AU-rich elements: characterization and importance in mRNA degradation

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Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

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Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

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Degradation of mRNA in eukaryotes

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The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

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Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

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Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.Preprint

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Complex Contribution of the 3′-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene

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UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002

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The Dynamics of Cytoplasmic mRNA Metabolism

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Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability

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Regulatory Functions of 3′UTRs

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Highly Selective Actions of HuR in Antagonizing AU-Rich Element-Mediated mRNA Destabilization

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Control of mRNA decay by phosphorylation of tristetraprolin

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Versatile Role for hnRNP D Isoforms in the Differential Regulation of Cytoplasmic mRNA Turnover

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Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling

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Modulation of mRNA stability as a novel therapeutic approach

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Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation

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Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

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The AU-Rich Transcriptome: More Than Interferons and Cytokines, and Its Role in Disease

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Specificity and Determinants of Sam68 RNA Binding

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Parallel and Independent Regulation of Interleukin-3 mRNA Turnover by Phosphatidylinositol 3-Kinase and p38 Mitogen-Activated Protein Kinase

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Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

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Gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

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Sequence, Haplotype, and Association Analysis of ADRβ2 in a Multiethnic Asthma Case-Control Study

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Nitric Oxide Increases the Decay of Matrix Metalloproteinase 9 mRNA by Inhibiting the Expression of mRNA-Stabilizing Factor HuR

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Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer

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The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

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Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

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Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock

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Posttranscriptional Regulation of IL-10 Gene Expression Through Sequences in the 3′-Untranslated Region

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Immunogenetics of Hashimoto's thyroiditis

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A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

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Chemokines and allergic disease

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Mnk kinase pathway: Cellular functions and biological outcomes

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The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.

Carrick, D. M., Lai, W. S., & Blackshear, P. J. (2004) · Arthritis Research · doi:10.1186/ar1441 · Cited by 163

A novel mRNA‐decapping activity in HeLa cytoplasmic extracts is regulated by AU‐rich elements

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The Wnt/β-Catenin→Pitx2 Pathway Controls the Turnover of Pitx2 and Other Unstable mRNAs

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Human TOB, an Antiproliferative Transcription Factor, Is a Poly(A)-Binding Protein-Dependent Positive Regulator of Cytoplasmic mRNA Deadenylation

Ezzeddine, N., Chang, T.-C., Zhu, W., Yamashita, A., Chen, C. A., Zhong, Z., Yamashita, Y., Zheng, D., & Shyu, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01254-07 · Cited by 162

Recognition of GU‐rich polyadenylation regulatory elements by human CstF‐64 protein

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ARED 2.0: an update of AU-rich element mRNA database

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Wilms' tumor 1-associating protein regulates G 2 /M transition through stabilization of cyclin A2 mRNA

Horiuchi, K., Umetani, M., Minami, T., Okayama, H., Takada, S., Yamamoto, M. P., Aburatani, H., Reid, P., Housman, D. E., Hamakubo, T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608357103 · Cited by 165

A CCCH-Type Zinc Finger Nucleic Acid-Binding Protein Quantitatively Confers Resistance against Rice Bacterial Blight Disease

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Defining a neuron: neuronal ELAV proteins

Pascale, A., Amadio, M., & Quattrone, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7017-y · Cited by 158

Translational Repression by RNA-Binding Protein TIAR

Mazan-Mamczarz, K., Lal, A., Martindale, J. L., Kawai, T., & Gorospe, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2716-2727.2006 · Cited by 159

Exonuclease hDIS3L2 specifies an exosome‐independent 3′‐5′ degradation pathway of human cytoplasmic mRNA

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Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements

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Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

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The K box, a conserved 3′ UTR sequence motif, negatively regulates accumulation of Enhancer of split Complex transcripts

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Mammalian CELF/Bruno-like RNA-binding proteins: molecular characteristics and biological functions

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The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance

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The Stability of Tristetraprolin mRNA Is Regulated by Mitogen-activated Protein Kinase p38 and by Tristetraprolin Itself

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Structural Basis of Dcp2 Recognition and Activation by Dcp1

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Cyclooxygenase-2 in oncogenesis

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Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling

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mRNA degradation machines in eukaryotic cells

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Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway

Stoecklin, G., Ming, X., Looser, R., & Moroni, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3753-3763.2000 · Cited by 153

Stability of a PKCI-1 -related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteinsPreprint

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MicroRNAs Distinguish Translational from Transcriptional Silencing during Endotoxin Tolerance

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RNA–protein interactions: disorder, moonlighting and junk contribute to eukaryotic complexity

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Functional Characterization of a Non-AUUUA AU-Rich Element from the c-jun Proto-Oncogene mRNA: Evidence for a Novel Class of AU-Rich Elements

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Rapid, Activity-Induced Increase in Tissue Plasminogen Activator Is Mediated by Metabotropic Glutamate Receptor-Dependent mRNA Translation

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Regulation of survival gene hsp70

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A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy

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Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk

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Regulation of innate immune response by MAP kinase phosphatase-1

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Differential Posttranscriptional Regulation of Androgen Receptor Gene Expression by Androgen in Prostate and Breast Cancer Cells

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Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

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MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Hegen, M., Gaestel, M., Nickerson‐Nutter, C. L., Lin, L., & Telliez, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1913 · Cited by 147

Regulation of c- myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant

Lemm, I., & Ross, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.3959-3969.2002 · Cited by 147

MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?

Clark, A. R. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780005 · Cited by 148

CD83: an update on functions and prospects of the maturation marker of dendritic cells

Prechtel, A. T., & Steinkasserer, A. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-007-0743-z · Cited by 150

Inhibition of Cd83 Cell Surface Expression during Dendritic Cell Maturation by Interference with Nuclear Export of Cd83 mRNA

Kruse, M., Rosorius, O., Krätzer, F., Bevec, D., Kuhnt, C., Steinkasserer, A., Schuler, G., & Hauber, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.9.1581 · Cited by 146

Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR

Mrena, J., Wiksten, J., Thiel, A., Kokkola, A., Pohjola, L. K., Lundin, J. E., Nordling, S., Ristimäki, A., & Haglund, C. H. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0764 · Cited by 144

Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma.

Erkinheimo, T.-L., Lassus, H. J., Sivula, A., Sengupta, S., Furneaux, H., Hla, T., Haglund, C. H., Bützow, R. C., & Ristimaki, A. P. (2003) · PubMed · Cited by 145

Xp54, the Xenopus Homologue of Human RNA Helicase p54, is an Integral Component of Stored mRNP Particles in Oocytes

Ladomery, M., Wade, E., & Sommerville, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.965 · Cited by 145

Identification of AUF1 (Heterogeneous Nuclear Ribonucleoprotein D) as a Component of the α-Globin mRNA Stability Complex

Kiledjian, M., DeMaria, C. T., Brewer, G., & Novick, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4870 · Cited by 145

Glucocorticoid-Induced Apoptosis of Healthy and Malignant Lymphocytes

Smith, L. K., & Cidlowski, J. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82001-1 · Cited by 147

RNA Sequence Elements Required for High Affinity Binding by the Zinc Finger Domain of Tristetraprolin

Brewer, B. Y., Malicka, J. B., Blackshear, P. J., & Wilson, G. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402551200 · Cited by 144

A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants

Chen, J., Férec, C., & Cooper, D. N. (2006) · Human Genetics · doi:10.1007/s00439-006-0218-x · Cited by 143

Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe

Sureban, S. M., Ramalingam, S., Natarajan, G., May, R. J., Subramaniam, D., Bishnupuri, K., Morrison, A. R., Dieckgraefe, B. K., Brackett, D. J., Postier, R. G., et al. (2008) · Oncogene · doi:10.1038/onc.2008.97 · Cited by 143

c‐jun N‐terminal kinase is involved in AUUUA‐mediated interleukin‐3 mRNA turnover in mast cells

Ming, X., Kaiser, M., & Moroni, C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.6039 · Cited by 141

Regulation of cellular homeostasis by galectins

Hsu, D. K., & Liu, F. (2002) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000014080.95829.52 · Cited by 142

Cell Cycle Regulation by Galectin-12, a New Member of the Galectin Superfamily

Yang, R., Hsu, D. K., Yu, L., Ni, J., & Liu, F. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010914200 · Cited by 142

Embryonic Lethal Abnormal Vision-Like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells

Aranda-Abreu, G. E., Behar, L., Chung, S., Furneaux, H., & Ginzburg, I. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06907.1999 · Cited by 142

GAPDH Binding to TNF-α mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism

Millet, P., Vachharajani, V., McPhail, L. C., Yoza, B. K., & McCall, C. E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501345 · Cited by 141

Novel Binding of HuR and Poly(C)-binding Protein to a Conserved UC-rich Motif within the 3′-Untranslated Region of the Androgen Receptor Messenger RNA

Yeap, B. B., Voon, D. C., Vivian, J. P., McCulloch, R. K., Thomson, A. M., Giles, K. M., Czyzyk-Krzeska, M., Furneaux, H., Wilce, M. C. J., Wilce, J. A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202883200 · Cited by 141

Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets

Winzen, R., Thakur, B. K., Dittrich‐Breiholz, O., Shah, M., Redich, N., Dhamija, S., Kracht, M., & Holtmann, H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01493-07 · Cited by 140

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

Nabeel‐Shah, S., Lee, H., Ahmed, N., Burke, G. L., Farhangmehr, S., Ashraf, K., Pu, S., Braunschweig, U., Zhong, G., Wei, H., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103562 · Cited by 145

Systems biology of the 2-cell mouse embryo

Evsikov, A. V., de Vries, W. N., Peaston, A. E., Radford, E. E., Fancher, K. S., Chen, F. H., Blake, J. A., Bult, C. J., Latham, K. E., Solter, D., et al. (2004) · Cytogenetic and Genome Research · doi:10.1159/000078195 · Cited by 144

Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR.

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A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice.

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The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

Schmidlin, M., Lu, M., Leuenberger, S. A., Stoecklin, G., Mallaun, M., Gross, B., Gherzi, R., Heß, D., Hemmings, B. A., & Moroni, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600477 · Cited by 138

A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3"-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression

Coy, J. F. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.7.1253 · Cited by 141

Adenosine-Dependent Airway Inflammation and Hyperresponsiveness in Partially Adenosine Deaminase-Deficient Mice

Chunn, J. L., Young, H. W. J., Banerjee, S. K., Colasurdo, G. N., & Blackburn, M. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4676 · Cited by 138

Tristetraprolin regulates TNF TNF-α mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways

Deleault, K. M., Skinner, S. J., & Brooks, S. A. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.05.017 · Cited by 137

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

Jain, A., Song, R., Wakeland, E. K., & Pasare, C. (2018) · Nature Communications · doi:10.1038/s41467-018-05489-7 · Cited by 137

Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins

Quattrone, A., Pascale, A., Nogues, X., Zhao, W., Gusev, P., Pacini, A., & Alkon, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191388398 · Cited by 137

Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation

Handy, D. E., Zhang, Y., & Loscalzo, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501452200 · Cited by 138

HuA and Tristetraprolin Are Induced following T Cell Activation and Display Distinct but Overlapping RNA Binding Specificities

Raghavan, A., Robison, R. L., McNabb, J., Miller, C. R., Williams, D. A., & Bohjanen, P. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109511200 · Cited by 136

The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U

Cok, S. J., Acton, S. J., & Morrison, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302547200 · Cited by 136

Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

Mugridge, J. S., Coller, J., & Gross, J. D. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0164-z · Cited by 133

The Search for Trans-Acting Factors Controlling Messenger RNA Decay

Wilson, G. M., & Brewer, G. (1998) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60510-3 · Cited by 135

Increased p21CIP1/WAF1 and B Cell Lymphoma Leukemia-xL Expression and Reduced Apoptosis in Alveolar Macrophages from Smokers

Tomita, K., Caramori, G., Lim, S., Ito, K., Hanazawa, T., Oates, T., Chiselita, I., Jazrawi, E., Chung, K. F., Barnes, P. J., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2104010 · Cited by 134

AU-rich Elements in the 3′-Untranslated Region of a New Mucin-type Gene Family of Trypanosoma cruzi Confers mRNA Instability and Modulates Translation Efficiency

Noia, J. M. D., D’Orso, I., Sánchez, D. O., & Frasch, A. C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10218 · Cited by 134

Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch

Zeng, X., Wang, S.-X., Zhu, Y., Zhu, S., & Li, W. (2004) · Peptides · doi:10.1016/j.peptides.2003.12.003 · Cited by 133

Helicobacter pyloriand interleukin-8 in gastric cancer

Lee, K. E. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i45.8192 · Cited by 132

The AU-rich element,an important element of post-transcriptional regulation

Zhang, W. (2011) · Basic & Clinical Medicine

AU-Rich Elements (ARE)

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_1342

Assays of Adenylate Uridylate-Rich Element-Mediated mRNA Decay in Cells

Ysla, R. M., Wilson, G. M., & Brewer, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)02403-8 · Cited by 29

AU-rich elements and associated factors: are there unifying principles?

Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 907

Perspectives on the ARE as it turns 25 years old

Beisang, D. J., & Bohjanen, P. R. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1125 · Cited by 56