Cited by 1,948RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

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AU-rich elements: characterization and importance in mRNA degradation

Chen, Chyi-Ying A., Shyu, Ann-Bin·1995·Trends in Biochemical Sciences

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Abstract

Adenylate/uridylate-rich elements (AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors and cytokines. They represent the most common determinant of RNA stability in mammalian cells. Moreover, ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene expression during cell growth and differentiation, and in the immune response.

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A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946
mRNA stability in mammalian cells
Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411
Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway
Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G. C. L., & Thompson, C. B. (1989) · Science · doi:10.1126/science.2540528 · Cited by 866
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
Piñol-Roma, S., & Dreyfuss, G. (1992) · Nature · doi:10.1038/355730a0 · Cited by 842
Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences
Treisman, R. (1985) · Cell · doi:10.1016/0092-8674(85)90285-5 · Cited by 776
Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences
Wilson, T., & Treisman, R. (1988) · Nature · doi:10.1038/336396a0 · Cited by 657
Degradation of mRNA in eukaryotes
Beelman, C. A., & Parker, R. (1995) · Cell · doi:10.1016/0092-8674(95)90326-7 · Cited by 656
The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation
Zubiaga, A. M., Belasco, J. G., & Greenberg, M. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2219 · Cited by 543
Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1
Zhang, W., Wagner, B., Ehrenman, K., Schaefer, A., DeMaria, C. T., Crater, D. L., DeHaven, K., Long, L., & Brewer, G. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7652 · Cited by 540
Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.Preprint
Shyu, A. B., Belasco, J. G., & Greenberg, M. E. (1991) · Genes & Development · doi:10.1101/gad.5.2.221 · Cited by 523
Self-citation

Show all 38 references

Research works printed but not linked: 9

Schiavi, 1992, Biochim. Biophys. Acta, 1114, 95
Caput, 1986, 83, 1670
Chen, 1994, Mol. Cell. Biol., 14, 416, 10.1128/MCB.14.1.416 · DOI
Lagnado, 1994, Mol. Cell. Biol., 14, 7984, 10.1128/MCB.14.12.7984 · DOI
Koeller, 1991, 88, 7778
Aharon, 1993, Mol. Cell. Biol., 13, 1971, 10.1128/MCB.13.3.1971 · DOI
Nakagawa, 1995, 92, 2051
Myer, 1995, RNA, 1, 171
Wodnar-Filipowicz, 1990, 87, 777

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Authors: Chen, C.-Y. A., & Shyu, A.-B.
Affiliations: The University of Texas Health Science Center at Houston (US)
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 1995-11
Volume: 20
Issue: 11
Pages: 465-470
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/s0968-0004(00)89102-1
OpenAlex: W2029706883
Cited by: 1,948
References: 38
Citations by year: 2026: 13 · 2025: 29 · 2024: 28 · 2023: 33 · 2022: 36 · 2021: 36 · 2020: 49 · 2019: 32 · 2018: 52 · 2017: 33 · 2016: 33 · 2015: 52 · 2014: 61 · 2013: 68 · 2012: 63
FWCI: 4.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM046454, GM-46454)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: AU-rich elements, mRNA degradation, 3' untranslated region, RNA stability, proto-oncogenes, transcription factors, cytokines, phorbol ester, calcium ionophore, gene expression regulation, cell growth and differentiation, immune response
MeSH terms: Adenine, Animals, Base Composition, Gene Expression Regulation, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Uracil, Signal Transduction, RNA-Binding Proteins, Conserved Sequence

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AU-rich elements: characterization and importance in mRNA degradation

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