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Cited by 66Neuroendocrine regulation and behaviorAnimal Behavior and ReproductionNeurotransmitter Receptor Influence on Behavior

Field tests of cis-regulatory variation at the prairie vole avpr1a locus: association with V1aR abundance but not sexual or social fidelity

OPHIR, A, CAMPBELL, P, HANNA, K, PHELPS, S·2008·Hormones and Behavior
DOI 10.1016/j.yhbeh.2008.07.009
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Abstract

The neuropeptide vasopressin and its receptor V1aR are broadly implicated in social behavior and play a central role in several key aspects of male mating tactics in voles. In the prairie vole, a microsatellite in the cis-regulatory region of the gene encoding V1aR (avpr1a) provides a potential genetic basis for individual variation in neural phenotype and behavior; recent studies found that allele length predicts V1aR expression and male social attachment in the laboratory. Here, we explore the relationship between avpr1a microsatellite length, V1aR neural phenotype, and field measures of monogamy and fitness in male prairie voles. We found significant effects of allele length on V1aR expression in structures integral to pairbond formation. These effects did not, however, translate to differences in mating tactics or reproductive success. Together, these data suggest that, while length polymorphism in the avpr1a microsatellite influences neuronal phenotype, this variation does not contribute significantly to male reproductive success and field behavior. We propose that previously reported behavioral effects may be mediated primarily by sequence variation at this locus, for which allele length is an imperfect proxy. By combining genetic, neuronal and ecological approaches, these data provide novel insights into the contribution of genotype to natural diversity in brain and behavior.

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Crossref · 10.1016/j.yhbeh.2008.07.009

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  • V1aR density in the posterior cingulated/retrosplenial cortex predicted reproductive success in "wanderers".

    “Instead, V1aR density in the posterior cingulated/retrosplenial cortex, a region of the brain involved in spatial learning and memory predicted reproductive success in “wanderers”.”

    From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [3]

  • Prairie voles and related vole species are easily maintained and housed in standard rodent vivariums.

    “Prairie voles and related vole species are easily maintained and housed in standard rodent vivariums and are also routinely studied in their natural and semi-natural habitats [3, 4] (Box 1).”

    From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [3]

  • Prairie voles are routinely studied in their natural and semi-natural habitats.

    “Prairie voles and related vole species are easily maintained and housed in standard rodent vivariums and are also routinely studied in their natural and semi-natural habitats [3, 4] (Box 1).”

    From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [3]

  • Levels of V1aR in the ventral pallidum and lateral septum did not correspond to male mating tactic, male mating success, nor the male's propensity to engage in extra-pair copulations.

    “Surprisingly, although AVPR1A in the ventral pallidum and lateral septum have been shown to be involved in the regulation of partner preference formation and paternal care, levels of V1aR in these regions did not correspond to male mating tactic, male mating success, nor the male’s propensity to engage in extra-pair copulations.”

    From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [3]

  • In Ophir et al. (2008), most male prairie voles (74%) were classified as a member of a bonded pair, while the remaining males assumed the "wandering" tactic.

    “Most males (74%) were classified as a member of a bonded pair, while the remaining males assumed the “wandering” tactic.”

    From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [3]

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Authors
OPHIR, A., CAMPBELL, P., HANNA, K., & PHELPS, S.
Affiliations
University of Florida (US)
Corresponding author
OPHIR, A
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2008-11
Volume
54
Issue
5
Pages
694-702
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2008.07.009
OpenAlex
W2056703671
Cited by
66
References
45
Citations by year
2024: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 10 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 3
FWCI
7.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
Microtus ochrogaster, AVPR1A, vasopressin V1a receptor, cis-regulatory variation, microsatellite polymorphism, allele length, monogamy, male reproductive success, mating strategies, social attachment, neuropeptide signaling
MeSH terms
Animals, Base Sequence, Arvicolinae, Embryo, Mammalian, Female, Genotype, Male, Molecular Sequence Data, Pregnancy, Regulatory Sequences, Nucleic Acid, Sexual Behavior, Animal, Genetic Variation, Receptors, Vasopressin, Ecosystem, Microsatellite Repeats

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