Brain mechanisms in normal and dyslexic readers
Abstract
Developmental dyslexics, individuals with an unexplained difficulty reading, have been shown to have deficits in phonological processing -- the awareness of the sound structure of words -- and, in some cases, a more fundamental deficit in rapid auditory processing. In addition, dyslexics show a disruption in white matter connectivity between posterior and frontal regions. These results give continued support for a neurobiological etiology of developmental dyslexia. However, more research will be required to determine the possible causal relationships between these neurobiological disruptions and dyslexia.
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Individuals with dyslexia have decreased activity relative to controls in left temporo-parietal cortex during phonological processing.
“Individuals with dyslexia have decreased activity (relative to controls) in left temporo-parietal cortex during phonological processing.”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [5]
Studies of brain function have shown a neural deficit in dyslexia during phonological processing.
“In addition to behavioral deficits in phonological processing, studies of brain function have shown a neural deficit in dyslexia during phonological processing (5).”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [5]
Left temporo-parietal cortex is involved in phonological processing in children and adults and is disrupted in children and adults with dyslexia during phonological processing.
“Left temporo-parietal cortex has been shown to be involved in phonological processing in children and adults and to be disrupted in children and adults with dyslexia during phonological processing (5, 12, 28–32).”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [5]
The commonly observed dysfunction in dyslexics' left temporo-parietal brain function can be at least partly ameliorated through behavioral remediation.
“Finally, these results demonstrated that the commonly observed dysfunction in dyslexics' left temporo-parietal brain function (5) can be at least partly ameliorated through behavioral remediation.”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [5]
After remediation, children with dyslexia showed increased activity in brain regions previously found underactive in children and adults with dyslexia compared with controls.
“Children with dyslexia showed increased activity after remediation in brain regions that had previously been underactive in children (and adults) with dyslexia as compared with controls (5, 12).”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [5]
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- Authors
- Temple, E.
- Affiliations
- Cornell University (US)
- Corresponding author
- Temple, Elise
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 12
- Issue
- 2
- Pages
- 178-183
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2007229377
- Cited by
- 173
- References
- 43
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 15
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- developmental dyslexia, phonological processing, white matter connectivity, reading, neural mechanisms
- MeSH terms
- Auditory Perception, Brain, Child, Child Development, Dyslexia, Frontal Lobe, Humans, Magnetic Resonance Imaging, Parietal Lobe, Reading, Speech Perception, Temporal Lobe
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