The effects of eicosapentaenoic acid-fortified food on inflammatory markers in healthy subjects – a randomized, placebo-controlled, double-blind study
Open accessAbstract
Epidemiological studies showed that habitual fish intakes were associated with lower blood inflammatory markers. In the present study the effects of a fish oil-containing food on inflammatory markers were investigated in healthy, mostly middle-aged subjects (59 men and 82 women) with normal to mildly elevated triglyceride levels. Study subjects were randomly allocated to two groups in a double-blind manner; one group ingested an eicosapentaenoic acid (EPA)-rich fish oil-fortified drink (0.60 g EPA+0.26 g docosahexaenoic acid/d. EPA group, n=68) for 12 wk. The rest of the subjects took a placebo (control group, n=73). Plasma levels of high sensitivity C-reactive protein (hs-CRP) and soluble tumor necrosis factor-receptors 1 and 2 (sTNF-Rs 1 and 2) were measured at the start and end of intervention. EPA concentrations in the total RBC phospholipid fraction significantly increased by 79% in the EPA group at the end of the study, and they changed very little in the control group (+0.68%). The inflammatory markers did not change in either group. It is likely that fish oil does not change hs-CRP or sTNF-Rs 1 or 2 in subjects without active inflammation.
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There was no association of vitamin D status with serum CRP concentration in 650 Amish adults.
“Likewise, there was no association of vitamin D status with serum CRP concentration in 650 Amish (742) or with CRP, sICAM-1, MCP-1, IFN-g, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13 or IL-17 concentrations in 437 overweight adults (743) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [742]
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- Authors
- FUJIOKA, S., HAMAZAKI, K., ITOMURA, M., HUAN, M., NISHIZAWA, H., SAWAZAKI, S., KITAJIMA, I., & HAMAZAKI, T.
- Affiliations
- University of Toyama (JP)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 2006
- Volume
- 52
- Issue
- 4
- Pages
- 261-265
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2034744372
- Cited by
- 36
- References
- 21
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- eicosapentaenoic acid, fish oil, docosahexaenoic acid, inflammatory markers, C-reactive protein, soluble tumor necrosis factor receptor, red blood cell phospholipids, omega-3 fatty acids, triglyceride levels, healthy adults
- MeSH terms
- Adult, Beverages, C-Reactive Protein, Double-Blind Method, Female, Fish Oils, Food, Fortified, Humans, Inflammation, Male, Middle Aged, Placebos, Eicosapentaenoic Acid, Biomarkers, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II
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