an energy-rich diet.([148]) As a result of its increasing prevalence, various therapeutic approaches have been applied to treat this disease, unless no particular treatment yet been discovered.”
Background
Purple Rice Berry Is Neuroprotective and Enhances Cognition in a Rat Model of Alzheimer's Disease
Pannangrong, W., Wattanathorn, J., Muchimapura, S., Tiamkao, S., & Tong-un, T. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1312 · Cited by 35
Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons
McGuire, S. O., Sortwell, C. E., Shukitt‐Hale, B., Joseph, J. A., Hejna, M. J., & Collier, T. J. (2006) · Nutritional Neuroscience · doi:10.1080/10284150601086134 · Cited by 34
“Additionally, flavonoids may alter recruitment of circulating immune cells to sites of injury (Nijveldt et al. 2001; Youdim et al. 2002), inhibit inflammatory activation of microglia (Lee et al.”
Background
The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry
Zhao, F., Wang, J., Wang, W., Lyu, L., Wu, W., & Li, W. (2023) · Molecules · doi:10.3390/molecules28062850 · Cited by 33
“…range of pharmacological effects, including anticancer effects [5], antioxidant effects [6,7], antiviral effects [8], anti-inflammatory effects [9,10], hypoglycemic effects [11,12], improvement of dyslipidemia [13], anti-obesity effects [14,15] and the prevention and treatment of age-related…”
Advanced Natural Food Colorant Encapsulation Methods: Anthocyanin Plant Pigment
Muhamad, I., Jusoh, Y., Nawi, N. M., Aziz, A. A., Padzil, A. M., & Lian, H. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811518-3.00015-6 · Cited by 21
Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model
Serra, D., Henriques, J. F., Sousa, F. J., Laranjo, M., Resende, R., Ferreira‐Marques, M., de Freitas, V. A. P., Silva, G., Peça, J., Dinis, T. C. P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169259 · Cited by 34
Immunostimulatory effects of oriental plum (Prunus salicina Lindl.)
Lee, S. H., Lillehoj, H. S., Cho, S., Chun, H., Park, H., Lim, C. I., & Lillehoj, E. P. (2008) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2007.12.001 · Cited by 33
“Finally, polyphenols isolated from blueberry and cranberries were found to protect endothelial cells against oxidative (H2O2) and inflammatory (TNF-a) insults [7].”
Background
Impact of Cyanidin-3-Glucoside on Glycated LDL-Induced NADPH Oxidase Activation, Mitochondrial Dysfunction and Cell Viability in Cultured Vascular Endothelial Cells
Xie, X., Zhao, R., & Shen, G. X. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131215867 · Cited by 33
“Previous studies demonstrated that anthocyanidins reduced susceptibility of vascular EC to ROS and tumor necrosis factor (TNF)-α [13].”
Use of a custom array to study differentially expressed genes during blood orange (Citrus sinensis L. Osbeck) ripening
Bernardi, J., Licciardello, C., Russo, M. P., Chiusano, M. L., Carletti, G., Recupero, G. R., & Marocco, A. (2009) · Journal of Plant Physiology · doi:10.1016/j.jplph.2009.09.009 · Cited by 33
Cardiovascular disease protective properties of blueberry polyphenols (Vaccinium corymbosum): a concise review
Onuh, J. O., Dawkins, N. L., & Aluko, R. E. (2023) · Food Production Processing and Nutrition · doi:10.1186/s43014-023-00139-y · Cited by 37
“2018), as well as reduction of oxidative and inflammatory damage to the endothelium by suppressing the release of inflammatory mediators (Curtis et al. 2022; Del Bo et al. 2022; Youdim et al. 2002).”
Background
Suppressive Effect of Punica granatum on the Production of Tumor Necrosis Factor (Tnf) in BV2 Microglial Cells
Jung, K. H., Kim, M., Ha, E., Uhm, Y. K., Kim, H. K., Chung, J., & Yim, S. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1258 · Cited by 31
The complex interplay between ferroptosis and atherosclerosis
Zhang, M., Li, J., & Hu, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117183 · Cited by 32
Anthocyanins and their metabolites are weak inhibitors of cytochrome P450 3A4
Dreiseitel, A., Schreier, P. H., Oehme, A., Locher, S., Hajak, G., & Sand, P. G. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800043 · Cited by 29
Effects of ginger and cranberry extracts on the physiological response to exercise and markers of inflammation in horses
Liburt, N. R., McKeever, K. H., STRELTSOVA, J., Franke, W. C., Gordon, M. E., Filho, H. C. M., Horohov, D. W., Rosen, R. T., Ho, C., Singh, A. P., et al. (2009) · Comparative Exercise Physiology · doi:10.1017/s175525401000005x · Cited by 29
Inhibitory effect of polyphenol cyanidin on TNF-α-induced apoptosis through multiple signaling pathways in endothelial cells
Xu, J., Ikeda, K., & Yamori, Y. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.09.006 · Cited by 28
“Recent studies have pointed out hat anthocyanins extracted from grape seeds, blueberries and ranberries down-regulated the H2O2- and TNF- induced xpression of VCAM-1 and IL-8, MCP-1, ICAM-1 in human ndothelial cells [7,8].”
Background
Crosstalk between phytochemicals and inflammatory signaling pathways
Prasad, S., Kumar, V., Singh, C., & Singh, A. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01206-z · Cited by 29
“2003), anthocyanins (Youdim et al. 2002), and emodin (Park et al.”
Background
Changes in anthocyanin and isoflavone concentrations in black seed-coated soybean at different planting locations
Ha, T. J., Lee, J. H., Shin, S., Shin, S.-H., Han, S., Kim, H.-T., Ko, J., Lee, M.-H., & Park, K.-Y. (2009) · Journal of Crop Science and Biotechnology · doi:10.1007/s12892-009-0093-9 · Cited by 27
“1991), inhibition of platelet aggregation (Morazzoni and Magistretti 1990), or endothelial protection (Youdim et al. 2002).”
BackgroundInfluential
Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats
Villegas, I., Casa, C. L., Orjales, A., & Alarcón‐de‐la‐Lastra, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02949-7 · Cited by 27
Influence of glucose on cyanidin 3‐glucoside absorption in rats
Felgines, C., Texier, O., Besson, C., Vitaglione, P., Lamaison, J., Fogliano, V., Scalbert, A., Vanella, L., & Galvano, F. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700377 · Cited by 26
“They may reduce the risk of coronary heart disease, exert anticarcinogenic and neuroprotective activities, reduce inflammatory insult and modulate the immune response [7–9].”
Background
Bioactive components and the effect of hydroalcoholic extract of Vaccinium myrtillus on postprandial atherosclerosis risk factors in rabbits
Madihi, Y., Mesripour, A., Karimi, A., Ansari, R., Shahinfard, N., Ghobadi, S., Baradaran, A., Setorki, M., Merrikhi, A., & Rafieian‐Kopaei, M. (2013) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.291(suppl).3539 · Cited by 26
An Examination of Anthocyanins' and Anthocyanidins' Affinity for Cannabinoid Receptors
Korte, G., Dreiseitel, A., Schreier, P. H., Oehme, A., Locher, S., Hajak, G., & Sand, P. G. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0243 · Cited by 26
Blueberry anthocyanins ameliorate cyclophosphamide-induced liver damage in rats by reducing inflammation and apoptosis
Shi, L., Liu, Y.-E., Tan, D., Yan, T., Song, D., Hou, M., & Meng, X. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.008 · Cited by 25
Cocoa flavanols and cardiovascular health
Keen, C. L., Holt, R. R., Polagruto, J. A., Wang, J. F., & Schmitz, H. H. (2002) · Phytochemistry Reviews · doi:10.1023/a:1022519719938 · Cited by 24
“…as flavonoids, to contribute to oxidant defense, and in doing so protect against cardiovascular disease (Lampe, 1999; Tribble, 1999; Pietta, 2000; Joshipura et al., 2001; Rice-Evans, 2001; Ross and Kasum, 2002; Bordoni et al., 2002; Chow et al., 2002; Stevens et al., 2002; Youdim et al., 2002).”
Background
Blueberry intervention improves metabolic syndrome risk factors: systematic review and meta-analysis
Carvalho, M. F., Lucca, A. B. A., Silva, V. R. R. E., de Macedo, L. R., & Silva, M. (2021) · Nutrition Research · doi:10.1016/j.nutres.2021.04.006 · Cited by 25
Anti-inflammatory Activities of Cranberry Fruit Extracts in Human THP-1 Monocytes are Influenced by Their Phytochemical Composition
Xue, L., Liu, C., Ma, H., Seeram, N. P., & Neto, C. C. (2022) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.1c00324 · Cited by 23
The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat
Bo’, C. D., Kristo, A. S., Kalea, A. Z., Ciappellano, S., Riso, P., Porrini, M., & Klimis‐Zacas, D. J. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.05.004 · Cited by 23
EVALUATION OF MEANS TO INCREASE THE CONTENT OF BIOACTIVE PHENOLIC COMPOUNDS IN SOFT FRUITS
Anttonen, M., & Karjalainen, R. (2009) · Acta Horticulturae · doi:10.17660/actahortic.2009.839.39 · Cited by 23
The impact of cranberry (Vaccinium macrocarpon) and cranberry products on each component of the metabolic syndrome: a review
Thimoteo, N. S. B., Scavuzzi, B. M., Simão, A. N. C., & Dichi, I. (2017) · Nutrire · doi:10.1186/s41110-017-0048-8 · Cited by 22
“In an in vitro study, anthocyanins were shown to be effective biomarkers of heart diseases and cancer, inhibiting the release of ROS from active human granulocytes [107] and suppressing free radical-mediated lipid peroxidation and apoptosis in cultured aortic endothelial cells [108, 109].”
Background
Quantitative determination of Amaryllidaceae alkaloids fromGalanthus reginae-olgaesubsp.vernalisandin vitroactivities relevant for neurodegenerative diseases
Conforti, F., Loizzo, M. R., Marrelli, M., Menichini, F., Statti, G. A., Uzunov, D., & Menichini, F. (2009) · Pharmaceutical Biology · doi:10.3109/13880200903029308 · Cited by 22
“Recent studies have focused on health functions of phenolics, including flavonoids from plants (You-dim et al., 2002; Qian et al., 2004).”
Background
Phenolic‐enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems
McCarthy, A. L., O’Callaghan, Y. C., Connolly, A., Piggott, C. O., Fitzgerald, R. J., & O’Brien, N. M. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6421 · Cited by 21
Identification and Comprehensive Genome-Wide Analysis of Glutathione S-Transferase Gene Family in Sweet Cherry (Prunus avium) and Their Expression Profiling Reveals a Likely Role in Anthocyanin Accumulation
Sabir, I. A., Manzoor, M. A., Shah, I. H., Liu, X., Jiu, S., Wang, J., Alam, P., Abdullah, M., & Zhang, C. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.938800 · Cited by 20
Cranberries ( Oxycoccus quadripetalus ) inhibit pro-inflammatory cytokine and chemokine expression in 3T3-L1 adipocytes
Kowalska, K., & Olejnik, A. M. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.069 · Cited by 20
Beneficial Effects of Blueberries in Experimental Autoimmune Encephalomyelitis
Xin, J., Feinstein, D. L., Hejna, M. J., Lorens, S. A., & McGuire, S. O. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203611t · Cited by 20
Botanics: a potential source of new therapies for Alzheimer's disease?
Devi, P., & Syad, A. N. (2014) · Botanics Targets and Therapy · doi:10.2147/btat.s33554 · Cited by 24
“104 108 It has been verified that brain endothelial cells play a crucial role as structural and functional components of the BBB. Abnormal increases in the BBB disruption are associated with neuroinflammation and, in turn, trigger the expression of matrix metalloproteinase expression.”
Cherry Juice Targets Antioxidant Potential and Pain Relief
Kuehl, K. S. (2012) · Medicine and sport science/Medicine and sport · doi:10.1159/000341965 · Cited by 19
Oxidative stress and antioxidant status in intensely exercising horses administered nutraceutical extracts
Smarsh, D. N., Liburt, N. R., STRELTSOVA, J., McKeever, K. H., & Williams, C. A. (2010) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2010.00182.x · Cited by 19
Aloe arborescens and American cranberry (Vaccinium macrocarpon) extracts inhibit tumor-induced cutaneous angiogenesis in mice
Skopiński, P., Zdanowski, R., Bałan, B. J., Siwicki, A. K., Kocik, J., Lewicki, S., Suska, M., Pastewka, K., Skopińska-Różewska, E., & Demkow, U. A. (2013) · Central European Journal of Immunology · doi:10.5114/ceji.2013.39765 · Cited by 18
“It has been demonstrated that cranberries inhibit oxidative and inflammatory damage to the vascular endothelium, oxidative processes including oxidation of low-density lipoproteins, and oxidative damage to rat neurons during simulated ischemia [13-18].”
Background
Phytochemical Composition, Antioxidant and Antimicrobial Activity of the Balkan Endemic Micromeria frivaldszkyana (Degen) Velen. (Lamiaceae)
Mladenova, T. R., Stoyanov, P. S., Denev, P. N., Dimitrova, S. Z., Katsarova, M. N., Teneva, D. G., Todorov, K. T., & Bivolarska, A. V. (2021) · Plants · doi:10.3390/plants10040710 · Cited by 19
“Polyphenols reduce inflammatory mediators, leukocyte migration and stabilize endothelial cells, thus being involved in the pathogenesis of vascular disorders [9].”
Background
Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro
Đorđević, N. O., Pejin, B., Novaković, M., Stanković, D. M., Mutić, J. J., Pajović, S. B., & Tešević, V. (2017) · Scientia Horticulturae · doi:10.1016/j.scienta.2017.07.045 · Cited by 18
Natural Antioxidants Effect of Mulberry Fruits (Morus nigra and Morus alba L.) On Lipids Profile and Oxidative Stress in Hypercholestrolemic Rats
Mahmoud, M. Y. (2013) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2013.665.672 · Cited by 18
“10% had lowest value regulation of inflammatory mediators in human in malonaldhyde (MDA) and nitric oxide (NO) followed by microvascular endothelial cells (Youdim et al., 2002).”
Background
Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats
Martinelli, I., Tomassoni, D., Bellitto, V., Roy, P., Bonaventura, M. V. M. D., Amenta, F., Amantini, C., Cifani, C., & Tayebati, S. K. (2022) · Biology · doi:10.3390/biology11050646 · Cited by 17
“As reviewed by Mazza [18], many studies have revealed that anthocyanins show an extensive variety of biological actions, such as antioxidant [19,20], anti-inflammatory [21,22], and anti-carcinogenic activities [23]; induction of apoptosis [24]; and neuroprotective effects [25,26].”
Background
An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its Efficacy in Reducing Microglia-Driven Neuroinflammation after Simulated Digestion
Serra, D., Henriques, J. F., Serra, T., Bento‐Silva, A., Bronze, M. R., Dinis, T. C. P., & Almeida, L. M. (2020) · Nutrients · doi:10.3390/nu12123670 · Cited by 16
Studies on the extraction of Jerusalem artichoke tuber phenolics using microwave-assisted extraction optimized conditions
Afoakwah, N. A., Zhao, Y., Tchabo, W., Dong, Y., Owusu, J., & Mahunu, G. K. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100507 · Cited by 16
Combined Osmotic and Membrane Distillation for Concentration of Anthocyanin from Muscadine Pomace
Anari, Z., Mai, C., Sengupta, A., Howard, L. R., Brownmiller, C., & Wickramasinghe, S. R. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14717 · Cited by 16
Anti-Inflammatory Effects of the Methanol Extract of Sedum telephium ssp. maximum in Lipopolysaccharide- Stimulated Rat Peritoneal Macrophages
Altavilla, D., Polito, F., Bitto, A., Minutoli, L., Miraldi, E., Fiumara, T., Biagi, M., Marini, H. R., Giachetti, D., Vaccaro, M., et al. (2008) · Pharmacology · doi:10.1159/000157626 · Cited by 16

Authors: Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A.
Affiliations: Tufts University (US)
Agriculture and Agri-Food Canada (CA)
Corresponding author: Youdim, Kuresh A.
ORCID: Youdim, Kuresh A.
Joseph, James A.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2002-05
Volume: 13
Issue: 5
Pages: 282-288
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/s0955-2863(01)00221-2
OpenAlex: W1868361743
Cited by: 319
References: 40
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 31 · 2012: 20
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Cranberry Institute
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: dietary flavonoids, blueberry polyphenols, cranberry polyphenols, anthocyanins, hydroxycinnamic acids, microvascular endothelial cells, oxidative stress, TNF-α, inflammation, antioxidant activity, interleukin-8, MCP-1, ICAM-1, vascular disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks