AU-rich elements: characterization and importance in mRNA degradation

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946

mRNA stability in mammalian cells

Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G. C. L., & Thompson, C. B. (1989) · Science · doi:10.1126/science.2540528 · Cited by 866

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

Piñol-Roma, S., & Dreyfuss, G. (1992) · Nature · doi:10.1038/355730a0 · Cited by 842

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

Treisman, R. (1985) · Cell · doi:10.1016/0092-8674(85)90285-5 · Cited by 776

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

Wilson, T., & Treisman, R. (1988) · Nature · doi:10.1038/336396a0 · Cited by 657

Degradation of mRNA in eukaryotes

Beelman, C. A., & Parker, R. (1995) · Cell · doi:10.1016/0092-8674(95)90326-7 · Cited by 656

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

Zubiaga, A. M., Belasco, J. G., & Greenberg, M. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2219 · Cited by 543

Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

Zhang, W., Wagner, B., Ehrenman, K., Schaefer, A., DeMaria, C. T., Crater, D. L., DeHaven, K., Long, L., & Brewer, G. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7652 · Cited by 540

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.Preprint

Shyu, A. B., Belasco, J. G., & Greenberg, M. E. (1991) · Genes & Development · doi:10.1101/gad.5.2.221 · Cited by 523

IL‐6 in inflammation, immunity, and disease

Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046

Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,911

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292

HuR and mRNA stability

Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095

AU-rich elements and associated factors: are there unifying principles?

Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 907

A large-scale analysis of mRNA polyadenylation of human and mouse genes

Tian, B. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki158 · Cited by 970

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

Fan, X. C., & Steitz, J. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3448 · Cited by 866

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

Wan, Y. Y., & Flavell, R. A. (2007) · Nature · doi:10.1038/nature05479 · Cited by 876

Tools for translation: non-viral materials for therapeutic mRNA delivery

Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799

The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism

Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C. A., Shyu, A., Müller, M., Gaestel, M., Resch, K., & Holtmann, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4969 · Cited by 770

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

Vandooren, J., den Steen, P. E. V., & Opdenakker, G. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.770819 · Cited by 790

Vascular endothelial growth factor in eye disease

Penn, J. S., Madan, A., Caldwell, R. B., Bartoli, M., Caldwell, R. W., & Hartnett, M. E. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.001 · Cited by 784

The cap-to-tail guide to mRNA turnover

Wilusz, C. J., Wormington, M., & Peltz, S. W. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067025 · Cited by 762

RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein

Peng, S., Chen, C. A., Xu, N., & Shyu, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3461 · Cited by 739

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00578-5 · Cited by 865

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Lai, W. S., Carballo, E., Strum, J. R., Kennington, E. A., Phillips, R. S., & Blackshear, P. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4311 · Cited by 730

Regulation of mRNA stability in mammalian cells

Guhaniyogi, J., & Brewer, G. (2001) · Gene · doi:10.1016/s0378-1119(01)00350-x · Cited by 729

A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes

Kent, O. A., & Mendell, J. T. (2006) · Oncogene · doi:10.1038/sj.onc.1209913 · Cited by 715

THE HIV-1 REV PROTEIN

Pollard, V. W., & Malim, M. H. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.491 · Cited by 715

Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

Bhat, N. R., Zhang, P., Lee, J. C., & Hogan, E. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01633.1998 · Cited by 714

TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis

Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu, Y., Scott, H. S., Hession, C. A., Garcia, I., & Browning, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32401 · Cited by 690

Intracellular functions of galectins

Liu, F. T. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00313-6 · Cited by 676

Patterns of Variant Polyadenylation Signal Usage in Human GenesPreprint

Beaudoing, E., Freier, S. M., Wyatt, J. R., Claverie, J., & Gautheret, D. (2000) · Genome Research · doi:10.1101/gr.10.7.1001 · Cited by 676

Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

Levy, N. S., Chung, S., Furneaux, H., & Levy, A. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6417 · Cited by 672

Regulation of cytoplasmic mRNA decay

Schoenberg, D. R., & Maquat, L. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3160 · Cited by 656

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

Orang, A., Safaralizadeh, R., & Kazemzadeh, M. (2014) · International Journal of Genomics · doi:10.1155/2014/970607 · Cited by 675

Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

Sharova, L. V., Sharov, A. A., Nedorezov, T., Piao, Y., Shaik, N., & Ko, M. S. H. (2009) · DNA Research · doi:10.1093/dnares/dsn030 · Cited by 591

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

Barrett, L. W., Fletcher, S., & Wilton, S. D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0990-9 · Cited by 641

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

Ji, Z., Lee, J. Y., Pan, Z., Jiang, B., & Tian, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900028106 · Cited by 609

Regulation by 3′-Untranslated Regions

Mayr, C. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024704 · Cited by 588

Diverse molecular functions of Hu proteins

Hinman, M. N., & Lou, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8252-6 · Cited by 587

Genome-wide screening and functional analysis identify a large number of long noncoding RNAs involved in the sexual reproduction of rice

Zhang, Y., Liao, J., Li, Z.-Y., Yu, Y., Zhang, J., Li, Q., Qu, L., Shu, W., & Chen, Y. (2014) · Genome biology · doi:10.1186/s13059-014-0512-1 · Cited by 553

vrille, Pdp1, and dClock Form a Second Feedback Loop in the Drosophila Circadian Clock

Cyran, S. A., Buchsbaum, A. M., Reddy, K. L., Lin, M.-C., Glossop, N. R. J., Hardin, P. E., Young, M. W., Storti, R. V., & Blau, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00074-6 · Cited by 546

HuR Regulates p21 mRNA Stabilization by UV Light

Wang, W., Furneaux, H., Cheng, H., Caldwell, M. C., Hutter, D., Liu, Y., Holbrook, N. J., & Gorospe, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.760-769.2000 · Cited by 539

The 3′ untranslated region of messenger RNA: A molecular ‘hotspot’ for pathology?

Conne, B., Stutz, A., & Vassalli, J. (2000) · Nature Medicine · doi:10.1038/76211 · Cited by 524

Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression

Abdelmohsen, K., Pullmann, R., Lal, A., Kim, H. H., Galbán, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.011 · Cited by 540

MK2‐induced tristetraprolin:14‐3‐3 complexes prevent stress granule association and ARE‐mRNA decay

Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S., Rigby, W. F., Blackwell, T. K., & Anderson, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600163 · Cited by 448

Posttranscriptional Upregulation by MicroRNAs

Vasudevan, S. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.121 · Cited by 536

Identification of a target RNA motif for RNA-binding protein HuR

de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306453101 · Cited by 502

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

Wu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

Pijlman, G. P., Funk, A., Kondratieva, N., Leung, J. Y., Torres, S., van der Aa, L. M., Liu, W. J., Palmenberg, A. C., Shi, P., Hall, R. A., et al. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.007 · Cited by 491

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1Preprint

Lykke‐Andersen, J., & Wagner, E. (2005) · Genes & Development · doi:10.1101/gad.1282305 · Cited by 486

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

Fan, X. C., & STEITZ, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15293 · Cited by 475

Analysis of Upstream Elements in the HuC Promoter Leads to the Establishment of Transgenic Zebrafish with Fluorescent Neurons

Park, H., Kim, C., Bae, Y., Yeo, S., Kim, S.-H., Hong, S., Shin, J., Yoo, K., Hibi, M., Hirano, T., et al. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9898 · Cited by 460

A KH Domain RNA Binding Protein, KSRP, Promotes ARE-Directed mRNA Turnover by Recruiting the Degradation Machinery

Gherzi, R., Lee, K., Briata, P., Wegmüller, D., Moroni, C., Karin, M., & Chen, C. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.002 · Cited by 463

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

Masamha, C. P., Xia, Z., Yang, J., Albrecht, T. R., Li, M., Shyu, A., Li, W., & Wagner, E. J. (2014) · Nature · doi:10.1038/nature13261 · Cited by 450

Mitogen-Activated Protein Kinase p38 Controls the Expression and Posttranslational Modification of Tristetraprolin, a Regulator of Tumor Necrosis Factor Alpha mRNA Stability

Mahtani, K. R., Brook, M., Dean, J. L. E., Sully, G., Saklatvala, J., & Clark, A. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.6461-6469.2001 · Cited by 450

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

Wang, W., Caldwell, M. C., Lin, S., Furneaux, H., & Gorospe, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2340 · Cited by 446

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation

Xie, M., Yu, T., Jing, X., Ma, L., Fan, Y. J., Yang, F., Ma, P., Jiang, H., Wu, X., Shu, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01208-3 · Cited by 433

Post-transcriptional control of cytokine production

Anderson, P. (2008) · Nature Immunology · doi:10.1038/ni1584 · Cited by 376

MAPKAP kinases — MKs — two's company, three's a crowd

Gaestel, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1834 · Cited by 413

Molecular mechanisms of glucocorticoid action and resistance

Schaaf, M. J. M., & Cidlowski, J. A. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00263-7 · Cited by 421

Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade

Lasa, M., Mahtani, K. R., Finch, A. J., Brewer, G., Saklatvala, J., & Clark, A. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4265-4274.2000 · Cited by 413

Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase

Münzel, T. F., Daiber, A., Ullrich, V., & Mülsch, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000168896.64927.bb · Cited by 421

Interleukin (IL-6) ImmunotherapyPreprint

Tanaka, T., Narazaki, M., & Kishimoto, T. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028456 · Cited by 419

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

Sethi, P., & Lukiw, W. J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.052 · Cited by 409

ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins

Bakheet, T. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.246 · Cited by 403

Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays

Tenenbaum, S. A., Carson, C. C., Lager, P. J., & Keene, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14085 · Cited by 407

MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels

Neininger, A., Kontoyiannis, D. L., Kotlyarov, A., Winzen, R., Eckert, R., Volk, H., Holtmann, H., Kollias, G. A., & Gaestel, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100685200 · Cited by 394

mRNA therapeutics in cancer immunotherapy

Beck, J. D., Reidenbach, D., Salomon, N., Sahin, U., Türeci, Ö., Vormehr, M., & Kranz, L. M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01348-0 · Cited by 385

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activationPreprint

Chen, C., Gherzi, R., Andersen, J., Gaietta, G. M., Jürchott, K., Royer, H. D., Mann, M., & Karin, M. (2000) · Genes & Development · doi:10.1101/gad.14.10.1236 · Cited by 380

Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

Brennan, C. M., Gallouzi, I., & STEITZ, J. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.1 · Cited by 377

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Lam, L. T., Pickeral, O. K., Peng, A. C., Rosenwald, A., Hurt, E. M., Giltnane, J. M., Averett, L., Zhao, H. G., Davis, R. E., Sathyamoorthy, M., et al. (2001) · Genome biology · doi:10.1186/gb-2001-2-10-research0041 · Cited by 371

The plasminogen activator system: biology and regulation

Irigoyen, J. P., Muñoz‐Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 370

Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay

Lykke‐Andersen, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.23.8114-8121.2002 · Cited by 368

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d

Hudson, B. P., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb738 · Cited by 336

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU‐rich elements

Mukherjee, D., Gao, M., O'Connor, J. P., Raijmakers, R., Pruijn, G. J. M., Lutz, C. S., & Wilusz, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.1.165 · Cited by 365

Multiple modes of RNA recognition by zinc finger proteins

Hall, T. M. T. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.04.004 · Cited by 365

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.

Matoulkova, E., Michalova, E., Vojtesek, B., & Hrstka, R. (2012) · RNA Biology · doi:10.4161/rna.20231 · Cited by 357

Modulation of the Fate of Cytoplasmic mRNA by AU-Rich Elements: Key Sequence Features Controlling mRNA Deadenylation and Decay

Xu, N., Chen, C. A., & Shyu, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4611 · Cited by 350

Stabilization of Interleukin-2 mRNA by the c-Jun NH 2 -Terminal Kinase Pathway

Chen, C., Gatto–Konczak, F. D., Wu, Z., & Karin, M. (1998) · Science · doi:10.1126/science.280.5371.1945 · Cited by 349

Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes

Meyer, S., Temme, C., & Wahle, E. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490513991 · Cited by 342

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

Tone, M., Tone, Y., Adams, E., Yates, S. F., Frewin, M. R., Cobbold, S. P., & Waldmann, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334901100 · Cited by 345

Genome-Wide Analysis of mRNA Stability Using Transcription Inhibitors and Microarrays Reveals Posttranscriptional Control of Ribosome Biogenesis Factors

Grigull, J., Mnaimneh, S., Pootoolal, J., Robinson, M. D., & Hughes, T. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5534-5547.2004 · Cited by 342

Endocan or endothelial cell specific molecule-1 (ESM-1): A potential novel endothelial cell marker and a new target for cancer therapy

Sarrazin, S., Adam, E., Lyon, M., Depontieu, F., Motte, V., Landolfi, C., Lortat‐Jacob, H., Béchard, D., Lassalle, P., & Delehedde, M. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.08.004 · Cited by 349

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

Diehn, M., Alizadeh, A. A., Rando, O. J., Liu, C. L., Stankunas, K., Botstein, D., Crabtree, G. R., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092284399 · Cited by 332

Evolution and Biological Roles of Alternative 3′UTRs

Mayr, C. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.012 · Cited by 343

Mechanisms of deadenylation‐dependent decay

Chen, C. A., & Shyu, A. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.40 · Cited by 353

Life and death in the cytoplasm: messages from the 3′ end

Wickens, M., Anderson, P., & Jackson, R. J. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80132-3 · Cited by 332

HuR binding to cytoplasmic mRNA is perturbed by heat shock

Gallouzi, I., Brennan, C. M., Stenberg, M. G., Swanson, M. S., Eversole, A., Maizels, N., & STEITZ, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3073 · Cited by 326

ARED 3.0: the large and diverse AU-rich transcriptome

Bakheet, T. M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj052 · Cited by 327

Post‐transcriptional regulation of gene expression by degradation of messenger RNAs

Bevilacqua, A., Ceriani, M. C., Capaccioli, S., & Nicolin, A. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10272 · Cited by 320

HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.

Nabors, B., Gillespie, G. Y., Harkins, L. E., & King, P. H. (2001) · PubMed · Cited by 312

Control of messenger RNA stability in higher eukaryotes

Ross, J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10016-0 · Cited by 313

The urokinase plasminogen activator system: a target for anti-cancer therapy

Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787314002 · Cited by 312

Cytoplasmic Polyadenylation in Development and Beyond

Richter, J. D. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.446-456.1999 · Cited by 299

Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay

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(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_1342

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