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Cited by 269

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)

Open access
Nissen, Steven L., Abumrad, Naji N.·1997·The Journal of Nutritional Biochemistry
DOI 10.1016/s0955-2863(97)00048-x
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Abstract

This review develops the hypothesis that a metabolite of leucine termed β-hydroxy β-methylbutyrate (HMB) plays a key role in animal metabolism and that in certain circumstances insufficient amounts of HMB are either consumed in the diet or produced endogenously to supply tissue needs. The origin and metabolism of HMB is reviewed including the role of HMB in cholesterol biosynthesis. HMB feeding studies in animals are reviewed, which indicate that dietary supplementation of HMB can improve immune function and health and can increase the fat content of milk in lactating animals. Seven human studies are reviewed where HMB was fed. The results of both animal and human studies indicate that dietary supplementation of HMB is safe, as evidenced by lack of physical adverse effects and a lack of effect on blood hematology and chemistry. The only consistent change in blood chemistry was a decrease in LDL cholesterol, which changed 7% (P < .01). In humans undergoing resistance training, HMB supplementation increased lean mass gains from 50 to 200%, with similar percentage increases in strength when compared with unsupplemented subjects. The effects of HMB on muscle size and function seems to result from a diminution of exercise-related muscle damage and muscle protein breakdown. A general hypothesis is proposed that HMB is metabolized to HMG-CoA in tissues such as muscle, mammary tissue, and certain immune cells and is used for de novo cholesterol synthesis. In times of stimulated growth and/or differentiation. HMG-CoA may be rate-limiting for cholesterol synthesis, which could limit cell growth or function. It is proposed that feeding HMB can provide a saturating source of cytosolic HMG-CoA for cholesterol synthesis and in turn allow for maximal cell growth and function.

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Metadata

Authors
Nissen, S. L., & Abumrad, N. N.
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
1997-06
Volume
8
Issue
6
Pages
300-311
ISSN
0955-2863 (ISSN-L)
DOI
10.1016/s0955-2863(97)00048-x
OpenAlex
W2009214395
Cited by
269
References
2
FWCI
2.05
Type
journal article
Language
en
Open access
hybrid

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